CN1739595A - Dangshen oral liquid - Google Patents
Dangshen oral liquid Download PDFInfo
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- CN1739595A CN1739595A CN 200510012819 CN200510012819A CN1739595A CN 1739595 A CN1739595 A CN 1739595A CN 200510012819 CN200510012819 CN 200510012819 CN 200510012819 A CN200510012819 A CN 200510012819A CN 1739595 A CN1739595 A CN 1739595A
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- radix codonopsis
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Abstract
The Dangshen oral liquid has the effective part extract of Dangshen and the effective part extract is prepared with Dangshen and through crushing, twice or thrice decoction in water of 7-10 times for 2-3 hr each, filtering to obtain filtrate, decompression concentrating to obtain the concentrated effective part extract. The Dangshen oral liquid has specific weight of 1.10-1.20 measured at 70-80 deg.c, contains Dangshen polysaccharide in 5-15 % and is packed in glass bottle, plastic bottle or aluminum foil bag in 10-30 ml each.
Description
Technical field
The present invention is a kind of preparation dangshen oral liquid of Radix Codonopsis effective part extract preparation.
Technical background
The Chinese crude drug Radix Codonopsis is traditional tcm clinical first-selection, be invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, strengthening the body resistance, strengthening by means of tonics and antidotal key medicine, be applicable to all cards of deficiency of both the splenic and pulmonary QI, many Chinese and overseas scholars have carried out extensive studies with regard to its kind, plant, pharmacology and each side such as clinical, confirm that Radix Codonopsis has many-sided pharmacological action, be made into the soft extract dosage form, be used for clinical.
In the prior art, traditional water alcohol method preparation technology, the asiabell effective ingredient glycocalix is used as " impurity " and is removed, and most of Radix Codonopsis polysaccharide composition is dropped behind precipitate with ethanol, affect the treatment, and alcohol precipitation process consumption alcohol amount is big.
In addition, commercially available Radix codonopsis pilosulae's oral liquid (the accurate word Z20059002 of traditional Chinese medicines), though with the Radix Codonopsis polysaccharide is to indicate component, carries the secondary alcohol precipitation process because of adopting water, causes the asiabell effective ingredient polysaccharide to be lost in a large number, with its Radix Codonopsis polysaccharide content of high-pressure liquid phase chromatogram therapy determining only about 1%, press Radix Codonopsis clinical treatment radiacmeter, take 10-15 at every turn and prop up, 2 times on the one, need 20-30 to prop up, just can reach therapeutic dose.
Summary of the invention
It is low to the present invention is directed to the Radix Codonopsis asiabell effective ingredient polyoses content that exists in the prior art, the technical problem of weak curative effect, the dangshen oral liquid that provides a kind of Radix Codonopsis active ingredient Radix Codonopsis polysaccharide content to make at Radix Codonopsis polysaccharide extract's concentrated solution of 5-15%.
The present invention realizes by following technical proposal:
Dangshen oral liquid is characterized in that being made by following method:
Step 1, the preparation method of Radix Codonopsis effective site Radix Codonopsis polysaccharide extract concentrated solution;
A, dedusting are cleaned: with the raw material Radix Codonopsis decontamination and the medicine that goes mouldy, flushing with clean water;
B, chopping:, be cut into the section of 2-4cm with codonopsis pilosula;
C, decoction: with the Radix Codonopsis section that cuts, put into Decocting pot and decoct, add the pure water that 7-10 doubly measures, decoct 2-3 time, each 2-3 hour, filter merging filtrate;
D, concentrated: the filtrate of merging, being evaporated to proportion is 1.10-1.20, temperature is 70-80 ℃ and records;
Step 2 prepares dangshen oral liquid with Radix Codonopsis effective site Radix Codonopsis polysaccharide extract concentrated solution;
A, be taken at temperature 70-80 ℃ and record, proportion is 1.10-1.20; Content is Radix Codonopsis polysaccharide extract's concentrated solution of 5-15%;
B, be that 10-30ml/ props up, be loaded in washed glass bottle, plastic bottle or the aluminium foil bag and seal sterilization promptly according to the cubage loading amount.
The proportion of dangshen oral liquid extract of the present invention is 1.10-1.11,70 ℃ of surveys, and it is 5-8% that high pressure lipuid chromatography (HPLC) records Radix Codonopsis polysaccharide content, loading amount is that 18-30ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
The proportion of dangshen oral liquid extract of the present invention is 1.11-1.15,75 ℃ of surveys, and high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 8-11%, loading amount is that 15-20ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
The proportion of dangshen oral liquid extract of the present invention is 1.15-1.20,80 ℃ of surveys, high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 11-15%, and loading amount is that 10-15ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
Technical scheme of the present invention is patent of invention " preparation method of a kind of Radix Codonopsis effective site and preparation Radix Codonopsis soft extract thereof " (this invention patent applied for the inventor, application number 200410012172.7, patent publication No. CN1559500A) the dangshen oral liquid preparation that development increases on the basis, physicochemical property according to the Radix Codonopsis effective part extract, take extraction process by water, effective site and active component group with codonopsis pilosula are all kept, and are prepared into the oral liquid of various content.The advantage accurate according to oral liquid formulations dosage, that the loading amount size is easily flexible has designed oral liquid effective site Radix Codonopsis polysaccharide content 5-15%, and all size dangshen oral liquid of loading amount 10-30ml is to satisfy clinical and demand market.
Advantage of the present invention and beneficial effect:
1, Radix Codonopsis effective site Radix Codonopsis polysaccharide and other effective part groups are all water-soluble, and Radix Codonopsis polysaccharide is insoluble to alcohol, and the extract that water extraction process obtains can keep the property of medicine of crude drug Radix Codonopsis;
2, the total sugar content of Radix Codonopsis is up to about 40%, and all the other are fructose and a small amount of glucose, sucrose to its component except that Radix Codonopsis polysaccharide, boil through decocting and are concentrated into debita spissitudo, can obtain meeting the oral liquid of regulation under the Chinese Pharmacopoeia mixture item;
3, the present invention is not with chemical preservative, the effective site Radix Codonopsis polysaccharide content that has guaranteed Radix Codonopsis is the pure natural medical preparation up to 15%, has kept peculiar fragrance, sweet, the steady quality of flavor of codonopsis pilosula, take safe ready, guaranteed curative effect, accepted by child and women easily;
4, the oral liquid taking dose is little, and it is accurate that the liquid preparation branch is got dosage, and the dosage size is easily flexible, and according to the requirement of clinical treatment dosage, but packing dosage is 10-30ml, and control, packing dosage are unit dose package easily, are convenient to take, carry and store.One of unit dose package can reach clinical treatment dosage, is sub-packed in vial, plastic bottle or the aluminium foil bag.
The specific embodiment
Embodiment 1, and preparation Radix Codonopsis polysaccharide content is 5%, and the branch loading amount is the oral liquid that 30ml/ props up;
Step 1 is extracted the Radix Codonopsis effective part extract, and this extract can obtain with following method, get the Radix Codonopsis raw medicinal material 100kg that quality standard meets, dedusting is cleaned, and the raw material Radix Codonopsis is removed impurity and the thing flushing with clean water of going mouldy, be chopped into the 2-4cm section, add the 700kg decocting and boil 2-3 time, each 2-3 hour, filter, merging filtrate, heavy clear, be evaporated to proportion 1.10-1.11,70 ℃ of concentrated solutions that record promptly get the Radix Codonopsis effective part extract.
Step 2 is got the concentrated solution of step 1 preparation, and high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 5%, this extracting solution is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag seals sterilization, the branch loading amount is that 30ml/ props up instructions of taking: each 1, and every day 2 times.
Embodiment 2, and preparation Radix Codonopsis polysaccharide content is 10%, and the branch loading amount is the dangshen oral liquid that 15ml/ props up;
Step 1 is extracted the Radix Codonopsis effective part extract, and this extract can obtain with following method, get the Radix Codonopsis raw medicinal material 100kg that quality standard meets, dedusting is cleaned, and the raw material Radix Codonopsis is removed impurity and the thing flushing with clean water of going mouldy, be chopped into the 2-4cm section, add the 700kg decocting and boil 2-3 time, each 2-3 hour, filter, merging filtrate, heavy clear, be evaporated to proportion 1.110-1.115,75 ℃ of concentrated solutions that record promptly get the Radix Codonopsis effective part extract;
Get the concentrated solution of step 1 preparation, high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 10%, this extracting solution is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag seals sterilization, and the branch loading amount is that 15ml/ props up instructions of taking: each 1, and every day 2 times.
Embodiment 3, and preparation Radix Codonopsis polysaccharide content is 15%, and the branch loading amount is the dangshen oral liquid that 10ml/ props up;
Step 1 is extracted the Radix Codonopsis effective part extract, and this extract can obtain with following method, get the Radix Codonopsis raw medicinal material 100kg that quality standard meets, dedusting is cleaned, and the raw material Radix Codonopsis is removed impurity and the thing flushing with clean water of going mouldy, be chopped into the 2-4cm section, add the 700kg decocting and boil 2-3 time, each 2-3 hour, filter, merging filtrate, heavy clear, be evaporated to proportion 1.115-1.200,80 ℃ of concentrated solutions that record promptly get the Radix Codonopsis effective part extract;
Get the concentrated solution of step 1 preparation, high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 15%, this extracting solution is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag seals sterilization, and the branch loading amount is that 10ml/ props up instructions of taking: each 1, and every day 2 times.
Claims (4)
1, a kind of dangshen oral liquid is characterized in that being made by following method:
Step 1, the preparation method of Radix Codonopsis effective site Radix Codonopsis polysaccharide extract concentrated solution;
A, dedusting are cleaned: with the raw material Radix Codonopsis decontamination and the medicine that goes mouldy, flushing with clean water;
B, chopping:, be cut into the section of 2-4cm with codonopsis pilosula;
C, decoction: with the Radix Codonopsis section that cuts, put into the decoction cylinder and decoct, add the pure water that 7-10 doubly measures, decoct 2-3 time, each 2-3 hour, filter merging filtrate;
D, concentrated: the filtrate of merging, being evaporated to proportion is 1.10-1.20, temperature is 70-80 ℃ and records;
Step 2 prepares dangshen oral liquid with Radix Codonopsis effective site Radix Codonopsis polysaccharide extract concentrated solution;
A, be taken at temperature 70-80 ℃ and record, proportion is 1.10-1.20; Content is Radix Codonopsis polysaccharide extract's concentrated solution of 5-15%;
B, be that 10-30ml/ props up, be loaded in washed glass bottle, plastic bottle or the aluminium foil bag and seal sterilization promptly according to the cubage loading amount.
2, dangshen oral liquid according to claim 1, it is characterized in that extracting solution proportion is 1.10-1.11,70 ℃ of surveys, it is 5-8% that high pressure lipuid chromatography (HPLC) records Radix Codonopsis polysaccharide content, loading amount is that 18-30ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
3, according to the described dangshen oral liquid of claim 1, it is characterized in that extracting solution proportion is 1.11-1.15,75 ℃ of surveys, high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 8-11%, loading amount is that 15-20ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
4, according to the described dangshen oral liquid that gets of claim 1, it is characterized in that extract proportion is 1.15-1.20,80 ℃ of surveys, high-pressure liquid phase chromatogram therapy determining Radix Codonopsis polysaccharide content is 11-15%, loading amount is that 10-15ml/ props up, and is sub-packed in washed glass bottle, plastic bottle or the aluminium foil bag and seals sterilization promptly.
Priority Applications (1)
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CN 200510012819 CN1739595A (en) | 2005-09-13 | 2005-09-13 | Dangshen oral liquid |
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CN 200510012819 CN1739595A (en) | 2005-09-13 | 2005-09-13 | Dangshen oral liquid |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525901A (en) * | 2012-01-19 | 2012-07-04 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
CN106176878A (en) * | 2016-07-11 | 2016-12-07 | 周晗生 | The extracting method of Radix Codonopsis extract |
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2005
- 2005-09-13 CN CN 200510012819 patent/CN1739595A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525901A (en) * | 2012-01-19 | 2012-07-04 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
CN102525901B (en) * | 2012-01-19 | 2013-10-30 | 江西新世纪民星动物保健品有限公司 | Animal codonopsis pilosula polysaccharide oral solution and preparation method thereof |
CN106176878A (en) * | 2016-07-11 | 2016-12-07 | 周晗生 | The extracting method of Radix Codonopsis extract |
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