CN1736411A - Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder - Google Patents
Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder Download PDFInfo
- Publication number
- CN1736411A CN1736411A CN 200510036222 CN200510036222A CN1736411A CN 1736411 A CN1736411 A CN 1736411A CN 200510036222 CN200510036222 CN 200510036222 CN 200510036222 A CN200510036222 A CN 200510036222A CN 1736411 A CN1736411 A CN 1736411A
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- Prior art keywords
- thick paste
- promptly
- ethanol
- extract
- tablet
- Prior art date
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Disclosed is a pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder, wherein the preparation has the advantages of quick release rate, high biological availability, accurate dosage, and easy administration.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of pharmaceutical preparation and preparation method thereof with heat clearing away, damp eliminating, function of gallbladder promoting function.
Background technology
The Chinese medicine Herba Rabdosiae Lophanthoidis is Labiatae scented tea Lay platymiscium Rabdosia lophanthoides Rabdosialophanthoides (Buch.Harn.exD-Don) Hara[Plectranthus striatus Benth. or Lsodon Striatus (Benth.) Kurn or Lsodon Lophanthoides (Buch.Harn.ex D.Don) H.Hara] dry herb, has clearing away heat-damp and promoting diuresis, jaundice eliminating, the function of cool the blood dissipate blood stasis; Be used for jaundice due to damp-heat, damp-heat dysentery, traumatic injury congestive edema; Closely be useful on acute icterohepatitis, acute cholecystitis and jaundice person is arranged.
Chinese medicine Ramulus Et Folium Picrasmae [Picrasma quassiodes (D.Don) Ben] is a Simarubaceae Quassia plant.Widely distributed in China, aboundresources.The nature and flavor bitter cold of this medicine, slightly poisonous.Return lung, large intestine channel.Function is anti-inflammation with curing mainly, the damp eliminating detoxifcation.There are some researches show that Ramulus Et Folium Picrasmae also has effects such as analgesic, blood pressure lowering, enhancing regional blood flow, transaminase lowering, anticancer, venom, malaria, the clinical hypertension, inflammation disease, snake venom of being used for the treatment of is bitten etc.
Herba Andrographis is the dry aerial parts of acanthaceous plant [Andrographis paniculata (Burm.F.) Ness], its chemical constituent is mainly diterpenoid-lactone and flavone compound, has anti-inflammation, antiviral, antitumor, prevents and treats multiple pharmacological effect such as cardiovascular disease, anti-liver injury, enhance immunity, antifertility.Wherein lactone is the main component of Herba Andrographis anti-inflammation.
The Chinese Pharmacopoeia nineteen ninety-five version XIAOYAN LIDAN PIAN that enlarged edition recorded in 1997 is the preparation that Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae, Herba Andrographis are made.But this Tabules adjuvant amount is big, and bioavailability is low, the deficiency that disintegration is long etc., and incompatibility is suitable for Chinese medicine modern development trend.
Application number is: 99113258.0 " preparation technologies of anti-inflammatory and choleretic granules " disclose a kind of preparation technology of anti-inflammatory and choleretic granules agent; The disclosure of the Invention of application number 200410041023.3 a kind of preparation of anti-inflammatory and choleretic drop pill.These are all tangible different with the present invention.
Summary of the invention
The present invention makes modern form of administration such as soft capsule, dispersible tablet, drop pill, oral cavity disintegration tablet, effervescent tablet, micropill by with adding appropriate amount of auxiliary materials in Herba Rabdosiae Lophanthoidis, Ramulus Et Folium Picrasmae, the Herba Andrographis prescription Chinese crude drug extract.Drug regimen of the present invention is preferably for the component weight proportion:
1 part of 1 part of Ramulus Et Folium Picrasmae of 1 part of Herba Rabdosiae Lophanthoidis of Herba Andrographis
Make soft capsule or pharmaceutical dosage forms such as dispersible tablet or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate;
Or more preferably:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g,
Make soft capsule or pharmaceutical dosage forms such as dispersible tablet or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill Deng with pharmaceutically alleged adjuvant or substrate; Make 500 or 1000 slice, or its integral multiple.
The present invention is achieved in that
The preparation soft capsule:
1. Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned dried cream or thick paste, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, additives etc., stir, after the degassing, insulation is left standstill, and makes the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
The disperse medium of making soft capsule is: olive oil or other crude vegetals; or triglyceride oils; or oleic acid sorbitol ester; or olein: propylene glycol is 90: 10 mixture by weight; or Oleum Cocois C8/C10 monoglyceride or dibasic acid esters; or Oleum Cocois C8/C10 propylene glycol ester; or Oleum Cocois triglyceride; or the acetylizad monoglyceride of purification; or olein; or glyceryl linoleate, or Polyethylene Glycol glyceryl laurate ester, or in the purification Oleum helianthi monoglyceride one or more.
The suspending agent of soft capsule is: can increase the solid matter of disperse medium viscosity, as Cera Flava, aluminum monostearate, ethyl cellulose, carbomer etc.
The antiseptic of soft capsule is: one or more in glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, the P-hydroxybenzoic acid phenyl ester.
Its adjuvant can preferably use by following proportioning:
A kind of medicinal substances extract 100g with heat clearing away, damp eliminating, function of gallbladder promoting function with disperse medium 30～360g, suspending agent 0～55g, antiseptic 0～5.5g, is modulated into stable capsule liquid and makes soft capsule.
Its capsule material is: weight ratio is 1: 0.24: 0.76: 0.12: 1.42 gelatin: arabic gum: glycerol: syrup: distilled water etc. are mixed and made into.
The preparation dispersible tablet:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get above-mentioned dried cream or thick paste, add adjuvant and granulate, drying adds adjuvants such as lubricant, mixing, and tabletting promptly gets dispersible tablet, or the coated coated dispersing tablet of making; Get 2 of this sheets, put jolting in the 100ml water, in 20 ℃ ± 1 ℃ water, the whole disintegrates of planted agent in 3 minutes are also passed through sieve No. 2.
Its The disintegrating agents of dispersible tablets is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, and low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.,
Binding agent in the dispersible tablet is: the alcoholic solution or the aqueous solution of 40% ethanol～95% alcoholic solution or starch slurry or polyvinylpyrrolidone;
Filler is in the dispersible tablet: starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc.,
Lubricant in the dispersible tablet is a magnesium stearate, or micropowder silica gel, or one or more of Pulvis Talci etc.
Its adjuvant can preferably use by following proportioning:
A kind of medicinal substances extract 100g with heat clearing away, damp eliminating, function of gallbladder promoting function is with filler 0～150g, disintegrating agent 3～85g, lubricant 0～25g proportioning;
The preparation drop pill:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get drop pill substrate heating and melting, other gets above-mentioned dried cream or thick paste and substrate mix homogeneously, splashes into coolant, makes drop pill;
Substrate in its drop pill is polyethylene glycol 6000, can also be: molecular weight be by cured etc. one or more of 2000～12000 Polyethylene Glycol, polyoxyethylene monostearate, sodium stearate or glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate, polyvinylpyrrolidone, carboxymethyl cellulose, worm, or the best is a polyethylene glycol 6000: the mixture of poloxamer (10: 0.5).Coolant in its drop pill preparation is one or more of dimethicone or liquid paraffin or Oleum Camelliae or vegetable oil etc.
Its adjuvant can preferably use by following proportioning:
Extract 100g, with consumption be that the drop pill substrate of 120～460g is used, the best 210g that uses.
The preparation oral cavity disintegration tablet:
Oral cavity disintegration tablet of the present invention is made like this:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get above-mentioned dried cream or thick paste, with filler, disintegrating agent, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned dried cream or thick paste,, make granule, add adjuvant mix homogeneously such as fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
A kind of medicinal substances extract 100g, filler 0～120g, disintegrating agent 3～75g, correctives 0～25g, lubricant 0.01～20g with heat clearing away, damp eliminating, function of gallbladder promoting function;
Described disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.;
Described lubricant is: micropowder silica gel, or one or more of magnesium stearate etc.;
Described correctives is: A Basi is sweet, stevioside, sucrose, maltose alcohol, citric acid etc. are edible or one or more of medicinal correctives; Preferably use A Basi sweet with citric acid 1: 1.5.
The preparation effervescent tablet:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get above-mentioned dried cream or thick paste, with filler, disintegrating agent, effervescent acid-base pair, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned dried cream or thick paste,, make granule, add adjuvant mix homogeneously such as effervescent acid-base pair, fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
The effervescent acid-base pair is formed for two kinds of materials of bronsted lowry acids and bases bronsted lowry of meeting water and can produce gas, as the citric acid of sodium bicarbonate and equivalent or tartaric acid etc.;
Filler is a lactose, or starch, or pregelatinized Starch, or one or more of microcrystalline Cellulose etc., and the best is preferably lactose: mannitol: precoking starch: microcrystalline Cellulose 3: 5: 1: 1 mixture;
Disintegrating agent is: crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or one or more of cross-linked carboxymethyl cellulose sodium etc.; Or the best crospolyvinylpyrrolidone that uses: low-substituted hydroxypropyl cellulose: the mixture of carboxymethyl starch sodium=4: 1: 0.5.
Its supplementary product consumption proportioning is: a kind of medicinal substances extract 100g, filler 0～140g, disintegrating agent 3～50g, correctives 0～25g, effervescent acid-base pair 5～75g, lubricant 0～20g with heat clearing away, damp eliminating, function of gallbladder promoting function.
Micropill of the present invention or pellet capsule are made like this:
(1) Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
(2) preparation of micropill: get above-mentioned dried cream or thick paste,, make the micropill of diameter less than 2.0mm with the adjuvant mix homogeneously; With gained micropill drying; Or the coating after drying, promptly.
100 parts of extracts of the present invention, 5～60 parts of carboxymethyl starch sodium, 2～40 parts of precoking starch, wetting agent are 60～95% alcoholic solution of 2～13% polyvinylpyrrolidones; Or be preferably: medicinal substances extract 100g, carboxymethyl starch sodium 45g, precoking starch 30g, wetting agent are 85% alcoholic solution of 11% polyvinylpyrrolidone.
The coating solution of making the various coated preparations of the present invention is a gastric solubility coating material, as Opadry, acrylic resin IV, hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyvinyl alcohol, methylcellulose one or more, or the coating solution formula optimization is:
Polyvinylpyrrolidone 12g, hydroxypropyl methylcellulose 4～8g, 90% alcoholic solution 200ml, Pulvis Talci 4～8g, magnesium stearate 2g, titanium dioxide 4～6g, Polyethylene Glycol
60004g, pigment 1～2g.
Extract of the present invention can be used for the preparation of preparation after the following steps enclose is handled: get Herba Andrographis, Ramulus Et Folium Picrasmae with 80～85% ethanol heating extraction secondaries, filter; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 70% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, and being condensed into relative density is 1.28～1.32 thick pastes under 50 ℃ of conditions.Merge thick paste, get the inclusion agents (β-CD, the cyclodextrin that are equivalent to thick paste weight 1/5～1/2, or the compositions of β-CD (cyclodextrin) and low-substituted hydroxypropyl cellulose), makes saturated solution, fully mix with above-mentioned thick paste, spray drying promptly gets the extract for preparing various dosage forms.
Composition by above-mentioned enclose is through stability test, and retention rate is higher in the preparation, the test effect art invention effect of seing before.Clathrate β-CD (cyclodextrin) also can select, and consumption is: β-CD: low-substituted hydroxypropyl cellulose 4: 1.
Effect of the present invention:
1, contains the effective ingredient diterpenoid-lactone in the preparation of the present invention, be mainly andrographolide and dehydrorographolide in its diterpenoid-lactone, have anti-inflammation, antiviral, antitumor, prevent and treat multiple pharmacological effect such as cardiovascular disease, anti-liver injury, enhance immunity, antifertility.The content that has document to be documented in andrographolide in the whole technical process of production XIAOYAN LIDAN PIAN reduces to original about 10%, the content of dehydrorographolide then constantly raises, and the declaratives andrographolide gradates in preparation process and is dehydrorographolide.Therefore, calculate content with dehydrorographolide, as the indicative index of andrographolide constituents content in the inflammation-diminishing and gallbladder-benefiting formulation.
Measure dehydrorographolide and can select high performance liquid chromatography for use; During mensuration with 70% dissolve with ethanol, with normal hexane extraction 3 times.
Get 20 of this product, porphyrize, the accurate title, decided 1.0g, and the dissolve with ethanol with 70% is used normal hexane extraction 3 times, and each 10ml discards normal hexane extraction liquid, with the ethanol evaporate to dryness, uses the dissolve with methanol residue, and standardize solution filters with microporous filter membrane, promptly gets need testing solution.Accurate respectively reference substance solution and each 5ul of need testing solution of drawing injects chromatograph of liquid, measures and calculates, and every of this product contains dehydrorographolide must not be less than 1.0mg.
Get the preparation that makes by the inventive method, carry out this product room temperature and accelerated stability test, this product dehydrorographolide stable content by the Chinese Pharmacopoeia prescriptive procedure.Behind following 12 months of the room temperature, dehydrorographolide content is more than 93% of first measured value.
Because the present invention adopts the technology of anti-inflammatory and choleretic extract and β-CD, low-substituted hydroxypropyl cellulose enclose, make that effective ingredient has increased stability in the extract, and, help absorption of human body from the complex structure supposition.
2, the invention preparation is used for the treatment of the observation of curative effect of bile reflux gastritis:
Bile reflux gastritis is the specific type in the chronic gastritis, belongs to categories such as the traditional Chinese medical science " gastric abscess ", " vomiting ", is one of clinical common frdquently encountered disease, and it is all dirty to relate generally to the liver and gall taste.According to the prescription characteristics, we use this medicine to control bile reflux gastritis 180 examples in March, 2002～2004 year October. and obtain significant curative effect, now be described below.Clinical data:
2.1 diagnostic criteria: formulate with reference to " chronic gastritis combination of Chinese and Western medicine diagnosis, dialectical with criterion of therapeutical effect (tentative program) " and relevant document.All possess following person and classify the object of observation as:
2.1.1 Western medicine diagnose standard:
(1) persistence gastralgia or glutted, belch, n or V, heartburn sense, returns acid or pour out one's grievances;
(2) the visible pylorus of gastroscopy has bile reflux or gastric mucus to be yellow;
(3) biopsy of some cases mucosa confirms to have chronic inflammatory disease to change.
2.1.2 tcm syndrome diagnostic criteria reference " new Chinese medicine clinical research guideline ":
Divide syndrome of incoordination between liver and stomach, syndrome of dampness-heat of spleen and stomach, weakness of the spleen and stomach 3 types, and get rid of the deficiency of YIN and asthenic cold type.
Clinical manifestation: the gastral cavilty distension, gastralgia connects the side of body, and heating installation is frequent, or vomiting bitter fluid, and is every because of the not smooth pain of feelings will increases, light red tongue, tongue is white, stringy pulse.
2.2 exclusion standard: should get rid of icterohepatitis, Peptic Ulcers and other digestive tract disease.
1.3 physical data 180 examples, male 102 examples, women 78 examples are divided into two groups at random.
Treatment group (preparation of the present invention) 150 examples, male 89 examples, 23～64 years old age; Woman's 61 examples, 21～63 years old age.Course of disease half a year to 11 year.
Matched group (XIAOYAN LIDAN PIAN) 30 examples, male 13 examples, 22～63 years old age; Woman's 17 examples, 24～61 years old age.Course of disease half a year to 10 year.Two groups of patient ages, courses of disease all do not have significant difference (P＞0.05), and comparability is arranged.
2 Therapeutic Method:
2.1 treatment group: preparation of the present invention, each 6, every day 3 times.
Be divided into 5 groups at random, use soft capsule, drop pill, dispersible tablet, pellet capsule, the oral cavity disintegration tablet of preparation of the present invention respectively.(dose all is equivalent to the amount of 10.4-13.0g crude drug)
2.2 the each 4-5 sheet of matched group XIAOYAN LIDAN PIAN (Guangdong Fushan medicine company limited), every day 3 times.
It is 1 course of treatment that two groups of patients took medicine 3 days, judges curative effect after two courses of treatment of all taking medicine.
3 observation of curative effect:
3.1 curative effect determinate standard is pressed healing, produce effects, effective, invalid 4 grades of evaluations with reference to relevant document:
Recovery from illness: symptom, sign disappear substantially, and check gastroscope bile reflux disappears, and distal esophagus or mucosa tissue are normal;
Produce effects: symptom, sign are obviously improved, and check gastroscope bile reflux obviously reduces, and distal esophagus or mucosa tissue change improvement;
Effectively: symptom, sign are improved, and check gastroscope bile reflux reduces, and distal esophagus or mucosa tissue change and alleviate or no change;
Invalid: symptom, sign and gastroscope finding do not have change or increase the weight of.
3.2 therapeutic outcome
3.2.1 two groups of clinical efficacies see Table 1,
Table 1 treatment group and matched group curative effect are relatively
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) | Total obvious effective rate (%) |
| Treatment group 1 | 30 examples | 10 | 13 | 2 | 4 | 86.7 | 80.0 |
| Treatment group 2 | 30 examples | 12 | 11 | 4 | 3 | 90.0 | 76.7 |
| Treatment group 3 | 30 examples | 11 | 11 | 3 | 5 | 83.3 | 73.3 |
| Treatment group 4 | 30 examples | 13 | 10 | 4 | 3 | 90.0 | 80.0 |
| Treatment group 5 | 30 examples | 11 | 12 | 3 | 4 | 86.7 | 76.7 |
| Matched group | 30 examples | 9 | 12 | 3 | 6 | 80.0 | 70.0 |
Adopt the T check, the total obvious effective rate of treatment group and matched group is P＜0.05 relatively, has the significance meaning.
3.2.2 two groups of upper digestive tract indigestion symptoms and chronic gastritis accompanied bile reflux symptom curative effect are relatively: 150 examples are organized in treatment, recovery from illness (upper abdomen distending pain, chronic gastritis) 59 examples, produce effects 67 examples, effective 13 examples. invalid 11 examples, total effective rate 92.7%.
Matched group 30 examples, recovery from illness (upper abdomen distending pain, chronic gastritis) 8 examples, produce effects 11 examples, effective 5 examples, invalid 6 examples, total effective rate 80.0%.Two groups of total effective rates compare P＜0.01, have utmost point significance meaning.
Because of preparation of the present invention is a kind of pharmaceutical preparation that improves bioavailability and drug effect, its prescription is identical with XIAOYAN LIDAN PIAN, through clinical observation relatively, can obviously shorten administration time, therapeutic effect is better than XIAOYAN LIDAN PIAN through check, cure rate is higher, so above-mentioned case also can be used preparation of the present invention, and can receive better curative effect.
The specific embodiment:
Embodiment 1: a kind of drug extract preparation with heat clearing away, damp eliminating, function of gallbladder promoting function:
1 part of 1 part of Ramulus Et Folium Picrasmae of 1 part of Herba Rabdosiae Lophanthoidis of Herba Andrographis
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50% ethanol heating extraction secondary; Herba Rabdosiae Lophanthoidis adds 13 times of amounts of water and decocts secondary, decocts 1.5 hours at every turn, and collecting decoction filters, and decocting liquid is concentrated into 1.20 (50 ℃), adds 60% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract; Maybe can continue drying, be ground into fine powder.
Embodiment 2: a kind of drug extract preparation with heat clearing away, damp eliminating, function of gallbladder promoting function:
2 parts of 2 parts of Ramulus Et Folium Picrasmaes of 2 parts of Herba Rabdosiae Lophanthoidiss of Herba Andrographis
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 95% ethanol heating extraction secondary; Herba Rabdosiae Lophanthoidis adds 12 times of amounts of water and decocts secondary, and each 1 hour, collecting decoction filtered, and it is 1.30 (50 ℃) that decocting liquid is concentrated into relative density, adds 75% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract; Maybe can continue drying, be ground into fine powder.
Embodiment 3: a kind of drug extract preparation with heat clearing away, damp eliminating, function of gallbladder promoting function:
1.5 parts of 1.5 parts of Ramulus Et Folium Picrasmaes of 1.5 parts of Herba Rabdosiae Lophanthoidiss of Herba Andrographis
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 82.5% ethanol heating extraction secondary; Herba Rabdosiae Lophanthoidis adds 15 times of amounts of water and decocts secondary, and each 1 hour, collecting decoction filtered, and decocting liquid is concentrated into 1.35 (50 ℃), adds 95% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract; Maybe can continue drying, be ground into fine powder.
Embodiment 4: a kind of drug extract preparation with heat clearing away, damp eliminating, function of gallbladder promoting function
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
More than three flavors, Herba Andrographis, Ramulus Et Folium Picrasmae are with 80～85% ethanol heating extraction secondaries, filtration; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 70% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, and being condensed into relative density is 1.28～1.32 thick pastes under 50 ℃ of conditions.Merge thick paste, get the inclusion agents (β-CD, the cyclodextrin that are equivalent to thick paste weight 1/5～1/2, or the compositions of β-CD (cyclodextrin) and low-substituted hydroxypropyl cellulose), makes saturated solution, fully mix with above-mentioned thick paste, spray drying promptly gets the extract for preparing various dosage forms.
Composition by above-mentioned enclose is through stability test, and retention rate is higher in the preparation, the test effect art invention effect of seing before.Clathrate β-CD (cyclodextrin) also can select, and consumption is: β-CD: low-substituted hydroxypropyl cellulose 4: 1.
Embodiment 5: a kind of preparation with medicinal soft capsule of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
The about 200g of said extracted thing
Cera Flava 20g
Olive oil 215g
Propylene glycol 2g
Soybean lecithin 8g
Make 1000
1. Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, be concentrated into 1.28 thick pastes under 50 ℃ of conditions, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned dried cream or thick paste, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 6: a kind of preparation with medicinal soft capsule of heat clearing away, damp eliminating, function of gallbladder promoting function:
Medicinal substances extract 100g
Peach kernel oil 15g
Soybean oil 90g
Cera Flava: 1.5: 3.5 12g of ethyl cellulose weight ratio
Ethylparaben 0.7g
Make 500
1. Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, be concentrated into 1.25 thick paste under 50 ℃ of conditions, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned dried cream or thick paste, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. its capsule material formula is weight ratio 1: 0.23: 0.76: 0.12: 1.42 gelatin: arabic gum: glycerol: syrup: distilled water etc. are mixed and made into.Get gelatin, water in heating in water bath dissolving down, mix homogeneously adds glycerol, antiseptic, additives, stirs, and after the vacuumize degassing, insulation is left standstill, and makes capsule material glue;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 7: a kind of preparation with medicinal soft capsule of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
Medical material is made extract (thick paste) 200g by embodiment 1～3.
Peach kernel oil 25g
Soybean oil 100g
Make 1000
Embodiment 8: a kind of preparation with medicine dispersible tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
Medical material is made extract (thick paste) 200g by embodiment 1～3.
Lactose: 100g
Microcrystalline Cellulose: 65g
Mannitol: 45g
Carboxymethyl starch sodium: 10g
Polyvinylpyrrolidone: 35g
Sodium lauryl sulphate: 2.5g
Magnesium stearate: 3.0g
Make extract by embodiment 1～3, use 75% alcohol granulation with lactose, carboxymethyl starch sodium, microcrystalline Cellulose, mannitol etc., drying adds polyvinylpyrrolidone, sodium lauryl sulphate, and the magnesium stearate mix homogeneously is pressed into 1000, promptly.
Embodiment 9: a kind of preparation with medicine dispersible tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
More than three flavors, Herba Andrographis, Ramulus Et Folium Picrasmae are with 80～85% ethanol heating extraction secondaries, filtration; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 70% ethanol quintuple, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, and being condensed into relative density is 1.28～1.32 thick pastes under 50 ℃ of conditions.Merge thick paste, get the β-CD (cyclodextrin) that is equivalent to thick paste weight 1/3rd, make saturated solution, fully mix spray drying with above-mentioned thick paste.
Continuing cooperates with the said extracted thing by following ratio of adjuvant, and mixing is made granule, and drying is pressed into 1000, sugar coating, promptly.
Lactose: 100g
Microcrystalline Cellulose: 65g
Mannitol: 45g
Carboxymethyl starch sodium: 10g
Polyvinylpyrrolidone: 35g
Sodium lauryl sulphate: 2.5g
Magnesium stearate: 3.0g
Embodiment 10: a kind of preparation with medicine dispersible tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
Medicinal substances extract (dried cream powder) 200g
Lactose: 30g
Hydroxypropyl emthylcellulose: 8g
Microcrystalline Cellulose: 25g
Crospolyvinylpyrrolidone: 12g
Micropowder silica gel: 2.3g
Make the extract thick paste by embodiment 1～3, with lactose, hydroxypropyl emthylcellulose, microcrystalline Cellulose, etc. granulate with 85% alcoholic solution moistening of 11% poly-second ketopyrrolidine, add volatile oil, dry, add polyvinylpyrrolidone, differential silica gel mix homogeneously, tabletting, coating is made 1000, and coating solution is:
Polyvinylpyrrolidone 12g
Hydroxypropyl methylcellulose 4～8g
90% alcoholic solution 200ml
Pulvis Talci 4～8g
Magnesium stearate 2g
Titanium dioxide 4～6g
Polyethylene glycol 6000 4g
Pigment 1～2g.
Embodiment 11: a kind of preparation with medicinal dropping ball of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
Medical material is made extract (thick paste) 200g by embodiment 1～3.
Polyethylene glycol 6000 235g
Macrogol 4000 15g
Poloxamer 10g
Make 5000.
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get drop pill substrate heating and melting, add medicinal substances extract dried cream powder, poloxamer mix homogeneously with it, be incubated under 95 ℃ of conditions, mix homogeneously splashes in the coolant and is shaped, and remove liquid coolant and promptly get drop pill, or coated again technology is made coated drop pill.
Keep 90 centimetres of cooling column effective column lengths when dripping system, 5 ℃ of liquid coolants are dripped 55 on every part of clock of speed, dropper mouth external diameter 2.4mm, and internal diameter 2.2mm, then dripping the drop pill of making does not have the tail of taking off, and outward appearance is bright and clean shaped.
Coating solution can be made by following proportioning:
Polyvinylpyrrolidone 30g
Hydroxypropyl methylcellulose 8g
95% alcoholic solution 200ml
Magnesium stearate 2g
Titanium dioxide 6g
Polyethylene glycol 6000 2g
Pigment 3g
Embodiment 12: a kind of preparation with medicinal dropping ball of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
β-CD 40g
Low-substituted hydroxypropyl cellulose 10g
Medical material and enclose adjuvant are made extract (thick paste) 250g by embodiment 4, continue to make drop pill with following adjuvant.
Polyethylene glycol 6000 260g
Poloxamer 10g
Make 5000.
Embodiment 13: a kind of preparation with drug port disintegrating tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
Get extract (thick paste) 210g that said ratio makes
Lactose: 40g
Microcrystalline Cellulose: 20g
Mannitol: 30g
Carboxymethyl starch sodium: 12g
Polyvinylpyrrolidone: 20g
The sweet 3.5g of A Basi
Citric acid 7.0g
Magnesium stearate: 7.0g
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
Get above-mentioned dried cream or thick paste, with 75% alcohol granulation, drying such as lactose, carboxymethyl starch sodium, microcrystalline Cellulose, mannitol, add volatile oil polyvinylpyrrolidone, sodium lauryl sulphate, A Basi is sweet, the magnesium stearate mix homogeneously, is pressed into 1000, promptly.
Embodiment 14: a kind of preparation with drug port disintegrating tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
The material extract 200g that gets it filled,
Carboxymethyl starch sodium: 17g
Polyvinylpyrrolidone: 22g
Magnesium stearate: 0.03g
Get said extracted thing and carboxymethyl starch sodium 75% alcohol granulation, drying adds polyvinylpyrrolidone, magnesium stearate mix homogeneously, is pressed into 1000, promptly.
Embodiment 15: a kind of preparation with drug port disintegrating tablet of heat clearing away, damp eliminating, function of gallbladder promoting function:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g
β-CD 60g
Low-substituted hydroxypropyl cellulose 15g
Medical material and enclose adjuvant are made extract (thick paste) 250g by embodiment 4, continue to make effervescent tablet with following adjuvant.
Lactose 90g
Mannitol 150g
Precoking starch 30g
Microcrystalline Cellulose 30g
Polyvinylpyrrolidone: 40g
Low-substituted hydroxypropyl cellulose 10g
Carboxymethyl starch sodium 5g
Sodium bicarbonate 45g
Citric acid 20g
Magnesium stearate: 0.03g
Embodiment 16: a kind of preparation with medicament pellet of heat clearing away, damp eliminating, function of gallbladder promoting function
The material extract 200g that gets it filled,
Carboxymethyl starch sodium 40g
Precoking starch 12g
85% alcoholic solution, the 25～35ml of 11% polyvinylpyrrolidone
(1) gets above-mentioned dried cream or thick paste,, make the micropill of diameter less than 2.0mm with agitation procedure with mix homogeneously such as carboxymethyl starch sodium, precoking starch;
(2) with gained micropill drying, or the coating after drying, promptly.Or the micropill filled capsules made pellet capsule.
Claims (12)
1. pharmaceutical preparation with heat clearing away, damp eliminating, function of gallbladder promoting function is characterized in that used medical material is:
Herba Andrographis Herba Rabdosiae Lophanthoidis Ramulus Et Folium Picrasmae
The treated medicinal substances extract of making is made soft capsule or pharmaceutical dosage forms such as dispersible tablet or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate.
2. a kind of pharmaceutical preparation with heat clearing away, damp eliminating, function of gallbladder promoting function according to claim 1 is characterized in that the component weight proportion is preferably:
Herba Andrographis 700～1000g Herba Rabdosiae Lophanthoidis 700～1000g Ramulus Et Folium Picrasmae 700～1000g
Make soft capsule or pharmaceutical dosage forms such as dispersible tablet or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate; Or more preferably:
Herba Andrographis 868g Herba Rabdosiae Lophanthoidis 868g Ramulus Et Folium Picrasmae 868g.
3. the medication preparation that has heat clearing away, damp eliminating, a function of gallbladder promoting function according to one kind of claim 1 becomes the method for soft capsule, it is characterized in that:
1. the preparation of medicinal substances extract:
More than three flavors, Herba Andrographis, Ramulus Et Folium Picrasmae are with 50～95% ethanol heating extraction secondaries, filtration; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned institute gets dry extract or thick paste is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned dried cream or thick paste, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, additives etc., stir, after the degassing, insulation is left standstill, and makes the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
4. the medicinal soft capsule that has heat clearing away, damp eliminating, function of gallbladder promoting function according to one kind of claim 3, it is characterized in that: the supplementary product consumption of making soft capsule can be preferably: the described medicinal substances extract 100g of claim 3, with disperse medium 30～360g, suspending agent 0～55g, antiseptic 0～5.5g, be modulated into stable capsule liquid and make soft capsule.
5. a kind of medicine with heat clearing away, damp eliminating, function of gallbladder promoting function according to claim 1 is characterized in that its method that is prepared into the dispersion sheet is:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned dried cream or thick paste are medicinal substances extract;
Get above-mentioned dried cream or thick paste, add adjuvant and granulate, drying adds adjuvants such as lubricant, mixing, and tabletting promptly gets dispersible tablet, or the coated coated dispersing tablet of making; Get 2 of this sheets, put jolting in the 100ml water, in 20 ℃ ± 1 ℃ water, the whole disintegrates of planted agent in 3 minutes are also passed through sieve No. 2.
6. according to a kind of dispersible tablet described in the claim 5, it is characterized in that with heat clearing away, damp eliminating, function of gallbladder promoting function:
Its adjuvant can be preferably: the described medicinal substances extract 100g of claim 5, with filler 0～150g, disintegrating agent 3～85g, lubricant 0～25g proportioning;
Its The disintegrating agents of dispersible tablets is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.
7. a kind of medicinal dropping ball with heat clearing away, damp eliminating, function of gallbladder promoting function according to claim 1 is characterized in that:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned dried cream or thick paste are medicinal substances extract;
Get drop pill substrate heating and melting, other gets above-mentioned dried cream or thick paste and substrate mix homogeneously, splashes into coolant, makes drop pill;
Substrate in its drop pill is polyethylene glycol 6000, can also be: molecular weight be by cured etc. one or more of 2000～12000 Polyethylene Glycol, polyoxyethylene monostearate, sodium stearate or glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate, polyvinylpyrrolidone, carboxymethyl cellulose, worm, or the best is a polyethylene glycol 6000: the mixture of poloxamer (10: 0.5);
Coolant in its drop pill preparation is one or more of dimethicone or liquid paraffin or Oleum Camelliae or vegetable oil etc.
8. have the drug port disintegrating tablet of heat clearing away, damp eliminating, function of gallbladder promoting function according to one kind of claim 1, it is characterized in that:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned dried cream or thick paste are medicinal substances extract;
Get above-mentioned dried cream or thick paste, with filler, disintegrating agent, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned dried cream or thick paste,, make granule, add adjuvant mix homogeneously such as fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
9. a kind of according to Claim 8 drug port disintegrating tablet with heat clearing away, damp eliminating, function of gallbladder promoting function, it is characterized in that: its supplementary product consumption proportioning is: the described medicinal substances extract 100g of claim 8, filler 0～120g, disintegrating agent 3～75g, correctives 0～25g, lubricant 0.01～20g;
Described disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.;
Described lubricant is: micropowder silica gel, or one or more of magnesium stearate etc.;
Described correctives can be selected: edible or medicinal correctivess such as A Basi is sweet, stevioside, sucrose, maltose alcohol, citric acid; Preferably use A Basi sweet with citric acid 1: 1.5.
10. have the medicine effervescent tablet of heat clearing away, damp eliminating, function of gallbladder promoting function according to one kind of claim 1, it is characterized in that:
Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned dried cream or thick paste are medicinal substances extract;
Get above-mentioned dried cream or thick paste, with filler, disintegrating agent, effervescent acid-base pair, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned dried cream or thick paste,, make granule, add adjuvant mix homogeneously such as effervescent acid-base pair, fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
11. the medicine effervescent tablet according to one kind of claim 10 has heat clearing away, damp eliminating, function of gallbladder promoting function is characterized in that:
Its supplementary product consumption proportioning is: the described medicinal substances extract 100g of claim 10, filler 0～140g, disintegrating agent 3～50g, correctives 0～25g, effervescent acid-base pair 5～75g, lubricant 0～20g;
The effervescent acid-base pair is formed for two kinds of materials of bronsted lowry acids and bases bronsted lowry of meeting water and can produce gas, as the citric acid of sodium bicarbonate and equivalent or tartaric acid etc.;
Filler is a lactose, or starch, or pregelatinized Starch, or one or more of microcrystalline Cellulose etc., and the best is preferably lactose: mannitol: precoking starch: microcrystalline Cellulose 3: 5: 1: 1 mixture;
Disintegrating agent is: crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or one or more of cross-linked carboxymethyl cellulose sodium etc.; Or the best crospolyvinylpyrrolidone that uses: low-substituted hydroxypropyl cellulose: the mixture of carboxymethyl starch sodium=4: 1: 0.5.
12, have heat clearing away for one kind according to claim 1, damp eliminating, the medicament pellet of function of gallbladder promoting function is characterized in that:
(1) Herba Andrographis, Ramulus Et Folium Picrasmae filter with 50～95% ethanol heating extraction secondaries; Herba Rabdosiae Lophanthoidis decocts with water secondary, and collecting decoction filters, and decocting liquid is concentrated in right amount, adds 60～95% ethanol quintuples, stirs evenly, and leaves standstill, and filters; Above two kinds of alcoholic solutions are reclaimed ethanol respectively, concentrate and promptly get thick paste, or dry, be ground into fine powder, promptly get dry extract, above-mentioned dried cream or thick paste are medicinal substances extract;
(2) get above-mentioned dried cream or thick paste, with the adjuvant mix homogeneously, make the micropill of diameter, gained micropill drying less than 2.0mm; Or the coating after drying, promptly.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN103006764A (en) * | 2012-12-27 | 2013-04-03 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Method for preparing anti-inflammation cholagogue soft capsule |
| CN107496500A (en) * | 2017-09-10 | 2017-12-22 | 广东罗浮山国药股份有限公司 | A kind of application of Chinese medicine composition in the medicine for the treatment of helicobacter pylori infections and acute urethritis is prepared |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251306A (en) * | 1999-09-21 | 2000-04-26 | 中外合资哈尔滨一洲制药有限公司 | Process for preparing anti-inflammatory and choleretic granules |
| CN1552381A (en) * | 2003-06-03 | 2004-12-08 | 毛友昌 | Antiphlogistic cholagogic pill and preparing method thereof |
| CN100488528C (en) * | 2004-06-18 | 2009-05-20 | 管建立 | Inflammation-diminishing gallbladder-benefiting dripping pills and its preparation method |
-
2005
- 2005-07-28 CN CNB200510036222XA patent/CN100427066C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN102397451B (en) * | 2011-11-26 | 2013-06-19 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN103006764A (en) * | 2012-12-27 | 2013-04-03 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Method for preparing anti-inflammation cholagogue soft capsule |
| CN107496500A (en) * | 2017-09-10 | 2017-12-22 | 广东罗浮山国药股份有限公司 | A kind of application of Chinese medicine composition in the medicine for the treatment of helicobacter pylori infections and acute urethritis is prepared |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100427066C (en) | 2008-10-22 |
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Assignee: GUANGDONG LUOFUSHAN SINOPHARM Co.,Ltd. Assignor: Ye Yaoliang Contract record no.: 2010440000859 Denomination of invention: Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder Granted publication date: 20081022 License type: Exclusive License Open date: 20060222 Record date: 20100625 |
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Effective date of registration: 20170119 Address after: Changning 516133 Guangdong Province, Huizhou city Boluo County town of Guangshan road Ling Pai Industrial Zone (Pharmaceutical Luofu Mountain City) Patentee after: GUANGDONG LUOFUSHAN SINOPHARM Co.,Ltd. Address before: 516100 Guangdong city of Huizhou province Boluo county Luo Yang Zhen Guan Road three East Park No. 36 Patentee before: Ye Yaoliang |
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Assignee: GUANGDONG LUOFUSHAN SINOPHARM Co.,Ltd. Assignor: Ye Yaoliang Contract record no.: 2010440000859 Date of cancellation: 20230721 |