CN1552381A - Antiphlogistic cholagogic pill and preparing method thereof - Google Patents
Antiphlogistic cholagogic pill and preparing method thereof Download PDFInfo
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- CN1552381A CN1552381A CNA031245226A CN03124522A CN1552381A CN 1552381 A CN1552381 A CN 1552381A CN A031245226 A CNA031245226 A CN A031245226A CN 03124522 A CN03124522 A CN 03124522A CN 1552381 A CN1552381 A CN 1552381A
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Abstract
A Chinese medicine 'Xiaoyan Lidan pill' for treating acute cholecystitis and billary tract inflammation is an improvement to existing relative medicine in the form of tablet. Its preparing process is also disclosed. Its advantages are high curative effect, high release speed, and high biologic utilization rate.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine pill, relates in particular to anti-inflammatory and choleretic ball and preparation method.
Background technology
Pill is a kind of conventional dosage forms, because quick development of modern science and technology, pharmaceutical machine equipment is brought in constant renewal in and is regenerated, the extensive use of the appearance of novel pellet processing machine and new adjuvant, for this ancient dosage form of medicine pill has shone youthful vigor, it has changed people to the traditional prejudice of traditional pill " black, big, thick ", advantages such as the pill that makes it to produce has that drug release rate is fast, bioavailability is high, divided dose is accurate, takes, easy to carry, good looking appearance.According to the relevant drug act of China, change dosage form as a kind of new drug research, original dosage form of anti-inflammatory and choleretic ball is: XIAOYAN LIDAN PIAN, listed in the 10th of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ", the technology features of former dosage form is: Herba Andrographis, Ramulus Et Folium Picrasmae 80-85% ethanol heating extraction, and the Herba Rabdosiae Lophanthoidis water extract-alcohol precipitation, above-mentioned two kinds of extracting solution reclaim ethanol respectively, be condensed into thick paste, merge, add adjuvant and granulate drying, tabletting, sugar coating forms.The coated tablet coating is loaded down with trivial details, prolonged disintegration.This tablets amount is big, dysphagia, and its quality standard still can further improve; This pharmaceutically dosage form is single simultaneously, far can not satisfy people's medication demand.We use the modern pharmaceutical technology this product technology are carried out necessary improvement based on this, form new preparation, improve the quality standard of product simultaneously, guarantee the quality monitoring of product, improve drug effect, benefit the common people, this is significant to inheriting and develop motherland's medicine legacy.
Summary of the invention
The purpose of this invention is to provide a kind of anti-inflammatory and choleretic ball and preparation method, improve the quality of products and curative effect, increase the stability of product, satisfy needs of medical treatment better.
The objective of the invention is such realization:
1. anti-inflammatory and choleretic ball and preparation method comprise the steps:
1.1 the prescription of anti-inflammatory and choleretic ball is formed
Herba Andrographis 868-4340g Herba Rabdosiae Lophanthoidis 868-4340g Ramulus Et Folium Picrasmae 868-4340g
Right amount of auxiliary materials is made 1000g altogether.
Its optimum formula amount:
Herba Andrographis 1736-3472g Herba Rabdosiae Lophanthoidis 1736-3472g Ramulus Et Folium Picrasmae 1736-3472g
Right amount of auxiliary materials is made 1000g altogether.
1.2 anti-inflammatory and choleretic ball preparation technology
Technology one cleans three flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, respectively use the 40-95% ethanol extraction behind the mixing, the extracting solution filtration is standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and filtrate is concentrated in right amount, adds ethanol and makes that to contain the alcohol amount be 40-70%, leave standstill, filter, ethanol is reclaimed in above-mentioned two kinds of alcoholic solution difference/merging, is condensed into thick paste/concentrate drying and makes dried cream powder, with the appropriate amount of auxiliary materials mixing, make ball, drying, promptly.
Technology two cleans three flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, respectively use the 40-95%7 alcohol extraction behind the mixing, extracting solution filters, and is standby behind the recovery ethanol; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and the extracting solution of filtrate and Herba Andrographis etc. merges, and is condensed into thick paste/concentrate drying and makes dried cream powder, with the appropriate amount of auxiliary materials mixing, makes ball, drying, promptly.
Technology three cleans three flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis 40-95% ethanol extraction, the extracting solution filtration, standby; Quassic acid is carried alkali deposited, and collecting precipitation or crushed after being dried become fine powder standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, be concentrated into an amount of, add ethanol and make the alcohol amount of containing be 40-70%, leave standstill, filter, merge/reclaim ethanol respectively with above-mentioned Herba Andrographis extracting solution, be condensed into thick paste/concentrate drying and make dried cream powder,, make ball with above-mentioned Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, drying, promptly.
Technology four cleans three flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis 40-95% ethanol extraction, extracting solution filters, and is standby behind the recovery ethanol; Quassic acid is carried alkali deposited, and collecting precipitation or crushed after being dried become fine powder standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and is concentrated in right amount, merges with above-mentioned Herba Andrographis extracting solution, is condensed into thick paste/concentrate drying and makes dried cream powder, adds above-mentioned Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, makes ball, drying, promptly.
1.3 by technology one, two, three, four prepared balls is the anti-inflammatory and choleretic ball.
Need be ground into coarse powder/be cut into the medical material of decoction pieces in the technology, generally be ground into 5-30 purpose coarse powder/be cut into decoction pieces, preferably be ground into 10-20 purpose coarse powder.
The condition that decocting boils in the prescription is: amount of water is that 6-12 doubly measures for the first time, and second and third time doubly measured for 4-10, decocts 1-3 time, and each 1-3 hour, best for amount of water is 10 times of amounts for the first time, was 8 times of amounts the second time, decocts each 2 hours 2 times.
The relative density of technology thick paste is 1.10-1.45 (60 ℃), and best relative density is 1.25 (60 ℃).
The ball of gained can wrap film-coat in the technology, and the film-coat material adopts stomach dissolution type film-coat pre-mixing agent (Opadry), hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl emthylcellulose, polyvinyl alcohol, methylcellulose etc., and one or more mix use.
Used adjuvant can be that one or more mixing such as sucrose, lactose, starch, beta-schardinger dextrin-, HP-, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethylstach sodium, Aspartane, polyvinylpolypyrrolidone, 30 POVIDONE K 30 BP/USP 30 are used in the technology.
The particle diameter of the ball of gained is 0.5-6mm in the technology, is preferably 1-4mm.
In the technology ball of gained can directly use or the capsulae vacuus of packing in use.
The ball drying can adopt vacuum drying, fluid bed drying, lyophilization etc. in the technology.
The drying of extract can adopt vacuum drying or adopt spray drying in the technology, and the vacuum drying temperature is controlled at 50-80 ℃, is preferably 60 ℃.The spray drying inlet temperature is 100-200 ℃, leaving air temp 50-150 ℃; Best relative density is 1.08-1.10 (60 ℃), and inlet temperature is 160-180 ℃, leaving air temp 80-100 ℃.
The condition of alcohol extraction is in the technology one, two: Ramulus Et Folium Picrasmae, Herba Andrographis coarse powder respectively/be solvent behind the mixing with the ethanol of 40-95%, adopt methods such as percolation or heating reflux method to extract; The best is that Ramulus Et Folium Picrasmae, Herba Andrographis coarse powder extract each 2 hours 2 times with the alcohol heating reflux of 80-85% respectively.
The alcohol extraction condition is in the technology three, four: the Herba Andrographis coarse powder is a solvent with 40-95% ethanol, adopts methods such as percolation or heating reflux method to extract; The best is that the Herba Andrographis coarse powder extracts each 2 hours 2 times with the alcohol heating reflux of 80-85% respectively.
Quassic acid is put forward the condition of alkali deposited and is in the technology three, four: the acid with 0.1-1.0% is solvent extraction, and extracting solution filters, with the adjusting PH with base value to 9-10, collecting precipitation; Best extracting solution filters for the hydrochloric acid with 2-5% is solvent extraction, and is to 9-10, centrifugal with NaOH liquid adjust pH, collecting precipitation.
The condition of precipitate with ethanol is in the technology: the water extract is concentrated in right amount, adds ethanol and makes the alcohol amount of containing be 40-70%; The best is: the water extract is concentrated in right amount (2-3g medical material/ml), add 5 times of amounts of 70% ethanol precipitate with ethanol.
Filter in the technology to adopt and conventionally filter, centrifugal, ultrafiltration, add filtration/centrifugal/methods such as ultrafiltration behind the clarifier.
2. the control of the quality standard of this product mainly is: discriminating, inspection and three aspects of assay.
The quality standard of this product is improved comprehensively, former dosage form standard has only two physicochemical identification on differentiating, the existing thin layer that has increased Herba Andrographis, Ramulus Et Folium Picrasmae is differentiated; Increased heavy metal limit in the inspection and must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths; Assay has increased Herba Andrographis has been carried out the content regulation.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, and stability improves greatly, and quality standard improves greatly, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product and curative effect that guarantee arranged.
The specific embodiment
Embodiment 1: three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards.Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, is solvent with 80-85% ethanol respectively, heating and refluxing extraction 2 times, each 2 hours, it is standby that extracting solution filters; Herba Rabdosiae Lophanthoidis decocts with water 2 times, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds 5 times of amounts of 70%7 alcohol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned Herba Andrographis, Ramulus Et Folium Picrasmae alcohol extract merge recovery ethanol, being concentrated into relative density is 1.08-1.10 (60 ℃), spray drying is made dried cream powder, with appropriate amount of auxiliary materials mixing, pill, drying, promptly.
Embodiment 2: three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards.Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, is solvent with 80-85% ethanol respectively, heating and refluxing extraction 2 times, each 2 hours, extracting solution filtered, and reclaimed behind the ethanol standby; Herba Rabdosiae Lophanthoidis decocts with water 2 times, and each 2 hours, collecting decoction filtered, and the extracting solution of filtrate and Herba Andrographis, Ramulus Et Folium Picrasmae merges, and being concentrated into relative density is 1.08-1.10 (60 ℃), and spray drying is made dried cream powder, with appropriate amount of auxiliary materials mixing, pill, drying, promptly.
Embodiment 3: three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards.Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis is solvent with 80-85% ethanol, heating and refluxing extraction 2 times, and each 2 hours, the extracting solution filtration, standby; Ramulus Et Folium Picrasmae is solvent extraction with the hydrochloric acid of 2-5%, and extracting solution filters, and to 9-10, centrifugal, collecting precipitation is standby with NaOH liquid adjust pH; Herba Rabdosiae Lophanthoidis decocts with water 2 times, and each 2 hours, collecting decoction filtered, be concentrated in right amount, add 5 times of amounts of 70% ethanol precipitate with ethanol, leave standstill, filter, merge recovery ethanol with above-mentioned Herba Andrographis extracting solution, being concentrated into relative density is 1.08-1.10 (60 ℃), and it is standby that spray drying is made dried cream powder; Above-mentioned dried cream powder and above-mentioned Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, pill, drying, promptly.
Embodiment 4: three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards.Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis is solvent with 80-85% ethanol, heating and refluxing extraction 2 times, and each 2 hours, extracting solution filtered, and is standby behind the recovery ethanol; Ramulus Et Folium Picrasmae is solvent extraction with the hydrochloric acid of 2-5%, and extracting solution filters, and to 9-10, centrifugal, collecting precipitation is standby with NaOH liquid adjust pH; Herba Rabdosiae Lophanthoidis decocts with water 2 times, and each 2 hours, collecting decoction filtered, and was concentrated in right amount, merged with above-mentioned Herba Andrographis extracting solution, and being concentrated into relative density is 1.08-1.10 (60 ℃), and it is standby that spray drying is made dried cream powder; Above-mentioned dried cream powder and above-mentioned Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, pill, drying, promptly.
Claims (10)
1. anti-inflammatory and choleretic ball and preparation method is characterized in that:
(1) Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, respectively use the 40-95% ethanol extraction behind the mixing, the extracting solution filtration is standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and filtrate is concentrated in right amount, adds ethanol and makes that to contain the alcohol amount be 40-70%, leave standstill, filter, ethanol is reclaimed in two kinds of alcoholic solution difference/merging, is condensed into thick paste/concentrate drying and makes dried cream powder, with appropriate amount of auxiliary materials mixing, pill, drying, promptly.
(2) Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Andrographis, the Ramulus Et Folium Picrasmae pulverize separately becomes coarse powder, respectively use the 40-95% ethanol extraction behind the mixing, extracting solution filters, and is standby behind the recovery ethanol; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and the extracting solution of filtrate and Herba Andrographis etc. merges, and be condensed into thick paste/concentrate drying and make dried cream powder, with the appropriate amount of auxiliary materials mixing, pill, drying, promptly.
(3) Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis 40-95% ethanol extraction, the extracting solution filtration, standby; Quassic acid is carried alkali deposited, and collecting precipitation/crushed after being dried becomes fine powder standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, be concentrated into an amount of, add ethanol and make the alcohol amount of containing be 40-70%, leave standstill, filter, merge/reclaim ethanol respectively with the Herba Andrographis extracting solution, be condensed into thick paste/concentrate drying and make dried cream powder, with Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, pill, drying, promptly.
(4) Herba Andrographis, Ramulus Et Folium Picrasmae, Herba Rabdosiae Lophanthoidis three flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Andrographis in the prescription, Ramulus Et Folium Picrasmae two flavor pulverize separately and become coarse powder, Herba Andrographis 40-95% ethanol extraction, extracting solution filters, and is standby behind the recovery ethanol; Quassic acid is carried alkali deposited, and collecting precipitation/crushed after being dried becomes fine powder standby; Herba Rabdosiae Lophanthoidis decocts with water 2-3 time, and collecting decoction filters, and is concentrated in right amount, merges with the Herba Andrographis extracting solution, is condensed into thick paste/concentrate drying and makes dried cream powder, adds Ramulus et Folium Picrasmae and appropriate amount of auxiliary materials mixing, pill, and drying, promptly.
2. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: be ground into coarse powder/be cut into decoction pieces medical material generally be ground into 5-30 purpose coarse powder/be cut into decoction pieces, the best was ground into 10-20 purpose coarse powder; The condition that decocting boils is: amount of water is that 6-12 doubly measures for the first time, and second and third time doubly measured for 4-10, decocts 1-3 time, and each 1-3 hour, best for amount of water is 10 times of amounts for the first time, was 8 times of amounts the second time, decocts each 2 hours 2 times.
3. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the relative density of thick paste is 1.10-1.45 (60 ℃), and best relative density is 1.25 (60 ℃).
4. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the ball of gained can wrap film-coat, the film-coat material adopt stomach dissolution type film-coat pre-mixing agent (Opadry), hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl emthylcellulose, polyvinyl alcohol, methylcellulose a kind of/multiple mixing uses; Used adjuvant can be sucrose, lactose, starch, beta-schardinger dextrin-, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethylstach sodium, Aspartane, polyvinylpolypyrrolidone, 30 1 kinds/multiple mixing use of 30 POVIDONE K 30 BP/USP.
5. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the particle diameter of the ball of gained is 0.5-6mm, and the best is 1-4mm; The ball drying can adopt vacuum drying, fluid bed drying, lyophilization; The ball of gained can directly use/pack in the capsulae vacuus and use.
6. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the drying of extract can adopt vacuum drying/employing spray drying, and the vacuum drying temperature is controlled at 50-80 ℃, and the best is 60 ℃, the spray drying inlet temperature is 100-200 ℃, leaving air temp 50-150 ℃; Best relative density is 1.08-1.10 (60 ℃), and inlet temperature is 160-180 ℃, leaving air temp 80-100 ℃.
7. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the condition of alcohol extraction is in the technology: Ramulus Et Folium Picrasmae, Herba Andrographis coarse powder respectively/be solvent behind the mixing with the ethanol of 40-95%, adopt method such as percolation/heating reflux method to extract; The best is that Ramulus Et Folium Picrasmae, Herba Andrographis coarse powder extract each 2 hours 2 times with the alcohol heating reflux of 80-85% respectively; The independent alcohol extraction condition of Herba Andrographis is: the Herba Andrographis coarse powder is a solvent with 40-95% ethanol, adopts method extractions such as percolation/heating reflux method; The best is that the Herba Andrographis coarse powder extracts each 2 hours 2 times with the alcohol heating reflux of 80-85% respectively; The condition that the Ramulus Et Folium Picrasmae separate acid is carried alkali deposited is: the acid with 0.1-1.0% is solvent extraction, and extracting solution filters, with the adjusting PH with base value to 9-10, collecting precipitation; Best extracting solution filters for the hydrochloric acid with 2-5% is solvent extraction, and is to 9-10, centrifugal with NaOH liquid adjust pH, collecting precipitation.
8. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the condition of precipitate with ethanol is: the water extract is concentrated in right amount, adds ethanol and makes the alcohol amount of containing be 40-70%; The best is: the water extract is concentrated in right amount (2-3g medical material/ml), add 5 times of amounts of 70% ethanol precipitate with ethanol.
9. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: filtration can adopt and conventional filter, centrifugal, ultrafiltration, add the method for filtration/centrifugal/ultrafiltration behind the clarifier.
10. according to described anti-inflammatory and choleretic ball of claim 1 and preparation method, it is characterized in that: the quality standard of this product is controlled at the thin layer that Herba Andrographis, Ramulus Et Folium Picrasmae are arranged in the discriminating and differentiates; Have heavy metal must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit detection; Assay has the quantitative of Herba Andrographis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031245226A CN1552381A (en) | 2003-06-03 | 2003-06-03 | Antiphlogistic cholagogic pill and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA031245226A CN1552381A (en) | 2003-06-03 | 2003-06-03 | Antiphlogistic cholagogic pill and preparing method thereof |
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| CN1552381A true CN1552381A (en) | 2004-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA031245226A Pending CN1552381A (en) | 2003-06-03 | 2003-06-03 | Antiphlogistic cholagogic pill and preparing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427066C (en) * | 2005-07-28 | 2008-10-22 | 叶耀良 | Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder |
| CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN102526179A (en) * | 2012-01-19 | 2012-07-04 | 叶耀良 | Purpose of anti-inflammation and bile benefiting preparation |
| CN108524599A (en) * | 2018-06-29 | 2018-09-14 | 广东万年青制药有限公司 | A kind of purposes of Chinese medicine composition in the drug for preparing treatment enteritis |
-
2003
- 2003-06-03 CN CNA031245226A patent/CN1552381A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427066C (en) * | 2005-07-28 | 2008-10-22 | 叶耀良 | Pharmaceutical preparation with functions of clearing heat, removing dampness and benefiting gallbladder |
| CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN102397451B (en) * | 2011-11-26 | 2013-06-19 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
| CN102526179A (en) * | 2012-01-19 | 2012-07-04 | 叶耀良 | Purpose of anti-inflammation and bile benefiting preparation |
| CN102526179B (en) * | 2012-01-19 | 2013-08-21 | 广东罗浮山国药股份有限公司 | Purpose of anti-inflammation and bile benefiting preparation |
| CN108524599A (en) * | 2018-06-29 | 2018-09-14 | 广东万年青制药有限公司 | A kind of purposes of Chinese medicine composition in the drug for preparing treatment enteritis |
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