CN1736345A - Bioceramic stopper and preparation method thereof - Google Patents
Bioceramic stopper and preparation method thereof Download PDFInfo
- Publication number
- CN1736345A CN1736345A CNA2004100511889A CN200410051188A CN1736345A CN 1736345 A CN1736345 A CN 1736345A CN A2004100511889 A CNA2004100511889 A CN A2004100511889A CN 200410051188 A CN200410051188 A CN 200410051188A CN 1736345 A CN1736345 A CN 1736345A
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- China
- Prior art keywords
- stopper
- bioceramic
- ion beam
- titanium
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003462 bioceramic Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title abstract description 4
- 239000002184 metal Substances 0.000 claims abstract description 22
- 229910052751 metal Inorganic materials 0.000 claims abstract description 22
- 238000010884 ion-beam technique Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011248 coating agent Substances 0.000 claims abstract description 9
- 238000000576 coating method Methods 0.000 claims abstract description 9
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000010936 titanium Substances 0.000 claims abstract description 7
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 7
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000010521 absorption reaction Methods 0.000 claims abstract description 5
- 239000011261 inert gas Substances 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 3
- 238000005137 deposition process Methods 0.000 claims abstract description 3
- 239000001301 oxygen Substances 0.000 claims abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims abstract description 3
- MTPVUVINMAGMJL-UHFFFAOYSA-N trimethyl(1,1,2,2,2-pentafluoroethyl)silane Chemical compound C[Si](C)(C)C(F)(F)C(F)(F)F MTPVUVINMAGMJL-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000002994 raw material Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- 238000005229 chemical vapour deposition Methods 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 6
- 229910052786 argon Inorganic materials 0.000 claims description 4
- 238000009954 braiding Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 229910021645 metal ion Inorganic materials 0.000 abstract description 5
- 208000007536 Thrombosis Diseases 0.000 abstract description 4
- 239000011241 protective layer Substances 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 239000010410 layer Substances 0.000 abstract description 2
- 208000002330 Congenital Heart Defects Diseases 0.000 description 10
- 208000028831 congenital heart disease Diseases 0.000 description 9
- 210000003017 ductus arteriosus Anatomy 0.000 description 5
- 208000035478 Interatrial communication Diseases 0.000 description 4
- 208000001910 Ventricular Heart Septal Defects Diseases 0.000 description 4
- 206010003664 atrial septal defect Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 201000003130 ventricular septal defect Diseases 0.000 description 4
- 208000013914 atrial heart septal defect Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229910052724 xenon Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- -1 xenon ion Chemical class 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005524 ceramic coating Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005566 electron beam evaporation Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000003278 patent ductus arteriosus Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of bioceramic stopper and preparation method thereof, be to adopt beam-plasma vapour deposition process sprayed biological pottery on the stopper surface, promptly under room temperature and vacuum condition with inert gas ion beam bombardment hydatogenesis at the nitrogen of the feeding of the titanium on stopper surface and absorption thereof, carbon, oxygen and synthetic titanium nitride, titanium carbide, titanium oxide, form the coating on stopper surface.This bioceramic can effectively promote combining of metal and cell, and form one deck natural sealing coat on its surface within a short period of time, has not only improved stifledly to close effect, and has improved the biocompatibility of stopper greatly.The bioceramic layer of metal surface also is the effective protective layer of one deck, and it has reduced blood to reactions such as the various physics of metal, chemistry and biologies, has reduced the leakage of metal ion, thereby can avoid inflammatory reaction or thrombosis.In addition, the bioceramic stopper that obtains through this method can also improve the fatigue resistance and the wearability of stopper.
Description
Technical field
The present invention relates to medical apparatus and instruments, particularly a kind of bioceramic stopper that is used for the congenital heart disease treatment and preparation method thereof.
Background technology
Congenital heart disease is that the mankind are threatened one of more serious heart disease.According to domestic statistics, the sickness rate of all kinds of congenital heart diseases for the highest, secondly is ventricular septal defect, patent ductus arteriosus and fallot's disease etc. with atrial septal defect.According to data from abroad, birth back survival baby's congenital heart disease sickness rate is about 0.8%～1%, and the nearest statistics of China is 0.13%～0.67%.If by nineteen ninety country census baby due rate is 2% to calculate, China has the birth of 140,000 children with congenital heart disease every year approximately.
In recent years, because the application of cardiac catheterization and cardioangiography, and the development of cardiac operation under direct vision under the extracorporeal circulation, make clinically the situation that congenital heart disease is difficult for diagnosis and lacks the treatment way that very big variation has taken place, popularizing of especially emerging interventional therapeutic technique more makes the diagnosis and treatment of congenital heart disease that very big change has been arranged.Interventional therapeutic technique is to develop a kind of rapidly clinical treatment technology in the last few years, and it has, and wound is little, safety, good effect, easy and simple to handle, advantage such as the hospital stays is short, patients ' recovery is fast.Along with updating of interventional medical device, the indication of its treatment also will constantly enlarge, because this technology has simple and direct safety, the reliable advantage of curative effect, believing in this century to have more wide application prospect.
The interventional therapy medical apparatus and instruments of existing congenital heart disease mainly contains following a few class: atrial septal defect plugging device, ventricular septal defect, patend ductus arteriosus occluder.This class interventional medical device clinically obtained good application, its danger that massive blood loss brings of can avoiding performing the operation, and the crowd who is suitable for is also increasing.
Although congenital heart disease is got involved medical product and obtained the prominent development that flies to jump suddenly, still exist a lot of problems to await further solution.At first, there is residual shunt at a specified future date in the stopper implant patient, and incidence rate on average can reach about 5%.Secondly, stopper metal surface endothelial cell growth speed is slower, is difficult for generating endodermis.In addition, common stopper is implanted its metal material of back and is directly contacted with blood, be subjected to the effect of multiple composite factors such as physics in the vital movement, chemistry, biology after implanting in the interior environment midium or long term of human body complexity, thereby often leak out a large amount of metal ions, cause symptoms such as inflammatory reaction or generation blood coagulation, blood compatibility is relatively poor, has 4% patient to have microthrombus according to statistics approximately.
Summary of the invention
Technical problem to be solved by this invention is, a kind of bioceramic stopper is provided, and can effectively promote combining of metal and cell, can not only improve stifledly to close effect, but also can improve the biocompatibility of stopper greatly.Simultaneously, the leakage of metal ion can be reduced, thereby inflammatory reaction or thrombosis can be avoided.
Adopted following technical scheme for solving the problems of the technologies described above the present invention: a kind of bioceramic stopper is provided, forms, be coated with one deck bioceramic on the surface of stopper by stopper and the choked flow film that is arranged on the stopper.
Described bioceramic is to strengthen vapour deposition process through ion beam to be coated in described stopper surface.Described bioceramic can be titanium nitride, titanium carbide or titanium oxide.
A kind of manufacture method of bioceramic stopper is provided, comprises the steps:
1) at first makes stopper;
2) then at stopper surface coating one deck bioceramic;
3) at last the choked flow film is set on the stopper that is covered with bioceramic.
Wherein, bioceramic step 2) is to adopt ion beam to strengthen CVD method to be coated in the stopper surface.It is under room temperature and vacuum condition that described ion beam strengthens CVD method, and with the titanium of inert gas ion beam bombardment hydatogenesis on the stopper surface, the reacting gas that its absorption feeds and synthesising biological pottery form the coating on stopper surface.Described reacting gas can be nitrogen, carbon or oxygen.Described stopper is to make the metal webmaster by knit wire or engraving metal tube, through heat-treating profiled, utilizes the end socket of argon arc or laser weld stopper and bolt head to form again.
And the manufacture method that a kind of bioceramic stopper is provided, comprise the steps:
1) making raw material surface coating one deck bioceramic of stopper earlier;
2) more above-mentioned raw material is processed to form stopper;
3) at last the choked flow film is set on the stopper that is provided with bioceramic.
Wherein, the bioceramic in the step 1) is to adopt ion beam to strengthen CVD method to be coated in the raw material surface.It is under room temperature and vacuum condition that described ion beam strengthens CVD method, and with the titanium of inert gas ion beam bombardment hydatogenesis on the raw material surface, the reacting gas that its absorption feeds and synthesising biological pottery form the coating on raw material surface.Described raw material is the metal tube that the braiding tinsel used of stopper or engraving stopper are used.
Bioceramic stopper among the present invention can effectively promote combining of metal and cell, and climb the cover speed of endothelium on the metal surface of its modification will be far faster than unmodified common metal.Thereby the bioceramic stopper can be expected to form the natural sealing coat of one deck on its surface within a short period of time, not only improved stifledly to close effect, and improved the biocompatibility of stopper greatly.The bioceramic layer of metal surface is the effective protective layer of one deck, and it has reduced blood to reactions such as the various physics of metal, chemistry and biologies, has reduced the leakage of metal ion, thereby can avoid inflammatory reaction or thrombosis.In addition, the bioceramic stopper that obtains through this method can also improve the fatigue resistance and the wearability of stopper.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described in further detail: the bioceramic stopper is applicable to patend ductus arteriosus occluder (PDA), atrial septal defect plugging device (ASD) and the ventricular septal defect (VSD) etc. of congenital heart disease therapeutic process among the present invention, will be that example is described the present invention with patend ductus arteriosus occluder (PDA) below.In the manufacturing process of the present invention, at first make the metal webmaster by knit wire or engraving metal tube, through heat-treating profiled, utilize the end socket and the bolt head of argon arc or laser weld stopper to produce the patend ductus arteriosus occluder of not being with the choked flow film again, carry out bio-ceramic coating in its metal surface again.Under the room temperature, the patend ductus arteriosus occluder surface chemistry is cleaned, after the oven dry, put into the target chamber of ion beam enhanced depositing system.Evacuation makes target chamber base vacuum degree reach 5 * 10
-7Holder feeds high pure nitrogen then in target chamber, make target chamber vacuum reduce to 5 * 10
-6Holder feeds xenon again in ion source, be 0.8 * 10 in target chamber vacuum
-5During holder, select the energy of 20Kev for use, 5 * 10
15Atomic number/cm
2The xenon ion bundle of dosage carries out pre-clean processes to the bombardment of stopper surface.Then, be the 10A/ condition of second with the deposition velocity, electron beam evaporation purity is 99% titanium at least, the nitrogen of titanium when evaporation adsorption target in the chamber.With its while, be 40Kev with energy, beam current density is that the xenon ion Shu Lianxu of 40 μ A/cm2 bombards, and synthetic titanium nitride forms the thick compact structure of 2 μ m until the stopper surface, and adhesion is firm, uniform and stable high-quality titanium nitride protective layer.Make the choked flow film at last.
This bioceramic can effectively promote combining of metal and cell, and the bioceramic stopper can be expected to form the natural sealing coat of one deck on its surface within a short period of time, has not only improved stifledly to close effect, and has improved the biocompatibility of stopper greatly.Simultaneously, reduce the leakage of metal ion, thereby can avoid inflammatory reaction or thrombosis.
In another embodiment of the present invention, also the metal tube that the braiding tinsel that use of stopper or engraving stopper can be used is coated bioceramic according to the method for the ion vapor deposited among the last embodiment on the surface, be made into the metal webmaster then, follow the various types of stoppers of heat-treating profiled acquisition, the end socket of argon arc and laser weld stopper and bolt head are made the choked flow film at last.
Claims (10)
1, a kind of bioceramic stopper is made up of stopper and the choked flow film that is arranged on the stopper, it is characterized in that being coated with one deck bioceramic on the surface of stopper.
2, bioceramic stopper according to claim 1 is characterized in that described bioceramic is to strengthen vapour deposition process through ion beam to be coated in described stopper surface.
3, bioceramic stopper according to claim 2 is characterized in that described bioceramic can be titanium nitride, titanium carbide or titanium oxide.
4, a kind of manufacture method of bioceramic stopper is characterized in that comprising the steps:
1) at first makes stopper;
2) then at stopper surface coating one deck bioceramic;
3) at last the choked flow film is set on the stopper that is covered with bioceramic.
5, the manufacture method of bioceramic stopper according to claim 4 is characterized in that step 2) in bioceramic be to adopt ion beam to strengthen CVD method to be coated in the stopper surface.
6, the manufacture method of bioceramic stopper according to claim 5, it is characterized in that it is under room temperature and vacuum condition that described ion beam strengthens CVD method, with the titanium of inert gas ion beam bombardment hydatogenesis on the stopper surface, the reacting gas that its absorption feeds and synthesising biological pottery form the coating on stopper surface; Described reacting gas can be nitrogen, carbon or oxygen.
7, according to the manufacture method of any described bioceramic stopper of claim 4 to 6, it is characterized in that described stopper is to make the metal webmaster by knit wire or engraving metal tube, through heat-treating profiled, utilize the end socket of argon arc or laser weld stopper and bolt head to form again.
8, a kind of manufacture method of bioceramic stopper is characterized in that comprising the steps:
1) making raw material surface coating one deck bioceramic of stopper earlier;
2) more above-mentioned raw material is processed to form stopper;
3) at last the choked flow film is set on the stopper that is provided with bioceramic.
9, the manufacture method of bioceramic stopper according to claim 8 is characterized in that the bioceramic in the step 1) is to adopt ion beam to strengthen CVD method to be coated in the raw material surface.
10, the manufacture method of bioceramic stopper according to claim 9, it is characterized in that it is under room temperature and vacuum condition that described ion beam strengthens CVD method, with the titanium of inert gas ion beam bombardment hydatogenesis on the raw material surface, the reacting gas that its absorption feeds and synthesising biological pottery form the coating on raw material surface; Described raw material is the metal tube that the braiding tinsel used of stopper or engraving stopper are used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100511889A CN100400012C (en) | 2004-08-19 | 2004-08-19 | Biological ceramic stopper and method for manufacturing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100511889A CN100400012C (en) | 2004-08-19 | 2004-08-19 | Biological ceramic stopper and method for manufacturing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1736345A true CN1736345A (en) | 2006-02-22 |
| CN100400012C CN100400012C (en) | 2008-07-09 |
Family
ID=36079424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100511889A Expired - Lifetime CN100400012C (en) | 2004-08-19 | 2004-08-19 | Biological ceramic stopper and method for manufacturing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100400012C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697528A (en) * | 2012-06-01 | 2012-10-03 | 姬尚义 | Closure device |
| CN106267356A (en) * | 2015-05-22 | 2017-01-04 | 先健科技(深圳)有限公司 | Implanted medical device prefabricated component, implanted medical device and preparation method thereof |
| CN108273142A (en) * | 2018-03-21 | 2018-07-13 | 上海形状记忆合金材料有限公司 | A kind of preparation method of the controllable degradable plugging device of degradation rate |
| CN108603277A (en) * | 2016-02-03 | 2018-09-28 | 弗劳恩霍夫应用研究促进协会 | For depositing methods on base material by CdTe- layers |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357243B (en) * | 2007-08-03 | 2013-03-27 | 东莞市拓扑光电科技有限公司 | Nano vascular inner rack and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976174A (en) * | 1997-12-15 | 1999-11-02 | Ruiz; Carlos E. | Medical hole closure device and methods of use |
| CN2518475Y (en) * | 2001-12-27 | 2002-10-30 | 龚善石 | Patent arterial duct blocking device |
| CN2566817Y (en) * | 2002-09-12 | 2003-08-20 | 深圳市先健科技股份有限公司 | Stopper for ventricular septal defect |
| CN2613248Y (en) * | 2003-03-21 | 2004-04-28 | 龚善石 | Ventricular septel defect block device |
-
2004
- 2004-08-19 CN CNB2004100511889A patent/CN100400012C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697528A (en) * | 2012-06-01 | 2012-10-03 | 姬尚义 | Closure device |
| CN102697528B (en) * | 2012-06-01 | 2014-02-26 | 姬尚义 | Closure device |
| CN106267356A (en) * | 2015-05-22 | 2017-01-04 | 先健科技(深圳)有限公司 | Implanted medical device prefabricated component, implanted medical device and preparation method thereof |
| CN106267356B (en) * | 2015-05-22 | 2020-01-03 | 先健科技(深圳)有限公司 | Implanted medical device prefabricated part, implanted medical device and preparation method thereof |
| CN108603277A (en) * | 2016-02-03 | 2018-09-28 | 弗劳恩霍夫应用研究促进协会 | For depositing methods on base material by CdTe- layers |
| CN108273142A (en) * | 2018-03-21 | 2018-07-13 | 上海形状记忆合金材料有限公司 | A kind of preparation method of the controllable degradable plugging device of degradation rate |
| CN108273142B (en) * | 2018-03-21 | 2021-01-12 | 上海形状记忆合金材料有限公司 | Preparation method of degradable occluder with controllable degradation rate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100400012C (en) | 2008-07-09 |
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Granted publication date: 20080709 |