CN114159624A - Coating method of woven artificial blood vessel and artificial blood vessel - Google Patents
Coating method of woven artificial blood vessel and artificial blood vessel Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention belongs to the technical field of medical instruments, and particularly relates to a coating method of a woven artificial blood vessel and the woven artificial blood vessel. The invention adopts a step-by-step coating mode, firstly coats the woven tube blank, and coats the flat tube blank to ensure that the contact surface tension of the coating solution and the artificial blood vessel is consistent, thereby solving the uniformity of the coating and simultaneously effectively reducing the water permeation quantity of the artificial blood vessel; the artificial blood vessel prepared by the invention has uniform coating, small integral water permeation amount and good biocompatibility, keeps good elasticity and compliance of the artificial blood vessel, is stored after being sterilized and does not need to be pre-coagulated before being implanted, and can be directly used for clinical transplantation after being soaked in normal saline.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a coating method of a woven artificial blood vessel and the artificial blood vessel.
Background
With the improvement of living standard of people, the incidence rate of cardiovascular diseases is higher and higher, and the demand of artificial blood vessels is increased year by year. At present, many studies on artificial blood vessels are made in China, but the clinical application mainly refers to import artificial blood vessels. The imported artificial blood vessels are expensive and have long supply periods.
At present, the coating technology is one of the main bottlenecks of the research and development of the domestic artificial blood vessels, the research and development of the domestic artificial blood vessels are more in the aspect of coatings, but most of the artificial blood vessels are coatings after texturing, the artificial blood vessels after texturing are spiral corrugated pipes formed by alternately combining convex shapes and concave shapes in a rotating mode, the whole artificial blood vessel is seen, the inner diameter of the artificial blood vessel is changed in the axial direction, the inner surface and the outer surface of the artificial blood vessel are extremely uneven, the surface tension of coating solution on the wave crests and the wave troughs of the artificial blood vessels is different, the uniform coating is difficult to realize, and a mature coating technology is not provided at present.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a coating method of a woven artificial blood vessel and the artificial blood vessel. The artificial blood vessel prepared by the invention is stored after being sterilized, pre-coagulation is not needed before implantation, and the artificial blood vessel can be directly used for clinical transplantation after being soaked in normal saline.
In order to achieve the purpose, the invention adopts the following technical scheme:
in order to solve the coating technology, the invention carries out decomposition research on the coating process of the artificial blood vessel, and finds that at least part of the reasons for causing the problems are as follows: the varying inner diameter of the artificial blood vessel affects the surface tension of the coating solution in contact with the artificial blood vessel, thereby affecting the uniformity of the coating of the artificial blood vessel. Based on the above findings, the present invention provides a method for coating an artificial blood vessel, comprising the step of braiding a raw tube coating.
In order to solve the problem of coating uniformity, the invention adopts a step-by-step coating mode, firstly, the woven tube blank is coated, and the coating is carried out on the flat blank tube, so that the contact surface tension of the coating solution and the artificial blood vessel is consistent, thereby solving the uniformity of the coating and simultaneously effectively reducing the water permeation quantity of the artificial blood vessel; the blank tube after the texture is coated again, so that the biocompatibility of the artificial blood vessel is further improved.
The coating solution of the woven blank tube is an organic solvent solution, the effective component contained in the organic solvent is one of biological-grade polyurethane, polyester, polytetrafluoroethylene and the like, and the concentration of the coating solution is 0.5-5%.
The invention finds that the specific solution for coating the braided blank pipe can effectively reduce the permeation quantity of the blank pipe.
In order to improve the firmness of the coating of the braided blank tube, the braided blank tube is preferably degreased in advance before the coating of the braided blank tube.
The invention also discovers that degreasing treatment is carried out in advance before the coating of the braided blank tube, and active groups on the surface of the blank tube are increased by adjusting the process parameters such as the dosage of a degreasing agent, an auxiliary agent, a bath ratio, the treatment time and the like.
Furthermore, the concentration of the deoiling agent used for the deoiling treatment is 1 g/L-10 g/L, and auxiliary NaHCO is used3The concentration is 0.5 g/L-5 g/L, the bath ratio is 1:10, the treatment is carried out for 30min at 98 ℃. After the deoiling treatment, removeWashing with ionized water for 3-5 times, and then drying at 60 ℃ for 10-60 min.
Preferably, the coating of the woven blank pipe adopts a padding coating, the coating pressure is 0-5 bar, and the vehicle speed is 0.2-20 m/min. The solution enters the pores of the yarn, and the permeation quantity of the artificial vascular water is reduced.
Preferably, the coating of the braided blank tube further comprises a drying step, and the drying mode is one of hot air drying and vacuum drying.
Furthermore, the drying temperature is 40-90 ℃ and the time is 0.5-8 h.
Preferably, the coating method further comprises a step of coating the corrugated blank pipe;
furthermore, the texture-forming blank pipe is a recoating layer which is formed by a texture-forming process after the coating of the weaving blank pipe, namely, the elasticity and the compliance of the artificial blood vessel are improved by the texture-forming process.
The concentration of the effective component of the coating solution for the corrugated pipe is 1-20% of one of heparin, silk fibroin, albumin, gelatin, collagen and the like in biological grade.
Preferably, the coating is a perfusion coating, chemical crosslinking is adopted after the coating, the chemical crosslinking agent is one of formaldehyde, acetaldehyde, glyoxal, genipin and glutaraldehyde, the concentration of the chemical crosslinking agent is 0.001% -1%, vacuum drying is adopted, the temperature is 20-45 ℃, and the time is 20-120 min.
In the invention, the coating which is sequentially subjected to deoiling treatment, coating and drying is prepared into a blank pipe for texturing, and then the texturing is coated. The contact area between the blank pipe and the coating solution is increased by weaving the blank pipe, the water permeation quantity of the artificial blood vessel is reduced, and the biocompatibility of the artificial blood vessel is further improved by the coating of the textured blank pipe.
As a preferred technical scheme of the invention, the coating method comprises the following steps:
(1) deoiling the braided blank pipe;
the deoiling agent used for deoiling treatment is a refining agent, the concentration is 1 g/L-10 g/L, the concentration of NaHCO3 is 0.5 g/L-5 g/L, the bath ratio is 1:10, the treatment is carried out for 30min at 98 ℃, deionized water is washed for 2-5 times, and then the drying is carried out for 10-60 min at 60 ℃;
(2) coating the deoiled braided blank tube;
the coating solution is an organic solvent solution, the effective component contained in the organic solvent is one of biological polyurethane, polyester, polytetrafluoroethylene and the like, and the concentration of the coating solution is 0.5-5%. A padding coating is adopted, the pressure of the padding coating is 0-5 bar, and the vehicle speed is 0.2-20 m/min; drying at low temperature, wherein the drying mode is one of hot air drying and vacuum drying, the drying temperature is 40-90 ℃, and the drying time is 0.5-8 h;
(3) the woven blank tube after coating is subjected to texturing treatment, so that the kinking resistance of the artificial blood vessel is reduced;
(4) coating the artificial blood vessel after the texture is formed; the coating solution contains one of heparin, silk fibroin, albumin, gelatin, collagen and the like with the concentration of 1-20% in the biological level of the effective components; the method is characterized in that a perfusion coating is adopted, chemical crosslinking is adopted after the coating, a chemical crosslinking agent is one of formaldehyde, acetaldehyde, glyoxal, genipin and glutaraldehyde, the concentration of the chemical crosslinking agent is 0.001% -1%, vacuum drying is adopted, the temperature is 20-45 ℃, and the time is 20-120 min.
The invention also provides a woven artificial blood vessel obtained by the coating method.
Advantageous effects
According to the artificial blood vessel coating method, the contact area between the coating solution and the artificial blood vessel is increased by weaving the blank tube coating, the coating is uniform and good in adhesion, and the whole water permeation quantity of the artificial blood vessel is small; the coating after the texture is formed adopts a protein solution coating, so that the biocompatibility of the artificial blood vessel is further improved, and the elasticity and the compliance of the artificial blood vessel are effectively protected. The coating method of the invention is simple and is suitable for large-scale and continuous production.
The artificial blood vessel prepared by the invention has uniform coating, small integral water permeation amount and good biocompatibility, and keeps good elasticity and compliance of the artificial blood vessel. The artificial blood vessel prepared by the invention is stored after being sterilized, and can be directly transplanted only by being soaked in normal saline for about 3min without pre-coagulation during transplantation, thereby shortening the waiting time of the operation and relieving the pain of a patient.
Drawings
FIG. 1: a scanning electron micrograph of platelet adhesion of the artificial blood vessel obtained in example 1;
FIG. 2: control endothelial cell proliferation inverted fluorescence microscopy images;
FIG. 3: inverted fluorescence micrograph of endothelial cell proliferation of the artificial blood vessel obtained in example 1.
Detailed Description
Hereinafter, the present invention will be described in detail. Before the description is made, it should be understood that the terms used in the present specification and the appended claims should not be construed as limited to general and dictionary meanings, but interpreted based on the meanings and concepts corresponding to technical aspects of the present invention on the basis of the principle that the inventor is allowed to define terms appropriately for the best explanation. Accordingly, the description proposed herein is just a preferable example for the purpose of illustrations only, not intended to limit the scope of the invention, so it should be understood that other equivalents and modifications could be made thereto without departing from the spirit and scope of the invention.
The following examples are given by way of illustration of embodiments of the invention and are not to be construed as limiting the invention, and it will be understood by those skilled in the art that modifications may be made without departing from the spirit and scope of the invention. Unless otherwise specified, reagents and equipment used in the following examples are commercially available products.
Example 1
8mm pipe diameter artificial blood vessel coating.
Deoiling the braided artificial blood vessel with 3g/L, NaHCO g refining agent35g/L, bath ratio 1:10, 90 ℃, for 30 min. Washing with deionized water for 3 times, and baking at 60 deg.C for 20 min.
And then coating the deoiled braided blank tube by adopting a biological-grade polyurethane solution as an effective component with the mass fraction of 5%. The padding coating is adopted, the pressure is 2Bar, the vehicle speed is 2m/min, the hot air type drying is adopted, the drying temperature is 50 ℃, and the drying time is 1 h.
Weaving a blank pipe coating, then texturing, preparing a 5% solution by using albumin as an effective component and ultrapure water as a solvent for the blank pipe after texturing, coating in a perfusion coating mode, then chemically crosslinking by using 0.05% acetaldehyde, and then drying in a vacuum drying oven at the drying temperature of 45 ℃ for 6h to obtain the artificial blood vessel with the diameter of 8 mm.
To test the coating effect, the total number of water permeabilities of the artificial blood vessel obtained in this example was 0mL/cm at 120mmHg2.min。
Blood compatibility of the artificial blood vessel obtained in this example: the hemolysis rate is less than 1 percent; the difference between the APTT time and the control sample is within 5 s; compared with the positive control sample, the calcium recovery time can improve the anticoagulation function of the material; platelet adhesion (see figure 1), whole blood adhesion and control sample ratio are not greatly different, and whole blood dynamic coagulation time and positive control group are not greatly different. Cell compatibility: promoting endothelial cell proliferation (see fig. 2, fig. 3). Tissue compatibility: has no anti-inflammatory and sensitization reaction. The artificial blood vessel obtained in the embodiment is proved to have better biocompatibility.
The artificial blood vessel obtained in the embodiment is applied with a longitudinal load of 0.294N-0.588N (30 g-60 g), and the elastic recovery rate in the length direction can reach more than 99.5 percent; the compliance is less than 1.0%/100 mmHg. The artificial blood vessel obtained in the embodiment has good elasticity and compliance.
Example 2
Coating the artificial blood vessel with the pipe diameter of 18 mm.
Deoiling the braided artificial blood vessel with 5g/L, NaHCO refining agent39g/L, bath ratio 1:10, 90 ℃, for 30 min. Washing with deionized water for 4 times, and baking at 60 deg.C for 30 min.
Then, the deoiled braided blank tube is coated by adopting a biological-grade polyester solution as an effective component with the mass fraction of 8%. The padding coating is adopted, the pressure is 2.5Bar, the vehicle speed is 2.5m/min, the hot air type drying is adopted, the drying temperature is 60 ℃, and the drying time is 1 h.
Weaving a blank tube coating, then texturing, using grade heparin as an effective component for the blank tube after texturing, using ultrapure water as a solvent to prepare a solution with the concentration of 8%, coating in a pouring coating mode, then using formaldehyde with the concentration of 1% to perform chemical crosslinking, and then putting the blank tube into a vacuum drying oven to be dried, wherein the drying temperature is 35 ℃, and the drying time is 8 hours, so that the artificial blood vessel with the diameter of 18mm is obtained.
To test the coating effect, the total number of water permeabilities of the vascular prosthesis was measured to be 0mL/cm at 120mmHg2.min。
Example 3
Coating the artificial blood vessel with the pipe diameter of 28 mm.
Deoiling the braided artificial blood vessel with 5g/L, NaHCO refining agent3Treating at 10g/L and bath ratio of 1:10 at 90 deg.C for 30 min. Washing with deionized water for 3 times, and baking at 60 deg.C for 40 min.
And then coating the deoiled braided blank tube by adopting a biological-grade polyurethane solution as an effective component with the mass fraction of 10%. The padding coating is adopted, the pressure is 3.0Bar, the vehicle speed is 3m/min, the hot air type drying is adopted, the drying temperature is 50 ℃, and the drying time is 1 h.
Weaving a blank tube coating, then texturing, preparing a 6% solution by using biological-grade silk fibroin as an effective component and ultrapure water as a solvent for the blank tube after texturing, coating by adopting a perfusion coating mode, then chemically crosslinking by using 0.1% glutaraldehyde, then drying in a vacuum drying oven at the drying temperature of 40 ℃ for 8h to obtain the artificial blood vessel with the diameter of 28 mm.
To test the coating effect, the total number of water permeabilities of the vascular prosthesis was measured to be 0mL/cm at 120mmHg2.min。
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. A coating method of a woven artificial blood vessel is characterized by comprising the following steps:
(1) coating of the braided blank tube: deoiling the braided blank pipe, coating the deoiled braided blank pipe with a braided blank pipe coating solution, and drying to obtain a coated braided blank pipe;
(2) coating of the corrugated blank pipe: and (2) carrying out texture forming treatment on the coating woven blank pipe obtained in the step (1) to obtain a texture blank pipe, then coating the texture blank pipe with a texture blank pipe coating solution, and drying.
2. The method for coating a woven artificial blood vessel according to claim 1, wherein in the step (1), the degreasing process comprises: and (3) treating with a deoiling solution at a bath ratio of 1:10 and 98 ℃ for 30min, washing with deionized water for 3-5 times after the deoiling treatment, and then drying at 60 ℃ for 10-60 min.
3. The method for coating a woven artificial blood vessel according to claim 2, wherein the degreasing solution used in the step (1) comprises a degreasing agent in an amount of 1g/L to 10g/L, NaHCO30.5 g/L-5 g/L; the deoiling agent is a refining agent.
4. The method for coating a woven artificial blood vessel according to claim 1, wherein in the step (1), the coating solution of the woven blank tube is an organic solvent solution, the organic solvent contains one of biological polyurethane, polyester, polytetrafluoroethylene and the like as an active ingredient, and the coating solution contains 0.5 to 5 weight percent of the active ingredient.
5. The method for coating a woven artificial blood vessel according to claim 1, wherein in the step (1), the coating is carried out by the following specific processes: a padding coating is adopted, the pressure is 0-5 bar, and the vehicle speed is 0.2-20 m/min; the specific drying process comprises the following steps: the drying temperature is 40-90 ℃, the time is 0.5-8 h, and the drying mode is one of hot air drying and vacuum drying.
6. The method for coating a woven artificial blood vessel according to claim 1, wherein in step (2), the effective component of the parison tube coating solution comprises one of biological-grade heparin, silk fibroin, albumin, gelatin, collagen, etc., and the weight part of the effective component in the parison tube coating solution is 1-20%.
7. The method for coating a woven artificial blood vessel according to claim 6, wherein in the step (2), the coating is carried out by the following specific processes: the perfusion coating is adopted, chemical crosslinking is adopted after the coating, and the chemical crosslinking agent is one of formaldehyde, acetaldehyde, glyoxal, genipin and glutaraldehyde, and the concentration is 0.001% -1%.
8. The coating method of the woven artificial blood vessel according to claim 7, wherein in the step (2), the drying process comprises the following specific steps: vacuum drying is adopted, the temperature is 20-45 ℃, and the time is 20-120 min.
9. A woven vascular prosthesis obtainable by the coating process of any one of claims 1 to 8.
10. The woven prosthesis of claim 9, wherein the total number of water penetrations of the prosthesis is 0mL/cm at 120mmHg2.min。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117427217A (en) * | 2023-11-23 | 2024-01-23 | 山东黄河三角洲纺织科技研究院有限公司 | Woven artificial blood vessel with slow-release coating and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117427217A (en) * | 2023-11-23 | 2024-01-23 | 山东黄河三角洲纺织科技研究院有限公司 | Woven artificial blood vessel with slow-release coating and preparation method thereof |
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