CN1735424A - Saposin C-DOPS: a novel anti-tumor agent - Google Patents
Saposin C-DOPS: a novel anti-tumor agent Download PDFInfo
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- CN1735424A CN1735424A CN 200480001127 CN200480001127A CN1735424A CN 1735424 A CN1735424 A CN 1735424A CN 200480001127 CN200480001127 CN 200480001127 CN 200480001127 A CN200480001127 A CN 200480001127A CN 1735424 A CN1735424 A CN 1735424A
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Images
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
The human cell | Cell death (%) | The known defective | |
Cancerous cell line | There is not treatment | Treatment | |
Breast breast: MCF-7 | 6.8±3.5 | 96.1±1.0 | Caspase-3 zero |
MCF-7 (transfection) | 7.5±3.5 | 18.9±6.8 | Caspases-9 DN |
MCF-7 (transfection) | 10.7±3.7 | 94.0±0.7 | Vector control |
BT-549 | 6.9±2.8 | 33.6±6.6 | The p53 sudden change |
Head and neck: SCC-25 | 7.4±2.8 | 57.8±4.6 | P53 zero |
FaDu | 14.6±5.7 | 91.0±0.2 | |
Melanoma: MeWo | 8.3±2.6 | 81.9±5.4 | The p53 sudden change |
SK-Mel-28 | 7.7±3.2 | 76.2±2.0 | Apaf-1 ﹠ p53 sudden change |
Leukemia: K-562 | 7.0±2.8 | 58.0±3.4 | Apaf-1 ﹠ p53 zero |
HL-60 | 21.2±5.4 | 44.2±3.6 | P53 zero |
Cervix uteri: Hela | 3.8±1.1 | 47.3±4.4 | The p53 sudden change |
Ovary: PA1 | 7.1±1.9 | 89.9±0.2 | |
PA1 (transfection) | 8.3±3.0 | 54.1±2.5 | Caspase-9 DN |
PA1-E6 | 10.6±3.9 | 71.2±2.7 | The p53 sudden change |
SK-OV3 | 11.8±5.9 | 47.4±12.1 | |
Prostate DU145 | 4.0±1.2 | 37.0±2.8 | |
PC3 | 9.0±2.6 | 48.9±16.8 | |
Neuroblastoma SK-N-SH | 12.4±4.6 | 51.7±19.1 | The Caspase-8 sudden change |
SK-SY-5Y | 3.7±0.6 | 68.0±12.3 | The Caspase-8 sudden change |
CHLA-79 | 3.6±0.6 | 52.5±6.5 | |
Ewing sarcoma: 5838 | 12.8±3.7 | 72.1±3.9 | |
T cell lymphoma | 12.1±2.0 | 77.2±5.8 | |
Rodu T | 6.1±2.9 | 22.2±8.5 | |
GCT | 3.4±1.4 | 26.6±1.4 | |
Lung A549 | 5.0±0.8 | 25.2±13.7 | The p53 sudden change |
H441 | 10.1±4.0 | 25.4±2.2 | The p53 sudden change |
Liver: HepG2 | 9.4±3.1 | 22.0±10.2 | |
Normal cell | |||
Breast: MCF-10A | 12.8±5.2 | 19.5±5.9 | |
Keratinocyte NIK | 16.1±8.4 | 18.2±6.7 |
Table 2SK-Mel-28 melanoma | ||
IC 50 | ||
Sample | saposin C | DOPS |
saposin C∶DOPS(1∶7) | 19.5±11.0 | 136.64±78.0 |
saposin C∶DOPS(1∶3) | 99.8±13.0 | 299.3±39.0 |
saposin C∶DOPS(1∶10) | 81.3±13.2 | 813.4±132.3 |
Only contain saposin C | 786.0±25.4 | |
Only contain DOPS | 14193.4±1886.0 | |
HNSC(saposin C(1-40))∶DOPS(1∶3) | 211±32 | 633±96.0 |
H-1 (saposin C spiral-1): DOPS (1: 3) | 327±36 | 981±108.0 |
H-2 (saposin C spiral-2): DOPS (1: 3) | 243±20 | 729±60.0 |
Claims (49)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US46616603P | 2003-04-28 | 2003-04-28 | |
US60/466,166 | 2003-04-28 | ||
US10/801,517 | 2004-03-16 |
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Publication Number | Publication Date |
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CN1735424A true CN1735424A (en) | 2006-02-15 |
CN100366286C CN100366286C (en) | 2008-02-06 |
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Application Number | Title | Priority Date | Filing Date |
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CNB200480001127XA Expired - Lifetime CN100366286C (en) | 2003-04-28 | 2004-03-17 | Saposin C-DOPS: a novel anti-tumor agent |
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Cited By (3)
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CN102614125A (en) * | 2011-02-01 | 2012-08-01 | 常州长吉生物技术开发有限公司 | SapC-phosphatide nano vesicle freezed-drying preparation, and preparation method and application thereof |
US10682411B2 (en) | 2018-03-23 | 2020-06-16 | Bexion Pharmaceuticals Inc. | Saposin C pharmaceutical compositions and methods of treating cancer |
CN111432816A (en) * | 2017-10-16 | 2020-07-17 | 辛辛那提大学 | Combination therapy of fractionated radiation with SAPC-DOPS for the treatment of tumors |
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US6271196B1 (en) * | 1996-03-05 | 2001-08-07 | Regents Of The University Of Ca | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
CN1224430A (en) * | 1996-03-05 | 1999-07-28 | 加州大学评议会 | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
IL141586A0 (en) * | 1998-08-28 | 2002-03-10 | Myelos Corp | Cyclic prosaposin-derived peptide and uses thereof |
PL348517A1 (en) * | 1998-09-09 | 2002-06-03 | Myelos Corp | Method of stimulating prosaposin receptor activity |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102614125A (en) * | 2011-02-01 | 2012-08-01 | 常州长吉生物技术开发有限公司 | SapC-phosphatide nano vesicle freezed-drying preparation, and preparation method and application thereof |
CN102614125B (en) * | 2011-02-01 | 2018-11-02 | 常州长吉生物技术开发有限公司 | SapC- phosphatide nano vesicles lyophilized preparation, preparation method and the usage |
CN111432816A (en) * | 2017-10-16 | 2020-07-17 | 辛辛那提大学 | Combination therapy of fractionated radiation with SAPC-DOPS for the treatment of tumors |
US10682411B2 (en) | 2018-03-23 | 2020-06-16 | Bexion Pharmaceuticals Inc. | Saposin C pharmaceutical compositions and methods of treating cancer |
CN114642720A (en) * | 2018-03-23 | 2022-06-21 | 百祥制药公司 | Pharmaceutical compositions of saposin C and methods of treating cancer |
US11590227B2 (en) | 2018-03-23 | 2023-02-28 | Bexion Pharmaceuticals, Inc. | Saposin C pharmaceutical compositions and methods of treating cancer |
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