CN1733121A - Product with dual purpose of medicine and food for preventing and treating constipation and manufacturing method thereof - Google Patents

Abstract

The invention provides a food product with medicinal effects for preventing and treating constipation and its production process, which is prepared from hemp seed, Lin seed, bunge cherry seed, cassia seed, bitter orange, Chinese angelica root, rhubarb horsetails, pericarpium trichosanthis as medicinal material. The production process comprises the preparation, extraction and application of organic and inorganic mixed solvents, normal temperature and high temperature extraction, using lactose to substitute starch and dextrin as adsorbent and filling agent, the drug slow release speed can be slowed down substantially.

Description

Control emplastic food dual purpose product and manufacture method

Motherland's medicine and pharmacology, promptly with its good curative effect, low toxic and side effects and far away historical and global well-known Chinese medicine and pharmacy, its representative characteristics are exactly all mainly to take effective " hope, hear, ask, cut " common approach to observe various disease and patient's concrete presentation, with various all kinds of numerous and complicated diseases of correct differentiation, diagnosis and treatment and patient.Because this class understanding disease and patient's method system and comprehensive, thoughtful, diagnosis and treatment various disease and patient's first-hand clinical investigation data is in general just correct and reliable, that carries out on this basis then suits the remedy to the case, just can ensure that debating disease executing controls substantially again, add the fast development and the systemic outstanding achievement of modern Chinese medicine pharmacy, solved in many estrangement, the difficult problem of pharmacy of western medicine theory and practice aspect, reach and promoted many common recognitions, make between the two class medicine and pharmacology complementary; Although different Chinese medicine workers are not the same to same disease and patient's diagnosis and treatment power (time and ability) level, even have than big gap, but also be particular about " art is specialized in " day by day at tcm field, learn today that (specially) section constantly segments, add for a long time and practise medicine, informed experience and constantly accumulation, just can constantly produce distillation by the qualitative leap of quantitative change to qualitative change, even the stage that reaches " high degree " is also done fully and is obtained and be not rare, and except that some " difficult miscellaneous diseases ", numerous diseases and patient generally have the feature of intercommunities such as " things of a kind come together, people of a mind fall into the same group ", make and debate disease executing and control regular following, even if difficult miscellaneous diseases also are comparatively speaking, along with research deeply equally also can have rule to follow, so Chinese medicine can receive that " As the medicine took effect, the symptoms lessened " and toxic and side effects are little, effects such as no Drug resistance have been exactly very natural thing.So Chinese medicine and pharmacy comprises pharmacy of western medicine origin and flourishing countries and regions more and more widely in the whole world, more and more promptly obtain approval and application, it shows more and more outstandingly to contribution of human health life-prolonging and importance, market is also therefore extremely wide, even rising and the Chinese medical theory of China of exporting country of Chinese medicine appear, especially modern Chinese medicine science and technology and product, industry does not catch up with especially many developed countries in the world and geographic development speed, must try hard to catch up and should constantly keep domestic and international leading position and level, should be China's duty-bound corporation responsibility of each Chinese medicine worker and lofty mission.

Constipation just has above-mentioned things of a kind come together, people of a mind fall into the same group intercommunity feature, and the cause of disease mainly is that gastrointestinal is damp and hot, the whole body absurd creature is descending is obstructed and accumulates symptom, and is common frdquently encountered disease.Multiple disease, Mies such as constipation initiation poisoning turn pale, the man is no longer graceful, since constipation, food in vivo the time of staying make too for a long time the various toxin of excessive resorption, nutrient excess and generation excessive retained of a specified duration, even cause that the oval lower limb is thick, lower abdomen proud flesh, abdominal pain and distension, mottle small pox, skin are slightly done, dim complexion, sleepy weak, amnesia, increase the weight of diseases of cardiovascular and cerebrovascular systems to some extent and cause that organs such as liver, rectum, mammary gland cancerate the grievous injury physical and mental health.

Western modern medicine has only the employing glycerin to constipation, liquid wax, medicines such as phenolphthalein carry out coloclysis, lubricated, rush down treatment down, have to when all not proving effective directly draw out feces by force from anus, these ways not only misery are felt bad, and all easily form serious dependency, not only very easily cause the function of intestinal canal disorder, constipation is shown effect repeatedly further worsen development, it is difficult to drag for a long time, so risk is too big, lose more than gain, so generally uneasily, especially repeatedly adopt, but what things turn out contrary to one's wishes is that constipation is the disease of easily showing effect repeatedly just, the state of an illness also can be more and more serious, causes vicious cycle.Therefore, Chinese medicine just in time can use with its above-mentioned good drug effect and effect advantages such as toxic and side effects is little, no Drug resistance, thereby the ample scope for abilities has been arranged.

Obviously, the basic solution of constipation is to remove absurd creature obstruction old complaint in the body, and old complaint one is gone, absurd creature gets final product smooth and easy descending and generation and cumulative amount and also all greatly minimizings of the time of staying, and disease is readily solved naturally.

For addressing this problem, the present invention prevents and treats the emplastic food dual purpose product and manufacture method is promptly arisen at the historic moment, with Fructus Cannabis, Semen Lini, Semen Pruni, Semen Cassiae, Fructus Aurantii, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei, Fructus Trichosanthis, Fructus Mori Chinese crude drug is raw material, adopt the modern Chinese medicine Technology to process, debate disease executing according to Chinese medicine and control important ultimate principle and the flexible prescription of principle difference.

The Chinese medicine cardinal principle of foundation of the present invention is as follows:

Fructus Cannabis sweet in the mouth, property are put down, and return liver, spleen, stomach, large intestine, pericardium, and effect is moisturized laxation, cures mainly the dryness of the intestine constipation;

Radix Et Rhizoma Rhei bitter in the mouth, cold in nature is returned liver, spleen, stomach, large intestine, pericardium, and the intestines and stomach stagnates, rushes down heat in blood, removing blood stasis under the effect, cures mainly constipation with heat retention, jaundice due to damp-heat, carbuncle furunculosis etc.;

Semen Lini sweet in the mouth, property are flat, return liver, spleen, lung, kidney, the effect nourishing the liver and kidney, moisturize laxation, cure mainly Liver and kidney weakness, dryness of the intestine constipation;

Fructus Trichosanthis sweet in the mouth, cold in nature is returned lung, stomach, large intestine, and effect removing heat-phlegm, loosening bowel to relieve constipation are controlled constipation, phlegm-heat cough;

Semen Pruni acrid in the mouth picric acid, property are put down, and return spleen, large intestine, small intestinal, and the effect loosening bowel to relieve constipation cures mainly the dryness of the intestine constipation;

Fructus Mori sweet in the mouth, cold in nature is returned liver, the heart, kidney, and the effect replenishing YIN and blood cures mainly the dryness of the intestine constipation, the deficiency of YIN is quenched one's thirst;

Radix Angelicae Sinensis sweet in the mouth suffering, warm in nature is returned liver, spleen, the heart, and effect is enriched blood and invigorated blood circulation, moisturizes laxation, controls ulcer sore pain, dryness of the intestine constipation;

Semen Cassiae sweet-bitter flavor, cold nature are returned liver, gallbladder, and effect liver heat removing and eyesight improving, loosening bowel to relieve constipation are controlled conjunctival congestion and swelling pain, constipation due to dry stool;

The acid of Fructus Aurantii bitter in the mouth, cold nature are returned spleen, stomach, effect promoting the circulation of QI, removing food stagnancy, reduce phlegm, and cure mainly stagnation of QI due to dyspepsia, constipation;

The manufacture method of product of the present invention is as follows:

1. the preparation of Chinese medicine extraction liquid

A. decoction pieces type Chinese crude drug Fructus Cannabis 1-3 part is on the waiting list in the choosing of raw material Chinese medicine; Radix Et Rhizoma Rhei 1-5 part; Semen Lini 1-3 part; Fructus Trichosanthis 2-4 part; Semen Pruni 1-3 part; Fructus Mori 3-5 part; Radix Angelicae Sinensis 1.5-3 part; Semen Cassiae 1.5-3 part; Fructus Aurantii 1-2 part joins in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heating (evaporation) device;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;

D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid.

2, the preparation of product of the present invention

With 1 described Chinese medicine extraction liquid, be concentrated to 25-30% weight ratio concentration with triple effect or multiple-effect vacuum evaporator and technology, adding lactose is the solution dry matter content that the concentration lifting is 35-40%, be spray dried into water content below 3%, products material of the present invention and water absorption is low and reduce fading of duration of storage and preserve easily, so storage life is that the commodity shelf life is long, economic worth is high; It is made type by the compression of Any shape (very easily) such as 0.3-0.5 gram/sheet, grain, ball, and being improved drug effect by the enteric protecting film to prolong slow-release time outward and reducing possible medicine stimulates, gets product.

The usage of product of the present invention, consumption and explanation:

Usage with 3 times for each person every day, preferably ante cibum edible, eat with a small amount of eliminating cold for resuscitation water and to avoid chewing food to improve drug effect but baby children answers porphyrize edible, consumption is advisable with the each 1-2 sheet of baby children, the each 2-3 sheet of child, the each 3-4 sheet of adult, very gentleness is without any side effects again because of belonging to the pure natural and the property of medicine, so need not segment crowd and age again.The lactose yield of taking in by product of the present invention is seldom, again an enteric slow release character, finally be degraded to the simple sugar glucose easily digested and assimilated and galactose, and transform lactose by the intestinal bacterial strain and become lactic acid by the intestinal Lactose enzyme, all can do utilization of energy for human body, so can not cause any lactose intolerance anaphylaxis, can also make human body adapt to lactose gradually on the contrary and reduce its anaphylaxis, these all with drink every day the milk amount big and for the lactose of the dissolved state of no slow release to cause that easily allergy has essential different.Lactic acid also the scalable intestinal microbial population balance and more help the recovery of intestinal beneficial bacterium strain such as bacillus bifidus etc., useful gastrointestinal function and be beneficial to the healing and the rehabilitation of disease.

Major advantage of the present invention is as follows:

1, flat, the temperature of the property of medicine of prescription medical material or be slightly cold, and a, temperate zone two cold with a flat rubber belting one is slightly cold, realized Chinese medicine property of medicine overall flat and and promote drug effect tidemark mutually, promptly avoided controlling and brought " exceeding the proper limits in righting a wrong " as rushing down, rush down sharply potential side effect even new disease such as more than big impairment of body fluid gas greatly because of calentura is cold, the traditional Chinese medical science is all understood this class situation in case occur often being difficult to control, and because of do not have toxic and side effects be suitable for any crowd serve wide, these just the present invention to the imbody of the wide main advantages of Chinese medicine adaptive surface.

2, medicine variety, function are simple and clear, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.

3, the main body common feature of constipation patient is for no patient crowd's sex but have to get old and weak and obviously be inclined to and the branch of the degree that is in a bad way, main body morbidity crowd and feature be mental work, old, motion less, the slow height unanimity of treatment, or Therapeutic Method careless slightly very easily transfer chronic disease to and control for a long time difficult more, so must obtain effectively treating as early as possible.Prescription silk silk of the present invention links closely, and the cause of disease, the state of an illness and formation effect promote mutually and reinforcement circulates benignly, and from solving its water, food metabolism not normal phenomenon stomach function regulating, intestinal, spleen, kidney, lung, cardiac function imbalance and recovering and strengthen their coordination ability system engineering roots between mutual and start with, event takes stopgap measures and effects a permanent cure and curative effect is remarkable fast, the healing cycle is short and cure rate is high (detailed aftermentioned clinical trial and curative effect and data introduction), has fundamentally captured this common frdquently encountered disease difficult medical problem.

4, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.

5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.

6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, the starch and the dextrin that adopt lactose to replace easily digesting and assimilating are made adsorbent and filler, can significantly slow down the medicine slow release speed and avoid taking treatment and the rehabilitation that traditional decocting Chinese medicine amount is very greatly and substantially the primary disease of water and favourable water metabolism imbalance, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.

Test, effect and data and explanation:

Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, test patient voluntary participation.Product of the present invention is because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, and make test be easy to just satisfactorily be finished, now further do following explanation (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: totally 80 of the test patients at different sexes age allow keeping in Patent Law about situation, it is 4 groups that 20 people are divided into for one group, two groups treat with traditional western modern medicine constant relieving constipation, in addition two groups are with products of the present invention and usages, the consumption treatment, the result is as follows: though the west, Chinese medicine effective percentage and cure rate are 100%, time is the also basic identical 5-10 of being about day of the course of treatment, but curing the back Western medicine group 15-20 that promptly leaves hospital has 15 people to recur back former prescription on individual diagnosis hospital therapy successively in day, and Chinese drug-treated group is not found a people and is recurred further consultation, prove that product of the present invention only needs promptly short can curing substantially 5-10 day 1 course of treatment, this is that traditional Chinese medicine therapy is difficult to do and obtains, tracing it to its cause, we think that removing product of the present invention is the dietotherapeutic product, after warning the patient to cure to be discharged from hospitals upon recovery, we should continue it as prevention and health care food and can take substantial connection for a long time, comprise that western modern medicine (20 person-times) cures to be discharged from hospitals upon recovery and in the above-mentioned time period, do not recur personnel because we pay a return visit (totally 33 person-times), mostly all adopt the suggestion of having accepted us, adhere to edible product of the present invention to some extent.This also from illustrate on the one hand Chinese medicine and the prophylactic effect of product of the present invention really also comparatively significantly, easier than the western modern medicine prevent disease for Chinese's institute's recognition and acceptance and put into practice, also be the more importantly concrete manifestation at mission and more bright following place of Chinese medicine, be worth showing great attention to evaluation.

Claims (3)

1, a kind of control emplastic food dual purpose product is characterized in that part by Chinese crude drug Fructus Cannabis 1-3; Radix Et Rhizoma Rhei 1-5 part; Semen Lini 1-3 part; Fructus Trichosanthis 2-4 part; Semen Pruni 1-3 part; Fructus Mori 3-5 part; Radix Angelicae Sinensis 1.5-3 part; Semen Cassiae 1.5-3 part; Fructus Aurantii 1-2 part is formed.

2, the manufacture method of control emplastic food dual purpose product, its feature is as follows:

The preparation of A Chinese medicine extraction liquid

A. decoction pieces type Chinese crude drug Fructus Cannabis 1-3 part is on the waiting list in the choosing of raw material Chinese medicine; Radix Et Rhizoma Rhei 1-5 part; Semen Lini 1-3 part; Fructus Trichosanthis 2-4 part; Semen Pruni 1-3 part; Fructus Mori 3-5 part; Radix Angelicae Sinensis 1.5-3 part; Semen Cassiae 1.5-3 part; Fructus Aurantii 1-2 part joins in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heating (evaporation) device;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage and is added the dilution of room temperature drinking water and makes the mixed solvent that alcoholic strength is the organic and inorganic two kinds of solvent compositions of the sterilization type of 55-75%V/V;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of vaporization of ethanol boiling point ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, used cooling water extracts water as preheating, and the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;

D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container soak at room temperature Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. inorganic solvent is proceeded to heat to extract to medicinal residues the medicinal residues after d handles is joined in the described empty of a, floods fully with the described preheating water of c, hermetic container, turn on agitator also stir, are warmed to simultaneously boiling with 20-60 rev/min of rotating speed and slowly lower the temperature about 20-30 minute to 60-70 ℃ after 3-5 minute naturally in order to pharmaceutical compositions continuation stripping, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, discard medicinal residues behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid.

The preparation of B product

With the described Chinese medicine extraction liquid of A, be concentrated to 25-30% weight ratio concentration with triple effect or multiple-effect vacuum evaporator and technology, adding lactose is the solution dry matter content that weight ratio concentration promotes and is 35-40%, being spray dried into water content must raw material 3% below; Raw material is pressed 0.3-0.5 gram/sheet, grain, ball compression moulding, got product by the enteric protecting film outward.

3, the purposes of the anti-food dual purpose product that treats constipation is used for producing control constipation medicine and food host, and consumption needs by ordinary production; As control constipation medicine and food, usage for each person every day 3 ante cibum edible, eat with a small amount of eliminating cold for resuscitation water and to avoid chewing food but baby children answers porphyrize edible, the each 1-2 sheet of consumption baby children, the each 2-3 sheet of child, the each 3-4 sheet of adult.