CN1824047A - Chinese medicine and food dual purpose nutritive product for preventing and treating cornea malacia and its manufacturing method - Google Patents
Chinese medicine and food dual purpose nutritive product for preventing and treating cornea malacia and its manufacturing method Download PDFInfo
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Abstract
A medical product used as both medicine and food for preventing and treating the keratomala caused by pantatrophia by Chinese medicine is prepared from wolfberry fruit, liquorice root, cassia seed and chrysanthemum flower. Its preparing process is also disclosed.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.
Keratomalacia, ulcer, perforation are one of main diseases causing blindnesses of China, account for critical role in prevention of blindness work.Nutrition of whole body and metabolism are bad to be this sick essence, so with multiple ophthalmic such as nyctalopia, conjunctiva and bitot's patches, cornea ulcer with perforation at last, only carry out the general nutrition treatment and just can effect a permanent cure.If at present at the drug main artificial tears of bitot's patches phase or cod-liver oil drop eye drip to replenish moisture content and VA mitigate the disease, but obviously can't solve the nutrition of whole body fundamental issue, nature can only take stopgap measures and can not effect a permanent cure, and the medication number of times frequently very bothers, also easily contaminated or use because of the impatient excess of patient and to cause the excessive poisoning of VA, the keratomalacia phase is many with secondary infection, use antibiotic eye drip and atropine mydriasis, same because of failing to solve trophopathy because of also being the act that takes stopgap measures, medical apparatus and instruments is mainly wears soft corneal contact lens to prevent perforation of cornea, we can say to be not only and cure the symptoms, not the disease, and be " beyond cure " this moment, final perforation is blind to settle substantially, prevent and treat day after the fair, do transplant operation unless can in time seek the cornea that is fit to, even the rebirth of great doctor Hua Tuo also difficulty has the power capable of saving a desperate situation, as long as can well-knownly be that operation all is difficult to avoid operation (reaching postoperative in the art) various risks and misery, in addition it is easier said than done again in time to seek the cornea that is fit to! Even if very lucky can seeking (China's legal provisions human organ can only be contributed, not allow to buy and sell so expense is low), though corneal transplantation is that the operation that success rate is the highest in organ and the tissue transplantation is (because of cornea does not have blood vessel, lymphatic vessel, cornea central authorities epithelium does not have the Langerhans cell yet, be in " absolution zone " relatively on the immunology), however, its surgery cost also high, non-everybody can both afford.So be that the morbidity essence reason that descends according to primary disease pantatrophia, opposing (disease) power of the present invention is carried out systemic treatment and is only unique correct wise selection of primary disease only according to the essence etiology of primary disease, can present several no similar schemes reports or product come out.So far, the key i.e. problem of effecting a permanent cure of preventing and treating this disease is that the supply and the metabolism of the corresponding nutrient substance how the full-scope safeguards general is enough and stable is abundantly clear.
The present invention is exactly for solving medicinal and edible Chinese medicine control keratomalacia dietetic product and the manufacture method that this difficult problem designs, product does not have crowd restriction, to preventing and treating xerophthalmia, improving eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For ophthalmic such as control keratomalacia etc., following health promulgated by the ministries or commissions of the Central Government and GB2760 and GB14880 officinal food dual purpose product and function becomes more important and outstanding, spy further are described below one by one:
Chinese medicine food aspect: Radix Glycyrrhizae sweet in the mouth cold nature, can eliminating fire and detoxication and relax the bias of various medicines.Fructus Gardeniae bitter in the mouth cold in nature, heat clearing away also make heat from urine discharge thus effect rapidly, cooling blood for hemostasis, control the jaundice disease of conjunctival congestion and swelling pain, pyretic toxicity carbuncle, whole body jaundice, and the impaired disease of this main just hepato-biliary function that makes eye bright, involve the eyes function to some extent naturally.Semen Cassiae cold nature, suppressing the hyperactive liver and subsiding YANG, clearing away heat to improve acuity of vision, liver opening at eye, liver heat removing are apt to and can be made eye bright, so be to control oculopathy key medicines such as two blurred visions are dark, blurred vision, conjunctival congestion photophobia.Flos Chrysanthemi sweet in the mouth, detoxifcation, suppressing the hyperactive liver make eye bright and move back corneal nebula.Wisdom is nourished heart, strengthens in sweet flat, the spleen reinforcing of Arillus Longan, controls palpitation and restlessness and the hypomnesis that heart spleen blood deficiency causes and people's intelligence is strengthened.The sweet temperature of Fructus Lycii, grow kidney and replenishing marrow, nourishing the liver to improve visual acuity goes wind, cloudy emerging sun to rise, it can yin nourishing, can supporing yangly be maximum characteristics and advantage again, so can control the prosperous disease such as have a dizzy spell of deficiency of the kidney yin, liver-yang.The Semen Phaseoli sweet in the mouth is acid flat, heat-clearing and toxic substances removing, diuretic detumescent, the red swelling of the skin that the Zhi Fanyin pyretic toxicity the causes diseases such as hepato-biliary function damage such as (comprising eyes), carbuncle sore tumefacting virus, jaundice of having a pain, the another name Semen Phaseoli of the non-jequirity of these product, the two acts on complete difference and the latter is poisonous should not take orally, must distinguish clear, can not use with.The Herba Menthae acrid in the mouth is cool in nature, refresh oneself's wind heat, controls the conjunctival congestion headache.Cold in nature, the liver heat removing removing heat from blood that makes eye bright of Folium Mori sweet-bitter flavor controls that conjunctival congestion is dizzy, the lung moistening removing heat from blood.Milk powder sweet in the mouth saltiness is flat, nourishing YIN Yiyang, please that face makes eye bright, vigorate qi and replenish the blood, control the red and swollen puckery pain of binocular, make eye bright, curative effect is very good, what can also promote the guarantee crystalline lens transparency that content in the normal crystalline lens is abundant and reverse the muddy cataractous important antioxidant glutathione of lenticular control synthesizes, specifically asks for an interview the relevant elaboration in the aftermentioned content.Herba Portulacae acid is cold, heat-clearing and toxic substances removing, controls the blurring of vision that pyretic toxicity causes or gives birth to the nebula film and swell and ache.Folium Camelliae sinensis bitter in the mouth cold nature, resolving heat and reducing pathogenic fire are controlled diseases such as the vertigo, mental weariness.And above these just this disease be long-term excess eye-using, vision over loading and extremely tired, add all diseases due to the bad and accumulation of nutrition and environment such as light, reading habit etc.
Keratomalacia is because the pathological changes of cornea own, especially for a long time see computer, TV make retina power consumption too high and produce a large amount of free radicals and the cornea that causes by the exchange of approach such as aqueous humor, crystalline lens, vitreous body light (poisonings) damages, and these crowds make the tear film rupture withered because of excessively absorbed, nictation very little, add that nictation makes cornea and atmosphere time of contact also significantly be prolonged very little the tear evaporation is strengthened, again because of the same very little reason of nictation be difficult to timely and effective refresh and rebuild the tear film take place with additional tear; As a same reason, aqueous humor is by ophthalmic corpus ciliare secretion displacement, just can obviously not feel within the eye that because of it resembling the outer tear of eye lets out loss because of for a long time direct ingress of air with through tear (little) bank of tubes, but still be understood that, if lack nutrition in the diet, also will inevitably cause hemodystrophy with not enough and cause in the tear of excretory aqueous humor of corpus ciliare and lacrimal secretion various nutrition especially the free radical resisting oxidation material reduce and metabolism slows down, make and directly from aqueous humor and tear, obtain the cornea chain-react of nutrition and easily bring out malnutrition as anterior drying, muddy, softening, ulcer even perforation are blind.
There is the increase of the glutathione content of powerful anti-oxidative damage function to make cornea, crystalline lens, vitreous body be tending towards transparent; corneal nutrition, thickness and intensity are increased and prevent and treat its drying, muddiness, softening, ulcer, perforation is blind, so glutathion is another key factor of vision protection and material base.Glutathion be one natural in the destructive antioxidant of opposing free radical; not only ensure cornea, crystalline lens, vitreous body transparency and can reverse muddiness and make it to recover transparent again and improve vision, also help the liver protecting to avoid the infringement of poisonous substance and some drugs; and Chinese medicine is thought " the liver being in charge of the eyes "; western modern medicine equally also proved liver function quality directly decision eyes health degree, as storage all fixed and concrete runnings of vitamin A, D, E and B with release, inversion quantity and time etc. by extreme miosis, determine directly whether the health had in mind to be so the health of liver is whether also inevitable.Yet directly take glutathion is not a wise move because its to belong to peptide class be the protein amino acid substance, most ofly during through digestive tract can seldom can be entered blood by gastric acid and digestive tract proteolytic enzyme digest.Therefore pharmacy seldom has the glutathion tonic to sell, but as taking the effect that the tonic that can make body produce more glutathion then can reach the compensation glutathion equally and remove free radical.Therefore the method for best raising body glutathion inside level is to take in enough synthetic glutathiones and promote its raw material synthetic and its effect of raising.
Lactalbumin is to increase the synthetic effective ways of body glutathion inside: scientist has compared the influence to glutathion inside of 20 gram lactalbumins, placebo and 20 gram caseins in 20 health volunteers, found that lactalbumin can make glutathione level rising 20% in the blood, shows and can improve antioxidant status.One of them explanation is because contain a kind of sulfur-containing amino acid---cysteine in the milk surum, replenishes the glutathione level that nitrogen acetylcysteine (NAC) can improve human body.But the nitrogen acetylcysteine of long-term overdose might bring side effect, shows that because of experiment is arranged exacting practice (producing a large amount of free radicals) back takes the nitrogen acetylcysteine in conjunction with vitamin C and can make on the contrary that the interior free yl level raises, and the remarkable infringement degree of increase muscle! So the effect about it is also not too clear and definite, does not recommend to be used for improving glutathione level.Therefore, lactalbumin is taken in recommendation rather than the nitrogen acetylcysteine stimulates body glutathion inside level, and that milk powder contains abundant lactalbumin, other nutrient substance is also very abundant, is undoubtedly superior choosing, adopts one of milk powder major reason so this also is the present invention.
To sum up state, it is all very high that product of the present invention and raw material belong to total inventive concept, helpfulness and a degree of association.
Product of the present invention is made of in right amount legal dietotherapeutic Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
The manufacture method of product of the present invention is as follows:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of medicinal and edible Chinese medicine control keratomalacia dietetic product is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get product below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
1, drinks 0.5 part of sheet type Chinese crude drug Radix Glycyrrhizae, 1.5 parts of Fructus Gardeniaes, 3 parts of Semen Cassiaes, 3 parts of Flos Chrysanthemis, 1.5 parts of Arillus Longans, 2 parts of Fructus Lyciis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
2, drink 1.5 parts of sheet type Chinese crude drug Radix Glycyrrhizae, 10 parts of Semen Cassiaes, 4 parts of Fructus Lyciis, 5 parts of Flos Chrysanthemis, 3 parts of Semen Phaseolis (fragmentation), 0.5 part of Herba Menthae, 1 part on Folium Mori, 1 part of Herba Portulacae, 1 part of Folium Camelliae sinensis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
3, drink 1 part of sheet type Chinese crude drug Radix Glycyrrhizae, 5 parts of Semen Cassiaes, 3 parts of Fructus Lyciis, 10 parts of Flos Chrysanthemis, 2 parts on Folium Mori, 3 parts of Herba Portulacaes, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high; And form particularly favourite " acid is sour-sweet sweet " the popular taste products of children and easily being accepted of most crowds jointly with the acescency of the sweet taste of lactose and Radix Glycyrrhizae and Fructus Lycii and Herba Portulacae, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally, and these also are the great novelty and the practicality of the legal approval of Patent Law.
2; the property of medicine of Chinese prescription medical material is with flat; cool; it is main and cold with flat rubber belting being slightly cold; also take into account simultaneously and liver (gallbladder); relevant other organ of order after one's own heart; lung; spleen; the protection of the function of kidney and coordination; make drug effect and function more comprehensive and mark; this double controlling; realized that Chinese medicine property of medicine general inclination is in gentle and promote the high boundary of drug effect mutually; potential side effect such as bringing " exceeding the proper limits in righting a wrong " impairment of YANG functional activities of the body fluid even new disease (traditional Chinese medical science is all understood this class situation in case occur often being difficult to control) have promptly been avoided controlling because of calentura is cold; especially can regulate simultaneously and of the application of Yin Yang balancing strength with the medicine of removing bias of medicine; thereby make the moon; sun balance of force and mutual regulating power all can reach balance and gentle; all kinds of diseases and ailments are spontaneous recovery; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the imbody of the wide main advantages of Chinese medicine adaptive surface.
3, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.
4, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.
6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed and avoid taking a very Peter Pans historic difficult problem beyond affordability of traditional decocting Chinese medicine amount, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) with allow keeping in Patent Law about situation under the prerequisite of necessary KNOW-HOW and business secret and please understand: it is 2 groups that totally 40 of the test patients at different sexes, age, 20 people are divided into for one group: one group with product of the present invention and usage and dosage prevent and treat, one group of not medication compares; Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: none the routine symptom of two test group personnel with product of the present invention is deepened, and 2 people's no changes are arranged, and has 18 people to improve; The matched group experimenter finds 16 people's sxs, 4 people's no changes, none improver.
Prompting: symptom does not deepen promptly to have proved absolutely that the state of an illness is controlled, is that product of the present invention is effective, and the direction that the doing well,improving explanation state of an illness is become better reverses, is that product efficacy of the present invention is remarkable.
Claims (3)
1, medicinal and edible Chinese medicine control keratomalacia dietetic product is made of in right amount dietotherapeutic Radix Glycyrrhizae 0.5-1.5 part, Semen Cassiae 3-10 part, Fructus Lycii 2-4 part, Flos Chrysanthemi 3-10 part, Fructus Gardeniae 0-3 part, Arillus Longan 0-3 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
2, the manufacture method of medicinal and edible Chinese medicine control keratomalacia dietetic product is as follows:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the centrifugal medicinal residues of abandoning of 1000-3000 rev/min rotating speed, medicinal liquid are incorporated isolated by filtration solution into and are equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of medicinal and edible Chinese medicine control keratomalacia dietetic product is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get the compound Chinese medicine raw material below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
3, the purposes of medicinal and edible Chinese medicine control keratomalacia dietetic product: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As food, nutriment, health product and medicine host or additive, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
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| CN100384455C CN100384455C (en) | 2008-04-30 |
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Family Cites Families (10)
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| CN1055399C (en) * | 1995-02-25 | 2000-08-16 | 王存民 | Acupoint application for myopia |
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| CN1824060B (en) * | 2005-12-29 | 2010-06-16 | 颜怀伟 | Applicaiton of a combination for preparing medicine and food dual purpose Chinese medicinal nutritive product for preventing true myopia |
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| CN1824058B (en) * | 2005-12-29 | 2010-06-16 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal product for preventing and treating nightblindness and its manufacturing method |
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2005
- 2005-12-29 CN CNB2005101365367A patent/CN100384455C/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100384450C (en) * | 2005-12-29 | 2008-04-30 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal product for preventing and treating vision syndrome due to television and computer display screen light injury and its manufacturing method |
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| CN100384451C (en) * | 2005-12-29 | 2008-04-30 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal nutritive product for preventing and treating vision syndrome due to computer and its manufacturing method |
| CN1824051B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing product for preventing pseudomyopia and true myopia |
| CN1824062B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of Chinese medicinal composition for preparing product for preventing and treating pseudomyopia |
| CN1824058B (en) * | 2005-12-29 | 2010-06-16 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal product for preventing and treating nightblindness and its manufacturing method |
| CN1824060B (en) * | 2005-12-29 | 2010-06-16 | 颜怀伟 | Applicaiton of a combination for preparing medicine and food dual purpose Chinese medicinal nutritive product for preventing true myopia |
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