CN1732901A - Environment protective type casting system of aerosol - Google Patents
Environment protective type casting system of aerosol Download PDFInfo
- Publication number
- CN1732901A CN1732901A CN 200510018728 CN200510018728A CN1732901A CN 1732901 A CN1732901 A CN 1732901A CN 200510018728 CN200510018728 CN 200510018728 CN 200510018728 A CN200510018728 A CN 200510018728A CN 1732901 A CN1732901 A CN 1732901A
- Authority
- CN
- China
- Prior art keywords
- aerosol
- propellant
- dimethyl ether
- type casting
- protective type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to an environment protective type casting system of aerosol, which comprises one or several propellants, by employing the environment-friendly type propellant separately, or using the environment-friendly type propellant system consisting of several propellants, the compatibility of the feed liquid can be improved substantially.
Description
Technical field
The present invention relates to a kind of environment protective type casting system of aerosol that is used for medical treatment.
Background technology
Aerosol generally is made up of agent material and propellant, according to the difference of agent material deployment conditions in propellant, aerosol can be divided into solution-type, three kinds on emulsion type and suspension type.During use, aerosol sprays from the nozzle of aerosol valve, and propellant is the power source of aerosol, is that constitute in the aerosol products integral body one of must obligato key component, and the energy that aerosol products is being stored by means of it just can spray application.And the effect of product, except the factor of prescription with preparing process itself, and outside valve and the actuator synergy influence, the performance of propellant, proportioning and kind also can produce bigger influence to effect.Whether according to the used propellant of aerosol is freon, and aerosol is divided into freon type aerosol and non-Freon type aerosol.Freon type propellant is owing to the destruction to atmospheric ozone layer causes the sickness rate of whole world skin carcinoma significantly to improve; eyes are suffered from cataract person and are increased or the like the ecological deterioration problem; in order to protect the safety of human health and habitable environment; council of United Nations Environment Programme formulates in JIUYUE, 1987 and has passed through Montreal Protocol on Substances that Deplete the Ozone Layer, and regulation has been controlled two the classes volume of production of totally 8 kinds of materials and the initial control limit benchmark and the control time of consumption figure that comprises freon.China also added above-mentioned protocol in 1991, became one of contracting party.So this class propellant is about to be forced to ban use of.Each state is all at the positive substitute of seeking these type propellant, makes the aerosol products after substituting neither can work the mischief or threaten the whole ecological environment, can keep or meet the serviceability of original aerosol products again.
Chinese patent application CN1097201A discloses a kind of dahurian rhododendron leaf oil aerosol and preparation method thereof, used complex spreading system comprises propellant and cosolvent in its aerosol, the selected isceon, also disclose with ethanol, propylene glycol, dichloromethane, dimethyl sulfoxide, vegetable oil in its technical scheme part is cosolvent to described cosolvent in embodiment; The selected dichlorodifluoromethane, also disclose with nitrogen, carbon dioxide, nitrous oxide, liquid gas Hydrocarbon, fluorine alkyl chloride chemical compound in its technical scheme part is propellant to described propellant in embodiment; Complex spreading system wherein only is fit to the aerosol that plant volatile oil is formed.
Summary of the invention
Problem to be solved by this invention provides a kind of environment protective type casting system of aerosol, and this environment protective type casting system applied range can be used for preparing that the agent material is uniformly dispersed, the aerosol of good stability, and cost is lower.
Technical scheme provided by the invention is: a kind of aerosol complex spreading system has the environment protective type casting agent that one or more environment protective type casting agent are formed.
Above-mentioned environment protective type casting agent is dimethyl ether, solubility Compressed Gas, alkanes propellant or hydrogen fluorohydrocarbon class propellant.
Above-mentioned solubility Compressed Gas is carbon dioxide or nitrous oxide, and the alkanes propellant is propane or iso-butane, and hydrogen fluorohydrocarbon class propellant is 1,1,1,2-tetrafluoroethane (HFC-134a).
The mixture of mixture, dimethyl ether and the propane of mixture, dimethyl ether and the iso-butane of mixture, dimethyl ether and nitrous oxide that above-mentioned environment protective type casting agent is dimethyl ether and carbon dioxide and iso-butane (A-46), dimethyl ether and 1,1,1, the mixture of 2-tetrafluoroethane (HFC-134a) or the mixture of propane and iso-butane.
First kind is 10-95: 5-80 with second kind or second kind of consumption weight ratio with first kind in the said mixture.
First kind is 10-75: 5-10 with second kind or second kind of consumption weight ratio with first kind in the said mixture.
The environment protective type casting agent system that the present invention adopts one or more propellant to form has the following advantages:
1, dimethyl ether itself is a kind of volatile organic matter (VOC), but because the intermiscibility of dimethyl ether and water is good, can dissolve the water that reaches 34% (W/W) ratio, so because adding of dimethyl ether, can make and introduce the more water of volume in the prescription, thereby help to reduce VOCs content total in the aerosol products end formulation, help reducing cost.The ozone depletion potential of dimethyl ether is zero, has illustrated that greenhouse effect also almost can be ignored to the lossless effect of ozone layer, so from the environmental conservation angle, dimethyl ether also is a good substitute.
2, carbon dioxide is as propellant; have other liquefied gas class propellant the advantage that do not have or be difficult to compare; low price makes it be in the champion status of low-cost propellant especially; especially global concern and attention to environmental conservation; the carbon dioxide propellant relatively is considered to a kind of noble gas; environmental sound also has the following advantages: also have the following advantages:
(1) consumption is few, uses separately as propellant, just is enough to make one jar of aerosol to spray fully as long as charge into the carbon dioxide of 5-20g, and its economy significantly as seen.
(2) the carbon dioxide propellant is not acted upon by temperature changes, and is therefore far better compared with other liquefied gas propellant in the higher temperature scope.
(3) the carbon dioxide propellant does not fire, can be near combustibles, because it has the function of stamping out the flames.
Another solubility Compressed Gas nitrous oxide has noninflammability equally, has good stress repeatability in suitable solvent, and is easy to be dissolved in the multiple solvent, and its ozone depletion potential can be considered 0.Has the advantage that freon class propellant does not have equally.
3, the intermiscibility of alkanes propellant A-31, A-46 and HFC-134a and dimethyl ether is good, and the intermiscibility of A-31, A-46 and HFC-134a and traditional Chinese medicine liquid is not fine, so the present invention has overcome the immiscible property of A-31, A-46 and HFC-134a and traditional Chinese medicine liquid, A-31, A-46 and HFC-134a can be widely used in medicinal herbs aerosol inhalation agent field.
If 4 dimethyl ether use as propellant separately, what form is the low pressure propellant, add with solubility Compressed Gas, A-31, A-46 and HFC-134a respectively, intermiscibility is good, better lytic agent material, the solution system of formation stable uniform, casting system is highly stable, both improve the shortcoming that high pressure propellant pressure descends along with the feed liquid ejection, also solved A-31, A-46 and HFC-134a and the immiscible problem of traditional Chinese medicine liquid.And the quality physicochemical property to medicine does not have influence.Therefore the present invention, can improve the intermiscibility of feed liquid greatly, product is mixed fully, final products (were put 2 years in 450C storing three months, room temperature with the treib gasaerosole that casting system of the present invention makes, no lamination, every index does not have significant change) there is not layering, solved the limitation that carbon dioxide, A-31, A-46 and HFC-134a use in the aerosol field.
The present invention has positive effect:
1, the aerosol for external use of the present invention's configuration can not contain or contain the freon propellant less, helps environmental conservation.
2, the present invention all can be dissolved basically for the agent material of various solution-types, forms well dispersion of stability.
3, the aerosol for external use of the present invention's preparation is uniformly dispersed, and helps large tracts of land wound, parasite killing etc.
4, the present invention is used to end grieved class aerosol for external use, is used for the traumatic injury position, and administration is even, helps grieved the recovery.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1:
Propellant is dimethyl ether and carbon dioxide, proportioning is dimethyl ether 27kg, carbon dioxide 1.5kg, during fill, be the agent material with the applicant's product Moschus pain relieving liquid, weight is 80kg, the agent material is poured in the tank body, seal then, dimethyl ether in the steel cylinder and carbon dioxide charged in the jar respectively, thus make Moschus dispel the pain aerosol.The aerosol that makes and the former Moschus pain aerosol of dispelling is compared, more economical, more environmental protection, and drug effect does not have any difference.
Embodiment 2:
Propellant is with embodiment 1, and proportioning is dimethyl ether 4kg, and carbon dioxide 16kg during fill, is the agent material with the applicant's product ambroxol hydrochloride liquid, and weight is 10kg, and all the other processes are substantially the same manner as Example 1.Thereby make aerosol of ambroxol hydrochloride.
Embodiment 3:
All the other are substantially the same manner as Example 1, and difference is that selected propellant is a nitrous oxide, and proportioning is dimethyl ether 8kg, and nitrous oxide is 0.5kg, and the agent material is 5kg.
Embodiment 4:
All the other are substantially the same manner as Example 2, and difference is that proportioning is dimethyl ether 18kg, and carbon dioxide is 12kg, and the agent material is 20kg.
Embodiment 5:
Propellant is dimethyl ether and A-31, and proportioning is dimethyl ether 13kg, and A-31 7kg is the agent material with the applicant's product diclofenac sodium, and weight is 80kg, and preparation process is with embodiment 1, thereby makes the diclofenac sodium aerosol.
Embodiment 6:
Propellant is dimethyl ether and carbon dioxide, and proportioning is dimethyl ether 9kg, and carbon dioxide 11kg is the agent material with the applicant's product diclofenac sodium, and weight is 40kg, and preparation process is with embodiment 1, thereby makes the diclofenac sodium aerosol.
Embodiment 7:
Propellant is dimethyl ether and carbon dioxide, and proportioning is dimethyl ether 9kg, and carbon dioxide 1.5kg is the agent material with the applicant's product diclofenac sodium, and weight is 40kg, and preparation process is with embodiment 1, thereby makes the diclofenac sodium aerosol.
Embodiment 8:
Propellant is dimethyl ether and A-46, and proportioning is dimethyl ether 13kg, and A-46 6kg is the agent material with the applicant's product diclofenac sodium, and weight is 80kg, and preparation process is with embodiment 1, thereby makes the diclofenac sodium aerosol.
Embodiment 9:
Propellant is dimethyl ether 28kg, during fill, is the agent material with the applicant's product Moschus pain relieving liquid, and weight is 80kg, and the agent material is poured in the tank body, seals then, charges into dimethyl ether, thus make Moschus dispel the pain aerosol.The aerosol that makes and the former Moschus pain aerosol of dispelling is compared, more economical, more environmental protection, and drug effect does not have any difference.
Embodiment 10:
Propellant is carbon dioxide 2kg, during fill, is the agent material with the applicant's product Moschus pain relieving liquid, and weight is 80kg, and the agent material is poured in the tank body, seals then, charges into carbon dioxide, thus make Moschus dispel the pain aerosol.The aerosol that makes and the former Moschus pain aerosol of dispelling is compared, more economical, more environmental protection, and drug effect does not have any difference.
Embodiment 11:
Propellant is A-31 24kg, during fill, is the agent material with the applicant's product Moschus pain relieving liquid, and weight is 80kg, and the agent material is poured in the tank body, seals then, charges into A-31, thus make Moschus dispel the pain aerosol.The aerosol that makes and the former Moschus pain aerosol of dispelling is compared, more economical, more environmental protection, and drug effect does not have any difference.
Embodiment 12:
Propellant is A-46 25kg, during fill, is the agent material with the applicant's product Moschus pain relieving liquid, and weight is 80kg, and the agent material is poured in the tank body, seals then, charges into A-46, thus make Moschus dispel the pain aerosol.The aerosol that makes and the former Moschus pain aerosol of dispelling is compared, more economical, more environmental protection, and drug effect does not have any difference.
Embodiment 13:
Propellant is dimethyl ether and nitrous oxide, proportioning is dimethyl ether 27kg, nitrous oxide 1.5kg, during fill, be the agent material with the applicant's product Moschus pain relieving liquid, weight is 80kg, the agent material is poured in the tank body, seal then, dimethyl ether in the steel cylinder and carbon dioxide charged in the jar respectively, thus make Moschus dispel the pain aerosol.
Claims (7)
1. an environment protective type casting system of aerosol is characterized in that: have the environment protective type casting agent that one or more environment protective type casting agent are formed.
2. environment protective type casting system according to claim 1 is characterized in that: the environment protective type casting agent is dimethyl ether, solubility Compressed Gas, alkanes propellant or hydrogen fluorohydrocarbon class propellant.
3. environment protective type casting system according to claim 2 is characterized in that: the solubility Compressed Gas is carbon dioxide or nitrous oxide, and the alkanes propellant is propane or iso-butane, and hydrogen fluorohydrocarbon class propellant is 1,1,1, the 2-tetrafluoroethane.
4. environment protective type casting system according to claim 1, it is characterized in that: the environment protective type casting agent is mixture, dimethyl ether and the propane of mixture, dimethyl ether and iso-butane of mixture, dimethyl ether and nitrous oxide of dimethyl ether and carbon dioxide and mixture, the dimethyl ether and 1 of iso-butane, 1,1, the mixture of the mixture of 2-tetrafluoroethane or propane and iso-butane.
5. environment protective type casting system according to claim 4 is characterized in that: first kind is 10-95: 5-80 with second kind or second kind of consumption weight ratio with first kind in the said mixture.
6. environment protective type casting system according to claim 4 is characterized in that: first kind is 10-85: 5-70 with second kind or second kind of consumption weight ratio with first kind in the said mixture.
7. environment protective type casting system according to claim 4 is characterized in that: first kind is 10-75: 5-10 with second kind or second kind of consumption weight ratio with first kind in the said mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510018728 CN1732901A (en) | 2005-05-18 | 2005-05-18 | Environment protective type casting system of aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510018728 CN1732901A (en) | 2005-05-18 | 2005-05-18 | Environment protective type casting system of aerosol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1732901A true CN1732901A (en) | 2006-02-15 |
Family
ID=36075657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510018728 Pending CN1732901A (en) | 2005-05-18 | 2005-05-18 | Environment protective type casting system of aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1732901A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106085649A (en) * | 2016-06-17 | 2016-11-09 | 广州保赐利化工有限公司 | A kind of carb cleaner and preparation method thereof |
| CN106562928A (en) * | 2016-08-30 | 2017-04-19 | 广东同德药业有限公司 | Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol |
| CN107034670A (en) * | 2017-06-13 | 2017-08-11 | 合肥远科服装设计有限公司 | A kind of shirt smoothing wrinkle spray and preparation method thereof |
| CN111394208A (en) * | 2020-04-30 | 2020-07-10 | 卓聪（上海）环保科技发展有限公司 | Mixed compressed gas propellant and manufacturing method thereof |
-
2005
- 2005-05-18 CN CN 200510018728 patent/CN1732901A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106085649A (en) * | 2016-06-17 | 2016-11-09 | 广州保赐利化工有限公司 | A kind of carb cleaner and preparation method thereof |
| CN106085649B (en) * | 2016-06-17 | 2018-10-02 | 广州保赐利化工有限公司 | A kind of carb cleaner and preparation method thereof |
| CN106562928A (en) * | 2016-08-30 | 2017-04-19 | 广东同德药业有限公司 | Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol |
| CN107034670A (en) * | 2017-06-13 | 2017-08-11 | 合肥远科服装设计有限公司 | A kind of shirt smoothing wrinkle spray and preparation method thereof |
| CN111394208A (en) * | 2020-04-30 | 2020-07-10 | 卓聪（上海）环保科技发展有限公司 | Mixed compressed gas propellant and manufacturing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013341646B2 (en) | Delivery of biologically-active agents using volatile, hydrophobic solvents | |
| CA2531847C (en) | Hfc solution formulations containing an anticholinergic | |
| EP0673240B1 (en) | Stabilized medicinal aerosol solution formulations | |
| CN1732901A (en) | Environment protective type casting system of aerosol | |
| SK17699A3 (en) | Pharmaceutical composition for application in an aerosol inhaler, use of low volatile component in said composition, aerosol inhaler and aerosol particles | |
| WO2004047713A3 (en) | Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs | |
| EP2170313A2 (en) | Aqueous formulations of acetaminophen for injection | |
| CN1054282C (en) | Stabilized medicinal aerosol solution formulations | |
| CN101342369A (en) | Safety environment-friendly type medicinal propellant | |
| MA28649B1 (en) | MEDICINAL AEROSOL FORMULATION PRODUCTS WITH IMPROVED CHEMICAL STABILITY | |
| JP2005514437A5 (en) | ||
| WO2009081283A2 (en) | Aqueous formulations of acetaminophen for injection | |
| CN1304727A (en) | Injection containing evericin or ivermectin and using benzyl benzoate or nitrone as co-solvent | |
| RU2528000C1 (en) | Liquid composition of irritative action for self-defence means | |
| CN1085524C (en) | Complex spreading system for externally-used aerosol solution | |
| TW200505427A (en) | A solid oral dosage form of metformin and glyburide and the method of preparation thereof | |
| US9011830B2 (en) | Poly(CPP-SA) anhydride as a reactive barrier matrix against percutaneous absorption of toxic chemicals | |
| CN1541526A (en) | Highly effective, non-combustible, inexplosive, and shaking-free environment-friendly type aerosol propellant | |
| CN105708945A (en) | Traditional Chinese medicine aerosol composition for external use | |
| US20080249088A1 (en) | Topical Delivery of Antifungal Drugs | |
| WO2005032529A1 (en) | Mycocide composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |