CN1709221A - Compound aloe micro emulsion composition and its preparing method - Google Patents
Compound aloe micro emulsion composition and its preparing method Download PDFInfo
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- CN1709221A CN1709221A CN 200510018891 CN200510018891A CN1709221A CN 1709221 A CN1709221 A CN 1709221A CN 200510018891 CN200510018891 CN 200510018891 CN 200510018891 A CN200510018891 A CN 200510018891A CN 1709221 A CN1709221 A CN 1709221A
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Abstract
The present invention relates to a compound aloe microemulsion composition and its preparation method. Its composition includes (by weight portion) 20-41 portions of Tween-80, 10-36 portions of 1.2-propylene alcohol, 0-21 portions of water, 1-13.5 portions of oleic acid, 15-64 portions of aloe raw juice and 0.5-2 portions of vitamin E. Said invention provides the concrete steps of its preparation method, and also provides its several health-care functions of relieving inflammation, resisting bacteria, resisting tumor, raising immunity of human body and others.
Description
Technical field
The present invention relates to a kind of cosmetics and preparation method thereof, be specifically related to a kind of compound aloe micro emulsion composition and preparation method.
Background technology
Aloe is an a kind of perennial meat section herbaceous plant, and the laudatory title of " first aid plant ", " noiseless doctor ", " ten thousand answer good medicine ", " rare treasures " is just arranged since ancient times, and magical function is arranged at aspects such as medicine, health care, beauty treatments.In recent years aloetic pharmacological research there has been bigger progress, functions such as aloetic medical treatment, health care, beauty treatment have been proved absolutely, think that Aloe contains abundant aloin, polysaccharide, organic acid and protein isoreactivity composition, have antiphlogistic antibacterial, antitumor strengthens body immunity, treatment acne, seat skin ulcer, whitening and speckle dispelling, promote wound healing, enhancing body toxin expelling and cleaning function also have special curative effect to constipation and hemorrhoid.. the fresh juice of normal directly use Aloe among the people, but easily cause allergic reaction.Multiple external and aloe products for oral administration are also arranged at present, but because aloetic active ingredient bioavailability particularly water-insoluble and slightly solubility solid content matter is not high, and influenced its result of use.
Therefore, seek a kind of preparation method that can improve the Aloe bioavailability, become the industry problem demanding prompt solution.
Summary of the invention
The purpose of this invention is to provide a kind of compound aloe micro emulsion composition and preparation method, this compound aloe micro emulsion composition has good bioavailability, and its preparation method is easy to realize.
The present invention passes through Aloe original juice, and vitamin E is prepared into the compound aloe micro emulsion composition with good bioavailability.Vitamin E is that good beauty care medicine microemulsion has slow release, promotes the advantage of drug absorption.
Realize that technical scheme of the present invention is:
A kind of compound aloe micro emulsion composition, its component and mass ratio are:
20～41 parts of tween 80s (polyoxyethylene sorbitan monoleate);
1,10～36 parts of 2-propylene glycol;
0～21 part in water;
1～13.5 part of oleic acid;
15～64 parts of Aloe original juices;
0.5～2 part of the plain E of little life.
The feature of compound aloe micro emulsion composition of the present invention is that particle diameter is 1nm～100nm.
The preparation method steps in sequence of compound aloe micro emulsion composition of the present invention is:
1st, the emerald green leaf of fresh aloe that will not have withered disease cleans peeling;
2nd, will break into serosity through the Aloe after step 1 is handled, and centrifugal slagging-off, centrifugal liquid got;
3rd, in the centrifugal liquid that step 2 obtains, add the active carbon of liquid volume 4%, be heated to 70 ℃ and decolour, and placed 〉=10 hours, filter colourless Aloe original juice clear liquid;
4th, under 10～30 ℃ of room temperatures, press mass ratio with 20～41 parts of tween 80s, 10～36 part 1,2-propylene glycol and 1～13.5 part of oleic acid fully mix, and add 15～64 parts of Aloe original juices again and fully stir, and Aloe original juice is dissolved fully, adding 0.5～2 part of plain E of little life then under stirring condition fully stirs, slowly splash into 0～21 part of water for injection, get transparent compound aloe micro emulsion composition, sealing is kept in Dark Place and is got final product.
Compound aloe micro emulsion composition of the present invention has antiphlogistic antibacterial, and antitumor strengthens body immunity, and treatment acne, seat skin ulcer, whitening and speckle dispelling promote wound healing, enhancing body toxin expelling and cleaning function, and constipation and hemorrhoid also had special curative effect.
Advantage of the present invention:
1, this product has good stable
(1) get the micro emulsion composition that makes and place in vitro, sealing, 10～30 ℃ of indoor down 3 months micro emulsion compositions of placement that leave standstill still keep clear, do not see the profit layering.
(2) get the micro emulsion composition that makes and place in vitro, sealing places in 37 ℃ the constant water bath box, still keeps clear through 8 days micro emulsion compositions of water-bath, does not see the profit layering.
(3) get the micro emulsion composition that makes and place in vitro, sealing places high speed centrifuge, carries out centrifugally with the rotating speed of 3000 commentaries on classics/min, still keeps clear through 5 hours centrifugal micro emulsion compositions, does not see the profit layering.
(4), recording this compound aloe micro emulsion composition solution pH value is 4.1, and the NaOH solution adjusting pH value to 10.5 that dropwise adds 0.1mol/L still is clear and bright microemulsion.
2, this product cut size is little, after measured≤and 100nm.
Compound aloe micro emulsion composition product bioavailability height of the present invention proves that through repetition test repeatedly this product has good bioavailability.
The specific embodiment
Embodiment 1
The preparation of compound aloe micro emulsion composition the steps include:
1, gets the emerald green leaf of the fresh aloe that does not have withered disease, clean peeling;
2, the Aloe after with beater step 1 being handled breaks into serosity, and with the centrifugal slagging-off of centrifuge, must centrifugal liquid;
3, in the centrifugal liquid that step 2 obtains, add the active carbon of liquid volume 4%, heat 70 ℃ and decolour, and placed 12 hours, filter colourless Aloe original juice;
4, under 25 ℃ with tween 80 (polyoxyethylene sorbitan monoleate) and 1,2-propylene glycol and oleic acid fully mix by 20: 10: 13.5 mass ratioes, the Aloe original juice that adds 15 times of quality of oleic acid again, fully stir, Aloe original juice is dissolved fully, the plain E of little life that adds oleic acid 15/100 quality under stirring condition fully stirs then, slowly splashes into the water for injection of 6.7 times of quality of oleic acid, promptly gets transparent compound aloe micro emulsion composition;
5, the sealing of the micro emulsion composition that makes is kept in Dark Place get final product.
Embodiment 2
Aloe original juice is pressed embodiment 1 preparation, then, descend to incite somebody to action for 25 ℃ in room temperature: tween 80,1,2-propylene glycol, oleic acid fully mix by 20: 10: 1.5 mass ratioes, the Aloe original juice that adds 42 times of quality of oleic acid more fully stirs, and Aloe original juice is dissolved fully, the plain E of little life that adds oleic acid 4/3 quality under stirring condition fully stirs then, promptly gets transparent compound aloe micro emulsion composition.
Embodiment 3
Aloe original juice is pressed embodiment 1 preparation, then, under 25 ℃ with 6.2582g tween 80,1,2-propylene glycol 5.4310g and oleic acid 0.756g fully mix, add the 2.4361g Aloe original juice again, fully stir, Aloe original juice is dissolved fully, under stirring condition, add the plain E of the little life of 0.085g then and fully stir, slowly splash into 2.4361g water for injection, promptly getting transparent compound aloe micro emulsion composition. the material mass ratio is 41 parts of tween 80s in the present embodiment, 1,36 parts of 2-propylene glycol, 16.3 parts in water, 5 parts of oleic acid, 16.3 parts of Aloe original juices, little 0.57 part of element of giving birth to
Embodiment 4
Aloe original juice is pressed embodiment 1 preparation, then under 20 ℃ with 5.4310g tween 80,3.5132g 1,2-propylene glycol, 0.792g oleic acid fully mix, add the 2g Aloe original juice again, fully stir, Aloe original juice is dissolved fully, under stirring condition, add the plain E of the little life of 0.088g then and fully stir, slowly splash into 1.35g water for injection, promptly get transparent compound aloe micro emulsion.The material mass ratio is 40.56 parts of tween 80s in the present embodiment, 1, and 26.7 parts of 2-propylene glycol, 10.2 parts in water, 6 parts of oleic acid, Aloe original juice 15.2,0.67 part of the plain E of little life.
Claims (4)
1, a kind of compound aloe micro emulsion composition is characterized in that the component of compositions and mass ratio are:
20～41 parts of tween 80s;
1,10～36 parts of 2-propylene glycol;
0～21 part in water;
1～13.5 part of oleic acid;
15～64 parts of Aloe original juices;
0.5～2 part of the plain E of little life.
2, compound aloe micro emulsion composition as claimed in claim 1 is characterized in that particle diameter is 1nm～100nm.
3, the preparation method of the described compound aloe micro emulsion composition of claim 1 is characterized in that steps in sequence is:
1st, the emerald green leaf of fresh aloe that will not have withered disease cleans peeling;
2nd, will break into serosity through the Aloe after step 1 is handled, centrifugal slagging-off gets centrifugal liquid;
3rd, in the centrifugal liquid that step 2 obtains, add the active carbon of liquid volume 4%, be heated to 70 ℃ and decolour, and placed 〉=10 hours, filter colourless Aloe original juice clear liquid;
4th, under 10～30 ℃ of room temperatures, press mass ratio with 20～41 parts of tween 80s, 10～36 part 1,2-propylene glycol and 1～13.5 part of oleic acid fully mix, and add 15～64 parts of Aloe original juices again and fully stir, and Aloe original juice is dissolved fully, under stirring condition, add 0.5～2 part of plain E of little life and fully stirring then, slowly splash into 0～21 part of water for injection, get transparent compound aloe micro emulsion composition, sealing is kept in Dark Place and is got final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100188914A CN1292728C (en) | 2005-06-10 | 2005-06-10 | Compound aloe micro emulsion composition and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100188914A CN1292728C (en) | 2005-06-10 | 2005-06-10 | Compound aloe micro emulsion composition and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1709221A true CN1709221A (en) | 2005-12-21 |
| CN1292728C CN1292728C (en) | 2007-01-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100188914A Expired - Fee Related CN1292728C (en) | 2005-06-10 | 2005-06-10 | Compound aloe micro emulsion composition and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269164B (en) * | 2008-04-29 | 2010-11-10 | 雷清莲 | Method of preparing virus bacterium blood serum Chinese aloe vaccine powder preparation and oral liquid for livestock, poultry biology and aquatic animal |
| CN1895222B (en) * | 2006-06-16 | 2012-01-11 | 齐红 | Production and use for micro-emulsion and its medicine-carrier preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869061A (en) * | 1996-06-04 | 1999-02-09 | Brugh; Bettie Sue | Protective hand lotion of aloe vera gel and vitamin E gel |
-
2005
- 2005-06-10 CN CNB2005100188914A patent/CN1292728C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895222B (en) * | 2006-06-16 | 2012-01-11 | 齐红 | Production and use for micro-emulsion and its medicine-carrier preparation |
| CN101269164B (en) * | 2008-04-29 | 2010-11-10 | 雷清莲 | Method of preparing virus bacterium blood serum Chinese aloe vaccine powder preparation and oral liquid for livestock, poultry biology and aquatic animal |
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| Publication number | Publication date |
|---|---|
| CN1292728C (en) | 2007-01-03 |
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Granted publication date: 20070103 |