CN1709202A - Digital demodulation mode mixing biological impedance measuring method - Google Patents
Digital demodulation mode mixing biological impedance measuring method Download PDFInfo
- Publication number
- CN1709202A CN1709202A CN 200510014308 CN200510014308A CN1709202A CN 1709202 A CN1709202 A CN 1709202A CN 200510014308 CN200510014308 CN 200510014308 CN 200510014308 A CN200510014308 A CN 200510014308A CN 1709202 A CN1709202 A CN 1709202A
- Authority
- CN
- China
- Prior art keywords
- phi
- sin
- frequency
- vrc
- xrc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The present invention relates to a method for measuring bioelectrical impedance by adopting digital demodulation mode under the mode of frequency mixing excitation. Said invention adopts frequency mixing current of high and low two frequencies to make excitation, and provides a measuring method based on virtual reference vector, and combines said measuring method with digital demodulation mode so as to implement bioelectrical impedance measurement. Said method can provide more complete and accurate information for clinical application.
Description
Technical field
The invention belongs to the bio information detection range, be specifically related under the mixing frequency excitation mode pattern, adopt digital demodulation mode to measure the method for bio-electrical impedance.
Background technology
The bio-electrical impedance measuring technology is to utilize the electrical characteristics of biological tissue and organ (impedance, admittance, dielectric constant etc.) and change, a kind of not damaged detection technique of extraction and Human Physiology, biomedical information that pathological condition is relevant.In early days, the main unifrequency motivation model that adopts, according to biological tissue's frequency impedance characteristic, in β frequency dispersion section, cell membrane electric capacity is basicly stable, increase along with frequency, the capacitive reactance of membrane capacitance reduces, impressed current is walked around the cell membrane extracellular fluid of flowing through during by low frequency and is passed the cell membrane fluid of inside and outside cell of flowing through during to high frequency, in order to obtain the cell internal information, must utilize the flow through characteristic of fluid of inside and outside cell of high frequency electric, therefore the biological tissue's electrical impedance information that records under the single driving frequency can not reflect the organism situation comprehensively, and the multifrequency motivation model of many at present employings promptly adopts the signal of different frequency to encourage respectively, and measure the bio-impedance of this frequency, but human body is dynamic, and this method can not be analyzed the information of same vital movement under different driving frequencies, and the different measuring frequency is when switching, newly the Time Created of bio-electrical impedance information measurement is longer under the frequency, so the data that method provided that this timesharing is measured can not accurately reflect certain electrical impedance information of organism constantly.Because the exciting current by human body must meet safety criterion, often adopt alternating current less than 1mA, therefore the signal of measuring is very faint, mainly carries out the measurement of signal by the method for phase demodulation, and demodulation method commonly used at present has switch demodulation, digital demodulation and multiplication demodulation.The switch demodulation method inevitably will introduce interference, and reference signal is not ideal square wave in amplifier gain handoff procedure, when driving frequency improved, its influence was increasing.The multiplication demodulation method generally realizes simulating phase demodulation with multiplier and low pass filter.Low pass filter is long Time Created, and after exponent number and cut-off frequency were determined, also determined that speed is uncontrolled Time Created thereupon, also is difficult to improve.
It is strong that digital demodulation is compared harmonic wave inhibition ability, no dc shift, and carrying out digital processing has good advantages such as motility.Can adjust sampling rate as required at any time, improve processing speed, the certainty of measurement height.Conventional switch demodulation, multiplication demodulation and digital demodulation is primarily aimed at the processing of single frequency signal.
Summary of the invention
The mixing bio-impedance measurement method that the purpose of this invention is to provide a kind of digital demodulation mode can be measured the bio-impedance under the synchronization different frequency simultaneously.
The present invention adopts the mixing electric current of two kinds of frequencies of height to encourage; At the phase shift problem in the signals transmission,, the measuring method based on empty reference vector has been proposed from the vector space angle.In order to improve the noiseproof feature of system, the mixing frequency digital demodulation scheme is adopted in the date processing motility, has realized synchronization is being measured in the bio-electrical impedance under to different driving frequencies.
Different electrical characteristics embody in biological tissue under different electric field frequencies, in α frequency dispersion section (10Hz-10kHz), and the pericellular ionic environment characteristic of measurement result dominant response; In β frequency dispersion section (10kHz-10MHz), cell membrane electric capacity is basicly stable, and along with the increase of frequency, the capacitive reactance of membrane capacitance reduces, and impressed current is walked around the cell membrane extracellular fluid of flowing through during by low frequency and passed the cell membrane fluid of inside and outside cell of flowing through during to high frequency; In γ frequency dispersion section, measurement result is main relevant with hydrone.In medical application, because most physiopathologic variations all are embodied in α and the β frequency dispersion section, therefore, these two frequency ranges are paid close attention to by people.The present invention is directed to this two frequency dispersion sections, adopt two kinds of frequencies to reach mixing frequency excitation mode mode mode, use the mixing frequency digital demodulation mode, obtain the real part and the imaginary part of the electrical impedance information under the different frequency simultaneously.
In order to obtain the value of biological complex impedance under the high and low frequency simultaneously, high and low different frequency sinusoidal signal is mixed the back as pumping signal, realize mixing frequency excitation mode.The empty reference vector method of impedance information extraction and application is finished in conjunction with the mixing frequency digital demodulation method under the mixing frequency excitation mode.
The present invention adopts high and low two kinds of mixing frequency digital demodulation modes, obtains the real part and the imaginary part of electrical impedance information under the different frequency simultaneously, and the amplitude of the measuring-signal of high and low two frequency content correspondences is respectively A
1And A
2, frequency is respectively f
1=n
1* f, f
2=n
2* f (n
1≠ n
2), sample frequency is f
s=N * f (N>2max (n
1, n
2)), the sampling period is q, and the sampling time is the integral multiple of two kinds of excitation signal cycles, and corresponding total sampling number is M=N * q,
If input signal Vs (k) is:
At f
1, f
2Two different frequencies, construct two homophases and orthogonal reference signal respectively:
Then Vs (k) and Vrs
1(k), Vrs
2(k) cross-correlation R
Xrs1, R
Xrs2, Vs (k) and Vrc
1(k), Vrc
2(k) cross-correlation R
Xrc1, R
Xrc2Be respectively
In like manner
R
Xrs1, R
Xrs2And R
Xrs1, R
Xrs2Represent the output of homophase output and quadrature respectively, can get that measuring voltage is the amplitude and the phase angle of reference to construct signal under two kinds of frequencies:
The impedance information of high and low two frequencies measured adopts empty reference vector measurement structure, make up two homophases and the empty reference signal of quadrature empty reference vector as all measurements with digital form,
In Fig. 1, reference resistance r is for electing pure resistance as, and the pressure drop on the reference resistance is V
r, V
rWith the exciting current homophase, the pressure drop in the tested impedance is V
x, vectogram as shown in Figure 2.For the ease of direct visual comparison, having set up is the actual coordinates (among Fig. 2 shown in the dotted line) of benchmark with the exciting current.Be in the actual coordinates of benchmark with the exciting current,
A
r=r×|I|,A
x=|Z
x|×|I|
Because precision resistance r is known, but adopts above-mentioned digital demodulation method measuring voltage V
xAnd V
rAmplitude and phase place, i.e. A
xAnd A
rKnown, so Z
xAmplitude can get
Z
xThe phase angle correspondence be the actual coordinates of benchmark with the exciting current, as shown in Figure 2,
∠Z
x=φ
x-φ
r
In the present invention, signal source produces sine voltage signal, and (VCCS) is converted to electric current by Voltage-controlled Current Source, and exciting current puts on tissue by leading.Because VCCS can produce phase shift with voltage transitions during for electric current, and the phase shift that produces for the voltage signal of different frequency is also different, directly adopts " signal source " output as empty reference signal, measures amplitude in the tested impedance and phase place with the drawing-in system error.
The present invention proposes empty reference vector method, measures at the impedance information of each frequency and adopts measurement structure shown in Figure 1, and two homophases of former surface construction and orthogonal reference signal are as the empty reference vector of all measurements.Utilize this empty reference vector method, the phase shift of exciting current signal I and the phase contrast between exciting current and the reference signal can be tried to achieve by known reference resistance r in the real system, therefore, and φ
x-φ
rEliminated the phase error of introducing thus.
The invention has the beneficial effects as follows: cooperate empty reference vector method by the mixing frequency excitation mode mode mode that adopts two kinds of frequencies, the Applied Digital demodulation mode, obtain the real part and the imaginary part of two kinds of electrical impedance information under the frequency simultaneously, and eliminated the error that phase shift causes in current conversion and the transmission course, adopt digital demodulation effectively to eliminate the interference that a large amount of analog devices do not match and noise is introduced simultaneously, thereby provide complete more information accurately for clinical practice.
Description of drawings
Accompanying drawing 1 is empty reference vector measuring method structure chart.
Accompanying drawing 2 is empty reference vector method vectogram.
The specific embodiment
Below by specific embodiment and in conjunction with the accompanying drawings 1~2, the present invention is further illustrated.
Present embodiment mixing frequency excitation mode signal contains high and low two frequency contents, is respectively f
1And f
2, wherein,
f
1=10kHz,f
2=100kHz
Sample frequency f
s=1MHz, 10000 points of sampling, the voltage signal Vs (k) in the tested impedance is:
Wherein, A
1, A
2And φ
1, φ
2For to be measured, at f
1, f
2Two different frequencies, construct two homophases and orthogonal reference signal respectively:
Then Vs (k) and Vrs
1(k) cross-correlation R
Xrs1For
In like manner
R
Xrs1, R
Xrs2And R
Xrc1, R
Xrc2Represent the output of homophase output and quadrature respectively, what can get measuring voltage under two kinds of frequencies is the amplitude and the phase angle of reference to construct signal:
Because precision resistance r is known, be reference vector with the structure signal, can adopt said method to measure its corresponding driving frequency f
1And f
2Amplitude be respectively Ar
lAnd Ar
2, phase angle is respectively φ
R1, φ
R2, for driving frequency f
1The amplitude that can get tested impedance is
Phase angle is φ
1-φ
R1, for driving frequency f
2The amplitude that can get tested impedance is
Phase angle is φ
2-φ
R2
Claims (1)
1. the mixing bio-impedance measurement method of digital demodulation mode, it is characterized in that: adopt high and low two kinds of mixing frequency digital demodulation modes, obtain the real part and the imaginary part of electrical impedance information under the different frequency simultaneously, the amplitude of the measuring-signal of high and low two frequency content correspondences is respectively A
1And A
2, frequency is respectively f
1=n
1* f, f
2=n
2* f (n
1≠ n
2), sample frequency is f
s=N * f (N>2max (n
1, n
2)), the sampling period is q, total sampling number is M=N * q,
Input signal Vs (k) is:
At f
1, f
2Two different frequencies, construct two homophases and orthogonal reference signal respectively:
Vs (k) and Vrs
1(k), Vrs
2(k) cross-correlation R
Xrs1, R
Xrs2, Vs (k) and Vrc
1(k), Vrc
2(k) cross-correlation R
Xrc1, R
Xrc2Be respectively:
R
Xrs1, R
Xrs2And R
Xrc1, R
Xrc2Represent that respectively homophase output and quadrature export, the amplitude and the phase angle of measuring voltage under two kinds of frequencies:
The impedance information of high and low two frequencies measured adopts empty reference vector measurement structure, make up two homophases and the empty reference signal of quadrature empty reference vector as all measurements with digital form,
Reference resistance r is for electing pure resistance as, and the pressure drop on the reference resistance is V
r, V
rWith the exciting current homophase, the pressure drop in the tested impedance is V
x, be in the actual coordinates of benchmark with the exciting current,
A
r=r×|I|,A
x=|Z
x|×|I|
Z
xAmplitude be:
Z
xThe phase angle correspondence be the actual coordinates of benchmark with the exciting current,
∠Z
x=φ
x-φ
r。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200510014308 CN1709202A (en) | 2005-07-01 | 2005-07-01 | Digital demodulation mode mixing biological impedance measuring method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200510014308 CN1709202A (en) | 2005-07-01 | 2005-07-01 | Digital demodulation mode mixing biological impedance measuring method |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1709202A true CN1709202A (en) | 2005-12-21 |
Family
ID=35705535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200510014308 Pending CN1709202A (en) | 2005-07-01 | 2005-07-01 | Digital demodulation mode mixing biological impedance measuring method |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1709202A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103584860A (en) * | 2013-11-07 | 2014-02-19 | 南京邮电大学 | Biological impedance imaging device |
CN105232042A (en) * | 2014-07-07 | 2016-01-13 | 北京大学深圳研究生院 | Detecting device and detecting system for electrical characteristics of human body surface |
CN106154048A (en) * | 2016-08-12 | 2016-11-23 | 浙江大学 | The anti-measurement apparatus of contactless fluid resistance based on digital phase-sensitive solution mediation virtual inductor technology and method |
CN107727914A (en) * | 2017-09-29 | 2018-02-23 | 苏州涟漪信息科技有限公司 | Signal measurement apparatus |
CN109394214A (en) * | 2018-11-20 | 2019-03-01 | 中山大学 | A kind of biological impedance apparatus and method based on isolation exciting current phase locking technique |
CN109938728A (en) * | 2019-01-31 | 2019-06-28 | 苏州长脉科技有限责任公司 | The measuring device and method that a kind of resistanceper unit length of external fluid is anti-and total water sub-resistance is anti- |
CN110584667A (en) * | 2019-09-12 | 2019-12-20 | 南京邮电大学 | Bioelectrical impedance detection method |
CN115363557A (en) * | 2022-08-26 | 2022-11-22 | 上海交通大学 | Multi-frequency electrical impedance measuring method based on arbitrary waveform and digital phase-sensitive demodulation |
-
2005
- 2005-07-01 CN CN 200510014308 patent/CN1709202A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103584860A (en) * | 2013-11-07 | 2014-02-19 | 南京邮电大学 | Biological impedance imaging device |
CN105232042A (en) * | 2014-07-07 | 2016-01-13 | 北京大学深圳研究生院 | Detecting device and detecting system for electrical characteristics of human body surface |
CN106154048A (en) * | 2016-08-12 | 2016-11-23 | 浙江大学 | The anti-measurement apparatus of contactless fluid resistance based on digital phase-sensitive solution mediation virtual inductor technology and method |
CN107727914A (en) * | 2017-09-29 | 2018-02-23 | 苏州涟漪信息科技有限公司 | Signal measurement apparatus |
CN109394214A (en) * | 2018-11-20 | 2019-03-01 | 中山大学 | A kind of biological impedance apparatus and method based on isolation exciting current phase locking technique |
CN109938728A (en) * | 2019-01-31 | 2019-06-28 | 苏州长脉科技有限责任公司 | The measuring device and method that a kind of resistanceper unit length of external fluid is anti-and total water sub-resistance is anti- |
CN110584667A (en) * | 2019-09-12 | 2019-12-20 | 南京邮电大学 | Bioelectrical impedance detection method |
CN115363557A (en) * | 2022-08-26 | 2022-11-22 | 上海交通大学 | Multi-frequency electrical impedance measuring method based on arbitrary waveform and digital phase-sensitive demodulation |
CN115363557B (en) * | 2022-08-26 | 2023-10-03 | 上海交通大学 | Multi-frequency electrical impedance measurement method based on arbitrary waveform and digital phase-sensitive demodulation |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1709202A (en) | Digital demodulation mode mixing biological impedance measuring method | |
CN1319490C (en) | Analog demodulation mode type frequency-mixing bio-impedance testing system | |
CN1709203A (en) | Analogue demodulation mode mixing biological impedance measuring method | |
CN1810204A (en) | Bioelectrical impedance measuring device and body composition measuring apparatus | |
CN100389721C (en) | Mixing bio-impedance measurement method based on Fourier conversion | |
CN105319445B (en) | A kind of impedance measurement method based on random demodulation device | |
CN104146709B (en) | A kind of multifrequency point bio-electrical impedance fast acquiring method | |
CN1723845A (en) | Digital demodulation mode type frequency-mixing bio-impedance testing system | |
CN1424577A (en) | Biosensor with sample type and volume test and method thereof | |
Bandarenka | Development of hybrid algorithms for EIS data fitting | |
CN109452938A (en) | A kind of HFECG signal characteristic frequency detecting method based on multiple dimensioned multi-fractal | |
CN103815905A (en) | Body composition analyzer achieving body random segmental measurement | |
CN203841697U (en) | Respiratory process three-dimensional electrical impedance tomography system based on PXI bus | |
CN105548711B (en) | A kind of multifrequency information filter recursive demodulation method | |
US11346805B2 (en) | Handheld electrochemical sensing platform | |
CN106725415A (en) | Method and device for processing electrophysiological signals | |
CN103829943A (en) | Complementary bone mineral density detector based on principle of electrical impedance and ultrasonic analysis | |
EP2313001B8 (en) | Method and device using shortened square wave waveforms in synchronous signal processing | |
CN105866211A (en) | Preparation method and application for ampicillin molecular engram sensor | |
CN110584667A (en) | Bioelectrical impedance detection method | |
Haibing et al. | Discrete wavelet soft threshold denoise processing for ECG signal | |
CN102781315B (en) | The structure of non-invasive analysis osseous tissue and chemical composition also can eliminate the method and apparatus of the impact of surrounding tissue | |
CN103584866A (en) | Bioelectrical impedance tidal volume monitoring method and device based on two channels | |
Zong et al. | Denoising method for surface electromyography signals combining CEEMDAN and interval total variation | |
CN204016284U (en) | Multifunction cardiovascular analyser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |