CN1700015B - Assembly type multifunctional sensing device - Google Patents
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- CN1700015B CN1700015B CN 200510040634 CN200510040634A CN1700015B CN 1700015 B CN1700015 B CN 1700015B CN 200510040634 CN200510040634 CN 200510040634 CN 200510040634 A CN200510040634 A CN 200510040634A CN 1700015 B CN1700015 B CN 1700015B
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Abstract
The invention discloses a component part multifunctional sensor which is suit for large batch production. It comprises: a plurality of same or different sensing function unit (1) with sensing responsive material, sensing transduction platform (2), magnetic generation means (3), wherein sensing function unit (1) is posited on sensing transduction platform (2); magnetic generation means (3) is below sensing transduction platform (2); the surface of sensing function unit (1) is connected with sensing responsive material; and inside it bundles magnetic particle (101). The invention also disclosesits large batch production method.
Description
Technical field
The present invention relates to a kind of sensor and preparation method thereof, especially a kind of sensor that is used for synchronous detection biology in enormous quantities, chemical substance, specifically a kind of assembled type multifunctional sensor device.
Background technology
Can detect simultaneously multiple material the multifunctional sensing device since its volume little, contain much information, functional, easy to use, reliability is high, be developing direction biological, the chemical sensitisation device, be subjected to showing great attention to of whole world researcher and sensor supplier.At present, biological, chemical material multifunctional sensing device mainly concentrates on array sensing chip and the micro-fluid chip.The array sensing chip mainly by certain carrier surface by point sample, original position synthetic prepare sensing responsive material array after with example reaction after the multiple biology of detection, chemical substance.It is low that the subject matter that this method exists is diffusion reaction time length, the sensing responsive storeroom may exist mutual pollution problems and usable range to be confined to nucleic acid and protein material and point sample method density, and the high problem of original position synthetic technology cost.The major advantage of this method is that flux is big.Micro-fluid chip also cry micro-fluidic chip it by the microchannel network function in whole laboratory is comprised sampling, dilutes, adds reagent, reaction, separation, detection etc. and be integrated on the reused microchip.The advantage of micro-fluid chip is applied widely.But exploitation that its subject matter comprises that flux is low, gordian technique is still needed etc. limits its widespread use.
Summary of the invention
The purpose of this invention is to provide a kind of array-type sensor spare that is suitable for standardized production in enormous quantities and preparation method thereof.
Technical scheme of the present invention is:
A kind of assembled type multifunctional sensor device, comprise some identical or different sensing function unit 1 that have the sensing responsive material, sensing transducing platform 2 and be used for sensing function unit 1 is fixed on magnetic force generating means 3 on the sensing transducing platform 2, magnetic force generating means 3 is positioned at the below of sensing transducing platform 2; The surface of described sensing function unit 1 is connected with the sensing responsive material, its internal package particle 101 that is magnetic, described sensing transducing platform 2 is for plane-shaped structure or be provided with hole 4, array hole, it is characterized in that described sensing function unit 1 is the tumbler structure, the sensing function unit 1 of tumbler structure is positioned on the planar shaped sensing transducing platform 2 under the effect of magnetic force generating means 3 or is positioned to have in the hole 4, array hole on the sensing transducing platform 2 in hole 4, array hole, and the one side that has a sensing responsive material upwards.
The size of sensing function unit 1 is equipped with the cover plate 5 that has at least one injection orifice 501 between 20 nanometers to 1 centimetre on the top of sensing function unit 1, and cover plate 5 is formed a transducing space 6 with sensing transducing platform 2.
Can be provided with the dam shape structure that several are divided into the district on the sensing transducing platform 2.
In the bottom of sensing transducing platform 2, the top of magnetic force generating means 3 is provided with the magnetic conductance plate that matches with sensing transducing platform 2.
Can being realized of said modules formula multifunctional sensing device by following preparation method:
A, at first will as organic material, inorganic material or the inorganic-organic composite material of preparation material by impression injection molding, microballoon synthetic method or offset printing-etching combined techniques simultaneously prepared in batches obtain the idiosome particle that inside has magnetic-particle;
Secondly b, the surface is not had the idiosome particle that the connects functional group method by chemistry or physics and make its surface form connection functional group; The surface itself is had the idiosome particle that connects functional group, then directly carry out next step operation;
C, then the method by chemistry or physics above-mentioned have connect functional group the idiosome particle surface fixedly the sensing responsive material promptly make sensing transducing unit;
D, prepare the diaphragm structure that the surface has hole hole array by offset printing-etching combined techniques or template stamped method again, and the size in hole, hole and the size of corresponding sensing transducing unit are complementary, promptly get sensing transducing platform;
E, at last the above-mentioned sensing transducing unit that makes, sensing transducing platform, magnetic force generating means are fitted together and promptly get assembled type multifunctional sensor device of the present invention.
A cover plate that has the injection orifice of injection sensing transducing unit is installed on the top of sensing transducing platform in the time of assembling sensing transducing unit, sensing transducing platform, magnetic force generating means, and is formed a sensing transducing space with sensing transducing platform; In addition, install in the bottom of sensing transducing platform one with it profile match be used to increase the magnetic conductor that makes reliable location on sensing transducing platform, sensing transducing unit.
Sensing transducing unit has sensing mark, this sensing mark or when the idiosome preparation of granules, make, or fixedly increasing in the sensing responsive material.
As mentioned above, sensing transducing of the present invention unit, sensing transducing platform and other auxiliary unit can be concentrated in batches by the standard component formula and produce, and its sensing transducing cell size is between between 20 nanometers to 1 centimetre; Can be earlier during manufacturing be prepared into the sensing transducing unit embryo of extraordinary 3D shape, prepare sensing transducing unit thereby functional group then by existing or the tool linkage function introduced such as hydroxyl, carboxyl, amido, aldehyde radical etc. connect the sensing responsive material by impression injection molding, microballoon synthetic method, offset printing-etching combined techniques.The material that described impression injection molding is characterized in that impressing injection molding comprises under the normal temperature normality for solid-state because dissolving, fusion, mixes the material into fluid state, also comprises and can become solid-state material by chemical reaction.The functional group that wherein introduces the tool linkage function introduces the functional group of tool linkage function or introduces the functional group of tool linkage function or the functional group that introduces the tool linkage function by methods such as vacuum coating, magnetron sputtering plating, vapour depositions behind the surface deposition film of the sensing transducing unit of extraordinary 3D shape by the plasma gas reaction or by chemical reaction by coupling reagent such as silane coupling agent, titanate coupling agent, aluminate coupling agent etc.Described sensing responsive material is characterized in that the sensing responsive material comprises cell, bacterium, virus, albumen, nucleic acid, ion-sensitive material, is loaded with the carrier of sensing responsive material as introducing the macromolecular material of sensing responsive functional group or functional group's group.Described sensing transducing unit is used for the sensing purpose by assembling on sensing transducing platform.Sensing transducing unit can be fixed on the sensing transducing platform by the external energy field, also can be dispersed in the sensing transducing space by the external energy field, and these two processes can repeat or circulate to carry out.Described external energy field can be magnetic field, electric field, sound field, electromagnetic field.Bottom, described sensing transducing unit is an arc, the shape on top then can be chosen wantonly, the shape of its upper surface is optional but be preferably arc and plane, and promptly sensing transducing unit center of gravity guarantees that sensing transducing unit can stand on the plane, also is our common tumbler planform.Sensing transducing unit can be fixed on the sensing transducing platform in Wu Keng hole by magnetic field, also can be fixed on the cratered sensing transducing platform by magnetic field, this moment is not when being spherical as sensing transducing unit, sensing transducing unit combines the cross section of the cross section near coal-mine place more than or equal to sensing transducing unit, near coal-mine below and junction, sensing transducing platform hole with sensing transducing platform, when sensing transducing unit when being spherical, the radian of sensing transducing unit smaller or equal to the radian in sensing transducing platform hole with the sensing responsive material of guaranteeing sensing transducing unit sensing transducing platform in conjunction with the hole outside.The material of making sensing transducing unit comprises that organic material comprises that high-molecular organic material, organic small molecule material, inorganic material comprise inorganic ceramic material, inorganic metal material and inorganic-organic composite material.Sensing transducing unit can be used for by the method for mark detecting also and can be used for detecting by cold method, and mark can increase when making sensing transducing unit idiosome particle, also can increase when connecting the sensing responsive material for the idiosome particle.The method of mark comprises that single or multiple fluorescent material carries out mark, single or multiple color material (comprising that dyestuff, non-ferrous metal, schemochrome material comprise interference, diffraction structure look material) and carries out mark, single or multiple luminescent material and carry out mark, simple or complex geometric shapes and comprise that the mode of geometry sizes carries out mark, utilizes the position to carry out mark, utilizes element to comprise that radioactive isotope carries out mark.The hole footpath size of hole, hole array that can carry sensing transducing unit on the sensing transducing platform is between 20 nanometers to 1 centimetre, and its surface can be loaded with the P.e.c. that links to each other with each hole, hole as required.Sensing transducing platform can be the single or multiple lift structure, but preferred sandwich construction, the upper strata is to be loaded with hole hole array and is the good conductor of energy field in the thin energy field poor conductor lower floor of hole hole sole, perhaps the upper strata is that the energy field good conductor lower floor that is loaded with hole hole array then is energy field poor conductor material with relative at the bottom of the hole, hole for energy field good conductor other parts, to guarantee the energy field useful effect in sensing transducing unit, make sensing transducing unit can be fixed in sensing transducing platform effectively or in sensing transducing space, disperse, the convenient switching between motion.It also can be that sensing transducing unit can switch between fixing on the sensing transducing platform and dispersion, motion that the sensing function unit can be fixed on the sensing transducing platform.The shape of sensing transducing platform comprises optional planar structures such as ribbon, rectangle, also can be band on rotating disk, micro-fluid chip shape, array chip shape, pen type etc.The assembling of multiple sensing function unit on sensing transducing platform can be controlled method by point sample method, micromachine arm, fluid is written into method and is written into assembling.Sensing transducing space is in sensing transducing unit and the outside of sensing transducing platform surface, can hold the sensing transducing unit that is not fixed into hole, sensing transducing platform hole and other reaction solution, reagent.Sensing transducing space is single chamber or surpasses a chamber that links to each other or separate and include the sample filling orifice and the discharging of waste liquid pond.Assembled type multifunctional sensor device can detect by absorption spectrum, fluorescence spectrum, element detection, Electrochemical Detection, luminous detection, piezoelectric detection, thermal conductance, electricity is led methods such as detection, optical microscope, fluorescent microscope, infrared microscope, elliptic polarization microscope, resistance detection, capacitance detecting, inductance detection and detected.The material that is detected comprises miniature organism bodies such as cell, bacterium, virus, biology, chemical micromolecule, gases such as the big molecule of biological chemistries such as albumen, nucleic acid, ion, sugar, amino acid.
Beneficial effect of the present invention:
The notion that the present invention produces standard component in batches is first introduced multifunctional bio chemical sensitisation device field, produces sensing transducing unit, sensing transducing platform and other auxiliary unit in batches by the standard component formula and produces multifunctional bio, chemical sensitisation device by assembling then.Can effectively disperse by the control of external energy field, move and the narrow application range, the sensing responsive material that fixedly have solved array biochip exists and pollute mutually and shortcoming such as diffusion reaction time length and the micro-fluid chip flux is low, prepare complicated problems because the multifunctional sensing device output of producing by this technology is big, cost is low, be easy to the multifunctional sensing device sensing transducing unit after the microminiaturized and assembling, can be efficient thereby can obtain, the high-performance multifunctional sensing device of the multiple biology of synchronous detection, chemical substance with cheap price.
The advantage applies of concentrated batch process assembly type sensing of the present invention is aspect following two:
The one, what use when making the idiosome particle of sensing transducing unit is the method for idiosome particle of specification of the same race of can be mass-produced, and the idiosome particle that the method that also can adopt chemistry or physics when the idiosome particle manufactured the sensing transducing unit that has the sensing responsive material obtains above-mentioned batch process is produced the sensing transducing unit of different sensing responsive materials again with form in batches, thereby available a kind of method obtains large batch of sensing transducing unit simultaneously, different combinations can be produced different sensing transducing unit in enormous quantities, therefore can reduce the manufacturing cost of sensing transducing unit greatly.
The 2nd, with sensing transducing unit and the assembling of sensing transducing platform the time, on same platform, can assemble the sensing transducing unit of multiple different sensing responsive materials simultaneously, make that a sensor can the different object of while batch detection.
Description of drawings
Fig. 1 is the structural representation of senser element of the present invention.
Embodiment
The present invention is further illustrated below in conjunction with drawings and Examples.
As shown in Figure 1.
A kind of assembled type multifunctional sensor device, comprise sensing function unit 1, sensing transducing platform 2, magnetic force generating means 3, cover plate 5, auxiliary unit 7, the array that sensing function unit 1 is installed on the sensing transducing platform 2 is cheated in the hole 4, and magnetic force generating means 3 is positioned at the below of sensing transducing platform 2; Hole 4, array hole on the profile of sensing function unit 1 and the sensing transducing platform 2 matches, its internal package particle 101 that is magnetic, its surface is connected with the sensing responsive material, the size of sensing function unit 1 is between 20 nanometers to 1 centimetre, on the top of sensing function unit 1 cover plate 5 that has injection orifice 501 is installed, cover plate 5 is formed a transducing space 6 with sensing transducing platform 2.Sensing transducing platform 2 is provided with several dam shape structures that is divided into the district.In the bottom of sensing transducing platform 2, the top of magnetic force generating means 3 is provided with the magnetic conductance plate that matches with sensing transducing platform 2.The outside at sensing transducing platform 2 is equipped with auxiliary unit 7; Auxiliary unit 7 can be miniature circulating pump.
Sensing transducing platform 2 is the functional units that can carry sensing transducing unit 1.Its effect mainly show selectivity conduction external energy field fixedly the sensing function unit in the hole, hole 4 of sensing transducing platform 1 in and guarantee sensing transducing unit 1 can be the hole, hole 4 of being fixed in sensing transducing platform 2 densely in and externally dispersion under the effect of energy field, move between switching.Sensing transducing platform 2 is main by forming with hole, hole 4 arrays of sensing transducing unit 1 driving fit and the magnetic force generating means 3 of below thereof.Magnetic force generating means 3 comprises can be reversible or irreversibly fixing or disperse the magnetic field, electric field, sound field, electromagnetic field etc. of sensing transducing unit.When sensing detection utilizes galvanochemistry, resistance, inductance, electric capacity etc. to relate to the use of electricity, also be printed on the P.e.c. that is communicated with external power source on the sensing transducing platform 2.When needs are separated different types of sensing transducing unit 1, also have dam formula structure dividing strip to make the distance at top in the top of dam formula dividing strip and sensing transducing space 6 on the sensing transducing platform 2 less than the size of sensing transducing unit 1.
Sensing transducing space 6 is can hold the sensing function unit 1 that leaves sensing transducing platform 2, detect the space with reagent and test sample.Sensing transducing space 6 can have only a chamber also can comprise a plurality of chambers.Can circulate fully between chamber also can be logical by valve controlling flow.Different types of sensing transducing unit chamber that can coexist also can be at different chamber, and reagent, the solution sensing transducing unit that can circulate then is subjected to the dam formula structure that exceeds on the sensing transducing platform and can not circulates between chamber.
Below be concrete manufacture method:
A, at first will prepare the idiosome particle that inside has magnetic-particle by impression injection molding, microballoon synthetic method or offset printing-etching combined techniques as organic material, inorganic material or the inorganic-organic composite material of preparation material;
Secondly b, the surface is not had the idiosome particle that the connects functional group method by chemistry or physics and make its surface form connection functional group; The surface itself is had the idiosome particle that connects functional group, then directly carry out next step operation;
C, then the method by chemistry or physics above-mentioned have connect functional group the idiosome particle surface fixedly the sensing responsive material promptly make sensing transducing unit;
D, prepare the diaphragm structure that the surface has hole hole array by offset printing-etching combined techniques or template stamped method again, and the size in hole, hole and the size of corresponding sensing transducing unit are complementary, promptly get sensing transducing platform;
E, at last the above-mentioned sensing transducing unit that makes, sensing transducing platform, magnetic force generating means are fitted together and promptly get assembled type multifunctional sensor device of the present invention.
Details are as follows:
Can at first be prepared into extraordinary 3D shape for sensing transducing unit by impression injection molding (being similar to the method for casting), microballoon synthetic method, offset printing-etching combined techniques, obtain the idiosome particle that inside includes magnetic-particle, if containing, the top layer of preparation material connects functional group, as hydroxyl, carboxyl, amido, aldehyde radical etc., the functional group that then need not introduce the tool linkage function; If not then need to comprise that silane coupling agent, titanate coupling agent, aluminate coupling agent etc. are introduced the functional group of tool linkage functions or by plasma gas reaction or the functional group that introduces the tool linkage function by chemical reaction by coupling reagent; As required can be if its surface is not suitable for fixedly connected functional group in the one side of fixing sensing responsive material by methods such as vacuum coating, magnetron sputtering plating, vapour depositions on the surface of the sensing transducing unit of extraordinary 3D shape by gas phase or liquid deposition film, and then introduce and connect functional group.For containing or having introduced fixedly sensing responsive material of method that the top layer that connects functional group then can be by chemical Covalent Immobilization or physisorption.The sensing responsive material comprises the material of albumen, nucleic acid, ion, micromolecule sensitivity and is loaded with the macromolecular material of the carrier of sensing responsive material as introducing sensing responsive functional group or functional group's group.Here the impression injection molding of being said refers to melted material, macromolecule is organic or inorganic material solution, can react the organic and inorganic small molecule material solution that becomes macromolecular material and inject the mould that can finally form required sensing transducing unit three-dimensional shape, the elimination of solvent in the organic or inorganic material solution by cooling, the macromolecule of fused solution, can form the germule of extraordinary sensing transducing unit by the elimination that reaction becomes the polymerization of organic and inorganic small molecule material solution of macromolecular material and solvent.The microballoon synthetic method refer to by in solvent or gas, utilize surface tension make macromolecular material solution or can form sphere by solution or the melted material that polymerization, other chemical reaction form macromolecular material, utilize then solvent in the macromolecule material solution elimination, can form the polymerization of solution of macromolecular material and the elimination of solvent by polymerization, other chemical reaction, the cooling of melted material obtains microballoon.Offset printing-etching method refers to by lithographic printing and at first is printed on special selected pattern then by selecting suitable lithographic technique to etch special three-dimensional appearance at certain material surface, can repeat offset printing-etching process if desired so that obtain final required three-dimensional appearance.Material therefor can be that fluent material also can be the potpourri of fluid and solid material or be the particle of solid-state material fully completely in impression injection molding and the microballoon synthetic method.
The diaphragm structure that can have hole, extraordinary hole array for sensing transducing platform by offset printing-etching combined techniques or the preparation of template stamped method.Template stamped method described here refers to the template that will be loaded with the thrust array corresponding with extraordinary pit structure and is pressed into owing to former thereby softening material surfaces such as fusion, dissolvings, can obtain hole, extraordinary hole array after the softener material hardening is solidified.The template that is loaded with the thrust array corresponding with extraordinary pit structure can be by offset printing-etching combined techniques or the preparation of other method.Can comprise as required that above the diaphragm structure that is printed on hole, extraordinary hole array processing such as film sedimentation, circuit printing, offset printing-etching make this structure and sensing transducing unit compatibility and suitable relevant detection means detect then and should print P.e.c. on the surface with galvanochemistry as needs.Be to have good energy field ducting capacity and can combine good material below the diaphragm structure that is printed on hole, extraordinary hole array, as magnetic field being had good ducting capacity and combining good macromolecular material with hole, hole array diaphragm structure macromolecular material with the diaphragm structure that is printed on hole, extraordinary hole array.Auxiliary unit comprises that micropump etc. can also be fixed on the sensing transducing platform except can being fixed on sensing transducing space top cover.
During concrete enforcement, sensing transducing platform also can be plate armature, and its surface can not process or process very shallow hole, aforesaid hole, the effect in the magnetic field that fixedly places one's entire reliance upon of sensing transducing unit.
The assembling of assembled type multifunctional sensor device (being about to structures such as cover plate, sensing transducing platform, magnetic conductive board connects) can method such as be sticked, inlay by tackifier, heat and be carried out.Can sensing transducing unit 1 be directed into the surface of sensing transducing platform 2 during concrete the use by point sample method, fluid transport method to the assembling of sensing transducing unit 1 on sensing transducing platform 2, realize fixing by the magnetic force generating means 3 of sensing transducing platform 2 belows then, and sensing transducing unit 1 leave hole, hole 4 on the sensing transducing platform 2 disperse, move also can by above the sensing transducing platform 2 or below magnetic force generating means 3 implement.
During use, can also can be to the detection of assembled type multifunctional sensor device by unmarked detection by marker detection.Unmarked detection mainly adopts units such as spectroscopic ellipsometry or microscope, white light interference spectrum, piezoelectric detection technology, surface sharp from spectral technique, waveguide detection.Labeling method in the marker detection comprises that single or multiple fluorescent material carries out mark, single or multiple color material (comprising that dyestuff, non-ferrous metal, schemochrome material comprise interference, diffraction structure look material) and carries out mark, single or multiple luminescent material and carry out mark, simple or complex geometric shapes and comprise that the mode of geometric configuration, size carries out mark, utilizes the position to carry out mark, utilizes element to comprise that radioactive isotope carries out mark.Mark can adopt a kind of labeling method, also can adopt two kinds or two or more labeling methods.That to comprise that absorption spectrum, fluorescence spectrum, element detection, Electrochemical Detection, luminous detection, piezoelectric detection, thermal conductance detect, electricity is led detection, optical microscope, fluorescent microscope, infrared microscope, elliptic polarization microscope, resistance detection, capacitance detecting, inductance detections, waveguide detection, white light interference spectrum, surface etc. first is sharp from spectral technique etc. for the method that detects by mark.Detection can adopt a kind of detection method also can adopt two kinds or two or more detection methods simultaneously.
The material of the detection by assembled type multifunctional sensor device comprises tiny organism bodies such as cell, bacterium, virus, biology, chemical micromolecule, gases such as albumen, nucleic acid etc. are biological, the big molecule of chemistry, ion, sugar, amino acid.
Claims (6)
1. assembled type multifunctional sensor device, comprise some identical or different sensing function unit (1) that have the sensing responsive material, sensing transducing platform (2) and be used for sensing function unit (1) is fixed on magnetic force generating means (3) on the sensing transducing platform (2), magnetic force generating means (3) is positioned at the below of sensing transducing platform (2); The surface of described sensing function unit (1) is connected with the sensing responsive material, its internal package particle (101) that is magnetic, described sensing transducing platform (2) is for plane-shaped structure or be provided with hole (4), array hole, it is characterized in that described sensing function unit (1) is the tumbler structure, the sensing function unit (1) of tumbler structure is positioned planar shaped sensing transducing platform (2) and goes up or be positioned to have in the array hole, hole (4) on the sensing transducing platform (2) in array hole, hole (4) under the effect of magnetic force generating means (3), and the one side that has a sensing responsive material upwards.
2. a kind of assembled type multifunctional sensor device according to claim 1 is characterized in that described sensing function unit (1) has sensing mark.
3. a kind of assembled type multifunctional sensor device according to claim 1, the size that it is characterized in that described sensing function unit (1) is between 20 nanometers to 1 centimetre, on the top of sensing function unit (1) cover plate (5) that has at least one injection orifice (501) is installed, cover plate (5) is formed a transducing space (6) with sensing transducing platform (2).
4. a kind of assembled type multifunctional sensor device according to claim 1 is characterized in that described sensing transducing platform (2) is provided with the dam shape structure that several are divided into the district.
5. a kind of assembled type multifunctional sensor device according to claim 1 is characterized in that in the bottom of sensing transducing platform (2), the top of magnetic force generating means (3) is provided with the magnetic conductance plate that matches with sensing transducing platform (2).
6. a kind of assembled type multifunctional sensor device according to claim 1 is characterized in that in the outside of sensing transducing platform (2) auxiliary unit (7) being installed.
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| CN 200510040634 CN1700015B (en) | 2005-06-20 | 2005-06-20 | Assembly type multifunctional sensing device |
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| CN 200510040634 CN1700015B (en) | 2005-06-20 | 2005-06-20 | Assembly type multifunctional sensing device |
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| CN1700015B true CN1700015B (en) | 2010-10-06 |
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| CN102279261B (en) * | 2011-06-20 | 2013-09-18 | 东南大学 | Inkjet printing preparation method of pattern code microcarrier |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| US4813277A (en) * | 1987-03-30 | 1989-03-21 | Amoco Corporation | Method for collecting magnetizable particles in an above ground storage tank |
| WO2002103371A2 (en) * | 2001-01-31 | 2002-12-27 | Board Of Regents, The University Of Texas System | Magnetic-based placement and retention of sensor elements in a sensor array |
| CN1625686A (en) * | 2002-01-29 | 2005-06-08 | 旭化成株式会社 | Biosensor, magnetic molecule measurement method, and measurement object measuring method |
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2005
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| US4813277A (en) * | 1987-03-30 | 1989-03-21 | Amoco Corporation | Method for collecting magnetizable particles in an above ground storage tank |
| WO2002103371A2 (en) * | 2001-01-31 | 2002-12-27 | Board Of Regents, The University Of Texas System | Magnetic-based placement and retention of sensor elements in a sensor array |
| CN1625686A (en) * | 2002-01-29 | 2005-06-08 | 旭化成株式会社 | Biosensor, magnetic molecule measurement method, and measurement object measuring method |
Non-Patent Citations (2)
| Title |
|---|
| US 4795698 A,全文. |
| 全文. |
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