CN1689410A - Highly efficient compound iodine disinfectant with strong permeability and its preparation method - Google Patents
Highly efficient compound iodine disinfectant with strong permeability and its preparation method Download PDFInfo
- Publication number
- CN1689410A CN1689410A CN 200410034158 CN200410034158A CN1689410A CN 1689410 A CN1689410 A CN 1689410A CN 200410034158 CN200410034158 CN 200410034158 CN 200410034158 A CN200410034158 A CN 200410034158A CN 1689410 A CN1689410 A CN 1689410A
- Authority
- CN
- China
- Prior art keywords
- iodine
- disinfectant
- permeability
- preparation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention relates to one kind of efficient composite iodine disinfectant with powerful permeability and its compounding process. The disinfectant consists of mixture of PVP aqua and potassium iodide solution of iodine in certain proportion, synergist, stabilizer and deionized water for diluting to certain concentration. Owing to iodine carrier as main component, the synergist and the stabilizer to regulate the property of the system, the disinfectant has the advantages similar to that of PVP-I and the features of high permeability, high stability, less iodine color residue, high bactericidal effect and wide use range. The present invention may be disintegrated naturally and is environment friendly. The present invention may be used in effective disinfection of air in ward, operation room, hotel, waiting room in station, household and other places, the disinfection of medical equipment, and the pre-operation disinfection of skin, mucous membrane, etc.
Description
Technical field
The present invention relates to strong efficient compound iodine disinfectant of a kind of permeability and preparation method thereof.
Background technology
Polyvinylpyrrolidone is a non-ionic surface active agent, can form complex compound with iodine, and this complex compound has functions such as the pathogen of killing, bacterium, fungi, and its use day by day increases.
This complex compound is often by obtaining polyvinylpyrrolidone with the form of solid or solution and the compound reaction of iodine or iodine.The complex compound that makes with these simple methods is usually because active ingredient-iodine wherein is more active, and is volatile and do not have a good stable; Because do not add additives such as synergist, activator, the permeability of system is bad, and sprays easy coloring behind body surface, forms xanthochromia.
Application number is that the patent of invention (" production method of quick-effective iodine disinfectant ") of 91106026.X takes the method for Solid complexing earlier iodine, potassium iodide, polyvinylpyrrolidone to be mixed grinding, add deionized water then and dilute, obtain the aqueous solution of complex compound.As previously mentioned, owing to wherein do not add synergist and increase steady agent, its permeability and stability can not reach higher requirement.
The disinfectant that with polyvinylpyrrolidone-iodine is main active ingredient is being used under the increasingly extensive situation, and above reason has hindered its development.Therefore, in the complex compound system, add suitable additive, become the direction that this class disinfectant develops, had the people to do some effort in this respect with stability, permeability and the germicidal efficiency etc. that improve system.
Application number is 99114144 patent of invention (" mixed povidone iodine disinfectant and preparation method thereof "), has wherein added phenmethylol to increase the stability of system.It is adjusted that but system infiltrative do not have, the absorption property that only relies on the carrier-polyvinylpyrrolidone of iodine itself to have comes near target surface, effective permeance property can not be provided, influence the degree of depth and sterilization validity that active ingredient is goed deep into object.
Application number is that 00812978.9 patent of invention (" with the method for aqueous solution production PVP(polyvinyl pyrrolidone)-iodine ") has added formic acid, and compounds such as oxalic acid and salt thereof, ester, acid amides are as increasing steady agent, and the stability of system is improved; With application number is that 99114144 patent of invention is identical, and the permeability of system does not have anything to take on a new look, and the permeability of its system can not reach higher requirement, and needs high temperature (as 70-110 ℃), preparation method's complexity during preparation.
The additive that these patents of invention are used is more single, and contains the derivative of benzene, and natural environment is caused bad influence.Select suitable additive, make it to form permeance property compound system good, eco-friendly, stable, high-efficiency steriliging, become the important content of current disinfectant research with complex compound.
Summary of the invention
The present invention will provide a kind of high permeability that has, and stable type is good, and low color is residual, and bactericidal effect is good, the compound iodine disinfectant of uniqueness applied widely.
The compound iodine disinfectant of high osmosis provided by the present invention except containing polyvinylpyrrolidone and the potassium iodide solubilizer as iodine, is also selected the synergist of SDS as system; Citric acid is as the steady agent of increasing of system; Add the exciting agent of Peracetic acid as iodine, with the rate of release of increase iodine, and the coloring of reduction system.
The object of the present invention is achieved like this: as the compound iodine disinfectant of high osmosis, be made up of following component: PVP, 5-15%; Iodine, 0.1-0.5%; Citric acid, 0.15-0.20%; SDS, 0.15-0.20%; Peracetic acid 0.01-0.10%; Deionized water, surplus.
Compound iodine disinfectant preparation method provided by the present invention is measured each component respectively according to above-mentioned percentage exactly, and PVP is complete with deionized water dissolving, adds the liquor kalii iodide of iodine, with ultrasonic effect 10 minutes; Add citric acid, SDS then; Add Peracetic acid, arrive suitable volume with the deionized water constant volume.
High osmosis compound iodine disinfectant provided by the present invention owing to added synergist SDS, makes the permeance property of system be greatly improved, and can make active ingredient go deep into body surface, thorough disinfection and sterilization; The adding of the exciting agent of iodine is improved the release efficiency of iodine, and greatly reduces the coloring of product, thereby makes the present invention can make things convenient for to the object surfaces disinfection, and needn't worry that object is damaged; The present invention also can be used for disinfecting of skin and mucous membrane, compares better effects if with other povidone iodine product; Raw material used in the present invention is easy to get, and environment is had no adverse effects, and is the disinfectant of an environment-friendly type.
Embodiment
Following example illustrates the present invention and does not limit the present invention:
Example one: take by weighing the PVP4.0 gram, be dissolved among the deionized water 60ml; Treat that dissolving fully, adds the liquor kalii iodide 15ml of iodine, ultrasonic effect 10min; Add citric acid 0.15 gram, mix; Add the SDS0.15 gram, mix; Add Peracetic acid, the quality that makes its Peracetic acid that contains is 0.012 gram; Adding deionized water to volume is 100ml.
Example two: take by weighing the PVP4.9 gram, be dissolved among the deionized water 60ml; Treat that dissolving fully, adds the solution of iodine and potassium iodide, ultrasonic effect 10min; Add citric acid 0.15 gram, mix; Add the SDS0.15 gram, mix; Add Peracetic acid, the quality that makes its Peracetic acid that contains is 0.012 gram; Adding deionized water to volume is 100ml.
Example three: take by weighing the PVP5.4 gram, be dissolved among the deionized water 60ml; Treat that dissolving fully, adds the solution of iodine and potassium iodide, ultrasonic effect 10min; Add citric acid 0.15 gram, mix; Add the SDS0.15 gram, mix; Add Peracetic acid, the quality that makes its Peracetic acid that contains is 0.008 gram; Adding deionized water to volume is 100ml.
Example four: take by weighing the PVP6.0 gram, be dissolved among the deionized water 60ml; Treat that dissolving fully, adds the solution of iodine and potassium iodide, ultrasonic effect 10min; Add citric acid 0.15 gram, mix; Add the SDS0.15 gram, mix; Add Peracetic acid, the quality that makes its Peracetic acid that contains is 0.005 gram; Adding deionized water to volume is 100ml.
Example five: take by weighing the PVP10.0 gram, be dissolved among the deionized water 60ml; Treat that dissolving fully, adds the solution of iodine and potassium iodide, ultrasonic effect 10min; Add citric acid 0.15 gram, mix; Add the SDS0.15 gram, mix; Add Peracetic acid, the quality that makes its Peracetic acid that contains is 0.012 gram; Adding deionized water to volume is 100ml.
The related experiment record:
One. disinfectant is to the acute inhalation test LC50 of small white mouse effect measuring: the diet of experimental group animal and other movable no abnormality seens, do not have deadly in the observation period, LD50 of the present invention is 5000mg/kgBW, the nontoxic level in true border.
Two. disinfectant is to tame lagophthalmos conjunctiva irritant test:
The highest acute eye irritation score index of rabbit is 0, belongs to nonirritant.
Three. bactericidal assay:
1. test strain: Escherichia coli, the false monospore AS1.1785 of green pus, candida albicans bacterium, staphylococcus aureus, pneumonia Carlos Kleiber gram.
2. experiment content and result: unit: cm
Annotate:
A. the inhibition zone determination method is adopted in test, promptly uses the qualitative filter paper sheet of diameter as 0.5cm, and sample to be determined is arranged on it, is affixed on the media surface that contains certain bacterium, measures the inhibition zone size.
B. result of the test is all got three times mean value, and the present invention is compared with the Iodophor product that abroad gone on the market.
C. bacterial density is 2 * 10
8Cfu/cm
2
Four. permeability test
1. test material: soluble starch, whatman filter paper, pipettor, baking oven, slide measure
2. test method: use 0.5% soluble starch solution soaking filter paper, dry the back and drip 10ul of the present invention with pipettor, the finish diameter of the blueness colour developing circle that the back forms of effect is about 1.4cm; The data that external on year-on-year basis Iodophor product drips the 10ul sample and the starch scraps of paper are respectively 1.1cm.
Claims (5)
1. efficient compound iodine disinfectant that a permeability is strong and preparation method thereof is characterized in that: its constituent and preparation method.
2. efficient compound iodine disinfectant according to claim 1 is characterized in that: it is to be made by the component of following weight: PVP, 3-15%; Iodine, 0.2-0.8%; Citric acid, 0.10-0.30%; SDS, 0.10-0.30%; Peracetic acid, 0.005-0.04%; Deionized water, surplus.
3. the efficient compound iodine disinfectant strong according to the described permeability of claim 1, it is characterized in that: with the citric acid is stabilizing agent, is synergist with SDS, is activator with the Peracetic acid.
4. the efficient compound iodine disinfectant strong according to the described permeability of claim 1 is characterized in that: unique preparing process.The liquor kalii iodide and the PVP of iodine are mixed, add citric acid and SDS then, mix, add Peracetic acid again, and be diluted to suitable concn with deionized water.
5. the preparation method who closes iodine disinfectant according to the strong reinstate of the described permeability of claim 4 is characterized in that: use the method for ultrasonic emulsification to carry out the bag quilt of iodine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410034158 CN1689410A (en) | 2004-04-26 | 2004-04-26 | Highly efficient compound iodine disinfectant with strong permeability and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410034158 CN1689410A (en) | 2004-04-26 | 2004-04-26 | Highly efficient compound iodine disinfectant with strong permeability and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1689410A true CN1689410A (en) | 2005-11-02 |
Family
ID=35345410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410034158 Pending CN1689410A (en) | 2004-04-26 | 2004-04-26 | Highly efficient compound iodine disinfectant with strong permeability and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1689410A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475678A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 5% povidone iodine solution |
| WO2012092776A1 (en) * | 2011-01-07 | 2012-07-12 | 上海宇昂化工科技发展有限公司 | High-stability non-ionic n-vinylbutyrolactam iodide solution and related formulation method therefor |
| CN103503863A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Aquatic product dedicated hanging bag colloidal iodine disinfection drug |
| CN104147043A (en) * | 2014-08-13 | 2014-11-19 | 武汉新大地环保材料有限公司 | Povidone iodine and preparation method and application thereof |
| CN107098314A (en) * | 2017-05-27 | 2017-08-29 | 农业部规划设计研究院 | A kind of atomic state fluid iodine and its derivative nanometer iodine and preparation method and purposes |
| CN110037050A (en) * | 2019-05-08 | 2019-07-23 | 山西大学 | A kind of high efficiency composition iodine solution and preparation method thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
-
2004
- 2004-04-26 CN CN 200410034158 patent/CN1689410A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475678A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 5% povidone iodine solution |
| WO2012092776A1 (en) * | 2011-01-07 | 2012-07-12 | 上海宇昂化工科技发展有限公司 | High-stability non-ionic n-vinylbutyrolactam iodide solution and related formulation method therefor |
| CN103503863A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Aquatic product dedicated hanging bag colloidal iodine disinfection drug |
| CN104147043A (en) * | 2014-08-13 | 2014-11-19 | 武汉新大地环保材料有限公司 | Povidone iodine and preparation method and application thereof |
| CN107098314A (en) * | 2017-05-27 | 2017-08-29 | 农业部规划设计研究院 | A kind of atomic state fluid iodine and its derivative nanometer iodine and preparation method and purposes |
| CN110037050A (en) * | 2019-05-08 | 2019-07-23 | 山西大学 | A kind of high efficiency composition iodine solution and preparation method thereof |
| CN110037050B (en) * | 2019-05-08 | 2021-02-02 | 山西大学 | High-efficiency compound iodine solution and preparation method thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3177148B1 (en) | Antiseptic product, process for preparing same and its use | |
| CN106172434B (en) | A kind of wall clothing biocide mildewcide and preparation method thereof | |
| EP0662783B1 (en) | Antimicrobial composition and method of preparation | |
| US20100233245A1 (en) | Nanoparticle composition and process thereof | |
| JP2012526777A (en) | Biocide Nanostructured Composition and Method for Obtaining Nanostructured Biocide Composition | |
| CN104126611A (en) | Preparation method of nano-silver composite antibacterial agent | |
| CN1689410A (en) | Highly efficient compound iodine disinfectant with strong permeability and its preparation method | |
| CN111454653A (en) | Environment-friendly antibacterial water-based wood coating and preparation method thereof | |
| CN103509423A (en) | Modified bactericidal paint and preparation method thereof | |
| DE112011104683B4 (en) | Nonionic N-vinylbutyrolactam-iodine solution with high stability and its manufacturing process | |
| WO2021196111A1 (en) | Broad-spectrum antiviral bactericidal plastic and application thereof | |
| EP0120301B2 (en) | Method of producing standardized iodophor preparations and such preparations | |
| CN112120042A (en) | Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof | |
| CN101028004A (en) | Nano-silver antibacterial powder | |
| CN1689409A (en) | A environmental friendly spray type compound iodine disinfectant and its preparation method | |
| US20050276862A1 (en) | Iron sequestering antimicrobial composition | |
| JP7073593B1 (en) | Antibacterial, antifungal, antiviral disinfectant composition | |
| CN1810121A (en) | Prepn process of chlorine containing disinfectant | |
| CN105532727A (en) | Formula of alcohol-free povidone iodine disinfectant | |
| CN113057175A (en) | High-stability peroxyacetic acid composite preparation for killing spores and preparation method | |
| CN112244009A (en) | Gel type chlorine dioxide sustained release agent and preparation method thereof | |
| CN101755757A (en) | Compound peracetic acid bromine chlorine hydantoin disinfectant | |
| US20140314738A1 (en) | Disinfecting composition | |
| CN111374150A (en) | Preparation method of nano-silver/hydrogen peroxide/salicylic acid composite disinfection material | |
| CN114072001B (en) | Instant disinfectant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |