CN1687052A - Method for extracting coumarin substances from rhodiola root of natural plant - Google Patents
Method for extracting coumarin substances from rhodiola root of natural plant Download PDFInfo
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- CN1687052A CN1687052A CNA2005100247166A CN200510024716A CN1687052A CN 1687052 A CN1687052 A CN 1687052A CN A2005100247166 A CNA2005100247166 A CN A2005100247166A CN 200510024716 A CN200510024716 A CN 200510024716A CN 1687052 A CN1687052 A CN 1687052A
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- natural plant
- rhodiola root
- coumarin substances
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The method for extracting coumarin from natural plant rhodiola kirilowii includes the following steps: a). pulverizing rhodiola root, sieving and adding entrainer, then resting for 5-25h.; b). placing the above-mentioned treated material into extraction kettle, adding entrainer and making circulating extraction by using supercritical CO2 fluid according to the flow rate of 20-30 kg/h; c). placing the extracled material into separation kettle and making the extract discharged from bottom of separation kettle undergo the process of centrifugal separation treatment so as to obtain final extract coumarin.
Description
Technical field
The present invention relates to a kind of method of utilizing liquid from natural phant, to extract active substance, relate to a kind of liquid that utilizes criticality extracts sunscreen actives composition coumarin substances from rhodiola root of natural plant method in particular.
Background technology
Rhodida plant is draft or semishrub plant for many years, often with all herbal medicine.Coumarin substances is one of effective constituent in the Root of Kirilow Rhodiola, has effects such as antisepsis and anti-inflammation, antiviral, antitumor, step-down, radioprotective.At present, systematic solvent extraction, alkali extraction and acid precipitation method or chromatography are adopted in the extraction of coumarin substances usually.The consumption of organic solvent is big when extracting coumarin substances with systematic solvent extraction and chromatography from rhodiola root of natural plant, and need just can obtain final extract with distillation method recovery solvent, not only energy consumption is big, process is complicated, and dissolvent residual is often arranged in the extract.With the heavy alkali solution technique of acid, extraction yield is low and be not suitable for meeting acid, alkali labile part coumarin substances, uses acid, alkali reagent also to cause environmental pollution easily.
Summary of the invention
Technical problem to be solved by this invention provides a kind of new method of extracting coumarin substances from rhodiola root of natural plant, and this procedure is simple, efficient pollution-free.
Technical scheme of the present invention: a kind of method of extracting coumarin substances from rhodiola root of natural plant comprises the following steps:
A. rhodiola root of natural plant is pulverized, sieved, add and place 4-25h after carrying agent;
B. the material after the above-mentioned processing is inserted to add in the extraction kettle and carry agent, with the CO of the supercritical state of 20-30kg/h flow velocity
2Fluid carries out cycling extraction to above-mentioned material;
C. the material after the extraction enters separating still, and the extract of emitting from the separating still bottom obtains final extract coumarin substances through centrifugation.This coumarin substances that extracts from Root of Kirilow Rhodiola can be used for preparing skin care product, functional foodstuff and as the raw material of medicine.
Step a described with rhodiola root of natural plant pulverize, sieving is meant 10-60 purpose sieve is pulverized, crossed to rhodiola root of natural plant.
The CO of the described supercritical state of step b
2Fluid temperature (F.T.) is 40-60 ℃, and pressure is 20-35MPa.
Describedly carry the mixture that agent is the second alcohol and water.
The described massfraction that carries second alcohol and water in the agent is 55-85%, and the quality of carrying agent is 0.8-1.2 a times of quality of material.
The pressure of separating still is 5-11MPa among the step c, and temperature is 40-60 ℃, and disengaging time is 1.0-2.5h.
The condition of centrifugation is centrifugal rotational speed 5000-8000r/min among the step c, and disengaging time is 10-25min, and final extract coumarin substances is paste.
The invention has the beneficial effects as follows: the principle that the present invention extracts has been utilized supercritical CO
2The viscosity that fluid is extremely low, (be general liquid 1%), high spread coefficient (be general liquid 100 times) are having very fast dissolution rate in the short time of balancing each other, thereby the coumarin substances in the raw material are being separated.The present invention has overcome the shortcoming of prior art, and process is simple, efficient pollution-free.
Embodiment
Below in conjunction with embodiment the present invention is described in further detail: a kind of method of from rhodiola root of natural plant, extracting coumarin substances, comprise the following steps: that a. pulverizes rhodiola root of natural plant, sieve, add and place 5-25h after carrying agent; B. the material after the above-mentioned processing is inserted to add in the extraction kettle and carry agent, with the CO of the supercritical state of 20-30kg/h flow velocity
2Fluid carries out cycling extraction to above-mentioned material; C. the material after the extraction enters separating still, and the extract of emitting from the separating still bottom obtains final extract coumarin substances through centrifugation.This coumarin substances that extracts from Root of Kirilow Rhodiola can be used for preparing skin care product, functional foodstuff and as the raw material of medicine.Step a described with rhodiola root of natural plant pulverize, sieving is meant 10-60 purpose sieve is pulverized, crossed to rhodiola root of natural plant.The CO of the described supercritical state of step b
2Fluid temperature (F.T.) is 40-60 ℃, and pressure is 20-35MPa.Describedly carry the mixture that agent is the second alcohol and water.The described massfraction that carries second alcohol and water in the agent is 55-85%, and the quality of carrying agent is 0.8-1.2 a times of quality of material.The pressure of separating still is 5-11MPa among the step c, and temperature is 40-60 ℃, and disengaging time is 1.0-2.5h.The condition of centrifugation is centrifugal rotational speed 5000-8000r/min among the step c, and disengaging time is 10-25min, and final extract coumarin substances is paste.
Embodiment
Get the Root of Kirilow Rhodiola rhizome, the 10-60 order of pulverizing, sieve, claim the 250g powder to add 200-350ml to carry agent, place 4-25h that the extraction kettle of packing into is heated to 40-60 ℃, open compression pump and be forced into 20-35MP and add and carry agent.With the flow velocity cycling extraction of 20-30kg/h, the pressure of separating still is 5-11MP, temperature 40-600C, extract 1.0-2.5h after, take out extract, (5000-8000r/min 10-25min) separates, and obtains the paste coumarin substances by centrifugal.Supercritical fluid technology extracts makeup, functional foodstuff and the medicine material that coumarin substances in the Root of Kirilow Rhodiola can be used for preparing effects such as antisepsis and anti-inflammation, antiviral, radioprotective.
Above said content only is the basic explanation of the present invention under conceiving, and according to any equivalent transformation that technical scheme of the present invention is done, all should belong to protection scope of the present invention.
Claims (7)
1. a method of extracting coumarin substances from rhodiola root of natural plant comprises the following steps:
A. rhodiola root of natural plant is pulverized, sieved, add and place 4-25h after carrying agent;
B. the material after the above-mentioned processing is inserted to add in the extraction kettle and carry agent, with the CO of the supercritical state of 20-30kg/h flow velocity
2Fluid carries out cycling extraction to above-mentioned material;
C. the material after the extraction enters separating still, and the extract of emitting from the separating still bottom obtains final extract coumarin substances through centrifugation.
2. the method for extracting coumarin substances from rhodiola root of natural plant according to claim 1 is characterized in that: step a described with rhodiola root of natural plant pulverize, sieving is meant 10-60 purpose sieve is pulverized, crossed to rhodiola root of natural plant.
3. the method for extracting coumarin substances from rhodiola root of natural plant according to claim 1 is characterized in that: the CO of the described supercritical state of step b
2Fluid temperature (F.T.) is 40-60 ℃, and pressure is 20-35MPa.
4. the method for extracting coumarin substances from rhodiola root of natural plant according to claim 1 is characterized in that: carry the mixture that agent is the second alcohol and water described in step a and the b.
5. the method for from rhodiola root of natural plant, extracting coumarin substances according to claim 4, it is characterized in that: the described massfraction that carries second alcohol and water in the agent is 55-85%, the quality of carrying agent is 0.8-1.2 a times of quality of material.
6. the method for from rhodiola root of natural plant, extracting coumarin substances according to claim 1, it is characterized in that: the pressure of separating still is 5-11MPa among the step c, and temperature is 40-60 ℃, and disengaging time is 1.0-2.5h.
7. the method for from rhodiola root of natural plant, extracting coumarin substances according to claim 1, it is characterized in that: the condition of centrifugation is centrifugal rotational speed 5000-8000r/min among the step c, disengaging time is 10-25min, and final extract coumarin substances is paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100247166A CN1687052A (en) | 2005-03-29 | 2005-03-29 | Method for extracting coumarin substances from rhodiola root of natural plant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100247166A CN1687052A (en) | 2005-03-29 | 2005-03-29 | Method for extracting coumarin substances from rhodiola root of natural plant |
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| CN1687052A true CN1687052A (en) | 2005-10-26 |
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| CNA2005100247166A Pending CN1687052A (en) | 2005-03-29 | 2005-03-29 | Method for extracting coumarin substances from rhodiola root of natural plant |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427173C (en) * | 2005-12-13 | 2008-10-22 | 浙江大学宁波理工学院 | Aglucone tyrcohol CO2 supercritical extraction with alcohol as entrainer |
| CN105018219A (en) * | 2015-06-29 | 2015-11-04 | 广西大学 | Method for supercritical CO2 extraction of coix seed oil |
| CN111569465A (en) * | 2020-05-28 | 2020-08-25 | 广西壮族自治区林业科学研究院 | Coumarin extraction device and use method thereof |
| CN111808060A (en) * | 2020-06-28 | 2020-10-23 | 湖南杰萃生物技术有限公司 | Method for extracting total coumarin from rhodiola rosea |
-
2005
- 2005-03-29 CN CNA2005100247166A patent/CN1687052A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427173C (en) * | 2005-12-13 | 2008-10-22 | 浙江大学宁波理工学院 | Aglucone tyrcohol CO2 supercritical extraction with alcohol as entrainer |
| CN105018219A (en) * | 2015-06-29 | 2015-11-04 | 广西大学 | Method for supercritical CO2 extraction of coix seed oil |
| CN111569465A (en) * | 2020-05-28 | 2020-08-25 | 广西壮族自治区林业科学研究院 | Coumarin extraction device and use method thereof |
| CN111569465B (en) * | 2020-05-28 | 2021-11-19 | 广西壮族自治区林业科学研究院 | Coumarin extraction device and use method thereof |
| CN111808060A (en) * | 2020-06-28 | 2020-10-23 | 湖南杰萃生物技术有限公司 | Method for extracting total coumarin from rhodiola rosea |
| CN111808060B (en) * | 2020-06-28 | 2023-11-14 | 湖南杰萃生物技术有限公司 | Method for extracting total coumarin from rhodiola rosea |
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