CN1660389A - Radiation resistant oral preparation of Chinese traditional medicine and preparing method - Google Patents
Radiation resistant oral preparation of Chinese traditional medicine and preparing method Download PDFInfo
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- CN1660389A CN1660389A CN 200410066035 CN200410066035A CN1660389A CN 1660389 A CN1660389 A CN 1660389A CN 200410066035 CN200410066035 CN 200410066035 CN 200410066035 A CN200410066035 A CN 200410066035A CN 1660389 A CN1660389 A CN 1660389A
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- ganoderma
- radix rhodiolae
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Abstract
An orally-taken Chinese medicine for improving the resistance to radiation is prepared from ganoderma and rhodiola root through proportionally mixing, crushing, extracting in hot water or edible alcohol solution, and freez (or spray) drying.
Description
Technical field
The present invention relates to Chinese medicine preparation, especially a radiation-resistant oral preparation of Chinese traditional medicinal and a preparation method.
Background technology
The Radix Rhodiolae of Xiao Shouing is generally single preparations of ephedrine in the market, and its anoxia enduring effect is approved by people.In the modern life, as the radiation of ultraviolet (the plateau ultraviolet is stronger), cellular radiation, computer, TV etc., radiation-induced health problem is more and more general and serious.Ganoderma is the rarity in the Chinese medicine, has to improve immunologic function, blood lipid regulation, blood sugar regulation, protect the liver, suppress multiple efficacies such as tumor anoxia enduring.In various radiotherapies or nuclear leakage accident, respectively organize illuminated back tissue fibering to take place and tumorigenesis easily, main cause is the collagen of fibroblastic abnormal proliferation and differentiation and supersecretion.The research of radiation injury has at present entered into molecular level, DNA is the main target of ionizing radiation, mammiferous some Study on gene mutations of radiation-actuate is shown, the gene mutation that ionizing radiation is brought out is but to lose, infer that antioncogene is the main target gene of radiation carcinogen, as antioncogene CDKN2 sudden change, Rb gene inactivation.Research has proved that the radiation resistance of ganoderan can be by integral level realization radiation resistances such as adjusting and reinforcement mouse immune systems.Do not see the middle medicament that Ganoderma with radioprotective effect and Radix Rhodiolae are formed.
Summary of the invention
The purpose of this invention is to provide a kind of radiation-resistant oral preparation of Chinese traditional medicinal and preparation method, summary of the invention is as follows: a kind of radiation-resistant oral preparation of Chinese traditional medicinal is characterized in that being made up of following raw materials by weight percent: Ganoderma 10%-80%, Radix Rhodiolae 20%-90%.Percentage by weight raw material proportion of composing preferably: Ganoderma 30%, Radix Rhodiolae 70%.The preparation method of above-mentioned oral preparation of Chinese traditional medicinal, it is characterized in that: Ganoderma, Radix Rhodiolae are pressed proportion of composing mix back coarse pulverization, hot water or the lixiviate of 20-80% edible ethanol, get extractum liquid, but lyophilization of extractum liquid or spray drying get the extract powder preparation or Ganoderma, Radix Rhodiolae are distinguished coarse pulverization in proportion, hot water or the lixiviate of 20-80% edible ethanol, get extractum liquid, but lyophilization of extractum liquid or spray drying get extract powder, and two extract powders (liquid) merge the back preparation.Can be made into granule, powder, electuary, oral liquid, capsule, tablet etc.
Ganoderma, made anoxia enduring, the radioprotective Chinese medicine preparation once irradiating of Radix Rhodiolae
60Co-gamma-rays radiation resistance experimental result sees Table 1, table 2, table 3.The result shows that Chinese medicine preparation of the present invention has radiation-resistant effect.
The influence of table 1 pair murine interleukin sum
| Group | Dosage (mg/kg.bw) | Number of animals (only) | Before the radiation (* 10 9/L) | After the radiation the 2nd day (* 10 9/L) | Number of animals (only) | The 1st week (* 10 after the radiation 9/L) |
| Dosage group high dose group in the matched group low dose group | ????0 ????73 ????147 ????440 | ????15 ????15 ????15 ????15 | ?10.04±2.19 ?10.67±2.11 ?9.84±2.53 ?11.15±1.84 | ??1.72±0.49 ??2.01±0.55 ??2.33±0.95 *??2.21±0.70 * | ????6 ????8 ????14 ????13 | ????0.14±0.10 ????0.22±0.18 ????0.21±0.14 ????0.25±0.17 |
Annotate: "
*" compare p＜0.05 with matched group.
The influence of table 2 pair mice 30d survival rate
| Group | Dosage (mg/kg.bw) | Number of animals (only) | Death toll (only) | Survival number (only) | Survival rate (%) |
| Dosage group high dose group in the matched group low dose group | ????0 ????73 ????147 ????440 | ????15 ????15 ????15 ????15 | ????15 ????15 ????15 ????11 | ????0 ????0 ????0 ????4 | ????0 ????0 ????0 ????27 ** |
Annotate: "
*" compare p＜0.01 with matched group.
Table 2 is the result show, high dose group mice 30d survival rate is apparently higher than matched group (p＜0.01) after the radiation.
On average the survive influence of natural law of table 3 pair mice
| Group | Dosage (mg/kg.bw) | Number of animals (only) | Average survival natural law (my god) |
| Dosage group high dose group in the matched group low dose group | ????0 ????73 ????147 ????440 | ????15 ????15 ????15 ????15 | ????9.1±2.6 ????11.5±5.6 ????15.5±5.6 **????17.7±9.5 ** |
Annotate: "
* *" compare p＜0.01 with matched group.
By table 3 result as seen, high, middle dosage group mice on average survives natural law apparently higher than matched group (P＜0.01).
*Compare p＜0.01 with the distilled water control value
Radiation-resistant Chinese medicine preparation that the present invention makes can be made granule, powder, electuary, oral liquid, capsule, tablet etc. according to a conventional method.
The specific embodiment
Embodiment 1
With Ganoderma 3kg, Radix Rhodiolae 7kg mixes, and coarse pulverization is put in the extraction pot, hot water lixiviate (60 ℃-100 ℃), and 2 hours, centrifugal filtration, filtering residue is carried once again, and merging filtrate concentrates, and spray drying gets extract powder, with extract powder, loads into capsule.
Embodiment 2, and is identical with embodiment 1, and different is will add suitable adjuvant in the extract powder, granulation, tabletting, tablet.
Embodiment 3, and is identical with embodiment 1, and different is to add sweeting agent, an amount of antiseptic in the spissated filtrate, to make oral liquid.
Embodiment 4, and is identical with embodiment 1, gets extract powder, adds suitable adjuvant in extract powder, granulates, and promptly makes granule.
Embodiment 5, get Ganoderma 30kg, Radix Rhodiolae 70kg, and coarse pulverization respectively, the hot water lixiviate, centrifugal filtration, filtrate concentrates, and drying gets Ganoderma extractum powder and Radix Rhodiolae extract powder, with two extract powder mix homogeneously, loads into capsule.
Embodiment 6, get Ganoderma 20kg, Radix Rhodiolae 80kg, coarse pulverization respectively, 50% alcohol heating reflux lixiviate, centrifugal filtration merges two kinds of lixiviating solution, standing over night, filter, add suitable sweeting agent (protein sugar, sucrose, glucose or xylitol also can add Mel), and antiseptic, can make oral liquid.
Embodiment 7, get Ganoderma 35kg, and Radix Rhodiolae 65kg mixes, coarse pulverization, and spray drying or drying under reduced pressure get extract powder, add suitable adjuvant and granulate, and load into capsule.
Embodiment 8, get Ganoderma 40kg, and Radix Rhodiolae 60kg mixes, coarse pulverization, and spray drying or drying under reduced pressure get extract powder, add suitable adjuvant and granulate, and tabletting is made tablet.
Embodiment 9, get Ganoderma 28kg, Radix Rhodiolae 72kg, and coarse pulverization respectively, the hot water lixiviate, centrifugal filtration, filtrate concentrates, and drying gets Ganoderma extractum powder and Radix Rhodiolae extract powder, with two extract powder mix homogeneously, loads into capsule
Embodiment 10, get Ganoderma 25kg, and Radix Rhodiolae 75kg mixes, coarse pulverization, and spray drying or drying under reduced pressure get extract powder, add suitable adjuvant and granulate, and load into capsule.
Embodiment 11, get Ganoderma 55kg, and Radix Rhodiolae 45kg mixes, coarse pulverization, and spray drying or drying under reduced pressure get extract powder, add suitable adjuvant and granulate, and tabletting is made tablet.
Embodiment 12, get Ganoderma 45kg, Radix Rhodiolae 55kg, and coarse pulverization respectively, the hot water lixiviate, centrifugal filtration, filtrate concentrates, and drying gets Ganoderma extractum powder and Radix Rhodiolae extract powder, with two extract powder mix homogeneously, loads into capsule.
Embodiment 13, get Ganoderma 15kg, Radix Rhodiolae 85kg, coarse pulverization respectively, 50% alcohol heating reflux lixiviate, centrifugal filtration merges two kinds of lixiviating solution, standing over night, filter, add suitable sweeting agent (protein sugar, sucrose, glucose or xylitol also can add Mel), and antiseptic, can make oral liquid.
Embodiment 14, get Ganoderma 10kg, and Radix Rhodiolae 90kg mixes, coarse pulverization, and spray drying or drying under reduced pressure get extract powder, add suitable adjuvant and granulate, and load into capsule.
Claims (3)
1, a kind of radiation-resistant oral preparation of Chinese traditional medicinal is characterized in that being made up of following raw materials by weight percent: Ganoderma 10%-80%, Radix Rhodiolae 20%-90%.
2, oral preparation of Chinese traditional medicinal according to claim 1 is characterized in that being made up of following raw materials by weight percent: Ganoderma 30%, Radix Rhodiolae 70%.
3, the preparation method of oral preparation of Chinese traditional medicinal according to claim 1 and 2, it is characterized in that: Ganoderma, Radix Rhodiolae are pressed proportion of composing mix back coarse pulverization, hot water or the lixiviate of 20-80% edible ethanol, get extractum liquid, but lyophilization of extractum liquid or spray drying get the extract powder preparation or Ganoderma, Radix Rhodiolae are distinguished coarse pulverization in proportion, hot water or the lixiviate of 20-80% edible ethanol, get extractum liquid, but lyophilization of extractum liquid or spray drying get extract powder, and two extract powders merge the back preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410066035 CN1660389A (en) | 2004-12-14 | 2004-12-14 | Radiation resistant oral preparation of Chinese traditional medicine and preparing method |
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| CN 200410066035 CN1660389A (en) | 2004-12-14 | 2004-12-14 | Radiation resistant oral preparation of Chinese traditional medicine and preparing method |
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| CN1660389A true CN1660389A (en) | 2005-08-31 |
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| CN 200410066035 Pending CN1660389A (en) | 2004-12-14 | 2004-12-14 | Radiation resistant oral preparation of Chinese traditional medicine and preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716173A (en) * | 2011-03-29 | 2012-10-10 | 赵军 | Rapid anoxia-relieving capsule, preparation formula and preparation method thereof |
| CN103960666A (en) * | 2014-05-22 | 2014-08-06 | 汤敏 | Rhodiola rosea oral liquid and preparation method thereof |
| CN109419001A (en) * | 2017-09-03 | 2019-03-05 | 大德仟年生物技术有限公司 | Immune curing capsule and preparation method thereof |
-
2004
- 2004-12-14 CN CN 200410066035 patent/CN1660389A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716173A (en) * | 2011-03-29 | 2012-10-10 | 赵军 | Rapid anoxia-relieving capsule, preparation formula and preparation method thereof |
| CN103960666A (en) * | 2014-05-22 | 2014-08-06 | 汤敏 | Rhodiola rosea oral liquid and preparation method thereof |
| CN103960666B (en) * | 2014-05-22 | 2016-04-27 | 汤敏 | A kind of Rhodiola root oral liquid and preparation method thereof |
| CN109419001A (en) * | 2017-09-03 | 2019-03-05 | 大德仟年生物技术有限公司 | Immune curing capsule and preparation method thereof |
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