CN1660330A - Medication for treating necrosis of femoral head and preparation method - Google Patents

Abstract

A Chinese medicine for treating femur head necrosis is prepared from 22 Chinese-medicinal materials including pilose antler, ginseng, wild aconite root, myrrh, etc. Its preparing process for preparing orally taken honeyed pills or exterior-applied plaster is also disclosed.

Description

Treatment femur head necrosis medicine and preparation method thereof

Affiliated technical field:

The present invention relates to a kind of osteonecrosis for the treatment of and especially treat medicine of femur head necrosis and preparation method thereof.

Background technology:

Femur head necrosis belongs to the traditional Chinese medical science " rheumatism involving the bone ", " osteomyelitis ", " atrophic debility of bones " category, and " flaccidity " is that flaccidity is soft unable, withered useless need not meaning, this disease disability rate is high.Since world's the first in 1888 was reported aseptic necrosis of femoral head, world medicine all circles concentrated on studies year surplus in the of 100, were still the problem of tackling key problem at present.The number of China's trouble femur head necrosis has reached 2,000,000 people (" healthy newspaper " on February 11st, 2004) according to statistics, and number of patients increases year by year.At present, the Therapeutic Method of employing is based on the prosthetic replacement, and patient's wound is big in the operation, and misery is many, and expense height, long-term effect are undesirable again, so most of patient requires the Chinese medicine expectant treatment.

Summary of the invention:

Problem at current femur head necrosis disease refractory, I am through undergoing, more than ten years of concentrating on studies have invented a kind of need not the operation and just can treat the femur head necrosis medicine, the technical scheme that is adopted is: 6 parts in Cornu Cervi Pantotrichum, 20 parts of Colla Plastri Testudinises, 20 parts of Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae 30,6 parts in Radix Glycyrrhizae, 30 parts of Herba Cistanches, 30 parts of Radix Rehmanniae Preparata, 30 parts of Rhizoma Cibotii, 30 parts of the Cortexs Eucommiae, 30 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Rhizoma Homalomenaes, 50 parts of Rhizoma Corydalis, 30 parts of Radix Notoginseng, 20 parts of Caulis Spatholobis, 20 parts of Semen Cuscutae, 20 parts of Zaocys, 15 parts of Ramulus Cinnamomi, 15 parts of Radix Saposhnikoviaes, 20 parts of Pyritums (each component ratio is calculated by weight), through processing, it is oral to be mixed with honeyed pill, also can directly decoct into decoction and take, play the effect of treatment femur head necrosis.In addition, the Cornu Cervi Pantotrichum in the above-mentioned composition, Colla Plastri Testudinis, Radix Ginseng three flavor medicines can also be removed, add Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha each 30 parts (all the other composition constant rates), be brewed into the plaster external, reach the effect of treatment femur head necrosis by fry, filtration.

Each component effect:

Cornu Cervi Pantotrichum: the tonifying YANG hemopoietic, beneficial marrow is mended smart

Colla Plastri Testudinis: invigorating function of kidney and strengthening bone, nourishing YIN for suppressing the hyperactive YANG

Radix Ginseng: strongly invigorating primordial QI, invigorating the spleen to benefit the lung

The Rhizoma Atractylodis Macrocephalae: air making-up and spleen enlivening, dampness diuretic

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, relieving spasm to stop pain is in harmonious proportion strong partially

Herba Cistanches: kidney invigorating and YANG supporting, support the gate of vitality, nourishing kidney gas

Radix Rehmanniae Preparata: nourishing the blood and yin, vital essence replenishing and marrow benifiting

Rhizoma Cibotii: invigorating the liver and kidney, strong waist knee joint, wind-damp dispelling

The Cortex Eucommiae: bone and muscle strengthening, invigorating the liver and kidney, Jiao Zhong Acid is painful, does not desire to trample ground

Radix Angelicae Sinensis: enrich blood, invigorate blood circulation, pain relieving

Rhizoma Chuanxiong: active circulation of qi promoting, wind-expelling pain-stopping

Rhizoma Homalomenae: wind-damp dispelling, strengthening bone and muscle

Rhizoma Corydalis: blood-activating and qi-promoting, pain relieving

Radix Notoginseng: promoting blood circulation by removing blood stasis, analgesic therapy

Caulis Spatholobi: promoting the circulation of blood, enrich blood relaxing muscles and tendons and activating QI and blood in the collateral

Semen Cuscutae: YANG invigorating tonifying YIN, controlling nocturnal emission with astringent drugs reducing urination

Zaocys: search wind to the marrow, active

Ramulus Cinnamomi: warming the meridian for promoting the flow of YANG QI

Radix Saposhnikoviae: dispel the wind, win and wet, pain relieving, spasmolytic

Pyritum: eliminating stasis to stop pain, synthetism is cured the wound

Radix Aconiti, Radix Aconiti Kusnezoffii: wind-expelling pain-stopping

Olibanum, Myrrha: reducing swelling and alleviating pain

Adopt the medicine of the present invention's preparation that femoral head necrosis therapeutic is had good result, avoided pain, the wound in the operation, but also had liver and kidney tonifying, invigorating the spleen and benefiting QI, strong muscles and bones, promoting blood circulation to remove obstruction in the collateral activates new osteanagenesis effect, does not produce toxic and side effects after taking.

The specific embodiment:

Below in conjunction with specific embodiment this working of an invention mode is described.

Embodiment one:

Selected Cornu Cervi Pantotrichum 6 grams, Colla Plastri Testudinis 20 grams, Radix Ginseng 20 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Radix Glycyrrhizae 6 grams, Herba Cistanches 30 grams, Radix Rehmanniae Preparata 30 grams, Rhizoma Cibotii 30 grams, the Cortex Eucommiae 30 grams, Radix Angelicae Sinensis 30 grams, Rhizoma Chuanxiong 30 grams, Rhizoma Homalomenae 30 grams, Rhizoma Corydalis 50 grams, Radix Notoginseng 30 grams, Caulis Spatholobi 20 grams, Semen Cuscutae 20 grams, Zaocys 20 grams, Ramulus Cinnamomi 15 grams, Radix Saposhnikoviae 15 grams, Pyritum 20 grams.

Manufacture method:

1, Colla Plastri Testudinis is fried, the Rhizoma Atractylodis Macrocephalae is fried, the Cortex Eucommiae is fried, Semen Cuscutae is fried; Radix Glycyrrhizae is processed; Rhizoma Cibotii is steamed; Pyritum is forged.

2, with all medicine components mixed grindings, stir, cross 120 mesh sieves.

3, the mixture after will sieving takes the traditional handicraft retrofit to become small honey pill.

Instructions of taking:

Take one hour ante cibum, every day three times, each 6 grams.

30 days is a course of treatment, according to ill weight, determines administration time length:

3 courses of treatment of I phase (initial stage) (90 days)

4 courses of treatment of II phase (mid-term) (120 days)

III phase (late period) 6 courses of treatment (180 days---about 300 days)

Embodiment two:

Selected Radix Aconiti 30 grams, Radix Aconiti Kusnezoffii 30 grams, Olibanum 30 grams, Myrrha 30 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Radix Glycyrrhizae 6 grams, Herba Cistanches 30 grams, Radix Rehmanniae Preparata 30 grams, Rhizoma Cibotii 30 grams, the Cortex Eucommiae 30 grams, Radix Angelicae Sinensis 30 grams, Rhizoma Chuanxiong 30 grams, Rhizoma Homalomenae 30 grams, Rhizoma Corydalis 50 grams, Radix Notoginseng 30 grams, Caulis Spatholobi 20 grams, Semen Cuscutae 20 grams, Zaocys 20 grams, Ramulus Cinnamomi 15 grams, Radix Saposhnikoviae 15 grams, Pyritum 20 grams.

Manufacture method:

1, it is boiled to get 3 kilograms of Oleum Gossypii semens, and the said medicine component is put into the oil frying to withered.

2, filter, remove medicinal residues.

3, red 750 grams of Jia Ru Wide in filtrate continue to fry when extremely smokelessly dripping into pearl, cool.

4, after 6 days, the heating of the ointment endured spread out on plaster dedicated paper (cloth) can be affixed on the affected part.

Concrete case:

The patient one: the man, and 52 years old, the doctor, in June, 2004 is from grinding autonomy.On June 2nd, 1, an eye nipple neuritis is taken place suddenly in the work, hospitalization because of excessive use glucocorticoid medicine, causes bilateral femoral head necrosis (III phase) at once, especially with the left side for very, pain is violent, afunction.Go the hospitalize of to several homies, all advise the prosthetic replacement, I accept as unavoidable should not, with the Chinese medicine conservative treatment of concentrating on studies, took this medicine 10 days in June, 2004, pain subtracts greatly, unbearably muscle spasm and pain also disappears substantially in the thigh.Continue to take medicine surplus in the of 40 day, symptom all disappears, and lower limb can be lifted to 70 degree by height, and inward turning, outward turning are all normal, and just the sensation walking is unable, and Jiu Zhan Acid is stranded.Afterwards, continued clothes 70 days, femoral head is normal on inspection, and X-ray film making result is that bone density branch is even, and profile is complete smooth, does not see narrow distortion, shows recovery from illness.

The patient two: the woman, 18 years old, students, when had physical education in June, 2004, it was unable to feel that little lower limb Acid is stranded, the time numbness is arranged, increase the weight of day by day afterwards, check in company with going before the father and mother.The X-ray film making is the result show: ischemic necrosis of femoral head, early stage (change of left side femoral head limitation capsule).Hospitalization immediately, the commentaries on classics but symptom is not got better.Listen the people to introduce afterwards, buied this medicine, took sx after seven days.Patient father and mother think that this medicine has no side effect, and after this woman took medicine 90 days continuously, symptomatology disappeared.Go to hospital to do X-ray film making more again, the result shows that disease fully recovers.

The patient three: man, Han nationality, 48 years old, the cadre of bank.Caused right side femur and tibia folding because of vehicle accident in 2003, and be in hospital after three months, the fracture recovery from illness, it is as usual to walk.Suffer from the prosperous fever of sense in February, 2004, though flu is cured after several days, right leg muscle pain, hip bone Acid is painful.Symptom is still increasing the weight of after several days, function of joint is limited, identify oneself fracture site and have inflammation, family members accompany and remove examination in hospital again, the nuclear-magnetism conclusion is: see in the right lateral thigh bone that strip of sheet and patch shape are unusual, and clutter shape, and see that the crack shape changes, the femoral head edge owes smooth, diagnostic comments: the right side ischemic necrosis of femoral head II phase.Come here to see a doctor upon somebody's introduction.Take surplus this medicine 40 day, pain disappears substantially, and joint movement function recovers, and the patient accepts as unavoidable and takes effect, and continues to take recovery from illness 90 days.Follow up a case by regular visits to, healthy so far.

The patient four: the man, and the Chinese, 60 years old, the farm hand, in JIUYUE, 2003 is fallen down accidentally, and femur and tibia folding in right side is through hospitalization recovery from illness in 4 months.2004 4 below the moon after the water work, the numb pain of right lower limb, especially with hip joint for very, check fracture site immediately, having a medical check-up all claims the positive.Consider once to have the fracture history, hospital's suggestion CT scan, the result is the right side ischemic necrosis of femoral head, goes to a doctor through the invalid here afterwards of hospitalization, takes this medicine 30 days, the commentaries on classics of getting better can be borrowed and singly be turned walking.Continued to take this medicine 120 days, and be almost recovered.Advise it to do the CT check, because of the financial difficulties refusal is checked.Recently follow up a case by regular visits to, movable normal, only feel unable.

The patient five: the man, and the Chinese, lower limb muscles fiber crops pain takes place in farm hand without reason in the work, can not stand for a long time, and identifying oneself to be short of physical strength or suffering from a deficiency of the kidney causes, rests for a few days and will get well.Behind the sky, the state of an illness is more serious surplus in the of 10, and limitation of activity be can't take care of oneself.Waist, hip, knee joint are stiff, pain very is sent to hospital by children, is diagnosed as the bilateral femoral head ischemic necrosis, deny that trauma history, habits of smoking and alcohol drinking history, glucocorticoid use history, because of economic cause, be reluctant hospitalization, here is bought and is taken this medicine afterwards, its effect of first meeting after 45 days, sky surplus continuing to obey 100, symptom disappears entirely, the self-induction recovery from illness.Follow up a case by regular visits to, all are normal.

Claims (3)

1, a kind of medicine for the treatment of femur head necrosis is characterized in that: adopt 6 parts in Cornu Cervi Pantotrichum, 20 parts of Colla Plastri Testudinises, 20 parts of Radix Ginsengs or 30 parts of Radix Aconitis, 30 parts of Radix Aconiti Kusnezoffii, 30 parts of Olibanums, 30 parts of Myrrhas and the Rhizoma Atractylodis Macrocephalae 30,6 parts in Radix Glycyrrhizae, 30 parts of Herba Cistanches, 30 parts of Radix Rehmanniae Preparata, 30 parts of Rhizoma Cibotii, 30 parts of the Cortexs Eucommiae, 30 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Rhizoma Homalomenaes, 50 parts of Rhizoma Corydalis, 30 parts of Radix Notoginseng, 20 parts of Caulis Spatholobis, 20 parts of Semen Cuscutae, 20 parts of Zaocys, 15 parts of Ramulus Cinnamomi, 15 parts of Radix Saposhnikoviaes, 20 parts of (each component ratio is calculated by weight) formulated of Pyritum.

2, the preparation method of treatment femur head necrosis medicine as claimed in claim 1, it is characterized in that: before grinding with Cornu Cervi Pantotrichum, Colla Plastri Testudinis, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Herba Cistanches, Radix Rehmanniae Preparata, Rhizoma Cibotii, the Cortex Eucommiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Homalomenae, Rhizoma Corydalis, Radix Notoginseng, Caulis Spatholobi, Semen Cuscutae, Zaocys, Ramulus Cinnamomi, Radix Saposhnikoviae, Pyritum medicine components, Colla Plastri Testudinis must be fried, the Rhizoma Atractylodis Macrocephalae is fried, the Cortex Eucommiae is fried, Semen Cuscutae is fried, Radix Glycyrrhizae is processed, Rhizoma Cibotii is steamed, Pyritum is forged.

3, the preparation method of treatment femur head necrosis medicine as claimed in claim 1, it is characterized in that: adopting Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Herba Cistanches, Radix Rehmanniae Preparata, Rhizoma Cibotii, the Cortex Eucommiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Homalomenae, Rhizoma Corydalis, Radix Notoginseng, Caulis Spatholobi, Semen Cuscutae, Zaocys, Ramulus Cinnamomi, Radix Saposhnikoviae, the red ratio with Oleum Gossypii semen of Pyritum component processing plaster process Zhong ， Wide is 1: 4 (calculating by weight).