CN1660149A - Soft capsule of cassia twig and Tuckahoe and preparation method - Google Patents
Soft capsule of cassia twig and Tuckahoe and preparation method Download PDFInfo
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- CN1660149A CN1660149A CN 200410004560 CN200410004560A CN1660149A CN 1660149 A CN1660149 A CN 1660149A CN 200410004560 CN200410004560 CN 200410004560 CN 200410004560 A CN200410004560 A CN 200410004560A CN 1660149 A CN1660149 A CN 1660149A
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- soft capsule
- cassia twig
- poria
- poria cocos
- extractum
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Abstract
A Chinese medicine 'Guizhi-fuling softgel' is composed of the surface layer prepared from gelatin, glycerine and water and the liquid medicine prepared from plant oil, suspensing aid and 5 Chinese-medicinal materials including cinammon twigs, tuckahoe, peach kernel, white peony root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly cassia twig and poria cocos soft capsule and preparation method thereof.
Background technology
GUIZHI FULING JIAONANG (hard capsule) commonly used, form by Ramulus Cinnamomi, Poria, the Radix Paeoniae Alba, Cortex Moutan, Semen Persicae etc., effect with blood circulation promoting and blood stasis dispelling, Huan Xiao wei piece, be used for lower abdomen Su You wei piece due to women's blood stasis, menorrhagia or persistent vaginal bloody discharge, color is purple dark, many clots, lower abdomen dull pain or abdominal pain with tenderness, tongue secretly have ecchymosis, hesitant pulse or symptom such as thin.
But GUIZHI FULING JIAONANG (hard capsule), after the capsule disintegrate stripping slow, bioavailability is not high.
Summary of the invention
Main purpose of the present invention is to provide a kind of cassia twig and poria cocos soft capsule dosage form, directly absorbs at gastrointestinal tract after this cassia twig and poria cocos soft capsule disintegrate, and its medicine has characteristics such as bioavailability height, good airproof performance, good uniformity, stable content, good looking appearance.
Another object of the present invention provides the preparation method of this cassia twig and poria cocos soft capsule.
The invention provides a kind of cassia twig and poria cocos soft capsule, comprise medicinal liquid (content of soft capsule) and softgel shell two large divisions, this medicinal liquid comprises medicinal major ingredient and pharmaceutic adjuvant; Medicinal major ingredient comprises following raw material: Ramulus Cinnamomi, Poria, Semen Persicae, the Radix Paeoniae Alba, Cortex Moutan; This pharmaceutic adjuvant comprises vegetable oil and suspending agent; This softgel shell comprises a certain proportion of gelatin, G ﹠ W.Described vegetable oil is medicinal soybean oil or salad oil, and described suspending agent is Cera Flava or soybean phospholipid.
Cassia twig and poria cocos preparation medicine provided by the present invention is for adopting the made cassia twig and poria cocos soft capsule of following weight proportion raw material: 1 part of Ramulus Cinnamomi, 1 part in Poria, 1 part in Semen Persicae, 1 part of the Radix Paeoniae Alba, 1 part of Cortex Moutan.
The weight that makes 1000 required each raw materials of cassia twig and poria cocos soft capsule is: Ramulus Cinnamomi 240g, Poria 240g, Semen Persicae 240g, Radix Paeoniae Alba 240g, Cortex Moutan 240g.
The method for preparing above-mentioned cassia twig and poria cocos soft capsule comprises the steps: half Poria pulverize separately of Ramulus Cinnamomi, Semen Persicae, the Radix Paeoniae Alba, Cortex Moutan and the recipe quantity of recipe quantity is become the coarse powder mixing, 90% ethanol that adds 8 times of amounts extracts twice for 75 ℃-85 ℃, each 1 hour, merge extractive liquid,, filter, distilling under reduced pressure is also reclaimed ethanol, simmer down to extractum (I); With residue with 6 times of water boiling water extraction twice, each 1 hour, merge leachate, concentrating under reduced pressure is extractum (II); Merge second half Poria fine powder mixing of extractum (I) and extractum (II) and recipe quantity, vacuum drying is ground into fine powder; Add an amount of vegetable oil and suspending agent, even with ball mill grinding, make suspension; An amount of gelatin, glycerol, water are changed glue by a certain percentage, above-mentioned suspension and glue are placed bolus molding machine respectively, be pressed into soft capsule, make cassia twig and poria cocos soft capsule.
The cassia twig and poria cocos soft capsule bioavailability height that makes, good airproof performance, good uniformity, stable content, good looking appearance.
The specific embodiment
Soft capsules for resisting cervicitis provided by the invention is chosen Ramulus Cinnamomi 240g, Poria 240g, Semen Persicae 240g, Radix Paeoniae Alba 240g, Cortex Moutan 240g respectively by prescription, as the raw material of 1000 cassia twig and poria cocos soft capsules of preparation.240g Ramulus Cinnamomi, 240g Semen Persicae, the 240g Radix Paeoniae Alba, 240g Cortex Moutan and 120g Poria pulverize separately are become the coarse powder mixing, and 90% ethanol that adds 8 times of amounts extracts twice, each 1 hour for 75 ℃-85 ℃, merge extractive liquid,, filter, distilling under reduced pressure is also reclaimed ethanol, simmer down to extractum (I); With residue with 6 times of water boiling water extraction twice, each 1 hour, merge leachate, concentrating under reduced pressure is extractum (II); Merge second half 120g Poria fine powder mixing of extractum (I) and extractum (II) and recipe quantity, vacuum drying is ground into fine powder; Add an amount of vegetable oil and suspending agent, even with ball mill grinding, make suspension; An amount of gelatin, glycerol, water are changed glue by a certain percentage, above-mentioned suspension and glue are placed bolus molding machine respectively, be pressed into soft capsule, make 1000 of cassia twig and poria cocos soft capsules.
Claims (6)
1, a kind of cassia twig and poria cocos soft capsule is characterized in that: comprise medicinal liquid and softgel shell,
This medicinal liquid comprises medicinal major ingredient and pharmaceutic adjuvant; Medicinal major ingredient comprises following raw material: Ramulus Cinnamomi, Poria, Semen Persicae, the Radix Paeoniae Alba, Cortex Moutan; This pharmaceutic adjuvant comprises vegetable oil and suspending agent;
This softgel shell comprises a certain proportion of gelatin, G ﹠ W.
2, cassia twig and poria cocos soft capsule according to claim 1 is characterized in that, described vegetable oil is medicinal soybean oil or salad oil.
3, cassia twig and poria cocos soft capsule according to claim 1 is characterized in that, described suspending agent is Cera Flava or soybean phospholipid.
4, cassia twig and poria cocos soft capsule according to claim 1 is characterized in that, it adopts the following weight proportion raw material made: 1 part of Ramulus Cinnamomi, 1 part in Poria, 1 part in Semen Persicae, 1 part of the Radix Paeoniae Alba, 1 part of Cortex Moutan.
5, cassia twig and poria cocos soft capsule according to claim 1 is characterized in that, the weight that makes 1000 required each raw materials of cassia twig and poria cocos soft capsule is: Ramulus Cinnamomi 240g, Poria 240g, Semen Persicae 240g, Radix Paeoniae Alba 240g, Cortex Moutan 240g.
6, a kind of preparation method of cassia twig and poria cocos soft capsule, at least comprise the steps: half Poria pulverize separately of Ramulus Cinnamomi, Semen Persicae, the Radix Paeoniae Alba, Cortex Moutan and the recipe quantity of recipe quantity is become the coarse powder mixing, 90% ethanol that adds 8 times of amounts extracts twice for 75 ℃-85 ℃, each 1 hour, merge extractive liquid,, filter, distilling under reduced pressure is also reclaimed ethanol, simmer down to extractum (I); With residue with 6 times of water boiling water extraction twice, each 1 hour, merge leachate, concentrating under reduced pressure is extractum (II); Merge second half Poria fine powder mixing of extractum (I) and extractum (II) and recipe quantity, vacuum drying is ground into fine powder; Add an amount of vegetable oil and suspending agent, even with ball mill grinding, make suspension; An amount of gelatin, glycerol, water are changed glue by a certain percentage, above-mentioned suspension and glue are placed bolus molding machine respectively, be pressed into soft capsule, make cassia twig and poria cocos soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410004560 CN1660149A (en) | 2004-02-24 | 2004-02-24 | Soft capsule of cassia twig and Tuckahoe and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410004560 CN1660149A (en) | 2004-02-24 | 2004-02-24 | Soft capsule of cassia twig and Tuckahoe and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1660149A true CN1660149A (en) | 2005-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410004560 Pending CN1660149A (en) | 2004-02-24 | 2004-02-24 | Soft capsule of cassia twig and Tuckahoe and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036709B (en) * | 2006-03-15 | 2011-02-09 | 北京因科瑞斯生物制品研究所 | Chinese medicine preparation for treating gynecopathy and its preparing process |
| CN102613543A (en) * | 2012-01-31 | 2012-08-01 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Multi-vitamin and multi-mineral soft capsules |
| WO2023197731A1 (en) * | 2022-04-13 | 2023-10-19 | 江苏康缘药业股份有限公司 | Traditional chinese medicine composition, preparation method therefor and use thereof |
-
2004
- 2004-02-24 CN CN 200410004560 patent/CN1660149A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036709B (en) * | 2006-03-15 | 2011-02-09 | 北京因科瑞斯生物制品研究所 | Chinese medicine preparation for treating gynecopathy and its preparing process |
| CN102613543A (en) * | 2012-01-31 | 2012-08-01 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Multi-vitamin and multi-mineral soft capsules |
| WO2023197731A1 (en) * | 2022-04-13 | 2023-10-19 | 江苏康缘药业股份有限公司 | Traditional chinese medicine composition, preparation method therefor and use thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |