CN1660129A - Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid - Google Patents
Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid Download PDFInfo
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- CN1660129A CN1660129A CN 200410093902 CN200410093902A CN1660129A CN 1660129 A CN1660129 A CN 1660129A CN 200410093902 CN200410093902 CN 200410093902 CN 200410093902 A CN200410093902 A CN 200410093902A CN 1660129 A CN1660129 A CN 1660129A
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Abstract
A uric acid absorbent is prepared through dissolving cellulose in NaOH solution, adding cross-linking agent, polymerizing reaction, proportionally adding cyclodextrin, reaction, drying, and pulverizing. It has high adsorptive speed and power to uric acid.
Description
Technical field
The invention relates to a kind of preparation method of agent of cyclodextrin-cellulose for adsorbing uric acid, belong to uric acid adsorbent technology.
Background technology
Uric acid is a kind of important metabolite in the human body, especially appears in the diseases such as chronic renal failure, hyperuricemia and hyperlipemia.Generally adopt the method for hemodialysis clinically, and oral adsorbent is a kind of novel, easy to use, effective Therapeutic Method, its principle is, after adsorbent under the clothes arrives the intestinal of human body, absorption is accumulated in intravital poisonous substance, excrete together in company with feces, thereby can reach the alleviation disease, suppress the purpose that the state of an illness further worsens.
The domestic so far research report that does not have about the oral adsorbent of uric acid.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of agent of cyclodextrin-cellulose for adsorbing uric acid, simple, the prepared adsorbent of this method preparation technology is to the uric acid high adsorption capacity, and is cheap.
The present invention is realized by following technical proposals, a kind of method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid, and its feature comprises following process:
1) cellulose is dissolved in the NaOH solution that concentration is 20-30%, the volume ratio 25-300% by itself and cross-linking agent adds cross-linking agent in aqueous slkali, carry out 2-10 hour polyreaction at 30-60 ℃;
2) in above-mentioned reactant liquor, be 2-6 by the mass ratio of polymer and cyclodextrin: 1 adds cyclodextrin, and 30-60 ℃ of reaction 2-6 hour, reaction finished back drying, pulverizing, obtains cyclodextrin-cellulose adsorbent.
Above-mentioned cellulose is microcrystalline Cellulose or alpha-cellulose.
Above-mentioned cross-linking agent is selected from epoxychloropropane, 1 diglycidyl ether or 1,2-butanediol diglycidyl ether.
Above-mentioned cyclodextrin is beta-schardinger dextrin-, methyl beta-schardinger dextrin-or hydroxypropyl.
The invention has the advantages that: preparation technology is simple, and obtained adsorbents adsorb speed is fast, binding ability strong, difficult drop-off, is 150 μ g/g at the 4h absorbability, and has no side effect, and it is convenient to make raw material sources, low price.
The specific embodiment
With embodiment the present invention is illustrated below.
Example 1
The 4g alpha-cellulose is added in the 24mL20%NaOH solution, slowly drip the 6mL epoxychloropropane, react 2h down at 30 ℃, filtration, drying add the 0.85g product in the 100mL30%NaOH solution then, add the 0.2g beta-schardinger dextrin-again, 30 ℃ of reaction 2h obtain cyclodextrin-cellulose adsorbent.
Example 2
The 4g alpha-cellulose is added in the 24mL25%NaOH solution, slowly drip 24mL1, the 2-Ethylene glycol diglycidyl ether, react 3h down at 40 ℃, filtration, drying add the 1.7g product in the 100mL30%NaOH solution then, add 0.7g methyl beta-schardinger dextrin-again, 40 ℃ of reaction 2h obtain cyclodextrin-cellulose adsorbent.
Example 3
The 4g microcrystalline Cellulose is added in the 24mL30%NaOH solution, slowly drip the 36mL epoxychloropropane, react 5h down at 50 ℃, filtration, drying, then the 3.4g product is added in the 100mL30%NaOH solution, add the 1.4g hydroxypropyl again, 50 ℃ of reaction 3h obtain cyclodextrin-cellulose adsorbent.
Example 4
The 4g microcrystalline Cellulose is added in the 24mL30%NaOH solution, slowly drip 48mL1, the 2-Ethylene glycol diglycidyl ether, react 7h down at 50 ℃, filtration, drying add the 5.1g product in the 1O0mL30%NaOH solution then, add the 1.4g hydroxypropyl again, 50 ℃ of reaction 5h obtain cyclodextrin-cellulose adsorbent.
Example 5
The 4g cellulose is added in the 24mL30%NaOH solution, slowly drip 72mL1, the 2-butanediol diglycidyl ether, react 10h down at 60 ℃, filtration, drying add the 8.5g product in the 100mL30%NaOH solution then, add the 1.4g hydroxypropyl again, 60 ℃ of reaction 6h obtain cyclodextrin-cellulose adsorbent.
Claims (4)
1, a kind of preparation method of agent of cyclodextrin-cellulose for adsorbing uric acid, its feature comprises following process:
1) cellulose is dissolved in the NaOH solution that concentration is 20-30%, the volume ratio 25-300% by itself and cross-linking agent adds cross-linking agent in aqueous slkali, carry out 2-10 hour polyreaction at 30-60 ℃;
2) in above-mentioned reactant liquor, be 2-6 by the mass ratio of polymer and cyclodextrin: 1 adds cyclodextrin, and 30-60 ℃ of reaction 2-6 hour, reaction finished back drying, pulverizing, obtains cyclodextrin-cellulose adsorbent.
2, by the preparation method of the described agent of cyclodextrin-cellulose for adsorbing uric acid of claim 1, it is characterized in that: cellulose is microcrystalline Cellulose or alpha-cellulose.
3, by the preparation method of the described agent of cyclodextrin-cellulose for adsorbing uric acid of claim 1, it is characterized in that: cross-linking agent is selected from epoxychloropropane, 1 diglycidyl ether or 1,2-butanediol diglycidyl ether.
4, by the preparation method of the described agent of cyclodextrin-cellulose for adsorbing uric acid of claim 1, it is characterized in that: cyclodextrin is beta-schardinger dextrin-, methyl beta-schardinger dextrin-or hydroxypropyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410093902 CN1256095C (en) | 2004-12-13 | 2004-12-13 | Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410093902 CN1256095C (en) | 2004-12-13 | 2004-12-13 | Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid |
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| Publication Number | Publication Date |
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| CN1660129A true CN1660129A (en) | 2005-08-31 |
| CN1256095C CN1256095C (en) | 2006-05-17 |
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| CN 200410093902 Expired - Fee Related CN1256095C (en) | 2004-12-13 | 2004-12-13 | Method for preparing agent of cyclodextrin-cellulose for adsorbing uric acid |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384479C (en) * | 2006-05-17 | 2008-04-30 | 天津大学 | Method for preparing bile acid adsorbent of beta cyclo dextrin polymer |
| CN100393735C (en) * | 2006-08-10 | 2008-06-11 | 东北林业大学 | Lignin-Based cyclodextrin ester multi-purpose sorbent preparation method |
| CN101816923A (en) * | 2010-04-07 | 2010-09-01 | 东北林业大学 | Method for preparing metal ion adsorbent |
| CN101798352B (en) * | 2010-01-05 | 2011-12-21 | 湖南中烟工业有限责任公司 | Modified cellulose with tar and harm reducing function, paper filter tip and preparation method thereof |
| CN102553545A (en) * | 2012-03-16 | 2012-07-11 | 川渝中烟工业有限责任公司 | Cellulose composite microsphere and preparation method thereof |
| CN106279723A (en) * | 2016-08-04 | 2017-01-04 | 东北林业大学 | A kind of preparation method of hydroxyethyl cellulose cyclodextrin hydrogel cage |
| CN107082903A (en) * | 2017-04-21 | 2017-08-22 | 南京理工大学 | A kind of method of modifying of bacteria cellulose film |
| CN112619612A (en) * | 2019-10-08 | 2021-04-09 | 四川大学 | Preparation method of high-strength cellulose/agarose composite microspheres |
| CN116510695A (en) * | 2023-03-28 | 2023-08-01 | 浙江坤泽环境科技有限公司 | Collagen fiber/beta-cyclodextrin adsorbent and preparation method thereof |
-
2004
- 2004-12-13 CN CN 200410093902 patent/CN1256095C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384479C (en) * | 2006-05-17 | 2008-04-30 | 天津大学 | Method for preparing bile acid adsorbent of beta cyclo dextrin polymer |
| CN100393735C (en) * | 2006-08-10 | 2008-06-11 | 东北林业大学 | Lignin-Based cyclodextrin ester multi-purpose sorbent preparation method |
| CN101798352B (en) * | 2010-01-05 | 2011-12-21 | 湖南中烟工业有限责任公司 | Modified cellulose with tar and harm reducing function, paper filter tip and preparation method thereof |
| CN101816923A (en) * | 2010-04-07 | 2010-09-01 | 东北林业大学 | Method for preparing metal ion adsorbent |
| CN101816923B (en) * | 2010-04-07 | 2012-09-05 | 东北林业大学 | Method for preparing metal ion adsorbent |
| CN102553545A (en) * | 2012-03-16 | 2012-07-11 | 川渝中烟工业有限责任公司 | Cellulose composite microsphere and preparation method thereof |
| CN102553545B (en) * | 2012-03-16 | 2013-09-04 | 川渝中烟工业有限责任公司 | Cellulose composite microsphere and preparation method thereof |
| CN106279723A (en) * | 2016-08-04 | 2017-01-04 | 东北林业大学 | A kind of preparation method of hydroxyethyl cellulose cyclodextrin hydrogel cage |
| CN107082903A (en) * | 2017-04-21 | 2017-08-22 | 南京理工大学 | A kind of method of modifying of bacteria cellulose film |
| CN112619612A (en) * | 2019-10-08 | 2021-04-09 | 四川大学 | Preparation method of high-strength cellulose/agarose composite microspheres |
| CN116510695A (en) * | 2023-03-28 | 2023-08-01 | 浙江坤泽环境科技有限公司 | Collagen fiber/beta-cyclodextrin adsorbent and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1256095C (en) | 2006-05-17 |
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