CN1660055A - Gel of chlormethine hydrochloride and preparing method - Google Patents
Gel of chlormethine hydrochloride and preparing method Download PDFInfo
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- CN1660055A CN1660055A CN 200410100401 CN200410100401A CN1660055A CN 1660055 A CN1660055 A CN 1660055A CN 200410100401 CN200410100401 CN 200410100401 CN 200410100401 A CN200410100401 A CN 200410100401A CN 1660055 A CN1660055 A CN 1660055A
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- gel
- mustine hydrochlcride
- alcoholic solution
- hydrochlcride
- mustine
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Abstract
A gel of dema hydrochloride for treating leukoderma is prepared through preparing the solution of dema hydrochloride and absolute alcohol, adding it to the matrix prepared from polyethylene glycol PEG400, propanediol and carbomer 940 NF, and stirring.
Description
Technical field:
The present invention relates to the leukodermic medicine of a kind of treatment, specifically a kind of gel of chlormethine hydrochloride and preparation method thereof.
Background technology:
At present, if drug main mustine hydrochlcride tincture related to the present invention, its main solvent is a dehydrated alcohol, and is extremely unstable in storage and transportation and under the hot environment, through investigating content decline three months storage periods about 25%.Mustine hydrochlcride is very easily dissolving in water, and tincture is because highly volatile when being subjected to packing, storing and frequently using, thereby makes the water content increase cause content to descend and lost efficacy.Tincture is used in the wound surface time of staying short, and Transdermal absorption and action time are shorter, thereby therapeutic effect is relatively poor.
Summary of the invention:
Deficiency in view of above-mentioned prior art exists the purpose of this invention is to provide a kind of stability and therapeutic effect gel of chlormethine hydrochloride and preparation method thereof preferably.
The objective of the invention is to realize by following technical solution: will join in the gel-type vehicle of making by Polyethylene Glycol PEG400, propylene glycol and Acritamer 940 NF by the mustine hydrochlcride alcoholic solution that mustine hydrochlcride and dehydrated alcohol are made and stir and to obtain; Wherein the percentage by weight of above-mentioned each raw material is: mustine hydrochlcride 0.02-0.08%; Dehydrated alcohol 15-40%; Polyethylene Glycol PEG400 40-80%; Propylene glycol 10-30%; Acritamer 940 NF0.5-2%.
Its preparation method is: take by weighing mustine hydrochlcride 0.02-0.08% and add dehydrated alcohol 15-40% to be dissolved into the mustine hydrochlcride alcoholic solution standby; Get carbomer 940NF0.5-2% and add Polyethylene Glycol PEG400 40-80% and propylene glycol 10-30%, heating 70-80 ℃ of stirring makes and is uniformly dispersed, drip the alcoholic solution of triethanolamine 5% again, adjust pH value between 3.0-6.0, can obtain to be the gel-type vehicle of transparence through stirring; Above-mentioned standby mustine hydrochlcride alcoholic solution is joined in the gel-type vehicle gradually, promptly can be made into gel of chlormethine hydrochloride through stirring.
Advantage of the present invention is that stability is better than tincture greatly, easily stores, and is not volatile.Accelerated test 6 months, quality is more stable, and room temperature was placed 12 months, and every index does not have significant change (seeing attached list 1).Gel is long in the wound surface retention time, and the time that plays a role is long, Transdermal absorption good, thereby therapeutic effect is better.
Below in conjunction with embodiment the present invention is explained.
The specific embodiment:
Embodiment 1
Pharmaceutical formulation: mustine hydrochlcride 2.5g; Dehydrated alcohol 947.5g; Polyethylene Glycol PEG400 3000g; Propylene glycol 1000g; Acritamer 940 NF 50g; The alcoholic solution 10ml of triethanolamine 5%.
Preparation method: take by weighing mustine hydrochlcride 2.5g and add dehydrated alcohol 947.5g to be dissolved into the mustine hydrochlcride alcoholic solution standby; Get carbomer 940NF 50g and add Polyethylene Glycol PEG400 3000g and propylene glycol 1000g, heating 70-80 ℃ of stirring makes and is uniformly dispersed, drip the alcoholic solution 10ml (adjusting pH value to 4.6) of triethanolamine 5% again, can obtain to be the gel-type vehicle of transparence through stirring; Above-mentioned standby mustine hydrochlcride alcoholic solution is joined in the gel-type vehicle gradually, promptly can be made into gel of chlormethine hydrochloride 5000g through stirring, then by 15g/ prop up, 20g/ props up, 30g/ props up or 40g/ props up packing.
Effect and purposes:
Cause the blackening of white macula place by stimulation, be used for the treatment of vitiligo skin.
Embodiment 2
Pharmaceutical formulation: mustine hydrochlcride 2.5g; Dehydrated alcohol 947.5g; Polyethylene Glycol PEG400 3000g; Propylene glycol 1000g; Acritamer 940 NF 50g; The alcoholic solution 10ml of triethanolamine 5%.
Preparation method: take by weighing mustine hydrochlcride 0.25g and add dehydrated alcohol 200g to be dissolved into the mustine hydrochlcride alcoholic solution standby; Get carbomer 940NF 10g and add Polyethylene Glycol PEG400 580g and propylene glycol 207.5g, heating 70-80 ℃ of stirring makes and is uniformly dispersed, drip the alcoholic solution 20ml (adjusting pH value to 4.2) of triethanolamine 5% again, can obtain to be the gel-type vehicle of transparence through stirring; Above-mentioned standby mustine hydrochlcride alcoholic solution is joined in the gel-type vehicle gradually, promptly can be made into gel of chlormethine hydrochloride 1000g through stirring, then by 15g/ prop up, 20g/ props up, 30g/ props up or 40g/ props up packing.
Table 1 three batch samples keep sample and test content and outward appearance result of the test
| Lot number | Time (moon) | Outward appearance and character | Differentiate | PH value | Content (%) |
| 20030317 ? ? ? ? ? ? ?20030318 ? ? ? ? ? ? ?20030319 ? ? ? ? ? ? | ????0 ????1 ????2 ????3 ????6 ????9 ????12 ????0 ????1 ????2 ????3 ????6 ????9 ????12 ????0 ????1 ????2 ????3 ????6 ????9 ????12 | Water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel water white transparency shape gel | Contain that mustine hydrochlcride and chloride contain mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride contains mustine hydrochlcride and chloride | ??4.6 ??4.6 ??4.2 ??4.5 ??4.6 ??3.7 ??3.5 ??4.3 ??4.2 ??4.6 ??4.1 ??3.8 ??4.7 ??4.3 ??3.9 ??4.2 ??3.6 ??4.6 ??4.4 ??4.0 ??3.7 | ??100.9 ??100.9 ??100.5 ??100.1 ??100.1 ??99.7 ??99.4 ??101.3 ??101.3 ??100.9 ??100.5 ??100.1 ??100.1 ??99.7 ??101.3 ??101.3 ??100.9 ??100.5 ??100.1 ??99.7 ??99.4 |
Claims (2)
1, a kind of gel of chlormethine hydrochloride is characterized in that: will be joined in the gel-type vehicle of being made by Polyethylene Glycol PEG400, propylene glycol and Acritamer 940 NF by the mustine hydrochlcride alcoholic solution that mustine hydrochlcride and dehydrated alcohol are made and stir and can obtain; Wherein the percentage by weight of above-mentioned each raw material is: mustine hydrochlcride 0.02-0.08%; Dehydrated alcohol 15-40%; Polyethylene Glycol PEG400 40-80%; Propylene glycol 10-30%; Acritamer 940 NF0.5-2%.
2, gel of chlormethine hydrochloride as claimed in claim 1 is characterized in that: the preparation method of this gel of chlormethine hydrochloride adds dehydrated alcohol 15-40% to be dissolved into the mustine hydrochlcride alcoholic solution standby for taking by weighing mustine hydrochlcride 0.02-0.08%; Get carbomer 940NF0.5-2% and add Polyethylene Glycol PEG400 40-80% and propylene glycol 10-30%, heating 70-80 ℃ of stirring makes and is uniformly dispersed, drip the alcoholic solution of triethanolamine 5% again, adjust pH value between 3.0-6.0, can obtain to be the gel-type vehicle of transparence through stirring; Above-mentioned standby mustine hydrochlcride alcoholic solution is joined in the gel-type vehicle gradually, promptly can be made into gel of chlormethine hydrochloride through stirring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101004010A CN1302770C (en) | 2004-12-17 | 2004-12-17 | Gel of chlormethine hydrochloride and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101004010A CN1302770C (en) | 2004-12-17 | 2004-12-17 | Gel of chlormethine hydrochloride and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1660055A true CN1660055A (en) | 2005-08-31 |
| CN1302770C CN1302770C (en) | 2007-03-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004101004010A Expired - Fee Related CN1302770C (en) | 2004-12-17 | 2004-12-17 | Gel of chlormethine hydrochloride and preparing method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1302770C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019002869A1 (en) * | 2017-06-29 | 2019-01-03 | The University Of Nottingham | Chemotherapy |
| CN114848586A (en) * | 2022-05-27 | 2022-08-05 | 河南锐博医药科技有限公司 | Cellulose-based nitrogen mustard hydrochloride gel and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1120722C (en) * | 1999-02-25 | 2003-09-10 | 吴克 | A topical medicine for treating vitiligo, leukoplakia vulvae and other leukoplakia, and its preparation method |
-
2004
- 2004-12-17 CN CNB2004101004010A patent/CN1302770C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019002869A1 (en) * | 2017-06-29 | 2019-01-03 | The University Of Nottingham | Chemotherapy |
| CN114848586A (en) * | 2022-05-27 | 2022-08-05 | 河南锐博医药科技有限公司 | Cellulose-based nitrogen mustard hydrochloride gel and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1302770C (en) | 2007-03-07 |
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Address after: 110179 Liaoning province Shenyang Hunnan New Long Street No. 10-1 203 Patentee after: Liaoning Zhengxin Drug Research Co., Ltd. Address before: Shenyang Hunnan New Century Road 110179 Liaoning city of Shenyang province No. 1 A1408 Patentee before: Liaoning Zhengxin Drug Research Co., Ltd. |
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Owner name: TANG XING Effective date: 20110826 |
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Effective date of registration: 20110826 Address after: 110179 Liaoning province Shenyang Hunnan New Long Street No. 10-1 203 Patentee after: Tang Xing Address before: 110179 Liaoning province Shenyang Hunnan New Long Street No. 10-1 203 Patentee before: Liaoning Zhengxin Drug Research Co., Ltd. |
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Owner name: XI AN HANFENG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: TANG XING Effective date: 20120809 |
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Effective date of registration: 20120809 Address after: Wen Ji County Industrial Park No. 15 Lantian Road Patentee after: Xi'an Hanfeng Pharmaceutical Co., Ltd. Address before: 110179 Liaoning province Shenyang Hunnan New Long Street No. 10-1 203 Patentee before: Tang Xing |
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Granted publication date: 20070307 Termination date: 20121217 |