CN1651010A - Chinese medicinal composition for warming and transforming stasis, dispersing swell and engendering bone - Google Patents
Chinese medicinal composition for warming and transforming stasis, dispersing swell and engendering bone Download PDFInfo
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- CN1651010A CN1651010A CNA2004101027648A CN200410102764A CN1651010A CN 1651010 A CN1651010 A CN 1651010A CN A2004101027648 A CNA2004101027648 A CN A2004101027648A CN 200410102764 A CN200410102764 A CN 200410102764A CN 1651010 A CN1651010 A CN 1651010A
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Abstract
A Chinese medicine for treating the ecchymoma, pain, bone fracture, broken tendon, lumbar intervetrebral disk protrusion and femur head necrosis is prepared from Dragon's blood, pangolin scales, etc.
Description
The present invention relates to the Chinese medicine composition of a kind of temperature Tonghua stasis of blood, detumescence bone growth promoting, particularly relate to a kind of Chinese medicine composition that is used for the treatment of one or more diseases in skin and flesh congestive edema, pain, fracture, tendon breaking, prolapse of lumbar intervertebral disc and the femur head necrosis.
Exist many Chinese medicine preparation can be used for warm Tonghua stasis of blood and detumescence bone growth promoting etc. at present, for example Chinese patent CN1435219A discloses a kind of promoting blood circulation and stopping pain sheet, it is made up of 13 herbal medicines such as kwan-yin grass, Borneolum Syntheticum and Colophonium, can be used for the treatment of diseases such as traumatic injury and soft tissue sprain.But the shortcoming that this medicine exists is: the Chinese medicine material category that contains is too many, needs 13 flavor Chinese medicines; In addition, its suitable disease is less, only can be used in treatment traumatic injury and soft tissue sprain.Another piece Chinese patent CN1471955A discloses the Chinese medicine tablet of a kind of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, it is by suppressing medicines such as worm and Pyritum and form when rule, Radix Notoginseng, Olibanum, Borneolum Syntheticum, soil, its shortcoming is: indication is few, the preparation method complexity, because contain Pyritum, so toxic and side effects is strong, in addition, material such as Radix Angelicae Sinensis, Radix Notoginseng is also somewhat expensive, thereby makes the production cost height.
The invention provides the Chinese medicine composition of a kind of temperature Tonghua stasis of blood, detumescence bone growth promoting, the Chinese medicine material preparation of the less kind of its need, preparation method is simple, and cost is low.Indication is wide, can be used in multiple diseases such as treatment skin and flesh congestive edema, pain, fracture, tendon breaking, prolapse of lumbar intervertebral disc and femur head necrosis.
One aspect of the present invention provides the Chinese medicine composition of a kind of temperature Tonghua stasis of blood, detumescence bone growth promoting, and said composition contains the Resina Draconis of 6-18 weight portion, the Squama Manis of 6-18 weight portion and the Rhizoma Corydalis of 0.5-1.5 weight portion.
A kind of preferred Chinese medicine composition of the present invention also contains the Rhizoma Chuanxiong of 2-6 weight portion and the Radix Salviae Miltiorrhizae of 2-5 weight portion.
As a kind of preferred Chinese medicine composition of the present invention, it can also contain the Fructus Amomi of 5-15 weight portion, the Fructus Crataegi of 0.5-1.5 part and the Semen Raphani of 2-5 weight portion except the Resina Draconis, Squama Manis and the Rhizoma Corydalis that contain aforementioned proportion.
In a kind of particularly preferred Chinese medicine composition of the present invention, it is except the Resina Draconis, Squama Manis, Rhizoma Corydalis, Fructus Amomi, Fructus Crataegi and the Semen Raphani that contain aforementioned proportion, and said composition also can contain the Radix Et Rhizoma Rhei of 2-6 weight portion and the river Niu Xi of 6-18 weight portion.
In the another kind of particularly preferred Chinese medicine composition of the present invention, it is except the Resina Draconis, Squama Manis, Rhizoma Corydalis, Fructus Amomi, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei and the river Niu Xi that contain aforementioned proportion, and said composition can also contain the Radix Et Rhizoma Rhei and and the river Niu Xi of 6-18 weight portion of 2-6 weight portion.
In a kind of pharmaceutical composition very preferably of the present invention, it contains: fry core 5-15 weight portion, Fructus Crataegi 0.5-1.5 weight portion, Semen Raphani 2-5 weight portion, the 2-6 of Radix Et Rhizoma Rhei weight portion, river cattle sunset 6-18 weight portion in Resina Draconis 6-18 weight portion, Squama Manis 6-18 weight portion, Rhizoma Corydalis 0.5-1.5 weight portion, Rhizoma Chuanxiong 2-6 weight portion, Radix Salviae Miltiorrhizae 2-5 weight portion, spring.
A kind of most preferred compositions of the present invention contains: fry core 10 weight portions, Fructus Crataegi 1 weight portion Semen Raphani 3.5 weight portions, Radix Et Rhizoma Rhei's 4 weight portions, river cattle sunset 12 weight portion in Resina Draconis 12 weight portions, Squama Manis 12 weight portions, Rhizoma Corydalis 1 weight portion, Rhizoma Chuanxiong 4 weight portions, Radix Salviae Miltiorrhizae 3.5 weight portions, spring.
In Chinese medicine composition of the present invention, medicines such as Resina Draconis and Squama Manis can blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Rhizoma Corydalis, Rhizoma Chuanxiong and Radix Salviae Miltiorrhizae etc. have circulation of qi promoting, invigorate blood circulation and analgesic can, and help blood circulation promoting and blood stasis dispelling; Medicines such as Fructus Amomi, Fructus Crataegi and the Semen Raphani the chest stuffiness relieving of can regulating the flow of vital energy is aid digestion, promotes diet; The unobstructed gastrointestinals of medicine removing blood stasis intestinal stasis relieving such as Radix Et Rhizoma Rhei and river Niu Xi.
Therefore compositions of the present invention has the function of warm Tonghua stasis of blood and detumescence bone growth promoting, can be used in the inside and outside soft tissue congestive edema of body that treatment skin and flesh congestive edema, fracture, wound, internal injury, knife injury cause, diseases such as ligament, tendon breaking, pain.
The invention still further relates to the application of above-mentioned Chinese medicine composition, be used to prepare the medicine of multiple diseases such as treatment skin and flesh congestive edema, pain, fracture, tendon breaking, prolapse of lumbar intervertebral disc and femur head necrosis.
Preparation of drug combination method of the present invention is as follows: according to aforementioned proportion, Rhizoma Corydalis (can preferably add Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei and river Niu Xizhong one or more) water is decocted 2 times, to concentrate behind twice decocting liquid hybrid filtering, make concentrated solution, Squama Manis and Resina Draconis (preferably add and fry core spring) are ground into powder according to described ratio, again gained powder and above-mentioned concentrated solution are made pill, drying is made the brown watered pill.
Except making compositions of the present invention the pill, can also be made into multiple dosage forms such as unguentum, powder, granule, tincture, suppository and tablet according to methods known in the art.
Pharmaceutical composition consumption of the present invention and usage are: restrain every days 5, divides 3 administrations.
Pharmaceutical composition of the present invention needs airtight preservation, and guards against damp.When taking medicine, the patient avoids the Herba Alii fistulosi Bulbus Allii, the careful usefulness of anemia of pregnant woman.
Embodiment
Embodiment 1
The Rhizoma Corydalis water of 1 weight portion is decocted 2 times,, the Resina Draconis of 12 weight portions and the Squama Manis of 12 weight portions are ground into powder, the powder of pulverizing is mixed with above concentrated solution, make the brown watered pill after the drying concentrating behind twice decocting liquid hybrid filtering.
Embodiment 2
According to the method for embodiment 1, replace making the brown watered pill among the embodiment 1 " Rhizoma Corydalis of 1 weight portion " with " Rhizoma Corydalis of the Radix Salviae Miltiorrhizae of the Rhizoma Chuanxiong of 4 weight portions, 3.5 weight portions and 1 weight portion ".
Embodiment 3,
The Semen Raphani water of the Fructus Crataegi of the Rhizoma Corydalis of the Radix Salviae Miltiorrhizae of the Rhizoma Chuanxiong of 4 weight portions, 3.5 weight portions, 1 weight portion, 1 weight portion, 3.5 weight portions is decocted 2 times, to concentrate behind twice decocting liquid hybrid filtering, the Resina Draconis of 12 weight portions and the Squama Manis of 12 weight portions are ground into powder, the powder of pulverizing is mixed with above concentrated solution, make the brown watered pill after the drying.
Embodiment 4
The river cattle sunset water of the Radix Et Rhizoma Rhei of the Semen Raphani of the Fructus Crataegi of the Rhizoma Corydalis of the Radix Salviae Miltiorrhizae of the Rhizoma Chuanxiong of 4 weight portions, 3.5 weight portions, 1 weight portion, 1 weight portion, 3.5 weight portions, 4 weight portions and 12 weight portions is decocted 2 times, to concentrate behind twice decocting liquid hybrid filtering, the Resina Draconis of 12 weight portions and the Squama Manis of 12 weight portions are ground into powder, the powder of pulverizing is mixed with above concentrated solution, make the brown watered pill after the drying.
Embodiment 5
1 weight portion Rhizoma Corydalis, 4 weight portion Rhizoma Chuanxiongs, 3.5 weight portion Radix Salviae Miltiorrhizaes, 1 weight portion Fructus Crataegi, 3.5 weight portion Semen Raphanis, 4 weight portion Radix Et Rhizoma Rhei and 12 weight portion river cattle sunset water decoct 2 times, will concentrate behind twice decocting liquid hybrid filtering.12 weight portion Resina Draconis, 12 weight portion Squama Maniss and 10 weight portions are fried core spring be ground into powder, the powder of pulverizing is mixed with above concentrated solution, make the brown watered pill after the drying.
Clinical experiment
The clinical experiment of 1, treatment fracture
180 examples are organized in the physical data treatment, male 144 examples, women 36 examples, be the fracture patient of certain hospital, age 8-75 year, medical history 2 days to 20 days, case is lumbar vertebra compression fracture, olecroanon bone fracture, forearm fracture, and this fracture is tired out by section, clavicular fracture, hip fracture is divided into 6 groups with it, these 6 groups are not all had significant difference in age, sex and sick and wounded situation, all take the photograph sheet through physical examination and X-ray before the treatment, treatment back one and a half months all gives X-ray and takes the photograph the sheet contrast, and all patients are closed fracture.
The compositions external application of Application Example 1-5 respectively of method: 1-5 group, the outside bandages, and uses small splints fixation then, renews medicine after 7 days.Matched group is according to the Therapeutic Method of doctor trained in Western medicine: reset+plaster fixation+the Western medicine symptomatic treatment these the 6 groups healing states of all taking the photograph sheet check fracture behind one and a half months, and the recovery situation of the clinical symptoms of contrast administration group and matched group.
The criterion of therapeutical effect healing: the X line is taken the photograph sheet inspection fracture and is reached anatomical reduction or approaching dissection para-position healing, and function is recovered normally to take part in the work and work fully, and activity is as good as with the normal person; Produce effects: union of fracture is good, and the affected part does not have pain or discomfort is slightly only arranged when rest or activity, and function is recovered substantially; Effectively: fracture heals, and the affected part feels uncomfortable slightly during rest, still has pain after the activity, and funtion part is recovered; Invalid: fracture is healing not, and symptom does not have improvement, dysfunction.
Shown in the following tabulation 1 of result:
Test group cure rate obvious effective rate effective percentage inefficiency
Matched group 50% 30% 10% 10%
Embodiment 1 Chinese medicine composition administration group 60% 10% 20% 10%
Embodiment 2 Chinese medicine composition administration groups 70% 10% 6.6% 3.3%
Embodiment 3 Chinese medicine composition administration groups 70% 10% 10% 0%
Embodiment 4 Chinese medicine composition administration groups 80% 10% 6.6% 3.3%
Embodiment 5 Chinese medicine composition administration groups 90% 3.3% 3.3% 3.3%
2, the clinical experiment of the early stage femur head necrosis of treatment
The case of early stage femur head necrosis is by early stage femur head necrosis due to the Fracture of femur, and diagnosis is a foundation with the hip joint plain film,
Its concrete standard is: (1) femoral head does not have and subsides; (2) the bone trabecula form normal, increase thick, distortion or cracked; (3) see the bone resorption band; (4) do not see osteosclerotic zone.
Collect 100 cases altogether, male 70 examples, women 30 examples, the downright bad time is 2-10 month from fracturing to finding, average 5 months.Above-mentioned case is divided into 5 groups, treats with the Chinese medicine composition of embodiment 1-5 respectively, administration time is 6-12 month, average 9 months.Compare with X line plain film before and after the treatment, the Chinese medicine composition that found that embodiment 1-5 has tangible curative effect to early stage femur head necrosis, after embodiment 1,2,3,4 and 5 the Chinese medicine composition medication, there is 95%, 85%, 80%, 75% and 65% case gratifying bone to occur respectively and rebuilds.
3, the clinical experiment of treatment prolapse of lumbar intervertebral disc
3.1 physical data: 250 routine patients are all from outpatient service and inpatient, all make a definite diagnosis wherein male 180 examples through X-ray sheet or CT or nuclear-magnetism, woman's 70 examples, 20 years old of age minimum, maximum 70 years old, average 38 years old, site of pathological change single-unit section vertebra dish was given prominence to 100 examples, and multi-segmental vertebra dish is given prominence to 150 examples.The shortest person of the course of disease 3 days, elder 3 years.
3.2 method: above-mentioned case is divided into 5 groups, treats with the Chinese medicine composition of embodiment 1-5 respectively, average administration 40 days.The treatment standard is: complete---lumbago and skelalgia disappears, and recovers former work fully; Take a turn for the better---competent operate as normal, than behind the heavy physical labour or the low back lower limb discomfort of catching cold; Invalid---symptom is not improved fully or is increased the weight of.
It is invalid that the treatment group is changeed entirely better
Embodiment 1 Chinese medicine composition administration group 48% 18% 34%
Embodiment 2 Chinese medicine composition administration groups 56% 28% 16%
Embodiment 3 Chinese medicine composition administration groups 64% 28% 8%
Embodiment 4 Chinese medicine composition administration groups 70% 26% 4%
Embodiment 5 Chinese medicine composition administration groups 80% 14% 6%
Claims (10)
1, the Chinese medicine composition of a kind of temperature Tonghua stasis of blood, detumescence bone growth promoting, it is characterized in that: said composition contains the Resina Draconis of 6-18 weight portion, the Squama Manis of 6-18 weight portion and the Rhizoma Corydalis of 0.5-1.5 weight portion.
2, the Chinese medicine composition of claim 1 is characterized in that: said composition also contains the Rhizoma Chuanxiong of 2-6 weight portion and the Radix Salviae Miltiorrhizae of 2-5 weight portion.
3, any one Chinese medicine composition of claim 1-2 is characterized in that: said composition also contains the Fructus Amomi of 5-15 weight portion, the Fructus Crataegi of 0.5-1.5 part and the Semen Raphani of 2-5 weight portion.
4, any one pharmaceutical composition of claim 1-2 is characterized in that: said composition also contains the Radix Et Rhizoma Rhei of 2-6 weight portion and the river Niu Xi of 6-18 weight portion.
5, the pharmaceutical composition of claim 3 is characterized in that: said composition also contains the Radix Et Rhizoma Rhei of 2-6 weight portion and the river Niu Xi of 6-18 weight portion.
6, the pharmaceutical composition of claim 5, it is characterized in that: said composition contains: fry core 5-15 weight portion, Fructus Crataegi 0.5-1.5 weight portion, Semen Raphani 2-5 weight portion, the 2-6 of Radix Et Rhizoma Rhei weight portion, river cattle sunset 6-18 weight portion in Resina Draconis 6-18 weight portion, Squama Manis 6-18 weight portion, Rhizoma Corydalis 0.5-1.5 weight portion, Rhizoma Chuanxiong 2-6 weight portion, Radix Salviae Miltiorrhizae 2-5 weight portion, spring.
7, the pharmaceutical composition of claim 6, it is characterized in that: said composition contains: fry core 10 weight portions, Fructus Crataegi 1 weight portion, Semen Raphani 3.5 weight portions, Radix Et Rhizoma Rhei's 4 weight portions, river cattle sunset 12 weight portion in Resina Draconis 12 weight portions, Squama Manis 12 weight portions, Rhizoma Corydalis 1 weight portion, Rhizoma Chuanxiong 4 weight portions, Radix Salviae Miltiorrhizae 3.5 weight portions, spring.
8, the application of any Chinese medicine composition of claim 1-7 is used for preparing the medicine of one or more diseases of treatment skin and flesh congestive edema, pain, fracture, tendon breaking, prolapse of lumbar intervertebral disc and femur head necrosis.
9, the method for the Chinese medicine composition of preparation claim 1, it is characterized in that: the Rhizoma Corydalis water of described weight portion is decocted 2 times, to concentrate behind twice decocting liquid hybrid filtering, make concentrated solution, Squama Manis and Resina Draconis are ground into powder according to described ratio, again gained powder and above-mentioned concentrated solution are made pill, drying.
10, the method for preparing any Chinese medicine composition of claim 5-7, it is characterized in that: Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei and river Niu Xi are mixed according to described weight proportion, water decocts 2 times, to concentrate behind twice decocting liquid hybrid filtering, make concentrated solution, be ground into powder with frying the Renhe Resina Draconis in Squama Manis, spring according to described ratio, again gained powder and above-mentioned concentrated solution made pill, drying.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101027648A CN1297305C (en) | 2004-12-29 | 2004-12-29 | Chinese medicinal composition for warming and transforming stasis, dispersing swell and engendering bone |
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| CNB2004101027648A CN1297305C (en) | 2004-12-29 | 2004-12-29 | Chinese medicinal composition for warming and transforming stasis, dispersing swell and engendering bone |
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| CN1651010A true CN1651010A (en) | 2005-08-10 |
| CN1297305C CN1297305C (en) | 2007-01-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434193A (en) * | 2018-05-21 | 2018-08-24 | 樊有山 | A kind of Chinese medicinal formulae for treating waist dish outstanding |
| CN108619218A (en) * | 2018-05-21 | 2018-10-09 | 樊有山 | A kind of production method of Chinese herbal medicine bag that treating waist dish outstanding |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1089244C (en) * | 1998-11-20 | 2002-08-21 | 段在义 | Chinese patent medicine for treating cancers and unknown toxic swellings (subcutaneous ulcer and carbuncle) and its preparing process |
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2004
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434193A (en) * | 2018-05-21 | 2018-08-24 | 樊有山 | A kind of Chinese medicinal formulae for treating waist dish outstanding |
| CN108619218A (en) * | 2018-05-21 | 2018-10-09 | 樊有山 | A kind of production method of Chinese herbal medicine bag that treating waist dish outstanding |
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| CN1297305C (en) | 2007-01-31 |
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Granted publication date: 20070131 Termination date: 20100129 |