CN1650929A - Preparation for free flowing ginew and bone and its preparation method - Google Patents
Preparation for free flowing ginew and bone and its preparation method Download PDFInfo
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Abstract
A Chinese medicine in the form of dispersing table or softcapsule for relaxing muscles, tendons and bones is prepared from 25 Chinese-medicinal materials including pilose antler, safflower honeysuckle flower, earthworm, etc.
Description
Technical field
The present invention relates to a kind of arthromyodynia that is used for the treatment of traditional Chinese medical science category, lumbago and skelalgia, muscle arthralgia, bend Chinese medicine preparation unblocking collaterals to treat arthritis preparation of the unfavorable and rheumatic arthritis of body, rheumatoid arthritis and preparation method thereof.
Background technology
The unblocking collaterals to treat arthritis preparation comprises tablet, dispersible tablet and soft capsule, the unblocking collaterals to treat arthritis preparation is the arthromyodynia that is used for the treatment of traditional Chinese medical science category, lumbago and skelalgia, muscle arthralgia, bend the Chinese medicine preparation of the unfavorable and rheumatic arthritis of body, rheumatoid arthritis, has expelling wind and cold, the effect of removing obstruction in the collateral to relieve pain.It is in the meridians fascicle that WANTONG JINGU PIAN is listed " country of National Drug Administration standard for traditional Chinese medicines compilation " brain in.Former dosage form technical characterstic is that 25-component medical material part crude drug is pulverized and to be added appropriate amount of auxiliary materials with the extracting section thing and make tablet.Along with the continuous variation and the human adaptive variation for medicine of environment, people have had higher requirement for the bioavailability and the drug effect of Chinese medicine.The present invention is a kind of unblocking collaterals to treat arthritis preparation and preparation method thereof; it has overcome starch such as Semen Strychni in the WANTONG JINGU PIAN, Radix Aconiti, Herba Asari, Myrrha; cause the more disadvantage of gastrointestinal side effect in the clinical use of this medicine; adopt pharmaceutically alleged adjuvant or substrate to make dispersible tablet or soft capsule respectively, can make that the active ingredient stripping is rapider maybe can better protect gastric mucosa.Not finding as yet at present has same disclosure of the Invention in the medicine of public publication and domestic use and technology.
Summary of the invention
The object of the invention is to add appropriate amount of auxiliary materials in the prescription medicinal substances extract based on Chinese medicine, has improved bioavailability and drug effect and orthopaedics compound Chinese medicinal preparation that reduced side effect---unblocking collaterals to treat arthritis preparation and preparation method and provide a kind of.
The present invention is achieved in that
The component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 15～30g Radix Aconiti Kusnezoffii Preparata 15～30g Semen Strychni (system) 15～30g
Herba Epimedii 25～35g Radix Achyranthis Bidentatae 15～30g Rhizoma Et Radix Notopterygii 15～30g
Rhizoma Osmundae 25～35g Cortex Phellodendri 15～30g Zaocys 15～30g
Cornu Cervi Pantotrichum 10～20g Radix Dipsaci 15～30g Fructus Mume 15～30g
Herba Asari 8.75～13.75g Herba Ephedrae 15～30g Ramulus Cinnamomi 15～30g
Flos Carthami 15～30g Radix Et Caulis Acanthopanacis Senticosi 15～30g Flos Lonicerae 15～30g
Pheretima 15～30g Herba Taxilli 15～30g Radix Glycyrrhizae 15～30g
Rhizoma Drynariae (scalding) 15～30g Cortex Illicii 15～30g Myrrha (processed) 15～30g
Radix Ginseng Rubra 15～30g
The present invention cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet, soft capsule by the extract of above-mentioned component.
The component weight proportion of extract of the present invention is optimized for:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5 Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, as making the unblocking collaterals to treat arthritis dispersible tablet with filler 50～300g, disintegrating agent 15～160g, lubricant 0.5～3g etc.
The component weight proportion of extract of the present invention more is optimized for:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
The red 22.5g that resembles
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, as making 1000 of unblocking collaterals to treat arthritis dispersible tablets with filler 175g, disintegrating agent 87.5g, lubricant 1.75g etc.
Adjuvant of the present invention or substrate are filler, disintegrating agent, lubricant.
Filler is:
Starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc., the best is a starch: precoking starch 5: 3.
Disintegrating agent is:
Crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium one or more, the best is a crospolyvinylpyrrolidone: 4: 1 mixture of carboxymethyl starch sodium;
Binding agent in its described its dispersible tablet is: the alcoholic solution of 40% ethanol～95% alcoholic solution or starch slurry or polyvinylpyrrolidone.
Lubricant is:
Magnesium stearate, or micropowder silica gel, or Pulvis Talci.
This dispersible tablet can coatedly be made coated dispersing tablet, and coating solution is made up of polymer film-forming material, plasticizer and solvent etc., can also add surfactant as defoamer, coloring agent etc.; As: a kind of preferable suitable unblocking collaterals to treat arthritis dispersible tablet film coating prescription is:
6% hypromellose (HPMC) (50%) alcoholic solution 1550g
Pulvis Talci 50g
Titanium dioxide 25g
Polyoxyethylene sorbitan monoleate 20g
Propylene glycol 20g;
The wherein effect of each component in the film coating liquid prescription:
1. hypromellose is the film-coat filmogen
2. ethanol is solvent
3. Pulvis Talci is a masking agent
4. titanium dioxide is masking agent
5. polyoxyethylene sorbitan monoleate is a plasticizer
6. propylene glycol is a plasticizer
Another kind of preparation of the present invention is the unblocking collaterals to treat arthritis soft capsule, and the component weight proportion of extract of the present invention is optimized for:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make soft capsule respectively, as making the unblocking collaterals to treat arthritis soft capsule with disperse medium 80～450g, suspending agent 5～60g, antiseptic 0.2～5g.
The component weight proportion of extract of the present invention more is optimized for:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make soft capsule respectively, as making the unblocking collaterals to treat arthritis soft capsule with disperse medium 265g, suspending agent 32.5g, antiseptic 2.6g.
The adjuvant of unblocking collaterals to treat arthritis soft capsule or substrate are disperse medium, suspending agent, antiseptic.
Disperse medium is:
I. oil phase disperse medium: olive oil or other crude vegetals; as soybean oil or Oleum Arachidis hypogaeae semen; or triglyceride oils; the oleic acid sorbitol ester; or olein: propylene glycol 90: 10; or Oleum Cocois C8/C10 monoglyceride; or dibasic acid esters or Oleum Cocois C8/C10 propylene glycol ester; or the Oleum Cocois triglyceride, or the acetylizad monoglyceride of purification, or olein; or glyceryl linoleate; or the Polyethylene Glycol glyceryl laurate ester, or one or more of purification Oleum helianthi monoglyceride etc., or the best Oleum Cocois that uses: olein 9: 2.
Ii. water-soluble medium is: the Polyethylene Glycol of molecular weight 300～800, as: PEG400 or Polyethylene Glycol 500, or Macrogol 600, or the best PEG400 that uses.
Suspending agent is one or more of the solid matter that increases dispersion medium viscosity such as Cera Flava, aluminum monostearate, ethyl cellulose, or best operating weight set of dispense is than Cera Flava: ethyl cellulose 6.5: 3.5.
Antiseptic comprises: one or more of glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester etc.
The preparation method of unblocking collaterals to treat arthritis preparation is achieved in that
The preparation method of unblocking collaterals to treat arthritis dispersible tablet is as follows:
Component weight proportion according to extract of the present invention is got:
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Osmundae 30.0g
Cortex Phellodendri 22.5g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Ephedrae 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Pheretima 22.5g
Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g Rhizoma Drynariae (scalding) 22.5g
Cortex Illicii 22.5g
Below totally ten three flavors add 7～12 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.25～1.30 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; It is characterized in that: the extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get disintegrating agent 6～70 gram mix homogeneously that add in adding filler 50～300 grams and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 9～90 gram and lubricant 0.5～3 restrains, the mix homogeneously tabletting, promptly get dispersible tablet; Or the coated again coated dispersing tablet of making.
The preparation method of unblocking collaterals to treat arthritis dispersible tablet is optimized for:
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get the disintegrating agent 38g mix homogeneously that adds in adding filler 175g and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 49.5g and lubricant 2.7g, mix homogeneously tabletting, promptly get dispersible tablet; Or the coated again coated dispersing tablet of making.
Unblocking collaterals to treat arthritis preparation of soft capsule method is as follows:
Component weight proportion according to extract of the present invention is got:
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Osmundae 30.0g
Cortex Phellodendri 22.5g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Ephedrae 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Pheretima 22.5g
Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g Rhizoma Drynariae (scalding) 22.5g
Cortex Illicii 22.5g
Below totally ten three flavors add 7～12 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.25～1.30 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; Cooperate the pharmaceutically alleged adjuvant or the substrate of the suitable kind of employing to make soft capsule respectively the extract of above-mentioned component, preparation soft capsule method is as follows: get above-mentioned medicinal substances extract, get suspending agent 5～60g be dissolved in the part disperse medium 60～350g, be preheated to 60～65 ℃ standby; Antiseptic 0.2～the 5g that gets the prescription share adds in 20～100g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, add medicinal substances extract, mix homogeneously grinds homogenizing, promptly get soft capsule content, be pressed into soft capsule.
Unblocking collaterals to treat arthritis preparation of soft capsule method is optimized for:
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of the suitable kind of employing to make soft capsule respectively, preparation soft capsule method is as follows: get above-mentioned medicinal substances extract, get suspending agent 32.5g be dissolved in the part disperse medium 205g, be preheated to 60～65 ℃ standby; The antiseptic 2.6g that gets the prescription share adds in the 60g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, adds medicinal substances extract, and mix homogeneously grinds homogenizing, promptly gets soft capsule content, is pressed into soft capsule.
Beneficial effect of the present invention is as follows:
The unblocking collaterals to treat arthritis dispersible tablet: be a kind of solidified liquid form of administration, disintegrate fully in 3 minutes at normal temperatures, the effective ingredient stripping is rapid.But solid state is taken, but also liquid condition is taken, and makes things convenient for the patient.The development of dispersible tablets of Chinese medicine need overcome and extract the difficult point that the extractum moisture absorption influences disintegrate, and the present invention is by the screening adjuvant, thereby it is stable to reach end product quality, and disintegrate is characteristics rapidly.
The unblocking collaterals to treat arthritis soft capsule: it is not have a kind of preparation that forms in sealings such as the non-water-soluble liquid of dissolution or suspension and the capsule shells with oils or to the gelatin thing.Soft capsule is the tablet that continues, and a kind of novel form that grows up after the injection, its shell are to form with the gelatin compacting, the aqueous medicinal liquid of bag in the softgel shell.Be characterized in slower than injection onset, but than tablet, capsule, granule is rapid-action.More easy to carry than oral liquid.Because the optimization of soft capsule liquid of the present invention prescription, its content can be in human body self emulsifying to a certain degree, increase absorption area, thus the bioavailability height.Among the present invention, because the gastric mucosal protective effect of soft capsule adjuvant makes the GI irritation sense of unblocking collaterals to treat arthritis preparation significantly descend.
The method for preparing the unblocking collaterals to treat arthritis preparation among the present invention can improve the bioavailability and the drug effect of medicine, and is remarkable to curative effect of disease such as treatment prolapse of lumbar intervertebral disc.
Clinical effectiveness of the present invention:
Unblocking collaterals to treat arthritis dispersible tablet treatment prolapse of lumbar intervertebral disc observation of curative effect
From in February, 2003, application unblocking collaterals to treat arthritis dispersible tablet, unblocking collaterals to treat arthritis soft capsule are treated prolapse of lumbar intervertebral disc and are compared with WANTONG JINGU PIAN, carry out the parallel paired observation of random packet, as a result satisfactory effect.Three groups are the out-patient, and all patients all make a definite diagnosis through CT examination, and meet the diagnostic criteria of the relevant prolapse of lumbar intervertebral disc that State Administration of Traditional Chinese Medicine issues, and get rid of tuberculosis of spine, tumor of spinal cord and centrum olisthe etc. simultaneously.Three groups of cases all do not comprise spinal function obstacle and recurrence after operation person.Be divided into dispersible tablet group (unblocking collaterals to treat arthritis dispersible tablet), soft capsule (unblocking collaterals to treat arthritis soft capsule), matched group (WANTONG JINGU PIAN) at random.
1 clinical data
1.1 two groups of sexes see Table 1.
Table 1 case sex distributes
| Group | Total routine number | The male | The women | ||
| The example number | ????％ | The example number | ????％ | ||
| The dispersible tablet group | ????42 | ????26 | ????61.90 | ????16 | ????38.09 |
| The soft capsule group | ????41 | ????24 | ????58.54 | ????17 | ????41.46 |
| Matched group | ????38 | ????23 | ????60.52 | ????15 | ????39.47 |
Two groups are compared with matched group respectively, check through t: P＞0.05, relatively there was no significant difference has comparability.
Dispersible tablet group minimal ages 21 years old, maximum 65 years old, the mean age was 38.45 ± 8.44 years old; Soft capsule group minimal ages 22 years old is 64 years old to the maximum, and the mean age is 38.63 ± 7.12; Minimum 23 years old of matched group, maximum 67 years old, the mean age was 39.67 ± 6.87 years old.
Course of disease dispersible tablet group is the shortest 1 month, and the longest is 5.9 years, and average course of disease is 1.03 ± 0.30 years; The soft capsule group is the shortest 1 month, and the longest is 5.6 years, and average course of disease is 1.05 ± 0.53; The matched group course of disease is the shortest to be 1 month, and the longest is 5.08, and average course of disease is 1.04 ± 0.41 years.Treatment group and matched group are learned by statistics on age, the course of disease and are handled, and difference does not have the significance meaning.
2 Therapeutic Method unblocking collaterals to treat arthritis dispersible tablets, 3 times/day, 2 slices/time, 15 days is a course of treatment, serve on 2 courses of treatment.The unblocking collaterals to treat arthritis soft capsule, 3 times/day, 2/time, 15 days is a course of treatment, serve on 2 courses of treatment.WANTONG JINGU PIAN, 3 times/day, 2 slices/time, 15 days is a course of treatment, serve on 2 courses of treatment.
3 criterions of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
With reference to " the disease of tcm diagnosis criterion of therapeutical effect that health ministry is issued ".Produce effects: lumbago and skelalgia disappears, and straight lower limb is raised experiment＞70., can recover original work.Effectively: lumbago and skelalgia sx, waist improving action.Invalid: treatment back symptom, sign do not have improvement.
3.2 therapeutic outcome
Two groups of curative effects relatively see Table 2.
Table 2 liang group curative effect comparative example (%)
| Group | Total routine number | Produce effects | Effectively | Invalid | Total effective rate | |||
| The example number | ????％ | The example number | ????％ | The example number | ????％ | ??????％ | ||
| The dispersible tablet group | ????42 | ????27 | ??64.28 | ????12 | ??26.19 | ????3 | ??7.14 | ????92.86 |
| The soft capsule group | ????41 | ????25 | ??60.98 | ????13 | ??31.71 | ????3 | ??7.32 | ????92.68 |
| Matched group | ????38 | ????23 | ??60.52 | ????9 | ??23.68 | ????6 | ??15.78 | ????84.22 |
Compare with matched group respectively, learn check by statistics, Ridit analyzes: P＜0.05, dominance difference is arranged, and treatment group curative effect is better than matched group.
4 conclusions
Lumbar intervertebral disc prolapse is a lumbago and skelalgia commonly encountered diseases therefore, the good physical labourer of being sent out in 30-55 year, and its main disease is lumbago and is radiated to an example or the bilateral leg pain.Motherland's medical science think intervertebral disk hernia be because deficiency of both QI and blood, deficiency of the liver and kindey, anemofrigid-damp arthralgia, tired blood resistance network, muscle arteries and veins lose and support, QI-blood circulation smooth due to.Unblocking collaterals to treat arthritis dispersible tablet, unblocking collaterals to treat arthritis soft capsule expelling wind and cold, removing obstruction in the collateral to relieve pain, can effectively eliminate the psoas muscle spasm, alleviate the pressure of intervertebral disc, annulus fibrosus disci intervertebralis tension force is reduced, stop the further bulging of outthrust or outstanding, alleviate the compressing of nerve root, make the adhesion in nerve root and little joint obtain to loosen, make inharmonic mechanical relationship obtain correcting, stop pathological changes further to increase the weight of, help the recovery of lumbar function.
Because the disperse medium of soft capsule liquid has comprised that vegetable oil, soybean lecithin etc. have the adjuvant of stomach year film protective effect, make former unblocking collaterals to treat arthritis coated tablet patient reflect that more GI irritation sense significantly descends.In this test, after matched group patient reflection is taken medicine the report rate of GI irritation sense being arranged in 1～2 hour is 17.5%, after the soft capsule group is taken medicine in the experimental group report rate of GI irritation sense being arranged in 1～2 hour is 1%, and after the dispersible tablet group is taken medicine the report rate of GI irritation sense being arranged in 1～2 hour is 3.5%.
The specific embodiment
Embodiment 1: the preparation of dispersible tablet
Among the present invention, the component weight of the extract of unblocking collaterals to treat arthritis dispersible tablet is joined as follows:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Below totally ten three flavors add 7 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.25 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get the disintegrating agent 6 gram mix homogeneously that add in adding filler 50 grams and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 9 gram and lubricant 0.5 restrains, the mix homogeneously tabletting, promptly get 1000 of unblocking collaterals to treat arthritis dispersible tablets; Or the coated again coated dispersing tablet of making.
Filler is: starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc., and the best is a starch: precoking starch 5: 3;
Disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium one or more, the best is a crospolyvinylpyrrolidone: 4: 1 mixture of carboxymethyl starch sodium;
Binding agent in its described its dispersible tablet is: 40% ethanol～95% alcoholic solution or starch slurry or contain 40～75% alcoholic solution of 3%～6% polyvinylpyrrolidone;
Lubricant is: magnesium stearate, or micropowder silica gel, or Pulvis Talci.
This dispersible tablet can coatedly be made coated dispersing tablet, and coating solution is made up of polymer film-forming material, plasticizer and solvent etc., can also add surfactant as defoamer, coloring agent etc.;
As: a kind of preferable suitable unblocking collaterals to treat arthritis dispersible tablet film coating prescription is:
6% hypromellose (HPMC) (50%) alcoholic solution 1550g
Pulvis Talci 50g
Titanium dioxide 25g
Polyoxyethylene sorbitan monoleate 20g
Propylene glycol 20g;
The wherein effect of each component in the film coating liquid prescription:
1. hypromellose is the film-coat filmogen
2. ethanol is solvent
3. Pulvis Talci is a masking agent
4. titanium dioxide is masking agent
5. polyoxyethylene sorbitan monoleate is a plasticizer
6. propylene glycol is a plasticizer
Embodiment 2: the preparation of dispersible tablet
Among the present invention, the component weight of the extract of unblocking collaterals to treat arthritis dispersible tablet is joined as follows:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Below totally ten three flavors add 10 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.28 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get the disintegrating agent 30 gram mix homogeneously that add in adding filler 210 grams and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 10 gram and lubricant 1.5 restrains, the mix homogeneously tabletting, promptly get 1000 of unblocking collaterals to treat arthritis dispersible tablets; Or the coated again coated dispersing tablet of making.
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, as making 1000 of unblocking collaterals to treat arthritis dispersible tablets with filler 175g, disintegrating agent 87.5g, lubricant 1.75g etc.
Adjuvant of the present invention or substrate are filler, disintegrating agent, lubricant.
Filler the best is a starch: precoking starch 5: 3; Coating solution is made up of polymer film-forming material, plasticizer and solvent etc., adds surfactant as defoamer, coloring agent etc.
Disintegrating agent the best is a crospolyvinylpyrrolidone: 4: 1 mixture of carboxymethyl starch sodium; Binding agent in its described its dispersible tablet is: 60% alcoholic solution.
Lubricant is a magnesium stearate.
Can coatedly again make coated dispersing tablet.Coating solution is with embodiment 1.
Embodiment 3: the preparation of dispersible tablet
Among the present invention, the component weight of the extract of unblocking collaterals to treat arthritis dispersible tablet is joined as follows:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Below totally ten three flavors add 12 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.30 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are ground into fine powder, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get the disintegrating agent 70 gram mix homogeneously that add in adding filler 300 grams and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 90 gram and lubricant 3 restrains, the mix homogeneously tabletting, promptly get dispersible tablet; Or the coated again coated dispersing tablet of making.
The extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, as making 1000 of unblocking collaterals to treat arthritis dispersible tablets with filler 175g, disintegrating agent 87.5g, lubricant 1.75g etc.
Adjuvant of the present invention or substrate are filler, disintegrating agent, lubricant.
Filler is: starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc., the best is a starch: precoking starch 5: 3.
Disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium one or more, the best is a crospolyvinylpyrrolidone: 4: 1 mixture of carboxymethyl starch sodium;
Binding agent in its described its dispersible tablet is: 40～75% alcoholic solution that contain 3%～6% polyvinylpyrrolidone; The best is 4% polyvinylpyrrolidone, 60% alcoholic solution.
Lubricant is: magnesium stearate, or micropowder silica gel, or Pulvis Talci.
Can coatedly again make coated dispersing tablet.Coating solution is with embodiment 1.
Embodiment 4 unblocking collaterals to treat arthritis preparation of soft capsule
Among the present invention, the component weight of the extract of unblocking collaterals to treat arthritis soft capsule is joined as follows:
The component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The method of medicinal material extract is identical with the extracting method of the foregoing description 1 or 2 or 3, and the adjuvant of capsule liquid is:
Cera Flava 5g;
Olive oil 60g
Propylene glycol 0.5g
Soybean lecithin 20
The preparation soft capsule: the material extract of getting it filled, be crushed to 100 orders, standby.The Cera Flava of getting above-mentioned share be dissolved in be preheated among 60 ℃ of disperse medium olive oil 480g standby; Soybean lecithin, the propylene glycol of getting above-mentioned share add in the olive oil of above-mentioned share remainder, stir, and are fully mixed to 37 ℃ with above-mentioned disperse medium, add above-mentioned medicinal substances extract fine powder, stir, grind homogenizing, make 1000 cervicitis soft capsules.
Cera Flava is a suspending agent, and the emulsifying agent soybean lecithin is an emulsifying agent in its soft capsule.
Olive oil is that the oil phase disperse medium also can be: the triglyceride oils of crude vegetal (as: soybean oil, Oleum Arachidis hypogaeae semen) or long-chain and medium-chain saturation in various degree, as: oleic acid sorbitol ester, olein: propylene glycol (90: 10), Oleum Cocois C8/C10 monoglyceride or dibasic acid esters, Oleum Cocois C8/C10 propylene glycol ester, Oleum Cocois triglyceride, the acetylizad monoglyceride of purification (Myvacet oil), olein, glyceryl linoleate, Polyethylene Glycol glyceryl laurate ester, purification Oleum helianthi monoglyceride.
Embodiment 5: the unblocking collaterals to treat arthritis preparation of soft capsule
Step 1: preparation medicinal substances extract
Among the present invention, the component weight of the extract of unblocking collaterals to treat arthritis soft capsule is joined as follows:
The component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Step 1: prepare medicinal substances extract: the method for medicinal material extract is identical with the extracting method of the foregoing description 1 or 2 or 3,
Step 2: preparation soft capsule:
Adjuvant component weight proportion:
PEG400 200g
Glycerol 7g
Water 25ml
Tween 80 0.5g
Suspending agent: Cera Flava: ethyl cellulose (6.5: 3.5), the 20g method for making: the material extract fine powder of getting it filled is standby.The Polyethylene Glycol of getting above-mentioned share is preheated to 40 ℃, adds glycerol, water tween, and supersound process makes mix homogeneously; The material extract fine powder of getting it filled mixes with it, stirs, and grinds homogenizing, makes 1000 cervicitis soft capsules.
Illustrate: PEG400 and water are disperse medium, and disperse medium can also be selected the Polyethylene Glycol of molecular weight 300～800 for use, as: PEG400 or Polyethylene Glycol 500, or Macrogol 600, or the best PEG400 that uses.
Suspending agent is one or more of the solid matter that increases dispersion medium viscosity such as Cera Flava, aluminum monostearate, ethyl cellulose, or best operating weight set of dispense is than Cera Flava: ethyl cellulose 6.5: 3.5,
Antiseptic is a propylene glycol, can also use: one or more of glycerol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester etc.
Embodiment 6: the unblocking collaterals to treat arthritis preparation of soft capsule
The component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Step 1: prepare medicinal substances extract: the method for medicinal material extract is identical with the extracting method of the foregoing description 1 or 2 or 3,
Step 2: preparation soft capsule: adjuvant component weight proportion:
PEG400 325g
Glycerol 7g
Water 25ml
Tween 80 0.5g
Suspending agent: Cera Flava: ethyl cellulose (6.5: 3.5), 60g
Get suspending agent, be dissolved in the part disperse medium 100g, be preheated to 60～65 ℃ standby; Antiseptic 0.2～the 5g that gets the prescription share adds in the 30g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, adds medicinal substances extract, and mix homogeneously grinds homogenizing, promptly gets soft capsule content, is pressed into soft capsule.
Embodiment 7: the unblocking collaterals to treat arthritis preparation of soft capsule
The component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
Step 1: prepare medicinal substances extract: the method for medicinal material extract is identical with the extracting method of the foregoing description 1 or 2 or 3,
Step 2: preparation soft capsule:
Adjuvant component weight proportion:
Cera Flava 32.5g;
Olive oil 265g
Propylene glycol 2.6g
Soybean lecithin 20
Get suspending agent 32.5g be dissolved in the part disperse medium 200g, be preheated to 60～65 ℃ standby; Antiseptic 0.2～the 5g that gets the prescription share adds in the 65g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, add medicinal substances extract, mix homogeneously grinds homogenizing, promptly get soft capsule content, be pressed into 1000 of soft capsules.
Soybean lecithin is an emulsifying agent.
Medical materials such as Cortex Illicii all use by 2000 editions regulations of Chinese Pharmacopoeia.
Semen Strychni (system), Rhizoma Drynariae (scalding), Myrrha (processed) etc. are meant the processed product after medical material is all concocted by the processing of Chinese Pharmacopoeia regulation.
Claims (11)
1, a kind of unblocking collaterals to treat arthritis preparation is characterized in that: the component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 15～30g Radix Aconiti Kusnezoffii Preparata 15～30g Semen Strychni (system) 15～30g
Herba Epimedii 25～35g Radix Achyranthis Bidentatae 15～30g Rhizoma Et Radix Notopterygii 15～30g
Rhizoma Osmundae 25～35g Cortex Phellodendri 15～30g Zaocys 15～30g
Cornu Cervi Pantotrichum 10～20g Radix Dipsaci 15～30g Fructus Mume 15～30g
Herba Asari 8.75～13.75g Herba Ephedrae 15～30g Ramulus Cinnamomi 15～30g
Flos Carthami 15～30g Radix Et Caulis Acanthopanacis Senticosi 15～30g Flos Lonicerae 15～30g
Pheretima 15～30g Herba Taxilli 15～30g Radix Glycyrrhizae 15～30g
Rhizoma Drynariae (scalding) 15～30g Cortex Illicii 15～30g Myrrha (processed) 15～30g
Radix Ginseng Rubra 15～30g
The present invention is made up of the extract of above-mentioned component and the pharmaceutically alleged adjuvant or the substrate of suitable kind and weight.
2, unblocking collaterals to treat arthritis preparation according to claim 1 is characterized in that: the component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The pharmaceutically alleged adjuvant or the substrate of the extract of above-mentioned component and suitable kind and weight are made dispersible tablet respectively, as making the unblocking collaterals to treat arthritis dispersible tablet with filler 50～300g, disintegrating agent 15～160g, lubricant 0.5～3g etc., or the coated again coated dispersing tablet of making.
3, unblocking collaterals to treat arthritis preparation according to claim 1 and 2 is characterized in that: the component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The pharmaceutically alleged adjuvant or the substrate of the extract of above-mentioned component and suitable kind and weight are made dispersible tablet respectively, as making the unblocking collaterals to treat arthritis dispersible tablet with filler 175g, disintegrating agent 87.5g, lubricant 1.75g etc.
4, unblocking collaterals to treat arthritis preparation according to claim 3 is characterized in that: adjuvant of the present invention or substrate are filler, disintegrating agent, lubricant;
Filler is: starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc., and the best is a starch: precoking starch 5: 3;
Disintegrating agent is:
Crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium one or more, the best is a crospolyvinylpyrrolidone: 4: 1 mixture of carboxymethyl starch sodium; Binding agent in its described its dispersible tablet is: the alcoholic solution of 40% ethanol～95% alcoholic solution or starch slurry or polyvinylpyrrolidone;
Lubricant is:
Magnesium stearate, or micropowder silica gel, or Pulvis Talci.
Coating solution is made up of polymer film-forming material, plasticizer and solvent etc., can also add surfactant as defoamer, coloring agent etc.;
5, unblocking collaterals to treat arthritis preparation according to claim 1 is characterized in that: the component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The pharmaceutically alleged adjuvant or the substrate of the extract of above-mentioned component and suitable kind and weight are made soft capsule respectively, as making the unblocking collaterals to treat arthritis soft capsule with disperse medium 80～450g, suspending agent 5～60g, antiseptic 0.2～5g.
6, unblocking collaterals to treat arthritis preparation according to claim 1 or 5, it is characterized in that: the component weight proportion of extract of the present invention is:
Radix Aconiti Preparata 22.5g Radix Aconiti Kusnezoffii Preparata 22.5g Semen Strychni (system) 22.5g
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Et Radix Notopterygii 22.5g
Rhizoma Osmundae 30.0g Cortex Phellodendri 22.5g Zaocys 22.5g
Cornu Cervi Pantotrichum 15g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Asari 11.25g Herba Ephedrae 22.5g Ramulus Cinnamomi 22.5g
Flos Carthami 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Flos Lonicerae 22.5g
Pheretima 22.5g Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g
Rhizoma Drynariae (scalding) 22.5g Cortex Illicii 22.5g Myrrha (processed) 22.5g
Radix Ginseng Rubra 22.5g
The pharmaceutically alleged adjuvant or the substrate of the extract of above-mentioned component and suitable kind and weight are made soft capsule respectively, as making the unblocking collaterals to treat arthritis soft capsule with disperse medium 265g, suspending agent 32.5g, antiseptic 2.6g.
7, unblocking collaterals to treat arthritis preparation according to claim 6 is characterized in that: adjuvant of the present invention or substrate are disperse medium, suspending agent, antiseptic;
Disperse medium is:
I. oil phase disperse medium: olive oil or other crude vegetals, as soybean oil or Oleum Arachidis hypogaeae semen, or triglyceride oils, the oleic acid sorbitol ester, or olein: propylene glycol 90: 10, or Oleum Cocois C8/C10 monoglyceride, or dibasic acid esters or Oleum Cocois C8/C10 propylene glycol ester, or the Oleum Cocois triglyceride, or the acetylizad monoglyceride of purification, or olein, or glyceryl linoleate, or the Polyethylene Glycol glyceryl laurate ester, or one or more of purification Oleum helianthi monoglyceride etc., or the best Oleum Cocois that uses: olein 9: 2;
Ii. water-soluble medium is: the Polyethylene Glycol of molecular weight 300～800, as: PEG400 or Polyethylene Glycol 500, or Macrogol 600, or the best PEG400 that uses;
Iii. suspending agent is one or more of the solid matter that increases dispersion medium viscosity such as Cera Flava, aluminum monostearate, ethyl cellulose, or best operating weight set of dispense is than Cera Flava: ethyl cellulose 6.5: 3.5;
Iv. antiseptic comprises: one or more of glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester etc. can add emulsifying agent increases capsule liquid as: soybean lecithin emulsifying.
8, a kind of method for preparing claim 1 or 2 described unblocking collaterals to treat arthritis preparations, get according to the component weight proportion of extract of the present invention:
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Osmundae 30.0g
Cortex Phellodendri 22.5g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Ephedrae 22.5g Radix Et Caulis Acanthopanacis Senticosi 22.5g Pheretima 22.5g
Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g Rhizoma Drynariae (scalding) 22.5g
Cortex Illicii 22.5g
Below totally ten three flavors add 7～12 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.25～1.30 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are ground into fine powder, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; It is characterized in that: the extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get disintegrating agent 6～70 gram mix homogeneously that add in adding filler 50～300 grams and the part, granulate with the wetting agent moistening, dry, granulate, add remaining and add disintegrating agent 9～90 gram and lubricant 0.5～3 restrains, the mix homogeneously tabletting, promptly get dispersible tablet; Or the coated again coated dispersing tablet of making.
9, a kind of method for preparing the described unblocking collaterals to treat arthritis preparation of claim 3, it is characterized in that: the extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of suitable kind of employing and weight to make dispersible tablet respectively, preparation dispersible tablet method is as follows: get the disintegrating agent 38g mix homogeneously that adds in adding filler 175g and the part, granulate with the wetting agent moistening, dry, granulate adds remaining and adds disintegrating agent 49.5g and lubricant 2.7g, mix homogeneously tabletting, promptly gets dispersible tablet; Or the coated again coated dispersing tablet of making.
10, a kind of method for preparing claim 1 or 5 described unblocking collaterals to treat arthritis preparations, get according to the component weight proportion of extract of the present invention:
Herba Epimedii 30.0g Radix Achyranthis Bidentatae 22.5g Rhizoma Osmundae 30.0g
Cortex Phellodendri 22.5g Radix Dipsaci 22.5g Fructus Mume 22.5g
Herba Ephedrae 22.5 g Radix Et Caulis Acanthopanacis Senticosi 22.5g Pheretima 22.5g
Herba Taxilli 22.5g Radix Glycyrrhizae 22.5g Rhizoma Drynariae (scalding) 22.5g
Cortex Illicii 22.5g
Below totally ten three flavors add 7～12 times of amount decoctions of water three times, 2 hours for the first time; Second and third time each 1 hour, collecting decoction filters, and it is 1.25～1.30 clear paste that filtrate is concentrated into relative density under 50 ℃ of conditions, standby; All the other 12 flavors are ground into fine powder, and are dry below 80 ℃ with above-mentioned clear paste mixing, are ground into fine powder, are the medicinal substances extract of preparation unblocking collaterals to treat arthritis preparation; It is characterized in that: the extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of the suitable kind of employing to make soft capsule respectively, preparation soft capsule method is as follows: get above-mentioned medicinal substances extract, get suspending agent 5～60g be dissolved in the part disperse medium 60～350g, be preheated to 60～65 ℃ standby; Antiseptic 0.2～the 5g that gets the prescription share adds in 20～100g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, add medicinal substances extract, mix homogeneously grinds homogenizing, promptly get soft capsule content, be pressed into soft capsule.
11, a kind of method for preparing the described unblocking collaterals to treat arthritis preparation of claim 6, it is characterized in that: the extract of above-mentioned component cooperates the pharmaceutically alleged adjuvant or the substrate of the suitable kind of employing to make soft capsule respectively, preparation soft capsule method is as follows: get above-mentioned medicinal substances extract, get suspending agent 32.5g be dissolved in the part disperse medium 205g, be preheated to 60～65 ℃ standby; The antiseptic 2.6g that gets the prescription share adds in the 60g disperse medium of above-mentioned share remainder, stirs, and is mixed to 37 ℃ with above-mentioned disperse medium, adds medicinal substances extract, and mix homogeneously grinds homogenizing, promptly gets soft capsule content, is pressed into soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100523477A CN1316997C (en) | 2004-11-18 | 2004-11-18 | Preparation for free flowing ginew and bone and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100523477A CN1316997C (en) | 2004-11-18 | 2004-11-18 | Preparation for free flowing ginew and bone and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1650929A true CN1650929A (en) | 2005-08-10 |
| CN1316997C CN1316997C (en) | 2007-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100523477A Expired - Fee Related CN1316997C (en) | 2004-11-18 | 2004-11-18 | Preparation for free flowing ginew and bone and its preparation method |
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| CN (1) | CN1316997C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428079B (en) * | 2007-11-05 | 2010-12-22 | 解明泉 | Chinese-medicinal wine for treating cervical vertebra disease |
| CN103565954A (en) * | 2012-07-29 | 2014-02-12 | 潘首德 | Application of Wantong muscle and bone patch in medicament for treating scapulohumeral periarthritis |
| CN103566130A (en) * | 2012-11-12 | 2014-02-12 | 刘喜梅 | Preparation method of medicine for treating rheumatoid arthritis |
| CN103948724A (en) * | 2014-04-23 | 2014-07-30 | 通化万通药业股份有限公司 | Muscle and bone plaster |
| CN104083497A (en) * | 2014-06-19 | 2014-10-08 | 通化万通药业股份有限公司 | Chinese patent medicine capable of expelling wind, removing cold, relaxing veins and relieving pain, and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186043C (en) * | 2002-02-04 | 2005-01-26 | 陈玉周 | Exterior-applied medicine for treating osteopathy |
| CN1250276C (en) * | 2003-10-30 | 2006-04-12 | 王志臣 | Drug for curing disease of proplapse of lumbar intervertebral disc |
-
2004
- 2004-11-18 CN CNB2004100523477A patent/CN1316997C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428079B (en) * | 2007-11-05 | 2010-12-22 | 解明泉 | Chinese-medicinal wine for treating cervical vertebra disease |
| CN103565954A (en) * | 2012-07-29 | 2014-02-12 | 潘首德 | Application of Wantong muscle and bone patch in medicament for treating scapulohumeral periarthritis |
| CN103566130A (en) * | 2012-11-12 | 2014-02-12 | 刘喜梅 | Preparation method of medicine for treating rheumatoid arthritis |
| CN103566130B (en) * | 2012-11-12 | 2015-11-11 | 刘萍 | A kind of preparation method for the treatment of the medicament of rheumatoid arthritis |
| CN103948724A (en) * | 2014-04-23 | 2014-07-30 | 通化万通药业股份有限公司 | Muscle and bone plaster |
| CN104083497A (en) * | 2014-06-19 | 2014-10-08 | 通化万通药业股份有限公司 | Chinese patent medicine capable of expelling wind, removing cold, relaxing veins and relieving pain, and preparation method thereof |
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| Publication number | Publication date |
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| CN1316997C (en) | 2007-05-23 |
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