CN1648623A - Thermal sensitive composition and disposable thermometer made therefrom - Google Patents
Thermal sensitive composition and disposable thermometer made therefrom Download PDFInfo
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- CN1648623A CN1648623A CN 200410016031 CN200410016031A CN1648623A CN 1648623 A CN1648623 A CN 1648623A CN 200410016031 CN200410016031 CN 200410016031 CN 200410016031 A CN200410016031 A CN 200410016031A CN 1648623 A CN1648623 A CN 1648623A
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Abstract
The present invention provides a disposable thermometer comprising base sheet with geometric notch as the temperature indicating end and thermosensitive composition set inside the notch. It has clear reading, high precision, high safety, no environmental pollution, simple making process, low cost and other features. One kind of thermosensitive composition for making the disposable thermometer is also provided, and it has no toxic side effect, fast temperature response, high color difference contrast, and other advantages.
Description
Technical field
The disposable thermometer that the present invention relates to a kind of heat-sensitive composition and make by this composition.Specifically, the present invention relates to a kind of disposable thermometer that does not have mercury type heat-sensitive composition and make by this composition.
Background technology
On medicine equipment market, the traditional thermometer that is used for take temperature is a glass mercury thermometer, and masses are very familiar.But this class thermometer remains in many weak points in clinical use.
In vast ill crowd, patient's disease and severity extent have nothing in common with each other, the state of an illness is numerous and diverse, illness is staggered, and in the outpatient service and ward of hospital, only with a limited number of thermometers in many state of an illness, the patient that sick kind is different is middle to be used alternately, many germs, sporinite, mycoplasma, Chlamydia, virus, the viral pathogen in the communicable disease particularly, as the first type, B-mode, hepatitis C virus, the venereal disease poison, SRAS and other variability virus etc., be difficult in the disinfecting process of short time, thoroughly kill, so these uncleanly thermometers, just become the infect indirectly instrument of some pathogen probably.
Along with modern society people's living standard improves constantly, the sense of self-protection of hygiene and health is strengthened, medical treatment safe, effectively become a kind of new concept of modern, the medicine equipment of therefore advocating the turnover human body now with disposable use for well.
Traditional glass mercury thermometer is placed on when surveying body temperature in the oral cavity, (as human body high temperature, obnubilation, tic spasm time) in some cases, be easy to thermometer is damaged, mercury metal on the body temperature gauge outfit will enter in the body, cause adverse consequencess such as mercury metal poisoning, if glass mercury thermometer in indoor breakage, the mercury metal is scattered in indoor, the mercury vapour that forms can cause the secondary pollution of environment space, and surrounding population and environment are had very big harm equally.
Glass mercury thermometer must be shed mercury showing rod after use and reset, and then sterilize in the immersion thimerosal, and under special conditions of contract, collect standby, so not only required great effort but also time-consuming, the loss of thimerosal, thermometric breakage rate is also higher, when particularly thermometer will be reused at short notice, the sterilisation quality of apparatus just can not get guaranteeing, medical nursing work is caused many inconvenience.
In this class glass mercury thermometer process of production, also need to consume a large amount of energy and precious metal-mercury.And the thermometric accumulation breakage of these glass mercurys causes mercury metal unrestrained at the earth's surface, and mercury can be deposited in the tissue, is difficult to nature and discharges.Therefore, mercuric thermometer is a kind of potential danger to human society, to environmental ecology.
In order to solve the problems such as security, reliability, convenience and mercury metal resource consumption of traditional thermometer in concrete the use, need a kind of not mercurous heat-sensitive composition at present, and the disposable thermometer that makes with this heat-sensitive composition.
Summary of the invention
In order to solve prior art problems, an object of the present invention is to provide a kind of heat-sensitive composition of novelty, it is mercurous and to environment and person poultry harmless.
Another object of the present invention provides a kind of no mercury type thermometer that is made by described heat-sensitive composition, and it has the simple and low cost and other advantages of safe, manufacturing process.
One aspect of the present invention provides a kind of heat-sensitive composition of aromatic-containing compound, and it comprises:
A) 0.5-60 weight % is selected from o-bromoaniline, 3-chloronitrobenzene, 1 chloromethyl naphthalene, 1-naphthalene acetonitrile, o-chlorphenol, 2,2-dichloronitrobenzene, 2, the compound of 4-dichloronitrobenzene, 2,4 dichloro aniline or its potpourri;
B) 39.5-99 weight % is selected from 2-bromo-6-nitrotoluene, 3,5-difluoroaniline, 2-bromo nitrobenzene, 2,4-two chloro-5-fluoro-3-nitrobenzoic acids, 3-bromo nitrobenzene, 2, the compound of 2-two bromo nitrobenzenes or its potpourri;
C) 0.01-0.5 weight % indicator, it is selected from, and quinoline is red, crystal violet lactones, crystal violet, cresol red, bromochlorophenol blue, dibromophenolphthalein, pinacyanol chlorine, pinacyanol iodine, methyl red, ethyl red, chlorophenol blue, chlorophenol red, titania, chlorocresol green, bromcresol green, bromine cresol red, basic fuchsin, bisphenol-A, oxalic acid, aerosil, beta naphthal, 2-naphthalene sulfonic acids, 3-nitrophenols, phenol or its potpourri;
Another aspect of the present invention provides a kind of heat-sensitive composition that contains steride, and it comprises:
A) 73-75 weight % is selected from compound or its potpourri of cholesteryl oleoyl carbonate, cholesteryl oleate, cholesteryl carbonate, Cholesteryl hexadecanoate;
B) the cholesterol chlorine of 20-23 weight %;
C) 4-5 weight % is selected from compound or its potpourri of Cholesteryl stearate, cholesteryl butyrate, cholesterol benzol carbonate, cholesteryl acetate.
The present invention provides a kind of thermometer on the other hand, and it comprises the table body substrate that has a plurality of how much depressions, and described concave array is formed temperature indicating end, and the aforementioned hot sensitive composition that places described how much depressions.
That heat-sensitive composition of the present invention has is not mercurous, no side effects, temperature become be swift in response, high color difference, to advantages such as environment and person poultry harmless.
Disposable thermometer of the present invention has that clear reading, precision height, security are good, non-environmental-pollution, manufacturing process is simple and low cost and other advantages.
The accompanying drawing summary
Fig. 1 is a thermometric synoptic diagram in the better example of the present invention;
Fig. 2 has described thermometric manufacture method shown in Figure 1;
Fig. 3 has described thermometric number reading method shown in Figure 1.
Embodiment
The inventor finds that through a large amount of experiment the potpourri of different aromatic organic compounds cooperates the potpourri of indicator or different cholesterol class unimolecule liquid-crystal compounds to have different discoloring temperatures, and the present invention finishes on the basis of this discovery.
Therefore, a first aspect of the present invention provides a kind of heat-sensitive composition of aromatic-containing compound, and it comprises:
A) 0.5-60 weight % is selected from o-bromoaniline, 3-chloronitrobenzene, 1 chloromethyl naphthalene, 1-naphthalene acetonitrile, o-chlorphenol, 2,2-dichloronitrobenzene, 2, the compound of 4-dichloronitrobenzene, 2,4 dichloro aniline or its potpourri;
B) 39.5-99 weight % is selected from 2-bromo-6-nitrotoluene, 3,5-difluoroaniline, 2-bromo nitrobenzene, 2,4-two chloro-5-fluoro-3-nitrobenzoic acids, 3-bromo nitrobenzene, 2, the compound of 2-two bromo nitrobenzenes or its potpourri;
C) 0.01-0.5 weight % indicator, it is selected from, and quinoline is red, crystal violet lactones, crystal violet, cresol red, bromochlorophenol blue, dibromophenolphthalein, pinacyanol chlorine, pinacyanol iodine, methyl red, ethyl red, chlorophenol blue, chlorophenol red, titania, chlorocresol green, bromcresol green, bromine cresol red, basic fuchsin, bisphenol-A, oxalic acid, aerosil, beta naphthal, 2-naphthalene sulfonic acids, 3-nitrophenols, phenol;
In the heat-sensitive composition of aromatic-containing compound of the present invention, component A is selected from o-bromoaniline, 3-chloronitrobenzene, 1 chloromethyl naphthalene, 1-naphthalene acetonitrile, o-chlorphenol, 2,2-dichloronitrobenzene, 2,4-dichloronitrobenzene, 2,4 dichloro aniline.In a preferred embodiments of the present invention, component A is selected from o-bromoaniline, 1 chloromethyl naphthalene, 1-naphthalene acetonitrile.
In the heat-sensitive composition of aromatic-containing compound of the present invention, component A can be selected from a kind of compound in the above-claimed cpd, also can be the potpourri of multiple above-claimed cpd.In a preferred embodiments of the present invention, component A is the potpourri of two kinds of above-claimed cpds.In another preferred embodiments of the present invention, component A is the potpourri of three kinds of above-claimed cpds.
In the heat-sensitive composition of aromatic-containing compound of the present invention, the content of component A is generally 0.5-60 weight %, is preferably 0.9-55 weight %, more preferably 1.0-54.7 weight %.
In the heat-sensitive composition of aromatic-containing compound of the present invention, B component is selected from 2-bromo-6-nitrotoluene, 3,5-difluoroaniline, 2-bromo nitrobenzene, 2,4-two chloro-5-fluoro-3-nitrobenzoic acids, 3-bromo nitrobenzene, 2,2-two bromo nitrobenzenes.In a preferred embodiments of the present invention, B component is selected from 2-bromo-6-nitrotoluene, 3,5-difluoroaniline, 2-bromo nitrobenzene, 2,4-two chloro-5-fluoro-3-nitrobenzoic acids.
Contain in the heat-sensitive composition of aromatics in the present invention, B component can be selected from a kind of compound in the above-claimed cpd, also can be the potpourri of multiple above-claimed cpd.In a preferred embodiments of the present invention, B component is the potpourri of two kinds of above-claimed cpds.In another preferred embodiments of the present invention, B component is the potpourri of three kinds of above-claimed cpds.
In the heat-sensitive composition of aromatic-containing compound of the present invention, the content of B component is 39.5-99 weight %, is preferably 44.5-99 weight %, more preferably 45.2-96.7 weight %.
In the heat-sensitive composition of aromatic-containing compound of the present invention, component C is selected from that quinoline is red, crystal violet lactones, crystal violet, cresol red, bromochlorophenol blue, dibromophenolphthalein, pinacyanol chlorine, pinacyanol iodine, methyl red, ethyl red, chlorophenol blue, chlorophenol red, titania, chlorocresol green, bromcresol green, bromine cresol red, basic fuchsin, bisphenol-A, oxalic acid, aerosil, beta naphthal, 2-naphthalene sulfonic acids, 3-nitrophenols, phenol.In a preferred embodiments of the present invention, component C is selected from basic fuchsin, bromochlorophenol blue, aerosil, bromcresol green, crystal violet, oxalic acid.
In the heat-sensitive composition of aromatic-containing compound of the present invention, component C can be selected from a kind of indicator in the above-mentioned indicator, also can be the potpourri of multiple above-mentioned indicator.In preferred embodiments of the present invention, component C is the potpourri of two kinds of above-mentioned indicator, and in another preferred embodiments of the present invention, component C is the potpourri of three kinds of above-mentioned indicator.
In the heat-sensitive composition of aromatic-containing compound of the present invention, the content of component C is generally 0.01-0.5 weight %, is preferably 0.05-0.3 weight %, more preferably 0.08-1.5 weight %.
Another aspect of the present invention provides a kind of heat-sensitive composition that contains steride, and it comprises:
A) 73-75 weight % is selected from compound or its potpourri of cholesteryl oleoyl carbonate, cholesteryl oleate, cholesteryl carbonate, Cholesteryl hexadecanoate;
B) the cholesterol chlorine of 20-23 weight %;
C) 4-5 weight % is selected from compound or its potpourri in Cholesteryl stearate, cholesteryl butyrate, cholesterol benzol carbonate, the cholesteryl acetate.
Contain in the heat-sensitive composition of steride in the present invention, component A is selected from cholesteryl oleoyl carbonate, cholesteryl oleate, cholesteryl carbonate, Cholesteryl hexadecanoate.In a preferred embodiments of the present invention, component A is selected from cholesteryl oleoyl carbonate, cholesteryl oleate.
Contain in the heat-sensitive composition of steride in the present invention, component A can be selected from a kind of compound in the above-claimed cpd, also can be the potpourri of multiple above-claimed cpd.In a preferred embodiments of the present invention, component A is the potpourri of two kinds of above-claimed cpds.In another preferred embodiments of the present invention, component A is the potpourri of three kinds of above-claimed cpds.
Contain in the heat-sensitive composition of steride in the present invention, the content of component A is generally 73-75 weight %, is preferably 73.5-74.5 weight %, more preferably 73.84-74.36 weight %.
Contain in the heat-sensitive composition of steride in the present invention, the content of B component is generally 20-23 weight %, is preferably 21-22 weight %, more preferably 21.40-21.85 weight %.
Contain in the heat-sensitive composition of steride in the present invention, component C is selected from Cholesteryl stearate, cholesteryl butyrate, cholesterol benzol carbonate, cholesteryl acetate.In an example of the present invention, component C is selected from cholesteryl butyrate, cholesterol benzol carbonate.
Contain in the heat-sensitive composition of steride in the present invention, component C can be selected from a kind of compound in the above-claimed cpd, also can be the potpourri in the multiple above-claimed cpd.In a preferred embodiments of the present invention, component C is the potpourri of two kinds of above-claimed cpds.In another preferred embodiments of the present invention, component C is three kinds of potpourris in the above-claimed cpd.
Contain in the heat-sensitive composition of steride in the present invention, the content of component C is generally 4-5 weight % and is preferably 4-4.5 weight %, more preferably 4.23-4.32 weight %.
The heat discoloration precision of heat-sensitive composition of the present invention is 0.1 ℃; when temperature reaches the discoloring temperature of thermally indicating material; obvious variation can take place in the color of heat-sensitive composition; an advantage of heat-sensitive composition of the present invention is that variable color is very obvious and sensitive; there is not the transition variable color that can occur usually; difference according to employed material; the change color of heat-sensitive composition is also different, can be: become salmon pink by green; become mazarine by yellow; become Transparent color by milk yellow; become redness by milk yellow; become Transparent color by green; become mazarine by light brown; become black by milk yellow; become mazarine etc. by light green color.
The variable color speed of heat-sensitive composition of the present invention is very fast, can finish variable color in 2 minutes usually, better can finish variable color in 1 minute.
In the present invention, the change color of heat-sensitive composition is irreversible.Such heat-sensitive composition just very is fit to be used for making disposable thermometer, even because when thermometer leaves human body, the heat-sensitive composition in the thermometer can the variable color once more along with environment temperature decline yet, thereby can show measured body temperature accurately.
The present invention provides a kind of disposable no mercury type thermometer that uses above-mentioned heat-sensitive composition on the other hand, and it has the precision height, security is good, manufacturing process is simple and low cost and other advantages.
Fig. 1 is the synoptic diagram of the thermometric preferred embodiments of the disposable no mercury type of the present invention.Wherein mark 1 is represented thermometric temperature indicating end, and mark 2 expression scales are represented a little, mark 3 expression temperature indicating points, and mark 4 expression temperature readings, mark 5 expressions are almost caved in, mark 6 expression base materials.As shown in Figure 1, thermometer 10 of the present invention comprises the table body base material 6 that has a plurality of how much depressions 5, and described how much depressions 5 rearrange temperature indicating end 1, and the heat-sensitive composition that places described depression.Comprised the aforesaid heat-sensitive composition of the present invention in the described depression 5, be used for the variation of take temperature, temperature scale that each how much depression 5 are corresponding different.
Thermometer of the present invention has been filled different heat-sensitive compositions in different depression 5, so just can utilize the different discoloring temperatures of different heat-sensitive compositions accurately to show measured body temperature.In a preferred embodiment of the present invention, corresponding to each depression composition of 5 of 35.5-40.4 ℃ shown in table 1 or table 2.
Table 1
| Temperature (℃) | The component A of aromatic-containing compound (weight %) | The B component of aromatic-containing compound (weight %) | The component C of aromatic-containing compound (weight %) |
| ????35.5 | ????53.7-54.7 | ????45.2-46.2 | ??0.05-0.5 |
| ????35.6 | ????52.7-53.6 | ????46.3-47.2 | ??0.05-0.5 |
| ????35.7 | ????51.7-52.6 | ????47.3-48.2 | ??0.05-0.5 |
| ????35.8 | ????50.7-51.6 | ????48.3-49.2 | ??0.05-0.5 |
| ????35.9 | ????49.7-50.6 | ????49.3-50.2 | ??0.05-0.5 |
| ????36.0 | ????49.0-49.6 | ????50.3-50.9 | ??0.05-0.5 |
| ????36.1 | ????47.3-48.3 | ????51.6-52.6 | ??0.05-0.5 |
| ????36.2 | ????46.3-47.2 | ????52.7-53.6 | ??0.05-0.5 |
| ????36.3 | ????45.2-46.2 | ????53.7-54.7 | ??0.05-0.5 |
| ????36.4 | ????44.2-45.1 | ????54.8-55.7 | ??0.05-0.5 |
| ????36.5 | ????43.1-44.1 | ????55.8-56.8 | ??0.05-0.5 |
| ????36.6 | ????42.1-43.0 | ????56.9-57.8 | ??0.05-0.5 |
| ????36.7 | ????41.0-42.0 | ????57.9-58.9 | ??0.05-0.5 |
| ????36.8 | ????40.0-40.9 | ????59.0-59.9 | ??0.05-0.5 |
| ????36.9 | ????38.7-39.7 | ????60.2-61.2 | ??0.05-0.5 |
| ????37.0 | ????37.6-38.6 | ????61.3-62.3 | ??0.05-0.5 |
| ????37.1 | ????36.4-37.4 | ????62.5-63.5 | ??0.05-0.5 |
| ????37.2 | ????35.3-36.3 | ????63.6-64.6 | ??0.05-0.5 |
| ????37.3 | ????34.7-35.2 | ????64.7-65.2 | ??0.05-0.5 |
| ????37.4 | ????33.6-34.6 | ????65.3-66.3 | ??0.05-0.5 |
| ????37.5 | ????32.5-33.5 | ????66.4-67.4 | ??0.05-0.5 |
| ????37.6 | ????31.6-32.4 | ????67.5-68.3 | ??0.05-0.5 |
| ????37.7 | ????30.2-31.2 | ????68.7-69.7 | ??0.05-0.5 |
| ????37.8 | ????29.1-30.1 | ????69.8-70.8 | ??0.05-0.5 |
| ????37.9 | ????28.1-29.0 | ????70.9-71.8 | ??0.05-0.5 |
| ????38.0 | ????27.0-28.0 | ????71.9-72.9 | ??0.05-0.5 |
| ????38.1 | ????26.1-26.9 | ????73.0-73.8 | ??0.05-0.5 |
The continuous table of going up
| ????38.2 | ????25.0-26.0 | ????73.9-74.9 | ????0.05-0.5 |
| ????38.3 | ????24.0-24.9 | ????75.0-75.9 | ????0.05-0.5 |
| ????38.4 | ????22.8-23.8 | ????76.1-77.1 | ????0.05-0.5 |
| ????38.5 | ????21.8-22.7 | ????77.2-78.1 | ????0.05-0.5 |
| ????38.6 | ????20.7-21.7 | ????78.2-79.2 | ????0.05-0.5 |
| ????38.7 | ????19.6-20.6 | ????79.3-80.3 | ????0.05-0.5 |
| ????38.8 | ????18.5-19.5 | ????80.4-81.4 | ????0.05-0.5 |
| ????38.9 | ????17.4-18.4 | ????81.5-82.5 | ????0.05-0.5 |
| ????39.0 | ????16.4-17.3 | ????82.6-83.5 | ????0.05-0.5 |
| ????39.1 | ????1?5.3-16.3 | ????83.6-84.6 | ????0.05-0.5 |
| ????39.2 | ????14.2-15.2 | ????84.7-85.7 | ????0.05-0.5 |
| ????39.3 | ????13.2-14.1 | ????85.8-86.7 | ????0.05-0.5 |
| ????39.4 | ????12.0-13.0 | ????86.9-87.9 | ????0.05-0.5 |
| ????39.5 | ????10.8-11.8 | ????88.1-89.1 | ????0.05-0.5 |
| ????39.6 | ????9.7-10.7 | ????89.2-90.2 | ????0.05-0.5 |
| ????39.7 | ????8.6-9.6 | ????90.3-91.3 | ????0.05-0.5 |
| ????39.8 | ????7.5-8.5 | ????91.4-92.4 | ????0.05-0.5 |
| ????39.9 | ????6.5-7.4 | ????92.5-93.4 | ????0.05-0.5 |
| ????40.0 | ????5.3-6.3 | ????93.6-94.6 | ????0.05-0.5 |
| ????40.1 | ????4.3-5.2 | ????94.7-95.6 | ????0.05-0.5 |
| ????40.2 | ????3.2-4.2 | ????95.7-96.7 | ????0.05-0.5 |
| ????40.3 | ????2.1-3.1 | ????96.8-97.8 | ????0.05-0.5 |
| ????40.4 | ????1.0-2.0 | ????97.9-98.9 | ????0.05-0.5 |
Table 2
| Temperature (℃) | The component A (weight %) that contains steride | The B component (weight %) that contains steride | The component C (weight %) that contains steride |
| ??40.4 | ????73.84 | ??21.85 | ????4.31 |
| ??40.3 | ????73.87 | ??21.84 | ????4.29 |
| ??40.2 | ????73.88 | ??21.81 | ????4.31 |
The continuous table of going up
| ??40.1 | ????73.88 | ????21.80 | ????4.32 |
| ??40.0 | ????73.89 | ????21.79 | ????4.32 |
| ??39.9 | ????73.91 | ????21.80 | ????4.29 |
| ??39.8 | ????73.89 | ????21.70 | ????4.31 |
| ??39.7 | ????73.95 | ????21.75 | ????4.30 |
| ??39.6 | ????73.93 | ????21.76 | ????4.31 |
| ??39.5 | ????73.92 | ????21.76 | ????4.32 |
| ??39.4 | ????73.96 | ????21.74 | ????4.30 |
| ??39.3 | ????73.95 | ????21.74 | ????4.31 |
| ??39.2 | ????73.97 | ????21.74 | ????4.29 |
| ??39.1 | ????74.00 | ????21.72 | ????4.28 |
| ??39.0 | ????74.01 | ????21.69 | ????4.30 |
| ??38.9 | ????73.99 | ????21.72 | ????4.29 |
| ??38.8 | ????74.01 | ????21.70 | ????4.29 |
| ??38.7 | ????74.02 | ????21.68 | ????4.30 |
| ??38.6 | ????74.03 | ????21.68 | ????4.29 |
| ??38.5 | ????74.04 | ????21.68 | ????4.28 |
| ??38.4 | ????74.03 | ????21.66 | ????4.31 |
| ??38.3 | ????74.06 | ????21.66 | ????4.28 |
| ??38.2 | ????74.07 | ????21.64 | ????4.29 |
| ??38.1 | ????74.07 | ????21.65 | ????4.28 |
| ??38.0 | ????74.08 | ????21.63 | ????4.29 |
| ??37.9 | ????74.08 | ????21.64 | ????4.28 |
| ??37.8 | ????74.10 | ????21.61 | ????4.29 |
| ??37.7 | ????74.12 | ????21.61 | ????4.27 |
| ??37.6 | ????74.12 | ????21.58 | ????4.30 |
| ??37.5 | ????74.15 | ????21.58 | ????4.27 |
| ??37.4 | ????74.16 | ????21.59 | ????4.25 |
| ??37.3 | ????74.17 | ????21.56 | ????4.27 |
| ??37.2 | ????74.17 | ????21.57 | ????4.26 |
| ??37.1 | ????74.20 | ????21.53 | ????4.27 |
The continuous table of going up
| ??37.0 | ????74.24 | ????21.50 | ????4.26 |
| ??36.9 | ????74.22 | ????21.52 | ????4.26 |
| ??36.8 | ????74.22 | ????21.53 | ????4.25 |
| ??36.7 | ????74.22 | ????21.54 | ????4.24 |
| ??36.6 | ????74.24 | ????21.52 | ????4.24 |
| ??36.5 | ????74.26 | ????21.47 | ????4.27 |
| ??36.4 | ????74.26 | ????21.48 | ????4.26 |
| ??36.3 | ????74.26 | ????21.49 | ????4.25 |
| ??36.2 | ????74.27 | ????21.48 | ????4.25 |
| ??36.1 | ????74.28 | ????21.47 | ????4.25 |
| ??36.0 | ????74.30 | ????21.45 | ????4.25 |
| ??35.9 | ????74.30 | ????21.46 | ????4.24 |
| ??35.8 | ????74.31 | ????21.44 | ????4.25 |
| ??35.7 | ????74.33 | ????21.44 | ????4.23 |
| ??35.6 | ????74.35 | ????21.40 | ????4.25 |
| ??35.5 | ????74.36 | ????21.40 | ????4.24 |
In the present invention, without any restriction, it can be any three-dimensional shape for the shape of base material.But, be preferably bar shaped, clavate etc. for easy to use.
In addition, also without any restriction, it can be any material with solid shape, but is based on the consideration of security and cost aspect, is preferably the use organic polymer material, as tygon, polypropylene etc. for the material of base material.
In the present invention, without any restriction, can be circular point shape, ellipse, rectangle, square etc., for the shape of described how much depressions 5 as long as can clearly express the different temperatures reading.
As shown in Figure 2, thermometer of the present invention also can cover layer of transparent film 7, to wrap the heat-sensitive composition in the depression 5 tightly.Material for described coverlay does not have concrete restriction, as long as it is transparent and avirulence.In a preferred embodiments of the present invention, described coverlay comprises thermoplastic polymer.In another preferred embodiments of the present invention, described coverlay comprises polyolefin resin, polyurethanes resin and carbamide resin.
Show the very heat-sensitive composition of large-temperature range by adjusting the composition of heat-sensitive composition, can forming, still, because thermometer of the present invention mainly is the body temperature that is used for measuring human body, therefore, in the present invention, thermometric temperature indicating end temperature displayed scope is 35.5-40.4 ℃.
Fig. 3 is the thermometric number reading method of the present invention, mark 8 expression variable color parts, and mark 9 is represented not variable color part.As shown in Figure 3, when reaching uniform temperature, the heat-sensitive composition in the corresponding depression 5 will variable color, thereby can demonstrate measured body temperature numerical value, and the reading shown in Fig. 3 is 38.5 ℃.By adjusting the composition of heat-sensitive composition, the shown temperature accuracy of thermometer of the present invention can reach 0.1 ℃.
There is not concrete restriction for depression 5 arrangement mode in the thermometer temperature indicating end of the present invention, as long as it can be known and to express temperature reading easily just passable.In a preferred embodiments of the present invention, it can be an arrangement mode shown in Figure 3.In another preferred embodiments of the present invention, it also can be placed upside down arrangement mode shown in Figure 3.
During use, with the hypogloeeis in thermometer insertion of the present invention oral cavity, shutting up makes temperature reach balance, after two minutes, takes out thermometer.Depression 5 variable color part 8 be a dark colour on the temperature indicating end, described variable color partly with the reading of the point of interface of not variable color part 9, be measured human body temperature.
Thermometer of the present invention can not be reused after using, thereby embodies the advantage of disposable use medicine equipment, has also avoided the possibility of cross-infection.
Describe the present invention in detail below in conjunction with embodiment, these embodiment are presented for purposes of illustration, do not limit the scope of the invention.
Embodiment
Embodiment 1 preparation heat-sensitive composition
With 35.2 gram o-bromoanilines (production of aldrich company), 64.7 grams 3; 5-difluoroaniline (production of aldrich company), 0.03 gram basic fuchsin (productions of Shanghai chemical reagents corporation), 0.02 gram bromochlorophenol blue (productions of Shanghai chemical reagents corporation) and 0.05 restrain aerosil (A200 of German DEGUSSA company production) and put into the 250ml beaker; under 55 ℃ of constant temperatures; adopt mechanical raking to mix 3 hours, the gained sample is a heat-sensitive composition.
Resulting heat-sensitive composition is placed in the high-accuracy and constant tepidarium, and since 35 ℃ of intensifications, heat-sensitive composition was the discoloring temperature of described heat-sensitive composition from light green temperature when becoming mazarine with 0.1 ℃/2 minutes speed.The discoloring temperature of above-mentioned heat-sensitive composition correspondence is 37.3 ℃.
As above-mentioned identical method, according to the ratio manufacturing of table 2 and each component shown in 3 heat-sensitive composition corresponding to different discoloring temperatures.
Table 3
| Temperature (℃) | O-bromoaniline (weight %) | 3,5-difluoroaniline (weight %) | Crystal violet (weight %) | Bromochlorophenol blue (weight %) | Aerosil (weight %) |
| ??35.5 | ??54.2 | ?45.7 | ?0.03 | ??0.02 | ??0.05 |
The continuous table of going up
| ????35.6 | ????53.3 | ????46.6 | ????0.03 | ????0.02 | ????0.05 |
| ????35.7 | ????52.3 | ????47.6 | ????0.03 | ????0.02 | ????0.05 |
| ????35.8 | ????51.2 | ????48.7 | ????0.03 | ????0.02 | ????0.05 |
| ????35.9 | ????50.2 | ????49.7 | ????0.03 | ????0.02 | ????0.05 |
| ????36.0 | ????49.4 | ????50.5 | ????0.03 | ????0.02 | ????0.05 |
| ????36.1 | ????47.8 | ????52.1 | ????0.03 | ????0.02 | ????0.05 |
| ????36.2 | ????46.8 | ????53.1 | ????0.03 | ????0.02 | ????0.05 |
| ????36.3 | ????45.7 | ????54.2 | ????0.03 | ????0.02 | ????0.05 |
| ????36.4 | ????44.7 | ????55.2 | ????0.03 | ????0.02 | ????0.05 |
| ????36.5 | ????43.7 | ????56.2 | ????0.03 | ????0.02 | ????0.05 |
| ????36.6 | ????42.6 | ????57.3 | ????0.03 | ????0.02 | ????0.05 |
| ????36.7 | ????41.5 | ????58.4 | ????0.03 | ????0.02 | ????0.05 |
| ????36.8 | ????40.4 | ????59.5 | ????0.03 | ????0.02 | ????0.05 |
| ????36.9 | ????39.2 | ????60.7 | ????0.03 | ????0.02 | ????0.05 |
| ????37.0 | ????38.1 | ????61.8 | ????0.02 | ????0.02 | ????0.06 |
| ????37.1 | ????36.9 | ????63.0 | ????0.02 | ????0.02 | ????0.06 |
| ????37.2 | ????35.9 | ????64.0 | ????0.03 | ????0.02 | ????0.05 |
| ????37.3 | ????35.2 | ????64.7 | ????0.03 | ????0.02 | ????0.05 |
| ????37.4 | ????34.1 | ????65.8 | ????0.02 | ????0.02 | ????0.06 |
| ????37.5 | ????33.0 | ????66.9 | ????0.02 | ????0.02 | ????0.06 |
| ????37.6 | ????32.1 | ????67.8 | ????0.02 | ????0.02 | ????0.06 |
| ????37.7 | ????30.7 | ????69.2 | ????0.02 | ????0.02 | ????0.06 |
| ????37.8 | ????29.6 | ????70.3 | ????0.02 | ????0.02 | ????0.06 |
| ????37.9 | ????28.6 | ????71.3 | ????0.02 | ????0.02 | ????0.06 |
| ????38.0 | ????27.5 | ????72.4 | ????0.03 | ????0.02 | ????0.05 |
| ????38.1 | ????26.5 | ????73.4 | ????0.02 | ????0.02 | ????0.06 |
| ????38.2 | ????25.4 | ????74.5 | ????0.03 | ????0.02 | ????0.05 |
| ????38.3 | ????24.5 | ????75.4 | ????0.02 | ????0.02 | ????0.06 |
| ????38.4 | ????23.3 | ????76.6 | ????0.03 | ????0.02 | ????0.05 |
| ????38.5 | ????22.3 | ????77.6 | ????0.02 | ????0.02 | ????0.06 |
| ????38.6 | ????21.2 | ????78.7 | ????0.03 | ????0.02 | ????0.05 |
The continuous table of going up
| ??38.7 | ????20.1 | ????79.8 | ????0.03 | ????0.02 | ????0.05 |
| ??38.8 | ????19.0 | ????80.9 | ????0.02 | ????0.02 | ????0.06 |
| ??38.9 | ????17.9 | ????82.0 | ????0.02 | ????0.02 | ????0.06 |
| ??39.0 | ????16.9 | ????83.0 | ????0.03 | ????0.02 | ????0.05 |
| ??39.1 | ????15.8 | ????84.1 | ????0.02 | ????0.02 | ????0.06 |
| ??39.2 | ????14.7 | ????85.2 | ????0.03 | ????0.02 | ????0.05 |
| ??39.3 | ????13.7 | ????86.2 | ????0.02 | ????0.02 | ????0.06 |
| ??39.4 | ????12.6 | ????87.3 | ????0.02 | ????0.02 | ????0.06 |
| ??39.5 | ????11.3 | ????88.6 | ????0.03 | ????0.02 | ????0.05 |
| ??39.6 | ????10.2 | ????89.7 | ????0.02 | ????0.02 | ????0.06 |
| ??39.7 | ????9.1 | ????90.8 | ????0.02 | ????0.02 | ????0.06 |
| ??39.8 | ????8.0 | ????91.9 | ????0.03 | ????0.02 | ????0.05 |
| ??39.9 | ????7.0 | ????92.9 | ????0.03 | ????0.02 | ????0.05 |
| ??40.0 | ????5.8 | ????94.1 | ????0.03 | ????0.02 | ????0.05 |
| ??40.1 | ????4.8 | ????95.1 | ????0.02 | ????0.02 | ????0.06 |
| ??40.2 | ????3.7 | ????96.2 | ????0.03 | ????0.02 | ????0.05 |
| ??40.3 | ????2.6 | ????97.3 | ????0.02 | ????0.02 | ????0.06 |
| ??40.4 | ????1.4 | ????98.5 | ????0.02 | ????0.02 | ????0.06 |
Embodiment 2 preparation thermometers
Use injection machine commonly used polyolefine material (PT1450 that the AFFINITY of Dow Chemical produces) to be made the substrate 6 of shape shown in Figure 1.In temperature indicating end 1, adopt the high-frequency electromagnetic spot heating, be pressed into the rectangle that is shaped as of how much depression 5, how much depressions 5.
Use TT-01A spray printing cutting packaging line (rise safe applicating technology company manufacture and design) to utilize numerical control spray printing mode to insert in the depression 5 corresponding to the heat-sensitive composition of different discoloring temperatures, the heat-sensitive composition with different discoloring temperatures and the corresponding relation of depression 5 are as shown in Figure 1.
On substrate 6, cover one deck polyolefin film (PF1840 that the AFFINITY of Dow Chemical produces) at last.
Embodiment 3 thermometric using method
The thermometer that the embodiment of the invention 2 is made inserts the hypogloeeis in oral cavity, and shutting up makes temperature reach balance, after two minutes, takes out thermometer.Depression 5 variable color part 8 be a dark colour on the temperature indicating end, described variable color partly with the reading of the point of interface of not variable color part 9, be measured human body temperature, the thermometer readings signify shown on Fig. 3 is 38.5 degrees centigrade.
Claims (10)
1. heat-sensitive composition, it comprises:
A) 0.5-60 weight % is selected from o-bromoaniline, 3-chloronitrobenzene, 1 chloromethyl naphthalene, 1-naphthalene acetonitrile, o-chlorphenol, 2,2-dichloronitrobenzene, 2, the compound of 4-dichloronitrobenzene, 2,4 dichloro aniline or its potpourri;
B) 39.5-99 weight % is selected from 2-bromo-6-nitrotoluene, 3,5-difluoroaniline, 2-bromo nitrobenzene, 2,4-two chloro-5-fluoro-3-nitrobenzoic acids, 3-bromo nitrobenzene, 2, the compound of 2-two bromo nitrobenzenes or its potpourri;
C) 0.01-0.5 weight % indicator, it is selected from, and quinoline is red, crystal violet lactones, crystal violet, cresol red, bromochlorophenol blue, dibromophenolphthalein, pinacyanol chlorine, pinacyanol 5 iodine, methyl red, ethyl red, chlorophenol blue, chlorophenol red, titania, chlorocresol green, bromcresol green, bromine cresol red, basic fuchsin, bisphenol-A, oxalic acid, aerosil, beta naphthal, 2-naphthalene sulfonic acids, 3-nitrophenols, phenol or its potpourri;
2. composition as claimed in claim 1, the content that it is characterized in that described component A are 0.9-55 weight %.
3. composition as claimed in claim 1, the content that it is characterized in that described B component are 44.5-99 weight %.
4. heat-sensitive composition, it comprises
A) 73-75 weight % is selected from compound or its potpourri of cholesteryl oleoyl carbonate, cholesteryl oleate, cholesteryl carbonate, Cholesteryl hexadecanoate;
B) the cholesterol chlorine of 20-23 weight %;
C) 4-5 weight % is selected from compound or its potpourri in Cholesteryl stearate, cholesteryl butyrate, cholesterol benzol carbonate, the cholesteryl acetate.
5. composition as claimed in claim 4, the content that it is characterized in that described component A are 73.5-74.5 weight %.
6. composition as claimed in claim 4, the content that it is characterized in that described B component are 21-22 weight %.
7. composition as claimed in claim 4, the content that it is characterized in that described component C are 4-4.5 weight %
8. thermometer, it comprises the table body base material (6) that has a plurality of how much depressions (5), described how much depressions (5) rearrange temperature indicating end (1), every depression corresponding to a temperature scale, and the heat-sensitive composition as claimed in claim 1 that places described how much depressions (5); Corresponding to the depression of different temperatures scale value, wherein the heat-sensitive composition that is comprised is composed as follows states:
The continuous table of going up
????38.4 ????22.8-23.8 ????76.1-77.1 ????0.05-0.5
????38.5 ????21.8-22.7 ????77.2-78.1 ????0.05-0.5
????38.6 ????20.7-21.7 ????78.2-79.2 ????0.05-0.5
????38.7 ????19.6-20.6 ????79.3-80.3 ????0.05-0.5
????38.8 ????18.5-19.5 ????80.4-81.4 ????0.05-0.5
????38.9 ????17.4-18.4 ????81.5-82.5 ????0.05-0.5
????39.0 ????16.4-17.3 ????82.6-83.5 ????0.05-0.5
????39.1 ????15.3-16.3 ????83.6-84.6 ????0.05-0.5
????39.2 ????14.2-15.2 ????84.7-85.7 ????0.05-0.5
????39.3 ????13.2-14.1 ????85.8-86.7 ????0.05-0.5
????39.4 ????12.0-13.0 ????86.9-87.9 ????0.05-0.5
????39.5 ????10.8-11.8 ????88.1-89.1 ????0.05-0.5
????39.6 ????9.7-10.7 ????89.2-90.2 ????0.05-0.5
????39.7 ????8.6-9.6 ????90.3-91.3 ????0.05-0.5
????39.8 ????7.5-8.5 ????91.4-92.4 ????0.05-0.5
????39.9 ????6.5-7.4 ????92.5-93.4 ????0.05-0.5
????40.0 ????5.3-6.3 ????93.6-94.6 ????0.05-0.5
????40.1 ????4.3-5.2 ????94.7-95.6 ????0.05-0.5
????40.2 ????3.2-4.2 ????95.7-96.7 ????0.05-0.5
????40.3 ????2.1-3.1 ????96.8-97.8 ????0.05-0.5
????40.4 ????1.0-2.0 ????97.9-98.9 ????0.05-0.5
Perhaps
Temperature (℃) Be selected from the component A (weight %) of steride Be selected from the B component (weight %) of steride Be selected from the B component (weight %) of steride
???40.4 ???????73.84 ??????21.85 ??????4.31
???40.3 ???????73.87 ??????21.84 ??????4.29
???40.2 ???????73.88 ??????21.81 ??????4.31
???40.1 ???????73.88 ??????21.78 ??????4.32
???40.0 ???????73.89 ??????21.80 ??????4.31
???39.9 ???????73.91 ??????21.80 ??????4.29
???39.8 ???????73.89 ??????21.79 ??????4.31
The continuous table of going up
????39.7 ????73.95 ????21.75 ????4.30
????39.6 ????73.93 ????21.76 ????4.31
????39.5 ????73.92 ????21.76 ????4.32
????39.4 ????73.96 ????21.74 ????4.30
????39.3 ????73.95 ????21.74 ????4.31
????39.2 ????73.97 ????21.74 ????4.29
????39.1 ????74.00 ????21.72 ????4.28
????39.0 ????74.01 ????21.69 ????4.30
????38.9 ????73.99 ????21.72 ????4.29
????38.8 ????74.01 ????21.70 ????4.29
????38.7 ????74.02 ????21.68 ????4.30
????38.6 ????74.03 ????21.68 ????4.29
????38.5 ????74.04 ????21.68 ????4.28
????38.4 ????74.03 ????21.66 ????4.31
????38.3 ????74.06 ????21.66 ????4.28
????38.2 ????74.07 ????21.64 ????4.29
????38.1 ????74.07 ????21.65 ????4.28
????38.0 ????74.08 ????21.63 ????4.29
????37.9 ????74.08 ????21.64 ????4.28
????37.8 ????74.10 ????21.61 ????4.29
????37.7 ????74.12 ????21.61 ????4.27
????37.6 ????74.12 ????21.58 ????4.30
????37.5 ????74.15 ????21.58 ????4.27
????37.4 ????74.16 ????21.59 ????4.25
????37.3 ????74.17 ????21.56 ????4.27
????37.2 ????74.17 ????21.57 ????4.26
????37.1 ????74.20 ????21.53 ????4.27
????37.0 ????74.24 ????21.50 ????4.26
????36.9 ????74.22 ????21.52 ????4.26
????36.8 ????74.22 ????21.53 ????4.25
????36.7 ????74.22 ????21.54 ????4.24
The continuous table of going up
????36.6 ????74.24 ????21.52 ????4.24
????36.5 ????74.26 ????21.47 ????4.27
????36.4 ????74.26 ????21.48 ????4.26
????36.3 ????74.26 ????21.49 ????4.25
????36.2 ????74.27 ????21.48 ????4.25
????36.1 ????74.28 ????21.47 ????4.25
????36.0 ????74.30 ????21.45 ????4.25
????35.9 ????74.30 ????21.46 ????4.24
????35.8 ????74.31 ????21.44 ????4.25
????35.7 ????74.33 ????21.44 ????4.23
????35.6 ????74.35 ????21.40 ????4.25
????35.5 ????74.36 ????21.40 ????4.24
9. thermometer as claimed in claim 8, it also comprises transparent polymer film.
10. thermometer as claimed in claim 8 is characterized in that described polymer film is polyolefin resin, polyurethanes resin and carbamide resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410016031 CN1648623A (en) | 2004-01-21 | 2004-01-21 | Thermal sensitive composition and disposable thermometer made therefrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410016031 CN1648623A (en) | 2004-01-21 | 2004-01-21 | Thermal sensitive composition and disposable thermometer made therefrom |
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| Publication Number | Publication Date |
|---|---|
| CN1648623A true CN1648623A (en) | 2005-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410016031 Pending CN1648623A (en) | 2004-01-21 | 2004-01-21 | Thermal sensitive composition and disposable thermometer made therefrom |
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| CN (1) | CN1648623A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101587128B (en) * | 2009-06-16 | 2011-11-16 | 华中农业大学 | Special ammonia indicator for analyzing ammonia content by flow injection instruments and preparation thereof |
| CN102658070A (en) * | 2012-05-14 | 2012-09-12 | 西北工业大学 | Method for preparing core-shell reversible heat-sensitive temperature indicating composite microspheres |
| CN105907377A (en) * | 2016-03-21 | 2016-08-31 | 东华大学 | Disposable annular thermometer |
| CN109796813A (en) * | 2019-01-16 | 2019-05-24 | 深圳九星印刷包装集团有限公司 | Color shifting ink and preparation method thereof and its application |
-
2004
- 2004-01-21 CN CN 200410016031 patent/CN1648623A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101587128B (en) * | 2009-06-16 | 2011-11-16 | 华中农业大学 | Special ammonia indicator for analyzing ammonia content by flow injection instruments and preparation thereof |
| CN102658070A (en) * | 2012-05-14 | 2012-09-12 | 西北工业大学 | Method for preparing core-shell reversible heat-sensitive temperature indicating composite microspheres |
| CN102658070B (en) * | 2012-05-14 | 2014-02-05 | 西北工业大学 | Method for preparing core-shell reversible heat-sensitive temperature indicating composite microspheres |
| CN105907377A (en) * | 2016-03-21 | 2016-08-31 | 东华大学 | Disposable annular thermometer |
| CN105907377B (en) * | 2016-03-21 | 2019-08-09 | 东华大学 | Disposable annulus temperature meter |
| CN109796813A (en) * | 2019-01-16 | 2019-05-24 | 深圳九星印刷包装集团有限公司 | Color shifting ink and preparation method thereof and its application |
| CN109796813B (en) * | 2019-01-16 | 2021-11-19 | 深圳九星印刷包装集团有限公司 | Color-changing ink and preparation method and application thereof |
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