CN1647802A - External use article for skin - Google Patents
External use article for skin Download PDFInfo
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- CN1647802A CN1647802A CN 200410001104 CN200410001104A CN1647802A CN 1647802 A CN1647802 A CN 1647802A CN 200410001104 CN200410001104 CN 200410001104 CN 200410001104 A CN200410001104 A CN 200410001104A CN 1647802 A CN1647802 A CN 1647802A
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- aloe gel
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- aloe
- nanometer silver
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Abstract
The present invention discloses a kind of external use article for skin formed with aloe gel as main material and nanometer silver as additive, and the external use article may be produced into lotion, ointment, suppository, flexible wound bandage. The present invention features that the aloe gel juice or concentrated aloe gel with bioactivity maintained is mixed with water solution of 1-1500 nm size silver colloid to obtain the product of the present invention.
Description
Technical field
The present invention relates to the aloe gel is that raw material is adding a kind of external preparation for skin product that form behind the nanometer silver.
Background technology
It is that raw material is adding a kind of external preparation for skin product that form behind the nanometer silver that the present invention relates to the aloe gel.Aloe is the plant of a kind of mystery of the Nature, have many laudatory titles such as " ten thousand answer good medicine ", " natural cosmetologist ", " family doctor ".1996, FAO (Food and Agriculture Organization of the United Nation) compared research to the wild plant resource in the whole world, had carried out overall ranking from the healthy angle that is beneficial to man, and Aloe is ranked the first, and was described as " human optimum medicines of 21 century " by FAO (Food and Agriculture Organization of the United Nation).Aloe is widely used in the production of cosmetics, food, health product and medicine by countries in the world, is the important raw materials of industry of these industries.Aloe is perennial Liliaceae herbaceous plant, and Aloe gel is the parenchyma that the Aloe leaf is peelled off crust, the liquiform product that makes through processing.Aloe gel concentrate is to remove part moisture, spissated by a certain percentage aloe products.As carrying out spissated aloe products, be called 2: 1 concentrated solutions (or 2: 1 concentrated juice of aloe leaf) of Aloe gel by 2: 1 ..., by that analogy.Unconcentrated aloe products is called aloe gel 1:1: 1 stock solution (or whole leaf aloe 1:1: 1 natural juice).
Be rich in the Aloe gel and be rich in multiple material in the Aloe gel, as tens kinds of active substances such as tinctura aloes Aloetin, Aloe sign indicating number south element, Aloe gram tincture A, Aloe gram tincture B, peaceful, the biological enzyme of Aloe bed ripples, bioactive vitamin, aloin, Aloe crow suffering, aloe-emodins.Tinctura aloes wherein, Aloe sign indicating number south is plain, Aloe gram tincture A, B, Aloe bed ripples are peaceful etc. is the very strong material of antibiotic property, has direct bactericidal action.And do not produce aloetic drug resistance bacterium, do not produce bacterium yet and replace phenomenon, finally can also kill the resistant bacterium that produces because of biocide very effectively.Aloe gel can produce natural degradation after the regular period, can not cause extra environmental pollution.
Nanometer silver antimicrobial mechanism is the novel antibacterial product based on nanotechnology, because quantum effect, small-size effect and have great specific surface area, have traditional inorganic antiseptic incomparable excellent antibacterial effect, have high safety, be a kind of long-acting antibiotic agent.At present, using more nano antibacterial agent is the nanometer silver product.The fungistatic effect of common metal silver is faint, still, argent is processed into nanometer silver after, its atomic arrangement shows as " Jie's attitude " between solid and molecule, the extremely strong nanometer silver microgranule of this activity has superpower antibacterial ability.Aloe is added nanometer silver and makes various curable products with strong antimicrbial power.It is widely used in antibacterial, fungus-caused diseases such as treatment burn and scald, wound, infection, suppuration, acne, dermatosis, gynaecopathia, has really realized not containing the organic long-acting broad-spectrum antibacterial effect of antibiotic and synthetic chemistry.It is nontoxic, tasteless, non-stimulated, the irritated reaction of nothing, and can not cause drug-resistance of bacteria, is pure green medical antibacterial product.
Summary of the invention
It is that raw material is adding the external preparation for skin product that form behind the nanometer silver that one of the object of the invention provides with the aloe gel.
It is that raw material is at the prescription that adds the external preparation for skin product that form behind the nanometer silver that two of the object of the invention provides the aloe gel.
These external preparation for skin product include aloe gel or the aloe gel concentrate of percentage by weight 5%-95%, percentage by weight is the nano silver colloid aqueous solution of 0.5%-15%, and the percentage by weight of nanometer silver is 0.5%-8% in this nano silver colloid aqueous solution.
To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is characterized in that to keep bioactive aloe gel natural juice (aloe gel juice is meant the Aloe gel product that does not add any additives) or concentration be product after 1: 1 to 100: 1 the bioactive aloe gel concentrate of maintenance is adding mean diameter 1-1500nm nano silver colloid aqueous solution (aqueous solution of any material all may form colloid solution under given conditions), wherein, the percentage by weight of nanometer silver is 0.5%-8% in this nano silver colloid aqueous solution, nanometer silver purity is between 10%-99.99%, operative temperature is between 15-35 ℃, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 50-5000 rev/min of rotating speed, its, in this mixed solution also contain the medical ventolin that percentage by weight is 0.5-5%, percentage by weight is that glycerol and the percentage by weight of 1-10% is the cellulose aqueous solution of 0.2-3%.
The effect of invention:
This product is antibiotic to have broad spectrum activity:
Nano silver colloid aqueous solution can suppress growing of about 650 various bacteria, and Aloe gel can directly kill 60 various bacteria, and effect is more obvious after combination collocation, and power is more powerful.
Excellent bacteriostasis property:
Aloe gel adds the external preparation for skin product that form behind the nanometer silver has remarkable advantages by passable finding out with conventional antibacterials experiment contrast.
The efficacy of a drug time is long:
Nanometer silver is not subjected to the variable effect of environment, and after 2 days, antibacterial effect is constant substantially in the skin surface reagent.
Pharmacokinetic:
Choosing the health rat is subjects, and the external preparation for skin product that form behind the Aloe gel interpolation nanometer silver are to skin acute toxicity test, irritant test and hypersensitive test, and experimental result proves this product avirulence, non-stimulated test and do not have irritated test.
Clinical verification:
Through after the above-mentioned test, carry out following work at clinicing aspect
First People's Hospital, Baoding has carried out the fungus clinical trial of skin superficial part.
The 5th the People's Hospital, Baoding has carried out burn and scald patient's clinical trial.
In order to allow above and other objects of the present invention, feature and the advantage can be more obvious, preferred embodiment of the present invention cited below particularly be described in detail below:
The specific embodiment
The embodiment of the invention is characterised in that: mixed liquor contains: (in the 10kg mastic)
Aloe gel 3kg nano silver colloid aqueous solution (containing nanometer silver 2g/L) 2kg
The room temperature state stirs down and adds:
Vaseline 50g glycerol 30g
Medical cellulose aqueous solution (containing medical cellulose 20g/L) 4800g.
In addition, this mixed liquor contains 1-200g tea polyphenols antioxidant in addition.
Mixed liquor mixing time 20-120 minute, 15 ℃-35 ℃ of temperature, and the stirring that remains a constant speed.
Embodiment 1
Aloe gel adds the external preparation for skin washing liquid product that forms behind the nanometer silver.To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is to be that the bioactive aloe gel concentrate of maintenance that 80% maintenance bioactive aloe gel natural juice or concentration are 20: 1 is 50nm adding mean diameter with percentage by weight, percentage by weight is the product behind 16% the nano silver colloid aqueous solution, wherein the purity of this nanometer silver nanometer silver in nano silver colloid aqueous solution is 99.9, operative temperature is at 25 ℃, add 5 times of pure water, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 4000 rev/mins of rotating speeds.
Embodiment 2
Aloe gel adds the external preparation for skin unguentum product that forms behind the nanometer silver.Aloe gel adds the external preparation for skin washing liquid product that forms behind the nanometer silver.To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is to be that the bioactive aloe gel concentrate of maintenance that 94% maintenance bioactive aloe gel natural juice or concentration are 10: 1 is adding mean diameter 50nm with percentage by weight, percentage by weight is the product behind 0.9% nano silver colloid aqueous solution, wherein the purity of nanometer silver in material is 97%, operative temperature is at 25 ℃, after adding the gelatin solution of stabilizing agent 5%, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 1000 rev/mins of rotating speeds.
Embodiment 3
The Aloe concentrated gel adds the external preparation for skin product suppository product that forms behind the nanometer silver.Aloe gel adds the external preparation for skin washing liquid product that forms behind the nanometer silver.To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is to be that 6% maintenance bioactive aloe gel natural juice or concentration are that to keep bioactive aloe gel concentrate adding mean diameter 30nm, percentage by weight at 20: 1 be product behind 14% the nano silver colloid aqueous solution with percentage by weight, wherein the purity of nanometer silver in material is 90.%, operative temperature is at 25 ℃, after adding the glycerite of moisturizing agent 15%, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 150 rev/mins of rotating speeds.
Embodiment 4
The external preparation for skin product that the Aloe concentrated gel forms behind the interpolation nanometer silver are used for wound plaster.Preparation method is as follows: Aloe gel adds the external preparation for skin washing liquid product that forms behind the nanometer silver.To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is to be product after the bioactive aloe gel concentrate of maintenance that 60% maintenance bioactive aloe gel natural juice or concentration are 1: 1 is adding mean diameter 10nm nano silver colloid aqueous solution with percentage by weight, wherein the percentage by weight total concentration of nanometer silver in material is 1%, nanometer silver purity is 99.99%, operative temperature is at 35 ℃, the vaseline that adds complexing agent 3%, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 5000 rev/mins of rotating speeds.Be coated on then on the support, make wound plaster.
Embodiment 5
The external preparation for skin product that the Aloe concentrated gel forms behind the interpolation nanometer silver are used for the burn and scald card.Preparation method is as follows: Aloe gel adds the external preparation for skin washing liquid product that forms behind the nanometer silver.To adopt the aloe gel be raw material adding the main prescription of nanometer silver is: it is to be that the bioactive aloe gel concentrate of maintenance that 30% maintenance bioactive aloe gel natural juice or concentration are 20: 1 is adding mean diameter 150nm with percentage by weight, percentage by weight is the product behind 1% the nano silver colloid aqueous solution, wherein the percentage by weight total concentration of nanometer silver in material is 1%, nanometer silver purity is between 90%, operative temperature is at 35 ℃, the vaseline that adds complexing agent 2%, two kinds of materials are placed in the container both can through the agitator mix homogeneously of 1500 rev/mins of rotating speeds.Be coated on then on the support, make wound plaster.
Claims (6)
1, a kind of external preparation for skin product, it includes aloe gel and nanometer silver, it is characterized in that: these external preparation for skin product include aloe gel that percentage by weight is 5%-95% or aloe gel concentrate, percentage by weight is the nano silver colloid aqueous solution of 0.5%-15%, and the percentage by weight of nanometer silver is 0.5%-8% in this nano silver colloid aqueous solution.
2, according to the described a kind of external preparation for skin product of claim 1, it is characterized in that: the mean diameter of this nano silver colloid aqueous solution nanometer silver is between 1-1500nm.
3, according to the described a kind of external preparation for skin product of claim 1, it is characterized in that: this nanometer silver purity is between 10%-99.99%.
4, according to the described a kind of external preparation for skin product of claim 1, it is characterized in that: this mixed solution also contains the medical ventolin that percentage by weight is 0.5-5%, glycerol and the percentage by weight that percentage by weight is 1-10% is the cellulose aqueous solution of 0.2-3%.
5, according to the described a kind of external preparation for skin product of claim 1, it is characterized in that: this mixed solution contains the tea polyphenols antioxidant that percentage by weight is 0.01%-2%.
6, according to the described a kind of external preparation for skin product of claim 4, it is characterized in that: this cellulose aqueous solution contains medical cellulose 20g/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410001104 CN1647802A (en) | 2004-01-19 | 2004-01-19 | External use article for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410001104 CN1647802A (en) | 2004-01-19 | 2004-01-19 | External use article for skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1647802A true CN1647802A (en) | 2005-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410001104 Pending CN1647802A (en) | 2004-01-19 | 2004-01-19 | External use article for skin |
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| CN (1) | CN1647802A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912516A (en) * | 2010-08-11 | 2010-12-15 | 哈尔滨大洋制药股份有限公司 | Chinese patent medicament for treating skin infection |
| CN104971345A (en) * | 2015-06-26 | 2015-10-14 | 重庆大学 | Novel emodin gelatin microsphere and nano-silver composite gel preparation for treating burn injury and scald injury |
| CN105363064A (en) * | 2015-11-02 | 2016-03-02 | 石森林 | Compound aloe vera polysaccharide gel antiseptic dressing for treating burns |
| CN105381159A (en) * | 2015-11-02 | 2016-03-09 | 浙江中医药大学 | Compound aloe barbadensis polysaccharide topical gel used for treating burn |
| CN115778883A (en) * | 2021-09-10 | 2023-03-14 | 绿之韵生物工程集团有限公司 | Nano silver particles and application thereof in cosmetics |
-
2004
- 2004-01-19 CN CN 200410001104 patent/CN1647802A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912516A (en) * | 2010-08-11 | 2010-12-15 | 哈尔滨大洋制药股份有限公司 | Chinese patent medicament for treating skin infection |
| CN104971345A (en) * | 2015-06-26 | 2015-10-14 | 重庆大学 | Novel emodin gelatin microsphere and nano-silver composite gel preparation for treating burn injury and scald injury |
| CN105363064A (en) * | 2015-11-02 | 2016-03-02 | 石森林 | Compound aloe vera polysaccharide gel antiseptic dressing for treating burns |
| CN105381159A (en) * | 2015-11-02 | 2016-03-09 | 浙江中医药大学 | Compound aloe barbadensis polysaccharide topical gel used for treating burn |
| CN105363064B (en) * | 2015-11-02 | 2018-06-05 | 石森林 | A kind of compound aloe barbadensis Miller polysaccharide gel antiseptic dressing for treatment burn |
| CN105381159B (en) * | 2015-11-02 | 2019-07-26 | 浙江中医药大学 | It is a kind of for treat burn compound aloe barbadensis Miller polysaccharide external-use gel |
| CN115778883A (en) * | 2021-09-10 | 2023-03-14 | 绿之韵生物工程集团有限公司 | Nano silver particles and application thereof in cosmetics |
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