CN1634589A - Injection using invert sugar water solution as carrier - Google Patents
Injection using invert sugar water solution as carrier Download PDFInfo
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- CN1634589A CN1634589A CN 200410079270 CN200410079270A CN1634589A CN 1634589 A CN1634589 A CN 1634589A CN 200410079270 CN200410079270 CN 200410079270 CN 200410079270 A CN200410079270 A CN 200410079270A CN 1634589 A CN1634589 A CN 1634589A
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Abstract
The invention relates to an invert sugar injection of propylgallate and other 26 kinds of drugs. It is composed of one kind of drug, equal glucose, water and reasonable addictive. The injection having the invert sugar aqueous solution as carrier is more suitable for insulin resistant patients, middle aged and old aged patients and patients with II type diabetes, cardiovascular and cerebrovascular disease and liver disease apart from its convenient operation and quick action. It can lower the harm of the large extent fluctuation of patients blood sugar to the basic diseases.
Description
Technical fieldThe invention belongs to medical technical field, relating to some is the injection liquid medicine of carrier with the Nulomoline aqueous solution.
Background technologyInjection is a class I liquid I injection, and medicine directly enters in human vas, tissue or the organ with liquid form, has to absorb soon, and effect is rapid, and being very suitable for rescuing critical patient and patient should not use under the case of oral administration.
In the process of healing with medicine, especially in the Therapeutic Method with intravenous injection, usually together inject use as carrier and medicine, as Gallate propyl ester glucose injection, lysine hydrochloride glucose injection, puerarin sodium chloride injection etc. with glucose or sodium chloride solution.It mainly acts on glucose in the injection and sodium chloride except the osmotic pressure of regulating injection, can also correct the disorder that the interior power and water of body is separated matter, regulates the acid-base balance of body fluid, and glucose can also replenish necessary nutrition, heat and moisture content.
For the medicine that uses in the intravenous injection mode, as osmotic pressure regulator its weak point is arranged respectively with glucose or sodium chloride, as sodium chloride solution for hypertension, hyperlipidemia, cardiovascular and cerebrovascular vessel wait the patient to use unusually, and D/W (being generally 5% glucose content) is as a kind of pharmaceutical carrier, be oxidized to carbon dioxide and water in vivo, and while energize, or store with the form of glycogen, detoxifcation is arranged, the effect that protects the liver, this is a kind of good rehabilitation support for the patient, helps the recovery of body function and the toxic and side effects of minimizing medicine.But, since glucose in vivo metabolism need consume insulin, should not use for diabetics and impaired glucose tolerance person, reduced the scope of application of glucose injection medicine to a great extent; In addition; clinical inpatient takes place at body stress be (as wound; burn wound; cardiovascular and cerebrovascular vessel are unusual; operation; puerperal; the shock stupor; chemicotherapy; infect etc.); when hypoimmunity and organism metabolic disorder; the patient usually can be in the insulin resistant state; the ability drop of utilizing to glucose; if carry out infusion treatment as carrier with glucose solution; be prone to hyperinsulinemia; hyperinsulinism again can inducing reaction property hypoglycemia when stopping to infuse; this is deleterious for itself with regard to the patient that is under the illness state; rehabilitation for its disease is very unfavorable, even can damage beta Cell of islet and impaired glucose tolerance and even type ii diabetes take place.
The injection medicine that the purpose of this invention is to provide some medicines, make the carrier composition that wherein is used to regulate osmotic pressure have pharmacological effect, and insulin resistant patient, impaired glucose tolerance person and type ii diabetes patient all can use safely as glucose.
Summary of the inventionIn order to achieve the above object, to adopt the aqueous solution that medicine is made with Nulomoline be the injection of carrier in the present invention.
Nulomoline is the equal amount of mixture of glucose and fructose, fructose and glucose be isomers each other, fructose has the optics levorotation, be called levulose again, its pharmacological action is identical substantially with glucose, glucose and fructose can transform during energy supply in vivo mutually, wherein the fructose metabolism does not rely on the regulation and control of insulin, its accretion rate is fast than glucose, can under the situation of no insulin, metabolism be glycogen, effectively blood sugar lowering fluctuation, glucose metabolism speed is slow than fructose, sustainable energy supply, but glucose can cause the fluctuation of blood sugar level.The less dependence insulin of the compound preparation----Nulomoline that fructose and glucose are formed participates in metabolism, and energy utilization rate can the influence to the blood sugar level fluctuation be significantly less than glucose significantly greater than monosaccharide when fully providing energy fast.Nulomoline is a more effective and safe non-enteral nutrition agent, and it has the advantage that glucose replenishes blood glucose, combines fructose tachymetabolism, rapid makeup energy again, blood sugar concentration is influenced metabolism characteristics and effects such as little.
The present invention is the medicaments injection of carrier with the Nulomoline aqueous solution, is the medicine of the liquid dosage form of injection use, and it is formed and comprises medicine, glucose, fructose and four kinds of compositions of water at least.Medicine is its principal agent composition; Glucose and fructose exist in injection with the content that equates, are to be used for regulating the osmotic pressure of injection and to have the heat of providing and complementary pharmacological action such as nutrition; Water has compositions such as dissolved substance, glucose and fructose as solvent, keeps the effect of liquid dosage form.
The medicine of indication of the present invention is a total notion title, and it comprises the medicine of following 27 kinds of clinical uses: the Gallate propyl ester, puerarin, lysine hydrochloride, arginine hydrochloride, levocarnitine, garlicin, asarone, Bisolvon, doxofylline, diprophylline, aminomethylbenzoic acid, tranexamic acid, tirofiban hydrochloride, sodium tanshinone IIA sulfate, adenosine cyclophosphate, famotidine, foscarnet sodium, dopamine hydrochloride, sotalol hydrochloride, Pamidronate Disodium, lappaconitine hydrobromide, tramadol hydrochloride, oxaliplatin, oxiracetam, ganciclovir, nefopam hydrochloride, Injectio natarii norcantharidatis.
More than these medicines be clinical commonly used, the pharmaceutical dosage form that has gone on the market has lyophilized injectable powder, aqueous injection, glucose injection injection, chloride injection injection etc., below it is done respectively with brief description:
Gallate propyl ester chemistry is by name: 3,4, the 5-Propylgallate, have antiplatelet aggregation, antiinflammatory, free radical resisting, blood vessel dilating and effects such as change hemorheology, microcirculation improvement, be used for thrombotic disease, coronary heart disease, angina pectoriss etc. such as ischemic cerebrovascular, coma sequela, cerebral trauma, cerebral concussion, thrombosis deep phlebitis clinically;
The puerarin chemical name is: 8-β-D-glucopyanosyl-4 ', and the 7-dihydroxy isoflavone is vasodilator, and the effect of coronary artery dilator and cerebrovascular, reduction myocardial oxygen consumption, microcirculation improvement and antiplatelet aggregation is arranged;
The lysine hydrochloride chemistry is by name: L-2, the 6-hydrochloride diaminocaproate, be 8 kinds of essential amino acids of human body it-, the effect that improves the central nervous tissue function is arranged, the clinical Neuroprotective Agents that is mainly used in treatment craniocerebral injury syndrome, cerebral tissue ischemia, anoxia disease, can also improve blood-brain barrier permeability, help medicine to enter in the brain cell;
The arginine hydrochloride chemistry is by name: L-2-amino-5-guanidine radicals valerate hydrochlorate, be Branchamin, in human body, participate in ornithine cycle, promote the formation of carbamide, make the ammonia that produces in the human body be transformed into nontoxic carbamide and discharge, thereby reduce ammonia concentration by in urinating through ornithine cycle;
Levocarnitine claims L-carnitine again, chemical name: (R)-and 3-carboxyl-2-hydroxyl N, N, N-trimethyl-1-propylamine hydroxide is the essential nutrient substance of the mankind and animal, be the biostearin nutrient, be used to improve nutritional status clinically and lack a series of complication that cause because of carnitine;
Garlicin chemistry allicin by name, belong to immune stimulating type broad spectrum antibiotic, be mainly used in double infection that respiratory tract infection, urinary system infection, bone injury infection, cutaneous fungal infection, Bacterium entericum infection, gynecological infection and prolonged application antibiotic cause etc.;
The asarone chemical name is: 2,4,5-trimethoxy-1-propenylbenzene is used for cough that bacterial pneumonia, intrapulmonary infection, acute/chronic bronchitis, bronchial asthma, obstructive emphysema, pulmonary heart disease, bronchiectasis and lung bronchogenic carcinoma and flu cause, coughs up phlegm, pants etc.;
Bisolvon has another name called the hydrochloric acid Bromhexine, and chemical name is: N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzene methylamine hydrochloride, be a kind of mucus regulator, have stronger dissolving to glue the expectorant effect, can make the plain cracking of polysaccharide fiber of apoplexy due to phlegm, the desaturation sputum lowers expectorant viscosity, is convenient to bring up;
The doxofylline chemistry is by name: 1,3-dimethyl-7-(1,3-dioxy cyclopenta-2 base) methyl-3,7-dihydro-1H-purine-2, the 6-diketone is xanthine drug, effect with lax bronchial muscular spasm, in addition coughing of bringing out of histamine had antitussive effect, phosphodiesterase is also had remarkable inhibitory action, be used for the pulmonary disease of bronchial asthma and other companion's bronchospasms;
The diprophylline chemical name is: 1, and 3-dimethyl-7-(2,3 dihydroxypropyl)-3,7-dihydro-1H-purine-2, the 6-diketone has direct relexation to airway smooth muscle, and its mechanism of action is identical with theophylline;
Aminomethylbenzoic acid chemistry is by name: paraaminomethyl benzoic acid, be antifibrinolytics, and be used for because of primary fibrinolysis excessively how caused hemorrhagely clinically, comprise that the high fibrinolytic of acute and chronic, limitation or general is hemorrhage;
The tranexamic acid chemistry is by name: anti--4-(aminomethyl) naphthenic acid, be the antifibrinolysin medicine, its chemical constitution is similar to lysine, can prevent the absorption of plasminogen on fibrin competitively, thereby prevent its activation, the protection fibrin is not degraded by fibrinolysin and is dissolved, and finally reaches haemostatic effect, and its action intensity is 2～5 times of aminomethylbenzoic acid;
The tirofiban hydrochloride chemical name is: N-(butyl sulfonyl)-O-[4-(4-piperidyl) butyl]-the L-tyrosine hydrochloride, be one species specific, efficiently, (GP) IIb/IIIa receptor antagonist of high selectivity, be used for the treatment of acute coronary syndrome;
Sodium tanshinone IIA sulfate is the water-soluble substances that isolating diterpene quinone tanshinone obtains through sulfonation in the Radix Salviae Miltiorrhizae, energy is coronary blood flow increasing significantly, improve the myocardial metabolism disorder that causes after the anoxia, improve myocardial hypoxia tolerance, have the effect of protection erythrocyte membrane simultaneously, and can dwindle myocardial infarction area;
The adenosine cyclophosphate another name: cyclic adenosine monophosphate (cAMP), for participating in regulating second message,second messenger's material of cell function, its effect is very extensive, and effects such as the myocardial ischemia of improvement, coronary artery dilating, enhancing myocardial contraction, increase cardiac output are arranged;
The famotidine chemical name is: the amino 3-[[[2-[(diamino methylene)]-the 4-thiazolyl] methyl] sulfo-]-N-sulfamoyl third amidine, be resistance amine-H2 beta blocker, have the characteristics high to the H2 receptor affinity, gastric acid secretion had the obvious suppression effect, the zoopery ulcer there is the certain protection effect, also pepsic secretion be can suppress, stomach, duodenal ulcer, stress ulcer, acute gastric mucosal bleeding, gastrinoma and reflux esophagitis are applicable to;
The foscarnet sodium chemical name is: foscarnet sodium salt, be viral inhibitors, and phosphate binding site that can noncompetitive ground blocking virus DNA polymerase prevents that pyrophosphate from separating and the prolongation of viral DNA chain from tri methylene phosphonic acid deoxidation nucleoside;
The dopamine hydrochloride chemical name is: 4-(2-amino-ethyl)-1,2-Benzodiazepines hydrochlorate, be a kind of adrenomimetic, effect with excited beta-receptor, alpha-receptor and dopamine receptor, excited heart beta-receptor can increase myocardial contraction, increase cardiac output, the clinical various shocks that myocardial infarction, wound, endotoxin etc. cause etc. that are mainly used in;
The sotalol hydrochloride chemical name is: (RS)-4 '-and (1-hydroxyl-2-isopropylamine base ethyl)-methylsulfonylphenylamine hydrochlorate, have II class and III class antiarrhythmic drug characteristic concurrently, advantages such as it is strong to have effect, and antiarrhythmic therapy is applied widely, side effect is little;
The Pamidronate Disodium chemical name is: 3-amino-1-hydroxy propylidene-1, the 1-Alendronic acid disodium salt, be bisphosphonate class of drugs, absorption to sclerotin has very significant inhibitory effect, pain due to the molten bone bone of cancer shifted has analgesic effect, clinically is mainly used in the concurrent hypercalcemia of malignant tumor and osteolytic cancer shifts the osteodynia that causes;
The lappaconitine hydrobromide chemical name is: (1 α, 14 α, 16 β) 20-ethyl-1,14,16-trimethoxy aconitane-4,8,9-triol-4-[2-(acetylamino) benzoate] hydrobromate, be non-addicted analgesics, have stronger analgesic activity;
The tramadol hydrochloride chemical name is: (±)-anti--1-(-methoxyphenyl)-the 2-[(dimethylamino)-methyl]-the Hexalin hydrochlorate, be central analgesics, mainly act on central nervous system's specific receptor relevant with pain, the clinical cancer pain that is mainly used in, various acute and chronic pain such as fracture or postoperative pain;
The oxaliplatin chemical name is: [(1R, 2R)-1,2-cyclohexanediamine-N, N '] [ethanedioic acid (2-)-O, O '] close platinum, and oxaliplatin is left-handed trans diamino cyclohexane extraction JM-216, it is third generation platinum kind anti-cancer drugs, combine with the specific site of dna single chain, realize in interchain and the chain crosslinkedly and stop dna replication dna, cause cancer cell death;
The oxiracetam chemical name is: 4-hydroxyl-2-OXo-1-pyrrolidine acetamide is a kind of pyrrolidinone compounds nootropics, is used for the treatment of the brain injury that chemical factors causes clinically, various cerebral anoxiies and chronic brain functional defect;
The ganciclovir chemical name is: 9-(1,3-dihydroxy-2-third oxygen methyl)-guanine, belong to the ucleosides antiviral agents, but competitive inhibition DNA polymerase, and mix among the DNA of virus and host cell, thereby it is synthetic to suppress DNA;
The nefopam hydrochloride chemical name is: 5-methyl isophthalic acid-phenyl-3,4,5, and 6-tetrahydrochysene-1H-2,5-paroxazine and suffering are a kind of novel non-narcotic analgesics because of hydrochlorate, have slight analgesic and flesh pine effect concurrently;
The Injectio natarii norcantharidatis chemical name is: 1,2-suitable-3,6-oxo bridge-hexahydro-phthalic acid sodium salt, cancer therapy drug, there is certain inhibition to render a service to mice ehrlich carcinoma, sarcoma 180 and liver substance type, can improves the respiratory control ratio and the lysosomal enzyme activities of ascites hepatocarcinoma H22 mouse tumor cytomicrosome, the interfere with cancer cells division, block the phase, and influence its periodic duty speed in M.
The present invention is the injection of carrier with the Nulomoline aqueous solution, is made up of a kind of medicine of the present invention, glucose, fructose, water and suitable additives.
What those skilled in the art were appreciated that is, because the different in kind of each medicine, in its invert srgar inj, safety in order to ensure injection, effectively and the stablizing of each component, character according to different pharmaceutical, can also add other suitable material, these materials are referred to as " additives ", additives commonly used comprise: pH value regulator (example hydrochloric acid, citric acid, potassium hydroxide (sodium), sodium dihydrogen phosphate, sodium hydrogen phosphate etc.), solubilizing agent and cosolvent are (as Tween-80, propylene glycol, glycerol, ethanol, HP-etc.), antioxidant is (as sodium sulfite, sodium sulfite, vitamin C, sodium pyrosulfite, thiourea etc.), metal chelating agent is (as ethylenediaminetetraacetic acid, calcio-disodium edetate etc.), noble gas (is used for replacing the air in medicinal liquid and the packing container, avoid the principal agent oxidation, for example often select nitrogen for use, carbon dioxide), suspensoid and emulsifying agent (make the principal agent composition of injection that dispersibility and stability highly be arranged, as soybean phosphatide commonly used, lecithin, Tween-80 etc.), analgesic (pain that owing to medicine itself stimulation or other reason of body generation is caused when using injection, the lidocaine hydrochloride of selecting for use as usual in order to alleviate, procaine hydrochloride, chlorobutanol etc.).More than these additives be not the composition that must use, but select to use according to the character of the invert srgar inj of drug prepared, its select for use with using method all be that those skilled in the art know and understand.
The present invention is that preparation technology's flow process of injection of carrier is similar to glucose injection of the prior art or sodium chloride injection with the Nulomoline aqueous solution, basic operating procedure is that glucose and the fructose of getting equivalent earlier are prepared into the Nulomoline aqueous solution, use activated carbon adsorption thermal source, decolouring after regulating pH value and adding other additives, add principal agent and additives behind the filtering active carbon, dissolving, fine straining, filling and sealing, sterilization gets final product.For various medicine; the preparation process of the injection of its Nulomoline can be different; but the invert srgar inj of the medicine of producing with any preparation method or technological process no matter; as long as contain the present invention specified a kind of medicine, glucose, fructose, water and additives in its finished product, all belong to the protection domain of the technology of the present invention.
These that the present invention protected are the injection of carrier with the Nulomoline aqueous solution; making its most important condition of injection liquid medicine and be medicine and Nulomoline can stable existence under the mixture state of aqueous solution and do not change; to guarantee its steady quality and clinical drug safety; the chemical property of said medicine is all more stable; respectively said medicine is made by the infusion solutions preparation method and contained appropriate amount of drug; the aqueous solution of 5% Nulomoline and suitable additives; deposit and three months accelerated tests by three months room temperatures; observe its color; pH value; the detection of projects such as principal agent thing and invert sugar content variation all meets the requirement of the stable quality standard of infusion solutions injection.
Medicine is made as invert srgar inj, except easy to use, rapid-action advantage with injection, compare the injection of glucose, being more suitable for insulin resistant patient, type ii diabetes, cardiovascular and cerebrovascular disease, hepatopath and middle-older patient uses, the safety that enlarged its scope of application, has improved flow of infusate is especially for the big spoke degree fluctuation of the insulin resistant patient blood glucose safety to the harm aspect of underlying diseases.
The specific embodimentThree embodiment with following further illustrate the composition of medicine invert srgar inj of the present invention by its preparation process, but do not represent the embodiment limitation of the present invention.
Embodiment 1: Gallate propyl ester invert srgar inj
Glucose and each 25 gram of fructose of getting equivalent add dissolving fully in an amount of water for injection, add the needle-use activated carbon of appropriate amount again, stir evenly, regulate pH value 4.0～5.5 with hydrochloric acid solution, 30 ℃ are incubated 30 minutes, and filtered while hot adds 0.8 gram sodium sulfite after removing active carbon; Other gets 0.6 gram Gallate propyl ester and dissolves fully in the above-mentioned Nulomoline filtrate of back adding with the 10ml propylene glycol, add the injection water to 1000ml, stir evenly, embedding 100ml is in standard transfusion vial behind the fine straining, in 115 ℃ of pressure sterilizings 30 minutes, detect check, packing promptly gets 5% invert srgar inj that every bottle of 100ml contains 60mg Gallate propyl ester.(annotate: glucose, fructose and Gallate propyl ester are the principal agent thing composition of medicine, and its addition is by 95%～110% of labelled amount.)
In above-mentioned preparation process, active carbon is used for adsorbing pyrogen and decolouring, the composition of this Gallate propyl ester invert srgar inj is: Gallate propyl ester, glucose and fructose, hydrochloric acid, sodium sulfite, propylene glycol and water, wherein hydrochloric acid is the pH value regulator, sodium sulfite is an antioxidant, and propylene glycol is a cosolvent.
Study on the stability test: each 3 batches of Gallate propyl ester invert srgar injs getting above-mentioned preparation, put in (40 ± 2) ℃ calorstat, and in sampling in 0,1,2,3 month, to the appearance luster of injection, clarity, pH value, content (3 meansigma methodss), the 5 hydroxymethyl furfural trap (A of solution the 3rd month the time
284) and invert sugar content investigate, its content and pH value etc. the results are shown in Table 1.
Table 1: the accelerated test result of Gallate propyl ester invert srgar inj
| Lot number | Project | 0 month | January | February | March | ?A 284 | Invert sugar content |
| I | Content (%) | 98.53 | ?97.47 | ?97.22 | ?96.38 | ?0.18 | ?5.05％ |
| PH value | 4.77 | ?4.67 | ?4.72 | ?4.71 | |||
| II | Content (%) | 98.11 | ?98.16 | ?97.37 | ?96.98 | ?0.15 | ?4.98％ |
| PH value | 4.34 | ?4.50 | ?4.39 | ?4.54 | |||
| III | Content (%) | 96.86 | ?95.71 | ?95.31 | ?95.17 | ?0.19 | ?5.02％ |
| PH value | 4.88 | ?4.89 | ?4.57 | ?4.52 |
Annotate: in the said determination scheme, all according to " stability requirement of relevant infusion solutions is carried out in the Chinese pharmacopoeia (2000 editions appendix), Gallate propyl ester assay is according to high performance liquid chromatography, and the detection wavelength is 272nm, and number of theoretical plate calculates by Gallate propyl ester peak should be not less than 2000; 5 hydroxymethyl furfural is the product that Nulomoline (glucose and fructose) decomposes variable color, and it is at the trap (A at 284nmm place
284) should be not more than 0.25; The detection of items such as Nulomoline is measured according to " Nulomoline standard (trying) " YBH00092004 of State Food and Drug Administration's frequency cloth.
The result shows that 3 batches of injection outward appearances are constant, are clear and bright solution, and clarity is all up to specification, as can be seen from Table 1, by 3 months accelerated stability tests, Gallate propyl ester invert srgar inj respectively detect the related request that index all meets great transfusion preparation.
Embodiment 2. puerarin invert srgar injs
After taking by weighing the about 900ml dissolving of puerarin 2 gram adding waters for injection, add 25 gram glucoses and 25 gram fructose, be stirred to CL, with dilute hydrochloric acid adjust pH to 4.5～6.0, add 0.05% needle-use activated carbon, insulation is 15 minutes about 35 ℃, add 0.8 gram sodium sulfite while hot behind the decarbonization filtering, add the injection water to 1000ml, after the content of mensuration solution and pH value are qualified, reuse microporous filter membrane fine straining, embedding 100ml is in infusion bottle, through 115 ℃ of pressure sterilizings 30 minutes, promptly get every bottle and contain the 0.2g puerarin, 2.5 gram glucoses and 2.5 restrain the injection of fructose.
The composition of this puerarin invert srgar inj is: puerarin, and glucose and fructose, hydrochloric acid, sodium sulfite and water, wherein hydrochloric acid and sodium sulfite are additives.
The study on the stability test: the mensuration mode is similar to embodiment 1 with method, and qualified stability, experimental data are slightly.
Embodiment 3. lysine hydrochloride invert srgar injs
After taking by weighing the about 2000ml dissolving of lysine hydrochloride 30 gram adding waters for injection, add 62.5 gram glucoses and 62.5 gram fructose, whisk to CL, about adjust pH to 4.5, add 0.07% needle-use activated carbon, insulation is 20 minutes about 50 ℃, add 0.25 gram calcium disodium edathamil while hot behind the decarbonization filtering, add the injection water, after the content of mensuration solution and pH value are qualified to 2500ml, reuse microporous filter membrane fine straining, the inflated with nitrogen embedding through 115 ℃ of pressure sterilizings 30 minutes, promptly gets every bottle and is 250ml in the 250ml infusion bottle, contain the 3g lysine hydrochloride, the injection of 6.25 gram glucoses and 6.25 gram fructose.
The composition of this lysine hydrochloride invert srgar inj is: lysine hydrochloride, glucose, fructose, hydrochloric acid; calcium disodium edathamil, nitrogen G﹠W, wherein hydrochloric acid; calcium disodium edathamil and nitrogen are additives, are respectively pH value regulator, metal chelating agent and protective gas.
The study on the stability test: the mensuration mode is similar to embodiment 1 with method, and qualified stability, experimental data are slightly.
Claims (4)
1. be the injection of carrier with the Nulomoline aqueous solution, it is characterized in that it is made up of a kind of medicine, glucose, fructose, water and suitable additives.
2. according to claim 1 is the injection of carrier with the Nulomoline aqueous solution, it is characterized in that medicine comprises: the Gallate propyl ester, puerarin, lysine hydrochloride, arginine hydrochloride, levocarnitine, garlicin, asarone, Bisolvon, doxofylline, diprophylline, aminomethylbenzoic acid, tranexamic acid, tirofiban hydrochloride, sodium tanshinone IIA sulfate, adenosine cyclophosphate, famotidine, foscarnet sodium, dopamine hydrochloride, sotalol hydrochloride, Pamidronate Disodium, lappaconitine hydrobromide, tramadol hydrochloride, oxaliplatin, oxiracetam, ganciclovir, nefopam hydrochloride, Injectio natarii norcantharidatis.
3. according to claim 1 is the injection of carrier with the Nulomoline aqueous solution, it is characterized in that additives comprise pH value regulator, solubilizing agent and cosolvent, antioxidant, metal chelating agent, noble gas, suspensoid and emulsifying agent, analgesic.
4. according to claim 1 is the injection of carrier with the Nulomoline aqueous solution, it is characterized in that the content of glucose in the injection and fructose equates.
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| CN 200410079270 CN1634589A (en) | 2004-10-04 | 2004-10-04 | Injection using invert sugar water solution as carrier |
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| CN 200410079270 CN1634589A (en) | 2004-10-04 | 2004-10-04 | Injection using invert sugar water solution as carrier |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293741A (en) * | 2011-08-24 | 2011-12-28 | 石家庄东方药业有限公司 | Bromhexine hydrochlorie injection, its preparation method and application |
| CN112569184A (en) * | 2020-12-30 | 2021-03-30 | 山东裕欣药业有限公司 | Tirofiban hydrochloride injection and preparation method thereof |
-
2004
- 2004-10-04 CN CN 200410079270 patent/CN1634589A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293741A (en) * | 2011-08-24 | 2011-12-28 | 石家庄东方药业有限公司 | Bromhexine hydrochlorie injection, its preparation method and application |
| CN112569184A (en) * | 2020-12-30 | 2021-03-30 | 山东裕欣药业有限公司 | Tirofiban hydrochloride injection and preparation method thereof |
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