CN1630726A - Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection - Google Patents

Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection Download PDF

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Publication number
CN1630726A
CN1630726A CNA038036932A CN03803693A CN1630726A CN 1630726 A CN1630726 A CN 1630726A CN A038036932 A CNA038036932 A CN A038036932A CN 03803693 A CN03803693 A CN 03803693A CN 1630726 A CN1630726 A CN 1630726A
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CN
China
Prior art keywords
anminoglycosides
lactamase
medicine
composition
fusion gene
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CNA038036932A
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Chinese (zh)
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CN1296483C (en
Inventor
陈秀枢
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Individual
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Publication of CN1630726A publication Critical patent/CN1630726A/en
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Publication of CN1296483C publication Critical patent/CN1296483C/en
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the isolation of antibiotics resistance enzyme genes, the preparation of their fusion gene, and the isolation of the expression products of the resistance enzyme genes and the fusion gene, the composition comprising the resistance enzyme proteins and fusion protein, as well as their uses in medicine and environmental protection. In particularly, the invention relates to the isolation of the genes coding for ss-lactamase, anminoglycosides modifying enzyme, the preparation of the ss-lactamase/anminoglycosides modifying enzyme fusion gene, and the isolation of their expression products, the composition comprising the fusion protein of the resistance enzyme proteins, as well as their uses in medicine and environmental protection.

Description

Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection
PCT domestic application, specification is disclosed.

Claims (1)

  1. PCT domestic application, claims are disclosed.
CNB038036932A 2002-02-11 2003-02-08 Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection Expired - Fee Related CN1296483C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB021050384A CN1191363C (en) 2002-02-11 2002-02-11 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use
PCT/CN2003/000119 WO2003068975A1 (en) 2002-02-11 2003-02-08 ss-LACTAMASE/ANMINOGLYCOSIDES MODIFYING ENZYME GENES, THEIR FUSION GENE AND THE EXPRESSION PRODUCTS, THE COMPOSITION THEREOF, AND THEIR USES IN MEDICINE AND ENVIRONMENTAL PROTECTION

Publications (2)

Publication Number Publication Date
CN1630726A true CN1630726A (en) 2005-06-22
CN1296483C CN1296483C (en) 2007-01-24

Family

ID=27672139

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB021050384A Expired - Fee Related CN1191363C (en) 2002-02-11 2002-02-11 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use
CNB038036932A Expired - Fee Related CN1296483C (en) 2002-02-11 2003-02-08 Beta-lactamase/anminoglycosides modifying enzyme genes, their fusion gene and the expression products, the composition thereof, and their uses in medicine and environmental protection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB021050384A Expired - Fee Related CN1191363C (en) 2002-02-11 2002-02-11 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use

Country Status (3)

Country Link
CN (2) CN1191363C (en)
AU (1) AU2003211845A1 (en)
WO (1) WO2003068975A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191363C (en) * 2002-02-11 2005-03-02 陈秀枢 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use
CN101003798B (en) * 2006-01-17 2010-05-12 温州医学院 Purified expression of recombined beta lactamase in superspectrum, and fermentation process in high density
FI20086225A (en) * 2008-12-22 2010-06-23 Tuula Heinonen Method and products for breaking down antibiotic residues
FR3027307B1 (en) * 2014-10-16 2016-11-04 Azurrx Sas HYBRID PROTEIN MOLECULE CAPABLE OF INHIBITING AT LEAST ONE ANTIBIOTIC AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
CN108355141B (en) * 2018-01-11 2019-06-18 广西壮族自治区人民医院 A kind of drug and preparation method thereof of the treatment allergic disease based on TIM-4-Fc fusion protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1707078A1 (en) * 1989-11-21 1992-01-23 Институт биоорганической химии им.М.М.Шемякина Recombinant plasmid dna pthy314, encoding polypeptide with properties of human @@@-thymosine, recombinant plasmid dna pthy12 - an intermediate product for its construction, and the strain of bacteria escherichia coli - a producer of polypeptide with properties of human @@@-thymosine
EP0467049A1 (en) * 1990-07-16 1992-01-22 American Cyanamid Company DNA sequences and amino acid sequences of class b beta-lactamase enzymes from bacteroides fragilis
FR2687410A1 (en) * 1992-02-14 1993-08-20 Pasteur Institut RECOMBINANT BETA-LACTAMASE, USEFUL AS A CARRIER MOLECULE FOR THE PREPARATION OF IMMUNOGENIC COMPOSITIONS.
EP0698106B1 (en) * 1993-05-13 2001-08-01 Aventis CropScience N.V. Marker gene
CN1191363C (en) * 2002-02-11 2005-03-02 陈秀枢 Beta-lactamase/amino-glucosidic passive zyme interfused gene, its expressed products and composition thereof and use

Also Published As

Publication number Publication date
CN1296483C (en) 2007-01-24
WO2003068975A1 (en) 2003-08-21
CN1191363C (en) 2005-03-02
CN1438315A (en) 2003-08-27
AU2003211845A1 (en) 2003-09-04

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Granted publication date: 20070124

Termination date: 20180208

CF01 Termination of patent right due to non-payment of annual fee