CN1620905A - Preparation method and uses of pumpkin polysaccharide healthcare food - Google Patents
Preparation method and uses of pumpkin polysaccharide healthcare food Download PDFInfo
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- CN1620905A CN1620905A CNA200310108964XA CN200310108964A CN1620905A CN 1620905 A CN1620905 A CN 1620905A CN A200310108964X A CNA200310108964X A CN A200310108964XA CN 200310108964 A CN200310108964 A CN 200310108964A CN 1620905 A CN1620905 A CN 1620905A
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- squash polyoses
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Abstract
The present invention belongs to the field of health food technology, and provides the method of extracting pumpkin polysaccharide from fresh pumpkin and making health food. The method of the present invention is simple and suitable for large scale production, and the pumpkin polysaccharide health food thus produced has obvious effect of lowering blood sugar content and is one excellent kind of health food.
Description
Technical field
The invention belongs to the health food technology field.Be specifically related to extract squash polyoses and the method for making health food from fresh pumpkin.
Background technology
Fructus Cucurbitae moschatae is common a kind of bread and cheese, and among the people that to be used for treating diabetes (diabetes) reflection good is more, also uses Fructus Cucurbitae moschatae dry powder as the health food supply on the market.The discovered in recent years squash polyoses is its active component, and alloxan diabetes rats is had blood sugar reducing function, and is used for type ii diabetes 30 examples clinically, and effective percentage can reach (Xiong Xuemin etc.: Jiangxi College of Traditional Chinese Medicine journal 10 No4.174,1998 years more than 87%; Xiong Xuemin etc.: Chinese patent medicine 22 No.8.563,2000; 23 No.7.495, calendar year 2001).But the described squash polyoses preparation method of this report is more numerous and diverse, and needs very easily to fire solvent with the extraction of steps such as dialysis and with ether, acetone etc.
Summary of the invention
Technical problem to be solved by this invention is to overcome the weak point of said method, a kind of easy preparation method that is suitable for suitability for industrialized production of research design.
The invention provides a kind of preparation method of squash polyoses health food.This method comprises the following steps:
The extraction separation of squash polyoses
(1) fresh pumpkin scrapes off crust, removes the base of a fruit and removes the flesh seed, and stripping and slicing breaks into lumps, respectively with 10 times of water in 60～80 ℃ of heating extraction secondaries, each 6～12 hours, merging filtrate, concentrating under reduced pressure, temperature is controlled at 40～60 ℃;
(2) concentrated solution adds 95% medicinal alcohol, adjusts to reach 25～75% ethanol contents, places cold preservation 48～72 hours, 1～0 ℃ of temperature;
(3) freezing liquid centrifugal filtration, collecting precipitation, and with after 95% washing with alcohol, in 40～50 ℃ of vacuum drying oven oven dry, 20 orders that sieve promptly get squash polyoses;
(4) with the above-mentioned squash polyoses that makes as raw material, prepare tablet, pill, powder, granule, electuary and capsule according to the conventional production method of pharmaceutical field.
The hypoglycemic activity test of the squash polyoses health food that makes by the inventive method, the result is as follows:
Cause the mice hyperglycemia model with alloxan, oral squash polyoses and be contrast with Western medicine glyburide (Glibenclamide), the result is as follows:
| Group dosage number of animals (g/Kg) (only) | Blood glucose value (mol/L) |
| Modeling 72 △H administration 4d administration 9d administration 16d | |
| Blank 10 7.7 ± 1.4 7.3 ± 4.9 7.4 ± 1.6 8.0 ± 0.8 model contrasts 12 20.5 ± 5.4 17.4 ± 5.0 △△???13.4±5.7 △△???16.5±5.3 △△Squash polyoses 0.625 12 20.2 ± 5.0 11.2 ± 2.8** 8.9 ± 3.5* 13.0 ± 4.0 squash polyoses 1.25 12 20.3 ± 5.1 13.4 ± 7.0 16.0 ± 6.2 14.6 ± 5.7 glibenclamide 5 12 20.5 ± 5.2 10.8 ± 6.1** 9.1 ± 5.9 15.5 ± 6.0 | |
*P＜0.05
*This model contrast ratio of P＜0.01
△P＜0.05
△This blank ratio of P＜0.01
Clinical observation is to type ii diabetes patient secondary every day, and each 2～3 squash polyoses capsules (every capsules contains squash polyoses 400mg) are after the week, and descending promptly appears in blood glucose.
Method of the present invention is easy, is suitable for the commercial production of scale especially, has got rid of the dialysis step in original technology, and avoids using very easily incendiary organic solvent, and is safer.With the squash polyoses health food that the inventive method makes, through pharmacological testing, hypoglycemic effect is obvious, is a kind of good health care food.
The specific embodiment
Embodiment 1
Get fresh pumpkin 15Kg and (remove melon skin, remove the base of a fruit and remove flesh) break into lumps after, 10 times of (150 liter) 80 ℃ of warm water of adding distil water stir, extract secondary, each 6 hours, water liquid was leached in leaching, concentrating under reduced pressure (60 ℃), be concentrated to 1/3, add ethanol (95%) then, make determining alcohol arrive 50%, placed refrigerator (0～1 ℃) 2 days, filter,, drain with 95% washing with alcohol, in vacuum drying oven drying (40 ℃), promptly get light yellowish-white powder agglomates shape, cross 20 mesh sieves and promptly get squash polyoses 150g (yield 1%), polysaccharide component content is 90% after measured.
Claims (2)
1. the preparation method of a squash polyoses health food is characterized in that this method comprises the following steps:
The extraction separation of squash polyoses
(1) fresh pumpkin scrapes off crust, removes the base of a fruit and removes the flesh seed, and stripping and slicing breaks into lumps, respectively with 10 times of water in 60～80 ℃ of heating extraction secondaries, each 6～12 hours, merging filtrate, concentrating under reduced pressure, temperature is controlled at 40～60 ℃;
(2) concentrated solution adds 95% medicinal alcohol, adjusts to reach 25～75% ethanol contents, places cold preservation 48～72 hours, 1～0 ℃ of temperature;
(3) freezing liquid centrifugal filtration, collecting precipitation, and with after 95% washing with alcohol, in 40～50 ℃ of vacuum drying oven oven dry, 20 orders that sieve promptly get squash polyoses;
(4) with the above-mentioned squash polyoses that makes as raw material, prepare tablet, pill, powder, granule, electuary and capsule according to the conventional production method of pharmaceutical field.
2. the application of squash polyoses in the preparation health-caring product capable of reducing blood sugar that makes by claim 1 method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310108964XA CN1620905A (en) | 2003-11-28 | 2003-11-28 | Preparation method and uses of pumpkin polysaccharide healthcare food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310108964XA CN1620905A (en) | 2003-11-28 | 2003-11-28 | Preparation method and uses of pumpkin polysaccharide healthcare food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1620905A true CN1620905A (en) | 2005-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200310108964XA Pending CN1620905A (en) | 2003-11-28 | 2003-11-28 | Preparation method and uses of pumpkin polysaccharide healthcare food |
Country Status (1)
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| CN (1) | CN1620905A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101220100B (en) * | 2007-01-10 | 2010-05-12 | 兰州大学 | Separation and purification method for squash polyoses and use of obtained component |
| CN106214623A (en) * | 2016-03-08 | 2016-12-14 | 兰州理工大学 | There is the preparation method of the squash polyoses composite aquogel of blood sugar reducing function |
| CN109306024A (en) * | 2018-09-19 | 2019-02-05 | 西安绿海生物科技有限公司 | A kind of preparation and application of the squash polyoses with biological regulation function |
-
2003
- 2003-11-28 CN CNA200310108964XA patent/CN1620905A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101220100B (en) * | 2007-01-10 | 2010-05-12 | 兰州大学 | Separation and purification method for squash polyoses and use of obtained component |
| CN106214623A (en) * | 2016-03-08 | 2016-12-14 | 兰州理工大学 | There is the preparation method of the squash polyoses composite aquogel of blood sugar reducing function |
| CN106214623B (en) * | 2016-03-08 | 2019-07-23 | 兰州理工大学 | The preparation method of squash polyoses composite hydrogel with blood sugar reducing function |
| CN109306024A (en) * | 2018-09-19 | 2019-02-05 | 西安绿海生物科技有限公司 | A kind of preparation and application of the squash polyoses with biological regulation function |
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