CN1611273A - Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy - Google Patents
Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy Download PDFInfo
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- CN1611273A CN1611273A CN 200310108368 CN200310108368A CN1611273A CN 1611273 A CN1611273 A CN 1611273A CN 200310108368 CN200310108368 CN 200310108368 CN 200310108368 A CN200310108368 A CN 200310108368A CN 1611273 A CN1611273 A CN 1611273A
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- plasma
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- delp
- liposome
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- 238000000502 dialysis Methods 0.000 title claims abstract description 29
- 208000006011 Stroke Diseases 0.000 title claims abstract description 24
- 206010008190 Cerebrovascular accident Diseases 0.000 title claims abstract description 22
- 210000004369 blood Anatomy 0.000 title claims abstract description 14
- 239000008280 blood Substances 0.000 title claims abstract description 14
- 238000001914 filtration Methods 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 16
- 230000002490 cerebral effect Effects 0.000 title abstract description 7
- 210000002381 plasma Anatomy 0.000 claims abstract description 54
- 239000012528 membrane Substances 0.000 claims abstract description 25
- 239000002502 liposome Substances 0.000 claims abstract description 16
- 101150071172 PCS2 gene Proteins 0.000 claims abstract description 4
- 239000004531 microgranule Substances 0.000 claims description 8
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 6
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- 230000008030 elimination Effects 0.000 claims description 3
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- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 4
- 206010008118 cerebral infarction Diseases 0.000 description 4
- 208000026106 cerebrovascular disease Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005374 membrane filtration Methods 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 238000005345 coagulation Methods 0.000 description 2
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- 229920000669 heparin Polymers 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010048962 Brain oedema Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- -1 Kynoar Polymers 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
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- 208000006752 brain edema Diseases 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
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- 230000000324 neuroprotective effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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Abstract
The present invention relates to an external blood plasma dialysis filtration method for curing cerebral apoplexy and its equipment. It can be connected together with centrifugal blood plasma separator (PCS2, made by American Blood Corporation), blood plasma pump and dialysis box to form a complete therapeutic equipment. It is charcterized by that the interior of described dialysis box is equipped with several layers of combined filter membranes, and said combined filter membrane is made up by using DELP membrane with liposome affinity adsorptivity, 90SA membrane with mechanical filtering function and membrane whose poer size is 0.2 micrometer through superposition and combination according to a certain order. When the blood plasma is passed through said combined filter membrane, the liposome and various particles can adsorbed and filtered.
Description
Technical field
The present invention is a kind of external plasma dialysis filter method and device thereof that is used for the treatment of apoplexy, relates to by human plasma being carried out the apparatus and method of extracorporeal filtration.
Technical background
At present, apoplexy has become one of three big reasons of whole world human mortality.According to data, the annual patient who dies from apoplexy surpasses 1,000,000 in China's population, and also has the trend that increases.At existing 4,000,000 apoplexy survivor, major part has been left over deformity in various degree, estimates at 75% maimed person, and wherein 40% is serious maimed.Apoplexy not only endangers the patient, brings heavy spirit and financial burden also for patient family and society.Apoplexy has become 21 century and has threatened one of main serious illness of human health and life.
In China, cerebral infarction accounts for the 70-75% of whole stroke onset rate, is the main type of apoplexy.Along with the increase of aged tendency of population and various risk factors, the cerebral infarction proportion can be increasing.In western countries, the ratio of ischemic cerebral stroke patients has reached 84%.Because the disability rate relapse rate of cerebral infarction is higher than hemorrhagic apoplexy, therefore, prevention and treatment cerebral infarction should become the emphasis of apoplexy control.
At present existing multiple alternative acute ischemic cerebral apoplexy Therapeutic Method.1. antiplatelet aggregation; 2. change blood viscosity; 3 anticoagulant therapies; 4. thromboembolism treatment; 5. adjust blood pressure is controlled cerebral edema; 6. neuroprotective; 7. surgical operation etc.
In principle, these methods all are to adopt medicine to stop blood constituent reunion coagulation, if reunited coagulation, then want timely depolymerization, but medicine is a double-edged sword, makes anticoagulant as extensively adopting heparin in the anticoagulant therapy, yet, intracranial external haemorrhage complication rate height, mortality rate height that anticoagulant heparin causes make many doctors hang back.Apoplexy can be described as the turning point that the blood of human body system transforms to qualitative change from quantitative change, if can adopt the mechanical-physical method, remove the small reunion microgranule that accumulates over a long period and accumulate in the blood fast, prevent thrombosis or stop existing thrombosis to continue to enlarge and prolong, significant for the control of apoplexy.
Chinese patent CN01126821 proposes a kind of compatible filtering method, and blood plasma is separated the back by a kind of defecator with hemocyte, adopts blood fat specificity affinitive material, as U.S. Cuno, and the DELP of Inc. company.When the intravital blood of patient after separating, blood plasma according to layer by the combination filter membrane.The affine filter membrane of blood fat will adsorb blood fat, and remaining filter membrane is the various graininess harmful substances of elimination then.Treated blood plasma feeds back to the patient again, finishes the overall process of blood fat reducing, and operating process is simple.But can not treat and alleviate the clinical symptoms of cerebral apoplexy patient in the above-mentioned patent.
Summary of the invention
The objective of the invention is to propose a kind of external plasma dialysis filter method and device thereof that is used for the treatment of apoplexy, can not cause malicious secondary hurt simultaneously, can not be subjected to the drug resistance influence simultaneously human body.
The objective of the invention is to realize by the following method: the present invention select for use the mechanical membrane filtration and or the compatible filtering method, reduce liposome and particle matter content in the blood plasma, thereby make blood vessel infraction symptom eliminate or alleviate, reach treatment and reduce the purpose of the clinical symptoms of cerebral apoplexy patient.
The present invention adopts three kinds of filter membrane material, as U.S. CUNO, Inc. company produces, be respectively the DELP film (to call the A film in the following text) with the affine adsorption function of liposome, 90SA and aperture 0.2um film (to call the C film in the following text) with mechanical filter function, the order of pressing A, B, A, C is superimposed, be placed in the dialysis cassette of a plastic casing formation, form and from a blood plasma, filter dialysis microgranule and liposome device.Again centrifugal plasma seperator (PCS2, U.S.'s blood corporate system), blood plasma pump and dialysis cassette are coupled together, form a complete therapy equipment.
Cerebral apoplexy patient is because blood plasma viscosity height mostly, a large amount of liposomees and other suspended particulates are arranged in the blood plasma, in the blood circulation flow process, when local condition changed, microgranule was reunited, and caused the blood vessel infraction, the present invention select for use the mechanical membrane filtration and or the compatible filtering method, reduce liposome and particle matter content in the blood plasma, thereby make blood vessel infraction symptom eliminate or alleviate, reach treatment and reduce the purpose of the clinical symptoms of cerebral apoplexy patient.
Mechanical filter is meant with the less various membrane materials in aperture liposome and microgranule is separated from blood plasma, the chemical composition of film must be a biologically inert, human body is not had toxic and side effects,, have a lot of commercial products available as cellulose, Kynoar, polysulfones etc.
Compatible filtering is meant the membrane filtration that liposome in the blood plasma and microgranule is had affinity with various, the film that contains silicon dioxide that is proposed as USP 4596660, have removal effect preferably for liposome, and for example the Positively charged membrane of USP2002019475 proposition all has intensive affine adsorption to various microgranules in the blood plasma.
Description of drawings
Fig. 1 is the vertical view of dialysis cassette of the present invention
Fig. 2 is the front view of dialysis cassette of the present invention
Fig. 3 is the partial sectional view of Fig. 2
Fig. 4 enforcement view of the present invention
Embodiment
A kind of enforcement the solution of the present invention is listed below as an example, and this does not also mean that the present invention only limits to adopt this method.
With reference to the accompanying drawings, in conjunction with the embodiments, the present invention is further described:
With reference to Fig. 1-3 plasma filtering device plasma filtering device of the present invention, comprise dialysis cassette housing and combination filter membrane 4, housing comprises loam cake 1 and lower cover 2, loam cake 1 is a disc, in being provided with plasma inlet 11 near center position, be provided with air vent 12 near the plasma inlet place, the periphery joint of loam cake 1 forms a circumferential projection 13.The lower surface of loam cake 1 is to having many spaced ribs 14, and these ribs 14 are that the center with loam cake is the center of circle, the evenly distributed circular arc of outwards dispersing.
Loam cake 1 is assembled on the lower cover 2, lower cover 2 is a disc, middle formation one receiving space 22 recessed down, in be provided with blood plasma outlet 21 near center position, the upper surface of lower cover 2 is provided with many spaced ribs 24, these ribs are that the center with lower cover 2 is the center of circle, the evenly distributed circular arc of outwards dispersing.The circumferential projection 13 of the corresponding loam cake of lower cover 2 joints is provided with a circumferential groove 23, and forms an annular breach 26 in the inboard.
Inner ring 3 comprises cylindrical side wall 31, the inwardly vertical certain-length formation bottom 32 of extending from sidewall 31 bases, and this length equals outermost circular arc rib 24 to the distance between lower cover 2 sidewalls, and sidewall 31 top margins stretch out and form an outside 33.
Combination filter membrane 4 is accommodated and is fixed in the receiving space 22 of dialysis cassette lower cover 2, this combination filter membrane 4 has several layers combination filter membrane, and be by the DELP film 41 with the affine adsorption function of liposome, 90SA42 and aperture 0.2um film 43 with mechanical filter function, set up jointly by the order stack of DELP-90SA-DELP-0.2 μ and to form, when blood plasma makes up filter membrane by this, liposome and various microgranule will be adsorbed and elimination.
During assembling, inner ring 3 places lower cover 2, and the bottom of inner ring 3 is placed on outermost circular arc rib 24 between lower cover 2 sidewalls, and accommodate in the annular breach 26 outside 33.Combination filter membrane 4 is accommodated and is fixed in the receiving space 22 of lower cover 2.Loam cake 1 fastens to that the blended rubber glue lumps together on the lower cover 2, and the circumferential projection 13 of loam cake 1 is accommodated in the circumferential groove 23 of lower cover 2, to increase gummed power.
In conjunction with reference to Fig. 4, press figure during use centrifugal plasma seperator (PCS2, U.S.'s blood corporate system), blood plasma pump and dialysis cassette are coupled together, form a complete therapy equipment.After separating plasma was handled, the blood plasma with certain pressure entered the top layer of defecator combined films core 4 by the plasma inlet 11 at top, and 12 of air vents can guarantee the smooth inflow of blood plasma.Because blood plasma has certain pressure, it flows into the back just directly by combined films core 4 downward seepages via porch 11.Since liposome in the blood plasma and microgranule can with can produce affinity with these filter membranes, it is combined with the medium of filter membrane.At last, treated blood plasma is flowed out by the outlet 21 of lower cover 2, and after measured, other protein in the blood plasma are not subjected to any loss.
Claims (10)
1. external plasma dialysis filter method that is used for the treatment of apoplexy, comprise centrifugal plasma seperator (PCS2, U.S.'s blood corporate system), blood plasma pump and dialysis cassette couple together, form a complete therapy equipment, it is characterized in that having in the described dialysis cassette several layers combination filter membrane, and be by the DELP film with the affine adsorption function of liposome, 90SA and aperture 0.2um film with mechanical filter function, superimposed in sequence combining, when blood plasma makes up filter membrane by this, liposome and various microgranule will be adsorbed and elimination.
2. external plasma dialysis filter method as claimed in claim 1 is characterized in that the combined films in the described dialysis cassette is to set up jointly by the order stack of DELP-90SA-DELP-0.2 μ to form.
3. filtering device of external plasma dialysis that is used for the treatment of apoplexy, at least comprise that housing and several layers filter membrane constitute dialysis cassette in, housing comprises loam cake and lower cover, on be covered with plasma inlet and air vent, under be covered with blood plasma outlet, it is characterized in that described several layers filter membrane is by the DELP film with the affine adsorption function of liposome, the 90SA with mechanical filter function and aperture 0.2um film, superimposed in sequence combining.
4. the filtering device of external plasma dialysis as claimed in claim 3, it is characterized in that described several layers filter membrane is by the DELP film with the affine adsorption function of liposome, the 90SA with mechanical filter function and aperture 0.2um film, set up jointly by the order stack of DELP-90SA-DELP-0.2 μ and form.
5. according to claim 3 or 4 described plasma dialysis defecators, it is characterized in that: the upper surface of lower cover is provided with many spaced projectioies, and combined films is fixed between loam cake and the lower cover, and is resisted against on the projection of lower cover.
6. plasma dialysis defecator according to claim 5, the projection that covers under it is characterized in that is the center of circle with the center of lower cover, evenly distributed circular arc.
7. plasma dialysis defecator according to claim 3 is characterized in that upper and lower covers is glued together with glue.
8. plasma dialysis defecator according to claim 3 is characterized in that loam cake is provided with corresponding annular protrusion in the junction, and corresponding these projectioies of lower cover are provided with annular groove, and the projection of loam cake is accommodated in the groove of lower cover.
9. plasma dialysis defecator according to claim 3 is characterized in that an inner ring accommodates in the lower cover, lower cover with the inboard breach that forms in loam cake junction, the inner ring lateral margin extends outwardly in this breach.
10. plasma dialysis defecator according to claim 3 is characterized in that plasma inlet is arranged on the general center of loam cake, and air vent is near plasma inlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200310108368A CN100581600C (en) | 2003-10-31 | 2003-10-31 | Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200310108368A CN100581600C (en) | 2003-10-31 | 2003-10-31 | Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1611273A true CN1611273A (en) | 2005-05-04 |
| CN100581600C CN100581600C (en) | 2010-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200310108368A Expired - Lifetime CN100581600C (en) | 2003-10-31 | 2003-10-31 | Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240417A (en) * | 2011-07-11 | 2011-11-16 | 薛磊 | Blood filtration and transfusion bag with double layers of filter membranes |
| CN106563183A (en) * | 2015-10-12 | 2017-04-19 | 江苏博发生物科技有限公司 | Blood purification filter for removing bilirubin |
| CN109045379A (en) * | 2018-07-12 | 2018-12-21 | 安陆恩彼饲料有限公司 | A kind of plasma purification method |
| CN110114102A (en) * | 2017-01-30 | 2019-08-09 | 东丽株式会社 | Decontaminating column |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015015597A1 (en) * | 2015-12-04 | 2017-06-08 | Fresenius Medical Care Deutschland Gmbh | Treatment of stroke by hemofiltration |
| CN114225142A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Blood purification device |
-
2003
- 2003-10-31 CN CN200310108368A patent/CN100581600C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240417A (en) * | 2011-07-11 | 2011-11-16 | 薛磊 | Blood filtration and transfusion bag with double layers of filter membranes |
| CN102240417B (en) * | 2011-07-11 | 2013-12-18 | 薛磊 | Blood filtration and transfusion bag with double layers of filter membranes |
| CN106563183A (en) * | 2015-10-12 | 2017-04-19 | 江苏博发生物科技有限公司 | Blood purification filter for removing bilirubin |
| CN110114102A (en) * | 2017-01-30 | 2019-08-09 | 东丽株式会社 | Decontaminating column |
| CN109045379A (en) * | 2018-07-12 | 2018-12-21 | 安陆恩彼饲料有限公司 | A kind of plasma purification method |
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| Publication number | Publication date |
|---|---|
| CN100581600C (en) | 2010-01-20 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20060414 Address after: Block A, building 10, No. 1399 West Beijing Road, Shanghai Applicant after: Shanghai Jiangxia Blood Technology Co.,Ltd. Address before: No. 1733 Lianhua Road, Shanghai Applicant before: Shanghai Jianfu Biotech Co.,Ltd. |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CI01 | Publication of corrected invention patent application |
Correction item: Inventor Correct: Huang Heping|Dong Qiang|Zhou Qingwen|Xue Jun|Han Xiang False: Huang Heping|Dong Qiang|Zhou Wenqing|Xue Jun|Han Xiang Number: 03 Volume: 26 |
|
| CI03 | Correction of invention patent |
Correction item: Inventor Correct: Huang Heping|Dong Qiang|Zhou Qingwen|Xue Jun|Han Xiang False: Huang Heping|Dong Qiang|Zhou Wenqing|Xue Jun|Han Xiang Number: 03 Page: The title page Volume: 26 |
|
| ERR | Gazette correction |
Free format text: CORRECT: INVENTOR; FROM: HUANG HEPING; DONG QIANG, ZHOU WENQING, XUE JUN, HAN XIANG TO: HUANG HEPING; DONG QIANG, ZHOU QINGWEN, XUE JUN, HAN XIANG |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20100120 |