CN217187206U - Plasma lipid filter - Google Patents

Abstract

The application discloses a plasma lipid filter, which comprises a first shell and a second shell, wherein the first shell is provided with a blood inlet; the second shell is jointed with the first shell to form an accommodating space, a bleeding opening is formed in the bottom surface of the second shell, which is opposite to the first shell, and the bottom surface is obliquely arranged; the accommodating space is provided with a filter element and a screen plate, and the screen plate is positioned below the filter element to support the filter element. The plasma lipid filter reduces the adhesion of plasma on the bottom surface of the filter, so that the plasma is easier to filter, and the possibility of breakage of a filter membrane of the filter element is reduced.

Description

Plasma lipid filter

Technical Field

The application relates to the technical field of medical equipment, in particular to a plasma lipid filter.

Background

Hyperlipidemia is a common disease caused by the rise of low density lipoprotein level in human blood, and can further cause atherosclerosis, coronary heart disease, cerebral apoplexy, cardiac and cerebral infarction and other cardiovascular and cerebrovascular diseases if the hyperlipidemia is not cleared in time. Conventional methods for treating hyperlipidemia include diet control, lifestyle modification, and drug therapy, but patients with familial hyperlipidemia and those who do not respond to these therapies can be treated clinically by extracorporeal lipid removal. The blood fat filtering method is one common extracorporeal eliminating treatment method, and has the blood plasma separated from patient, relatively great molecules, such as low density lipoprotein, filtered out in the blood plasma, and returned to the body. However, in the existing filtering device, the blood plasma of the patient is often adhered to the bottom surface of the filtering device due to high viscosity, so that a certain degree of loss is caused, and the filtering effect is influenced.

SUMMERY OF THE UTILITY MODEL

The application provides a plasma lipid filter can reduce the adhesion of plasma at the filter bottom surface, promotes the filter effect.

A plasma lipid filter is provided that includes a first housing and a second housing. The first shell is provided with a blood inlet; the second shell is jointed with the first shell to form an accommodating space, a bleeding opening is formed in the bottom surface, opposite to the first shell, of the second shell, the bottom surface of the second shell is obliquely arranged, and specifically, the bottom surface of the second shell is obliquely inclined towards the direction opposite to the first shell; because the bottom surface is inclined at a certain angle, blood plasma is easier to flow to the bleeding port under the influence of gravity, thereby reducing the adhesion of the blood plasma on the bottom surface of the filter.

Optionally, in some embodiments of the present application, a filter element and a mesh plate are disposed in the receiving space, and the mesh plate is located below the filter element to support the filter element. Because the bottom surface is the slope setting, if set up directly on the bottom surface and filter the core, often can cause the cracked condition of filter core under the impact of liquid, add the otter board in filter core below, the otter board can support and filter the core, reduces and filters the cracked condition of core, and is equipped with a plurality of meshs on the otter board, and the plasma of being convenient for flows through the otter board and flows to the hemorrhage mouth.

Optionally, in some embodiments of the present application, the filter core includes a first filter membrane, a second filter membrane, and a third filter membrane, and the filter core is configured according to an arrangement of the first filter membrane, the second filter membrane, the first filter membrane, and the third filter membrane along the plasma flow direction, wherein the first filter membrane is a DELP membrane with liposome and fibrinogen affinity adsorption function, specifically, the first filter membrane is a DELP membrane with liposome and fibrinogen affinity adsorption function produced by 3M company of usa; the second filtering membrane is a 90SP deep filtering membrane for adsorbing inflammatory factors and free radicals, and specifically, the second filtering membrane adopts a 90S deep filtering membrane which is produced by American 3M company and used for adsorbing partial inflammatory factors and free radicals generated in the hyperlipemia attack stage; the third filter membrane is a 0.2 micron membrane for filtering various granular substances with the pore diameter larger than 0.2 micron, for example, a 020 nylon sterile filter membrane or a 020 polyethersulfone sterile filter membrane manufactured by PALL corporation in America, which has better pressure resistance and pollutant carrying capacity compared with other materials.

The application selects a mechanical membrane filtration and/or affinity filtration method, reduces the contents of liposome, fibrinogen, partial inflammatory factors and free radicals and particulate matters smaller than 0.2 micron in blood plasma, and improves the hemorheology of patients with hyperlipidemia. Mechanical filtration means that various membrane materials with smaller pore diameters are used for separating liposome, fibrinogen, inflammatory factors, free radicals, particles smaller than 0.2 micron and the like from blood plasma, and the chemical composition of the membrane must have biological inertness and has no toxic or side effect on human bodies, such as cellulose, diatomite and the like. Affinity filtration refers to filtration with various membranes having affinity for liposomes, fibrinogen, inflammatory factors, free radicals and particulate matter smaller than 0.2 microns in plasma, the functional particles of which adsorb liposomes and the like in plasma to the filtration membrane of the filter as the plasma passes through the filtration membrane, including but not limited to: the film containing silicon dioxide, the positively charged film and the like have strong affinity to various particles in blood plasma and meet the requirements of human biocompatibility.

Optionally, in some embodiments of the present application, the plasma lipid filter further comprises a shell surrounding and wrapping the sides of the first shell and the second shell to fixedly connect the first shell and the second shell. The shell can reinforce the connection of first casing and second casing, makes the filter structure more stable, firm, does benefit to the transportation.

Optionally, in some embodiments of the present application, the first shell has a convex structure and a bottom opening, the second shell has an inverted convex structure and a top opening, the bottom opening of the first shell and the top opening of the second shell are joined and form a receiving space, and the first shell overlaps with the second shell side edge portion; to further enhance the seal and prevent leakage of plasma during use.

Optionally, in some embodiments of the present application, the shell has a first limiting portion and a second limiting portion that are disposed opposite to each other, the first limiting portion abuts against an outer surface of the first shell portion, and the second limiting portion abuts against an outer surface of the second shell portion. And the shell sleeve locks the first shell and the second shell, further strengthens the connection of the first shell and the second shell and prevents leakage.

Optionally, in some embodiments of the present application, a side of the second casing is pressed against a lower surface of the first position-limiting part; to provide sufficient accommodation for the filter element.

Optionally, in some embodiments of the present application, the inner surface of the bottom surface of the second casing is provided with a plurality of annular drainage grooves, the annular drainage grooves are arranged in a divergent manner with the bleeding opening as a center, so as to introduce the filtered plasma into the bleeding opening, and the heights of the annular drainage grooves are on the same plane, so as to support the mesh plate.

Optionally, in some embodiments of the present application, a plurality of drainage channels are provided along the radial direction of the annular drainage groove, and the drainage channels guide the liquid contained in the annular drainage groove to the bleeding opening.

Optionally, in some embodiments of the present application, the inner surface of the bottom surface of the second casing is provided with at least two protrusions, and the protrusions are located on the periphery of the annular drainage groove and symmetrically distributed around the bleeding opening; the screen plate is provided with a positioning hole, the positioning hole corresponds to the position of the lug boss of the second shell, and the positioning hole is matched and connected with the lug boss so as to fix the screen plate on the second shell; for example, the inner surface of the bottom surface of the second casing is provided with four protrusions, the four protrusions are positioned on the periphery of the annular drainage groove and symmetrically distributed with the blood outlet as the center, the corresponding positions on the screen plate are provided with positioning holes, and the positioning holes are connected with the protrusions in a matching manner.

Optionally, in some embodiments of the present application, the first housing is further provided with a vent for venting gas from the plasma lipid filter.

The plasma lipid filter of the present application has the following beneficial effects:

(1) the bottom surface of the plasma lipid filter inclines towards the direction opposite to the blood inlet, so that the flow of plasma to the blood outlet is increased, the adhesion of the plasma on the bottom surface is reduced, and the plasma filtering effect is improved;

(2) the screen plate is added below the filter element, so that the filter element can be arranged on a plane, and the problem that the filter element is broken in the process of filtering blood plasma due to the inclined bottom surface is avoided;

(3) the lipid filter can remove blood fat with overhigh content in blood plasma by a method of mechanical membrane filtration and affinity filtration, and can not damage other components of the blood, and meanwhile, the filtering membrane has good blood compatibility.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic diagram of a plasma lipid filter;

FIG. 2 is a cross-sectional view of the first housing;

FIG. 3 is a cross-sectional view of the second housing;

FIG. 4 is a schematic view of a structure of a net sheet.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application. Furthermore, it should be understood that the detailed description and specific examples, while indicating exemplary embodiments of the invention, are given by way of illustration and explanation only, and are not intended to limit the scope of the invention. In the present application, unless indicated to the contrary, the use of the directional terms "upper" and "lower" generally refer to the upper and lower positions of the device in actual use or operation, and more particularly to the orientation of the figures of the drawings; while "inner" and "outer" are with respect to the outline of the device.

The embodiment of the application provides a plasma lipid filter. The following are detailed below. It should be noted that the following description of the embodiments is not intended to limit the preferred order of the embodiments.

The first embodiment,

This example provides a preferred embodiment of a plasma lipid filter:

fig. 1 shows a schematic structure of a plasma lipid filter. The plasma lipid filter comprises a first shell 10, a second shell 20 and a shell 40. The first casing 10 has a convex structure and is open at the bottom, the second casing 20 has an inverted convex structure and is open at the top, the bottom opening of the first casing 10 and the top opening of the second casing 20 are joined and form a receiving space, and the first casing 10 is partially overlapped with the side edge of the second casing 20. The shell 40 surrounds and covers the side surfaces of the first shell 10 and the second shell 20 to fixedly connect the first shell 10 and the second shell 20. The first shell, the second shell and the shell are made of polycarbonate materials.

The filter element 30 and the mesh plate 50 are arranged in the accommodating space formed by the first shell and the second shell, and the mesh plate 50 is positioned below the filter element 30 to support the filter element 30 to be not easy to break. The filter core 30 comprises a first filter membrane 31, a second filter membrane 32 and a third filter membrane 33, and the filter core 30 is formed according to the arrangement mode of the first filter membrane 31, the second filter membrane 32, the first filter membrane 31 and the third filter membrane 33 along the plasma flow direction, wherein the first filter membrane 31 is a DELP membrane with liposome and fibrinogen affinity adsorption functions; the second filtering membrane 32 is a 90SP deep filtering membrane for adsorbing inflammatory factors and free radicals; the third filtering membrane 33 is a 0.2 micron membrane for filtering out various particulate matters with a pore size larger than 0.2 micron. The filter core of the embodiment is overlapped according to the mode to form a filter for sequentially adsorbing and filtering fibrinogen, liposome, partial inflammatory factors and free radicals.

The first housing 10 is provided with a blood inlet 11 and an exhaust port 12, and in this embodiment, the diameter of the first housing 10 is 155mm, the distance between the blood inlet 11 and the exhaust port 12 is 24.5mm, and the diameters of the blood inlet 11 and the exhaust port 12 are both 3.5 mm. In this embodiment, the diameter of the second casing 20 is 161mm, the bottom surface of the second casing 20 opposite to the first casing 10 is provided with a bleeding port 21, and the bottom surface of the second casing 20 is inclined in a direction opposite to the first casing 10 by an angle of 2 °. The plasma enters the plasma lipid filter from the blood inlet 11, flows through the filter element 30, is drained from the inclined bottom surface and is discharged from the blood outlet 21.

The shell 40 has a first position-limiting portion 41 and a second position-limiting portion 42 disposed oppositely, the first position-limiting portion 41 presses against a part of the outer surface of the first housing 10, and the second position-limiting portion 42 presses against a part of the outer surface of the second housing 20. The side edge of the second housing 20 abuts against the lower surface of the first stopper 41.

As shown in fig. 2, which is a cross-sectional view of the first housing 10, the first housing is provided with a blood inlet 11 and an exhaust port 12, two ribs 13 are provided on the inner surface of the top surface of the first housing 10 at an interval of 30 ° with respect to the blood inlet 11 and the exhaust port 12, and the adjacent ribs 13 in the same radial direction have a certain interval.

As shown in fig. 3, which is a cross-sectional view of the second casing 20, a plurality of annular drainage grooves 22 are formed on the inner surface of the bottom surface of the second casing 20, the annular drainage grooves 22 are divergently arranged with respect to the blood outlet 21 to guide the filtered plasma into the blood outlet 21, and the heights of the annular drainage grooves 22 are on the same plane to support the mesh plate 50. A plurality of drainage channels 24 are arranged along the radial direction of the annular drainage groove 22, and the drainage channels 24 lead the liquid contained in the annular drainage groove 22 to the bleeding hole 21. The inner surface of the bottom surface of the second casing is provided with four protrusions 23 which are positioned on the periphery of the annular drainage groove 22 and are symmetrically distributed by taking the bleeding opening 21 as the center.

As shown in fig. 4, which is a schematic structural diagram of the screen 50, the screen 50 is provided with a mesh 52 and four positioning holes 51, the positioning holes 51 correspond to the positions of the protrusions 23 of the second housing 20, and the positioning holes 51 and the protrusions 23 are connected in a matching manner to fix the screen 50 to the second housing 20. The mesh plate 50 is made of polycarbonate material, and the diameter of the mesh plate 50 is 135mm, the diameter of the mesh 52 is 4.5mm, and the diameter of the positioning hole 51 is 2mm in this embodiment.

EXAMPLE II plasma filtration protocol

The plasma filtration procedure using the plasma lipid filter of this example was as follows:

1) the blood inlet and the exhaust port are respectively connected with a plasma bag pipeline and an air filtering exhaust pipe, and the blood outlet is connected with a blood plasma return pipeline;

2) the plasma is injected into the filtering device from the blood inlet;

3) the plasma is filtered by a first filtering membrane, a second filtering membrane, a first strand of filtering membrane and a third filtering membrane which are arranged in sequence, wherein the first filtering membrane 31 is a DELP membrane with liposome and fibrinogen affinity adsorption functions; the second filtering membrane 32 is a 90SP deep filtering membrane for adsorbing inflammatory factors and free radicals; the third filtering membrane 33 is a 0.2 micron membrane for filtering various granular substances with the aperture larger than 0.2 micron;

4) the filtered plasma is drained from the bleeding port through the bottom surface drainage of the second shell through the screen plate, and then the purpose of filtering blood is achieved.

The application provides a plasma lipid filter can filter the lipid composition in plasma, has reduced the adhesion of plasma in the filter bottom surface in filtering process, makes plasma change more and passes through the filter, and filters the difficult damage of core filter membrane, has promoted the filter effect.

The present application provides a plasma lipid filter, which is described in detail above, and the principles and embodiments of the present application are explained herein using specific examples, which are merely provided to help understand the method and the core concept of the present application; meanwhile, for those skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

Claims (11)

1. A plasma lipid filter comprising:

the blood purifier comprises a first shell, a second shell and a blood outlet, wherein the first shell is provided with a blood inlet; and

the second casing with first casing joint forms an accommodation space, the second casing on with the bottom surface that first casing is relative is equipped with the hemorrhage mouth, the bottom surface is the slope and sets up.

2. The plasma lipid filter of claim 1, wherein the receiving space has a filter element and a mesh plate disposed therein, the mesh plate being positioned below the filter element to support the filter element.

3. The plasma lipid filter according to claim 2, wherein the filter core comprises a first filter membrane, a second filter membrane and a third filter membrane, and the filter core is configured in an arrangement of the first filter membrane, the second filter membrane, the first filter membrane and the third filter membrane along the plasma flow direction, wherein the first filter membrane is a DELP membrane having liposome and fibrinogen affinity adsorption function, the second filter membrane is a 90SP deep layer filter membrane adsorbing inflammatory factors and free radicals, and the third filter membrane is a 0.2 micron membrane filtering various particulate matters with a pore size larger than 0.2 micron.

4. The plasma lipid filter of claim 1, further comprising a shell that surrounds the sides of the first shell and the second shell to fixedly connect the first shell to the second shell.

5. The plasma lipid filter of claim 1, wherein the first shell is of a convex configuration and is open at the bottom, the second shell is of an inverted convex configuration and is open at the top, the bottom opening of the first shell and the top opening of the second shell are joined and form the containment space, and the first shell overlaps the second shell side portions.

6. The plasma lipid filter of claim 4, wherein the shell has a first and a second opposing stop, the first stop bearing against the outer surface of the first housing portion and the second stop bearing against the outer surface of the second housing portion.

7. The plasma lipid filter of claim 6, wherein the side of the second shell is pressed upward against the lower surface of the first retainer.

8. The plasma lipid filter of claim 2, wherein the inner surface of the bottom surface of the second casing is provided with a plurality of annular drainage grooves, the annular drainage grooves are divergently arranged with the bleeding opening as the center to introduce the filtered plasma into the bleeding opening, and the heights of the annular drainage grooves are on the same plane to support the mesh plate.

9. The plasma lipid filter of claim 8, wherein a plurality of drainage channels are provided along the radial direction of the annular drainage groove, and the drainage channels guide the liquid contained in the annular drainage groove to the bleeding port.

10. The plasma lipid filter according to claim 8, wherein the inner surface of the bottom surface of the second casing is provided with at least two protrusions which are located at the periphery of the annular drainage groove and symmetrically distributed around the bleeding opening; the screen plate is provided with a positioning hole, the positioning hole corresponds to the position of the boss of the second shell, and the positioning hole is matched and connected with the boss so as to fix the screen plate on the second shell.

11. The plasma lipid filter of claim 1, wherein the first housing is further provided with a vent.

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