CN1594266A - Method for recovering 2-keto-L-gluconic acid from gluconic acid crystallization mother liquor - Google Patents
Method for recovering 2-keto-L-gluconic acid from gluconic acid crystallization mother liquor Download PDFInfo
- Publication number
- CN1594266A CN1594266A CN 200410041060 CN200410041060A CN1594266A CN 1594266 A CN1594266 A CN 1594266A CN 200410041060 CN200410041060 CN 200410041060 CN 200410041060 A CN200410041060 A CN 200410041060A CN 1594266 A CN1594266 A CN 1594266A
- Authority
- CN
- China
- Prior art keywords
- ancient
- ketone group
- acid
- mother liquor
- imperial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012452 mother liquor Substances 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000002425 crystallisation Methods 0.000 title claims abstract description 12
- 230000008025 crystallization Effects 0.000 title claims abstract description 11
- VBUYCZFBVCCYFD-YVZJFKFKSA-N 2-dehydro-L-gluconic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-YVZJFKFKSA-N 0.000 title abstract 4
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 title abstract 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 title abstract 2
- 235000012208 gluconic acid Nutrition 0.000 title abstract 2
- 239000000174 gluconic acid Substances 0.000 title abstract 2
- 238000000909 electrodialysis Methods 0.000 claims abstract description 19
- 238000005341 cation exchange Methods 0.000 claims abstract description 4
- 239000002253 acid Substances 0.000 claims description 48
- 239000013078 crystal Substances 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 239000000049 pigment Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- 239000010413 mother solution Substances 0.000 claims description 5
- 238000002203 pretreatment Methods 0.000 claims description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017550 sodium carbonate Nutrition 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 3
- 239000012670 alkaline solution Substances 0.000 claims description 3
- 239000013505 freshwater Substances 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000005204 segregation Methods 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000003456 ion exchange resin Substances 0.000 description 3
- 229920003303 ion-exchange polymer Polymers 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- -1 albumen Substances 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000012262 fermentative production Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 235000012204 lemonade/lime carbonate Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000088 plastic resin Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410041060 CN1273436C (en) | 2004-06-23 | 2004-06-23 | Method for recovering 2-keto-L-gluconic acid from gluconic acid crystallization mother liquor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410041060 CN1273436C (en) | 2004-06-23 | 2004-06-23 | Method for recovering 2-keto-L-gluconic acid from gluconic acid crystallization mother liquor |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1594266A true CN1594266A (en) | 2005-03-16 |
CN1273436C CN1273436C (en) | 2006-09-06 |
Family
ID=34664864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410041060 Expired - Lifetime CN1273436C (en) | 2004-06-23 | 2004-06-23 | Method for recovering 2-keto-L-gluconic acid from gluconic acid crystallization mother liquor |
Country Status (1)
Country | Link |
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CN (1) | CN1273436C (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101717133B (en) * | 2009-12-14 | 2012-11-21 | 安徽丰原发酵技术工程研究有限公司 | Method for removing pigment in gulonic acid mother solution |
CN101704737B (en) * | 2009-10-10 | 2013-01-30 | 安徽丰原发酵技术工程研究有限公司 | Method for separating gulonic acid from gulonic acid crystallization mother liquor by adopting ion exchange and bipolar electrodialysis membrane stack |
CN104892693A (en) * | 2015-06-01 | 2015-09-09 | 南京鼎仕和膜科技有限公司 | Method for recovering 2-one-L-gulonic acid from gulonic acid crystal mother solution |
CN105777533A (en) * | 2014-12-15 | 2016-07-20 | 宁夏启元药业有限公司 | Method for recovering gulonic acid from gulonic acid mother liquor |
CN108774125A (en) * | 2018-05-28 | 2018-11-09 | 苏州澄江环境科技有限公司 | A kind of technique recycling raw material from gulonic acid mother solution |
CN111592455A (en) * | 2019-02-21 | 2020-08-28 | 上海凯赛生物技术股份有限公司 | Decoloring method of mixed long-chain dibasic acid and mixed long-chain dibasic acid |
CN112028766A (en) * | 2020-09-08 | 2020-12-04 | 山东鲁维制药有限公司 | Process for refining gulonic acid |
-
2004
- 2004-06-23 CN CN 200410041060 patent/CN1273436C/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101704737B (en) * | 2009-10-10 | 2013-01-30 | 安徽丰原发酵技术工程研究有限公司 | Method for separating gulonic acid from gulonic acid crystallization mother liquor by adopting ion exchange and bipolar electrodialysis membrane stack |
CN101717133B (en) * | 2009-12-14 | 2012-11-21 | 安徽丰原发酵技术工程研究有限公司 | Method for removing pigment in gulonic acid mother solution |
CN105777533A (en) * | 2014-12-15 | 2016-07-20 | 宁夏启元药业有限公司 | Method for recovering gulonic acid from gulonic acid mother liquor |
CN104892693A (en) * | 2015-06-01 | 2015-09-09 | 南京鼎仕和膜科技有限公司 | Method for recovering 2-one-L-gulonic acid from gulonic acid crystal mother solution |
CN108774125A (en) * | 2018-05-28 | 2018-11-09 | 苏州澄江环境科技有限公司 | A kind of technique recycling raw material from gulonic acid mother solution |
CN111592455A (en) * | 2019-02-21 | 2020-08-28 | 上海凯赛生物技术股份有限公司 | Decoloring method of mixed long-chain dibasic acid and mixed long-chain dibasic acid |
CN112028766A (en) * | 2020-09-08 | 2020-12-04 | 山东鲁维制药有限公司 | Process for refining gulonic acid |
Also Published As
Publication number | Publication date |
---|---|
CN1273436C (en) | 2006-09-06 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU JIANGSHAN PHARMACEUTICAL CO. Free format text: FORMER OWNER: XU CHANGHONG Effective date: 20090724 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090724 Address after: 66, Jiangshan Road, Jingjiang, Jiangsu Province, China: 214500 Patentee after: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) Co.,Ltd. Address before: 1206, Huafu building, 31 Fujian Road, Nanjing, Jiangsu, zip code: 210003 Co-patentee before: Kong Tai Patentee before: Xu Changhong |
|
C56 | Change in the name or address of the patentee |
Owner name: ALAND (JIANGSU) NUTRACEUTICAL CO., LTD. Free format text: FORMER NAME: JIANGSHAN PHARMACEUTICAL CO., LTD., JIANGSU PROV. |
|
CP03 | Change of name, title or address |
Address after: 214500, 61 Jiangshan Road, Taizhou, Jiangsu, Jingjiang Patentee after: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO.,LTD. Address before: 214500, Jiangshan Road, Jiangsu, Jingjiang 66 Patentee before: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) Co.,Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20060906 |
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CX01 | Expiry of patent term |