CN1589844A - Cerebrum nurishment intensification prescription - Google Patents
Cerebrum nurishment intensification prescription Download PDFInfo
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- CN1589844A CN1589844A CN 03150542 CN03150542A CN1589844A CN 1589844 A CN1589844 A CN 1589844A CN 03150542 CN03150542 CN 03150542 CN 03150542 A CN03150542 A CN 03150542A CN 1589844 A CN1589844 A CN 1589844A
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- ginkgo biloba
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Abstract
A medicine for nourishing brain, intensifying the activity of cerebral cells, and delaying the senility of cerebral cells is prepared from the liquid extract of ginkgo leaf, L-acetylcarnitine and creatine.
Description
The present invention relates to a kind of brain nutrition and strengthen prescription, its function helps to strengthen brain cell activity, promotes the rehabilitation of brain cell, delays the brain cell aging.
The nerve information transitive dependency of sound neural network structure and agility is in heredity, nutrition and education.The foundation that isostatic brain cell nutritional support is a neutral net and the transmission of nerve information provide material base and the power support, and escort for the synthetic of the structure of neutral net and neurotransmitter, help to strengthen brain cell activity, promote the rehabilitation of brain cell, delay the brain cell aging.
Brain function and brain cell membrane: brain cell memory is the process that neuron dendron and aixs cylinder are set up synaptic contact and transmission mediator with the process of thinking activities, and it is that brain cell membrane extends and sets up neutral net that neuron dendron and aixs cylinder are set up synaptic contact.The main component of brain cell membrane is a phospholipid.Phosphatidylcholine and Phosphatidylserine constitute brain cell membrane phospholipid 80%.The brain cell membrane fatty acids in phospholipids mainly is the long-chain polyunsaturated fatty acids, comprise with the linoleic acid being the n-6 series (arachidonic acid of raw material, Arachidonic, AA) with alpha-linolenic acid (α-Linolenic, ALA) be the n-3 series (docosahexenoic acid of raw material, Docosahexanoic, DHA).Infant and Childhood, the extension of neuron dendron and aixs cylinder and the foundation of synaptic contact all need exogenous additional phosphatidylcholine, Phosphatidylserine, linoleic acid and alpha-linolenic acid, for brain development is supplied raw materials.
Brain function and neurotransmitter: brain cell is to transmit chemical substance (neurotransmitter) between mat work neurocyte to communicate with each other, and wherein most important neurotransmitter is acetylcholine (Acetyl-Choline).The process of brain cell memory, thinking activities is that neurotransmitter transmits between brain cell and metabolic process; Acetylcholine is a topmost neurotransmitter in brain cell operation memory and the thinking activities process.It is to be raw material and to be power with the energy with choline (Choline) and acetyl-CoA that acetylcholine transmits between brain cell with metabolic process.Acetyl-CoA is mainly derived from the oxidation of acyl CoA in the mitochondrion in the brain cell, but acyl CoA must be carried just by the L-acetylcarnitine and can enter mitochondrion.
Brain function and mitochondrion: the brain cell memory is to be power with the energy with the process of thinking activities.Mitochondrion is the synthetic processing factory of cellular energy, and creatine is the raw material of the synthetic shortcut of ATP in the brain cell mitochondrion.A large amount of superoxide radicals that mitochondrion produces in the energy building-up process are main causes of variation of neurocyte degeneration and apoptosis, are the main mechanism that alzheimer disease and parkinsonism take place.The L-acetylcarnitine is the most effective free radical scavenger in the mitochondrion.Folium Ginkgo terpene lactones is platelet activating factor (PAF) antagonist in the ginkgo biloba succi, helps to improve the cerebral blood flow circulation, strengthens brain cell activity.Ginkgo flavonoid glycoside and Folium Ginkgo terpene lactones M-J are effective anti-oxidants and free radical scavengers in the natural plant extracts in the ginkgo biloba succi; can significantly alleviate the neurocyte degeneration changes and apoptosis; the protection brain cell promotes the brain cell rehabilitation, delays the brain cell aging.
The domestic prescription that is used for brain nutrition mainly contains following a few class at present: A--melatonin (based on melatonin, add multiple vitamin, major function is to improve sleep); B--clever (based on the a-linolenic acid, major function is an essential fatty acid in the added body, supplies raw materials for DHA is synthetic, helps child's brain development) difficult to understand; C--Jin Sili (phosphatidylcholine/a-linolenic acid=1/1, major function are choline and essential fatty acid in the added body, supply raw materials for cell membrane phospholipid is synthetic, help child's brain development); D--never forgets (with the bathypelagic fish oil is raw material, includes DPA/EPA/DHA, and major function is to replenish essential fatty acid, supplies raw materials for brain cell membrane phospholipid is synthetic, helps child's brain development); The E--brain is (with lecithin is raw material, adds multiple vitamin, supplies raw materials for cell membrane phospholipid is synthetic, helps child's brain development) easily.The main health care of product A is to improve sleep.The main health care of product B-E is to strengthen brain cell activity, but B-E only provides part material for brain cell membrane phospholipid is synthetic, one side raw material supply imbalance, Gong Ying raw material (because energy and power deficiency) can not synthesize brain cell membrane phospholipid effectively on the other hand.
This prescription is compared with other brain nutrient formulations, has strengthened the effectiveness of the balance and the raw material metabolic conversion of raw material supply.This prescription mates (phospholipid complexes--phosphatidylcholine/Phosphatidylserine=2/1 with the essential raw material of cerebral metabolism in brain cell metabolic demand ratio; Essential fatty acid--linoleic acid/a-linolenic acid=5/1), and providing power by strengthening the energy support for brain cell membrane phospholipid anabolism, is that brain cell membrane phospholipid anabolism escorts by strengthening anti-oxidation protection.Isostatic raw material replenishes, the energy support has improved the metabolic efficient of brain cell with anti-oxidation protection, helps to strengthen brain cell activity, and the rehabilitation of promotion brain cell delays the brain cell aging.
The present invention strengthens brain nutrition by the following method: a kind of brain nutrition strengthens prescription, it is characterized in that by phospholipid complexes and essential fatty acid formation base prescription, adds that the enhancing prescription that is made of ginkgo biloba succi, L-acetylcarnitine and creatine forms.Basic components (adult's dosage every day, the child reduces by half) contains phospholipid complex 300mg and essential fatty acid 3000mg; Phospholipid complexes is made up of in the ratio of 2/1 (parts by weight) phosphatidylcholine and Phosphatidylserine, and essential fatty acid is made up of in the ratio of 5/1 (parts by weight) linoleic acid and alpha-linolenic acid.Strengthen prescription (adult's dosage every day, the child reduces by half) and contain Folium Ginkgo extracting solution 60mg, L-acetylcarnitine 300mg and creatine 3000mg.This prescription mates the essential raw material of cerebral metabolism in brain cell metabolic demand ratio, and provides power by strengthening the energy support for the brain cell metabolism, escorts for the brain cell metabolism by strengthening anti-oxidation protection.Isostatic raw material replenishes, the energy support has improved the metabolic efficient of brain cell with anti-oxidation protection, helps to strengthen brain cell activity, and the rehabilitation of promotion brain cell delays the brain cell aging.
Phosphatidylcholine and Phosphatidylserine are the main components that constitutes brain cell membrane phospholipid, and phosphatidylcholine/Phosphatidylserine=2/1 helps the synthetic and distribution of phospholipid at brain cell membrane.Experimentation shows in this formula development process: the C57 mice feed (per 10 grams) of giving birth to 4 weeks of back contains that PC/PS=20mg/10mg (A group) feedstuff * after 3 weeks, the labyrinth deadline of mice is significantly organized (feed PS=30mg * 3 weeks) faster than B group (feed PC=30mg * 3 weeks) with C; And neurite and synapse connect significantly more than B group and C group in the A group mouse brain tissue.
Linoleic acid and alpha-linolenic acid are the synthesis materials of long-chain polyunsaturated fatty acids in the brain cell membrane fat, and linoleic acid/a-linolenic acid=5/1 helps keeping the optimal proportion of AA/DHA in the brain cell membrane fat.Clinical studies show in this formula development process: the neonate of giving birth to 4 weeks of back is fed formulas (per 100 grams) and is contained that LA/ALA=2500mg/500mg (A group) * after 8 weeks, baby's motor behavior developmental level (MDI/PDI) is significantly higher than B group (feed formulas and contain LA=2500mg * 8 weeks) and C group (hello formulas contains ALA=500mg * 8 weeks); And the content of DHA is the highest in the A group baby red blood cell membrane lipids.
Acetylcholine is a topmost neurotransmitter in brain cell operation memory and the thinking activities process; the L-acetylcarnitine can promote acyl CoA to enter the mitochondrion oxidation; supply raw materials for acetylcholine is synthetic, and remove the free radical that oxidation produces in the mitochondrion, neuroprotective unit.Experimentation shows in this formula development process: the C57 mice feed (per 10 grams) of giving birth to 4 weeks of back contains L-acetylcarnitine 30mg (A group) after feedstuff X3 week, the labyrinth deadline of mice is significantly faster than B group (feed does not contain the feedstuff of L-acetylcarnitine), and the acetyl choline content work is higher than the B group in the A group mouse brain tissue.
ATP is the brain cell operation memory and the thinking activities process medium power energy, and creatine is the raw material of the synthetic shortcut of ATP in the brain cell mitochondrion.Experimentation shows in this formula development process: the C57 mice feed (per 10 grams) of giving birth to 4 weeks of back contains creatine 300mg (A group) feedstuff * after 3 weeks, the labyrinth deadline of mice is significantly faster than B group (feed does not contain the feedstuff of creatine), and ATP content work is higher than the B group in the A group mouse brain tissue.Experimentation shows in this formula development process: after giving birth to the C57 anoxia in mice ischemic brain injury in 4 weeks of back, feed (per 10 gram) contains creatine 300mg (A group) feedstuff * after 3 weeks, the survival rate of mice is significantly higher than B group (feed does not contain the feedstuff of creatine), and the apoptosis brain cell significantly is less than the B group in the A group mouse brain tissue.
This prescription has added the physiological dose ginkgo biloba succi.Folium Ginkgo terpene lactones A-C is platelet activating factor (PAF) antagonist in the ginkgo biloba succi, helps to improve the cerebral blood flow circulation, strengthens brain cell activity.Ginkgo flavonoid glycoside and Folium Ginkgo terpene lactones M-J are effective anti-oxidants and free radical scavengers in the natural plant extracts in the ginkgo biloba succi; can significantly alleviate the neurocyte degeneration changes and apoptosis; the protection brain cell promotes the brain cell rehabilitation, delays the brain cell aging.Experimentation shows in this formula development process: the C57 mice feed (per 10 grams) of giving birth to 4 weeks of back contains that Folium Ginkgo extracting solution 6mg (A group) feedstuff * after 3 weeks, the labyrinth deadline of mice is significantly organized (feed does not contain the feedstuff of Folium Ginkgo extracting solution) faster than B.Experimentation shows in this formula development process: after giving birth to the C57 anoxia in mice ischemic brain injury in 4 weeks of back, feed (per 10 gram) contains Folium Ginkgo extracting solution 6mg (A group) feedstuff * after 3 weeks, the survival rate of mice is significantly higher than B group (feed does not contain the feedstuff of Folium Ginkgo extracting solution), and the apoptosis brain cell significantly is less than the B group in the A group mouse brain tissue.Clinical studies show in this formula development process: give veteran form dementia patients ginkgo biloba succi 60mg/ day (A group) * June, patient's memory function of 18% is improved, and is significantly higher than B group (not giving ginkgo biloba succi).
By phospholipid complexes and essential fatty acid formation base prescription, add that the enhancing prescription that is made of ginkgo biloba succi, L-acetylcarnitine and creatine forms.Clinical studies show in the development process: neonate birth back adopts same recipe milk to feed, A group is added 1 bag/day of full formula (1. every bag contain 2. 3. 4. 5. creatine 1500mg of essential fatty acid 1500mg of phospholipid complexes 150mg of L-acetylcarnitine 150mg of ginkgo biloba succi 30mg), B group is added basic components (every bag contains phospholipid complex 150mg and essential fatty acid 1500mg) 1 bag/day, after feeding June, A group baby Bayler mental development index MDI is higher than B group 16%, and Motor development indices P DI is higher than B group 12%.Clinical studies show in the development process: the veteran form dementia patients, the A group gives 4 bags/day of full formulas, and the B group gives 4 bags/day of basic components, and after June, patient's memory function of A group 30% is improved, and is significantly higher than B group (6%).
The present invention is further described in conjunction with the embodiments: a kind of brain nutrition strengthens prescription, it is characterized in that by phospholipid complexes and essential fatty acid formation base prescription, adds that the enhancing prescription that is made of ginkgo biloba succi, L-acetylcarnitine and creatine forms.Basic components (adult's dosage every day, the child reduces by half) contain phospholipid complex 300mg and essential fatty acid 3000mg, phospholipid complexes is made up of in the ratio of 2/1 (parts by weight) phosphatidylcholine and Phosphatidylserine, and essential fatty acid is made up of in the ratio of 5/1 (parts by weight) linoleic acid and alpha-linolenic acid.Strengthen prescription (adult's dosage every day, the child reduces by half) and contain Folium Ginkgo extracting solution 60mg, L-acetylcarnitine 300mg and creatine 3000mg.Production technology is identical with the babies ' formula milk powder production technology, adopts the homogenate of dissolving raw material, and spray drying forms powder-product, aseptic aluminum bag packing.1. every bag contain 2. 3. 4. 5. creatine 1500mg of essential fatty acid 1500mg (linoleic acid/a-linolenic acid=5/1) of phospholipid complexes 150mg (phosphatidylcholine/Phosphatidylserine=2/1) of L-acetylcarnitine 150mg of ginkgo biloba succi 30mg (ginkgo flavonoid glycoside 24%, Folium Ginkgo terpene lactones 6%).Adult 2 bags of every days, 1 bag of child every day.
Claims (6)
1. a brain nutrition strengthens prescription, it is characterized in that by phospholipid complexes and essential fatty acid formation base prescription, add by ginkgo biloba succi (Ginkgo Biloba Extract, GBE), the enhancing prescription that constitutes of L-acetylcarnitine (L-Acetyl-Carnitine) and creatine (Creatine) forms; Its function helps to strengthen brain cell activity, promotes the brain cell rehabilitation, delays the brain cell aging.
The described phospholipid complexes of claim 1 by phosphatidylcholine (Phosphatidyl-Choline, PC) and Phosphatidylserine (Phosphatidyl-Serine PS) forms in the ratio of 1 ~ 5/1 (parts by weight).
The described essential fatty acid of claim 1 by linoleic acid (Linoleic, LA) and alpha-linolenic acid (α-Linolenic ALA) forms in the ratio of 2 ~ 20/1 (parts by weight).
4. the described ginkgo biloba succi of claim 1 (Ginkgo Biloba Extract, GBE) contain ginkgo flavonoid glycoside (Flavone Glycosides) 24% and Folium Ginkgo terpene lactones (Terpene Lactones) 6%, ginkgo biloba succi 20 ~ 200mg (adult's dosage every day, the child reduces by half) is the safe and effective dosage that strengthens brain nutrition.
5. the described L-acetylcarnitine of claim 1 (L-Acetyl-Carnitine) 100 ~ 1000mg (adult's dosage every day, the child reduces by half) is the safe and effective dosage that strengthens brain nutrition.
6. the described creatine of claim 1 (Creatine) 500 ~ 5000mg (adult's dosage every day, the child reduces by half) is the safe and effective dosage that strengthens brain nutrition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031505422A CN1308007C (en) | 2003-08-26 | 2003-08-26 | Cerebrum nurishment intensification prescription |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031505422A CN1308007C (en) | 2003-08-26 | 2003-08-26 | Cerebrum nurishment intensification prescription |
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| Publication Number | Publication Date |
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| CN1589844A true CN1589844A (en) | 2005-03-09 |
| CN1308007C CN1308007C (en) | 2007-04-04 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007030495A1 (en) | 2007-06-30 | 2009-01-15 | Alzchem Trostberg Gmbh | Use of creatine containing preparation e.g. for improving memory, retentivity, long-term memory and for preventing mental fatigue condition, comprising e.g. Ginkgo biloba, ginseng and niacin |
| CN102695428A (en) * | 2010-01-06 | 2012-09-26 | 雀巢产品技术援助有限公司 | Dietary regimens useful for mimicking caloric restriction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1221266C (en) * | 2001-11-22 | 2005-10-05 | 中国科学院地理科学与资源研究所 | Compound prepn containing alpha-linolic acid, lecithin and ginkgetin |
| CN1459253A (en) * | 2002-05-22 | 2003-12-03 | 殷惠军 | Drink with functions of being beneficial to intelligence and taking care of liver and preparing process |
-
2003
- 2003-08-26 CN CNB031505422A patent/CN1308007C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007030495A1 (en) | 2007-06-30 | 2009-01-15 | Alzchem Trostberg Gmbh | Use of creatine containing preparation e.g. for improving memory, retentivity, long-term memory and for preventing mental fatigue condition, comprising e.g. Ginkgo biloba, ginseng and niacin |
| CN102695428A (en) * | 2010-01-06 | 2012-09-26 | 雀巢产品技术援助有限公司 | Dietary regimens useful for mimicking caloric restriction |
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| Publication number | Publication date |
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| CN1308007C (en) | 2007-04-04 |
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