CN1583210A - Multicomponent split reacting separator and method thereof - Google Patents
Multicomponent split reacting separator and method thereof Download PDFInfo
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- CN1583210A CN1583210A CN 200410024964 CN200410024964A CN1583210A CN 1583210 A CN1583210 A CN 1583210A CN 200410024964 CN200410024964 CN 200410024964 CN 200410024964 A CN200410024964 A CN 200410024964A CN 1583210 A CN1583210 A CN 1583210A
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- 238000000034 method Methods 0.000 title abstract description 9
- 238000000926 separation method Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000006243 chemical reaction Methods 0.000 claims description 16
- 239000003480 eluent Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 230000001351 cycling effect Effects 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 210000003022 colostrum Anatomy 0.000 description 3
- 235000021277 colostrum Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 238000007445 Chromatographic isolation Methods 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000011017 operating method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000004885 white matter Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
A multi-component split-flow reaction-separation apparatus and its method are disclosed. Its main body is composed of two or more same units. Each unit has two or more pairs of pipelines for the entrance and exit of material. Each pair of pipelines has a switch-type autocontrol valve for switching between two pipelines.
Description
Technical field
The present invention relates to a kind of multi-flow reaction-separation device and its method.
Background technology
In the prior art, the continuous separation unit that attracts attention is simulation moving-bed, and Chinese patent CN1116088C, CN1087640C, CN1176838A and CN1374146A etc. all have a detailed description.In the operating procedure of these devices, logistics is the cross-flow form.Promptly both existed the hoop between the tandem chromatographic column to flow, exist some through type or deflector type to flow again, turnover along with logistics, each chromatogram intercolumniation flow velocity, flow direction change are frequently, separate back-mixing takes place in the bed easily, and have the cumulative bad cross pollution, and then influence the purity that product separates, reduce technology stability.For the not too complicated technical process of some logistics conditions, as isomer separation, supercritical extract etc., simulation moving-bed isolation technics has stronger applicability.Particularly, present simulation moving-bed isolation technics mainly is applicable to two component Reaction Separation technologies.But, for prosperous day by day fields such as biochemical industry, medicine separation, ocean and deep processing of farm products, often must relate to the complicated more process of logistics state, require to carry out many components integrated reacting and separate.And an urgent demand device simplification on the one hand of this type of production technology, miniaturization, low cost and integrated are on the other hand to higher technological requirements of proposition such as the purity of product, operational stabilities.Therefore, by the restriction that " cross-flow " pattern is brought, just seem particularly outstanding.
Summary of the invention
The purpose of this invention is to provide a kind of multi-flow reaction-separation device and its method.
Polynary shunting reaction separating device: material liquid storage tank M, flow control valve KM, constant flow pump PM and internally piloted valve M1, M2, after the Mn serial connection, respectively with unit X1, X2, the feed passageway of Xn connects, eluent loop D1, D2, Di and internally piloted valve D11, D12, after the Din serial connection, respectively with unit X1, X2, the wash-out path of Xn connects, raffinate storage tank B, detector channel C B and internally piloted valve B1, B2, after the Bn serial connection, respectively with unit X1, X2, the raffinate path of Xn connects, final products loop A1, A2, Ai is by detector channel C A1, CA2, CAi and internally piloted valve A11, A12, after the Ain serial connection, respectively with unit X1, X2, the extraction path of Xn connects.
Use the separation method of above-mentioned polynary shunting reaction separating device: in a flash in office, in each unit, only allowing a pair of logistics pipeline opens, by the given period, the logistics pipeline switches once synchronously, the pipeline of newly opening after the switching advances a unit to same direction, carries out cycling again and again, realizes that the continuous integrated reacting of many components separates.
Advantage of the present invention:
1) device is more succinct, does not have circulation pipeline and the circulatory system and equipment between complicated unit, is easy to the miniaturization, integrated and integrated of implement device;
2) operating procedure is more succinct orderly, and shunt mode helps controlling rate of flow of fluid, and low cost movement is easy to apply in medium and small enterprise;
3) system is more reliable and more stable, helps improving product purity, is more suitable for can realizing that in liquid stream comparatively complicated Reaction Separation system and biochemical process many components integrated reacting separates.
Description of drawings
Fig. 1 is polynary many components of shunting reaction separating device structural representation;
Fig. 2 is ternary shunting, dual flow path two component reaction separating device structural representations;
Fig. 3 is hexa-atomic shunting, four streams, four component reaction separating device structural representations.
The specific embodiment
As shown in Figure 1, polynary shunting reaction separating device: material liquid storage tank M, flow control valve KM, constant flow pump PM and internally piloted valve M1, M2, after the Mn serial connection, respectively with unit X1, X2, the feed passageway of Xn connects, eluent loop D1, D2, Di and internally piloted valve D11, D12, after the Din serial connection, respectively with unit X1, X2, the wash-out path of Xn connects, raffinate storage tank B, detector channel C B and internally piloted valve B1, B2, after the Bn serial connection, respectively with unit X1, X2, the raffinate path of Xn connects, final products loop A1, A2, Ai is by detector channel C A1, CA2, CAi and internally piloted valve A11, A12, after the Ain serial connection, respectively with unit X1, X2, the extraction path of Xn connects.
Polynary shunting reaction separation method: main body is made up of the unit that two or two above structures, function and configurations are equal to, each unit has logistics import and export pipeline more than two pairs or two pairs, and be equipped with switching automatic control valve respectively, in a flash in office, in each unit, only allowing a pair of logistics pipeline opens, by the given period, the logistics pipeline switches once synchronously, the pipeline of newly opening after the switching advances a unit to same direction, carry out cycling again and again, realize that the continuous integrated reacting of many components separates.
Embodiment 1
The edible eggs white matter of from colostrum, separating biologically active
Colostrum with after the pure water dilution, is passed through from the chromatography column of certain filler particles of filling.The object molecular energy is adsorbed by filler particles and is stranded in the chromatography column bed, and the non-object molecule that molecular weight is bigger can not adsorb and be expelled in the raffinate feeder in company with diluent.To the chromatography column absorption saturated after, make eluant, eluent with certain density NaCl solution again, target substance is eluted in the extract storage tank, pass through post processing again, the acquisition final products.
Adopt ternary shunting shown in Figure 2, dual flow path two component chromatographic separation devices.At first, under manual state of a control, it is saturated to make three chromatographic isolation unit all reach absorption, enters the automation production that circulates continuously then.If the time period of automaticallying switch is Δ t, list the control instruction such as the following table of an operation cycle:
| Sequence number | The instruction name | Issue an order constantly | The Controlled valve name | State | Period when holding | The chromatography column operating mode | ||
| 1 | 2 | 3 | ||||||
| ??1 | ????t 1 | ????0 | D1，A1 | Open | ????Δt | Wash-out | Absorption | Absorption |
| M3，B3 | Open | ????2Δt | ||||||
| ??2 | ????t 2 | ????Δt | D2，A2 | Open | ????Δt | Absorption | Wash-out | Absorption |
| M1，B1 | Open | ????2Δt | ||||||
| ??3 | ????t 3 | ????2Δt | D3，A3 | Open | ????Δt | Absorption | Absorption | Wash-out |
| M2，B2 | Open | ????2Δt | ||||||
" chromatography column operating mode " opened sequence by selected logistics and determined that adsorption rate is slower than wash-out in this example in the last table, thereby need open the double time period.
The edible eggs white matter new technology of from colostrum, separating multiple biologically active
The main distinction of new technology and embodiment 1 is: three wash-outs of NaCl solution of employing variable concentrations replace the single wash-out in the example 1, thereby can obtain three kinds of products, realize the integrated separation of four components.
Adopt as shown in Figure 3 hexa-atomic shunting, four streams, four component chromatographic separation devices.At first, under manual state of a control, it is saturated to make six chromatographic isolation unit all reach absorption, enters the automation production that circulates continuously then.If the time period of automaticallying switch is Δ t, list the control instruction such as the following table of an operation cycle:
| Sequence number | The instruction name | Issue an order constantly | The Controlled valve name | State | Carry out the period |
| ????1 | ????t 1 | ??Δt | ?D11，D22，D33，A11，A22，A33 | Open | ????Δt |
| ?M6，B6 | Open | ????3Δt |
| ????2 | ????t 2 | ??2Δt | ?D12，D23，D34，A12，A23，A34 | Open | ????Δt |
| ?M1，B1 | Open | ????3Δt | |||
| ????3 | ????t 3 | ??3Δt | ?D13，D24，D35，A13，A24，A35 | Open | ????Δt |
| ?M2，B2 | Open | ????3Δt | |||
| ????4 | ????t 4 | ??4Δt | ?D14，D25，D36，A14，A25，A36 | Open | ????Δt |
| ?M3，B3 | Open | ????3Δt | |||
| ????5 | ????t 5 | ??5Δt | ?D15，D26，D31，A15，A26，A31 | Open | ????Δt |
| ?M4，B4 | Open | ????3Δt | |||
| ????6 | ????t 6 | ??6Δt | ?D16，D21，D32，A16，A21，A32 | Open | ????Δt |
| ?M5，B5 | Open | ????3Δt |
From the contrast of above two embodiment as can be seen, suitably increasing the number of unit in the reaction separating device, help satisfying the needs of the different process sequence of operation, is only but get three to ten unit; Suitably increasing the logistics path logarithm in the unit, can be applicable to the demand of working procedures and product, is only but get two to four flow path; The present invention can realize that the integrated reacting of many components separates, and is only but get two to five kinds.
Claims (8)
1, a kind of polynary shunting reaction separating device, it is characterized in that: material liquid storage tank M, flow control valve KM, constant flow pump PM and internally piloted valve M1, M2, after the Mn serial connection, respectively with unit X1, X2, the feed passageway of Xn connects, eluent loop D1, D2, Di and internally piloted valve D11, D12, after the Din serial connection, respectively with unit X1, X2, the wash-out path of Xn connects, raffinate storage tank B, detector channel C B and internally piloted valve B1, B2, after the Bn serial connection, respectively with unit X1, X2, the raffinate path of Xn connects, final products loop A1, A2, Ai is by detector channel C A1, CA2, CAi and internally piloted valve A11, A12, after the Ain serial connection, respectively with unit X1, X2, the extraction path of Xn connects.
2, a kind of polynary shunting reaction separating device according to claim 1, it is characterized in that: said unit is: isometrical, contour, have splitter, tower or the reactor of quality inserts such as of the same race.
3, a kind of polynary shunting reaction separating device according to claim 1, it is characterized in that: said unit: be not only to have had the reactor function, but also have the separation function unit, perhaps have reactor functional unit equipment, perhaps have the separation function unit.
4, a kind of polynary shunting reaction separating device according to claim 1, it is characterized in that: said n is 3～10, i is 2～5.
5, a kind of polynary shunting reaction separating device according to claim 1, it is characterized in that: said pipe path is 2～4 pairs.
6, a kind of application rights requires the separation method of 1 described polynary shunting reaction separating device, it is characterized in that: in a flash in office, in each unit, only allowing a pair of logistics pipeline opens, by the given period, the logistics pipeline switches once synchronously, and the pipeline of newly opening after the switching advances a unit to same direction, carry out cycling again and again, realize that the continuous integrated reacting of many components separates.
7, separation method according to claim 6 is characterized in that: said structure and the unit that is equal to of configuration are: isometrical, contour, have splitter, tower or the reactor of quality inserts such as of the same race.
8, separation method according to claim 6, it is characterized in that: the unit of said functional equivalent: be not only to have had the reactor function, but also have the unit of separation function, or unit, or has the unit of separation function with reactor function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024964 CN1267177C (en) | 2004-06-04 | 2004-06-04 | Multicomponent split reacting separator and method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024964 CN1267177C (en) | 2004-06-04 | 2004-06-04 | Multicomponent split reacting separator and method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1583210A true CN1583210A (en) | 2005-02-23 |
| CN1267177C CN1267177C (en) | 2006-08-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410024964 Expired - Fee Related CN1267177C (en) | 2004-06-04 | 2004-06-04 | Multicomponent split reacting separator and method thereof |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455603C (en) * | 2005-04-30 | 2009-01-28 | 浙江大学 | Integrated reaction separation device for preparing chitin |
| CN102168282A (en) * | 2011-02-23 | 2011-08-31 | 浙江大学 | Integrated reaction-separation method and device for preparing mannitol |
| CN102816875A (en) * | 2012-09-13 | 2012-12-12 | 浙江华康药业股份有限公司 | Region selective control method and device for separating and preparing fructose glucose syrup by integrated reaction |
-
2004
- 2004-06-04 CN CN 200410024964 patent/CN1267177C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455603C (en) * | 2005-04-30 | 2009-01-28 | 浙江大学 | Integrated reaction separation device for preparing chitin |
| CN102168282A (en) * | 2011-02-23 | 2011-08-31 | 浙江大学 | Integrated reaction-separation method and device for preparing mannitol |
| CN102168282B (en) * | 2011-02-23 | 2013-02-13 | 浙江大学 | Integrated reaction-separation method and device for preparing mannitol |
| CN102816875A (en) * | 2012-09-13 | 2012-12-12 | 浙江华康药业股份有限公司 | Region selective control method and device for separating and preparing fructose glucose syrup by integrated reaction |
| CN102816875B (en) * | 2012-09-13 | 2013-11-06 | 浙江华康药业股份有限公司 | Region selective control method and device for separating and preparing fructose glucose syrup by integrated reaction |
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| Publication number | Publication date |
|---|---|
| CN1267177C (en) | 2006-08-02 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Zhejiang Chengxin Pharm & Chem Equipment Co., Ltd. Assignor: Zhejiang University Contract fulfillment period: 2009.5.26 to 2015.12.25 contract change Contract record no.: 2009330001893 Denomination of invention: Multicomponent split reacting separator and method thereof Granted publication date: 20060802 License type: Exclusive license Record date: 2009.8.10 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.5.26 TO 2015.12.25; CHANGE OF CONTRACT Name of requester: ZHEJIANG CHENGXIN PHARM+CHEM EUIPMENT CO.,LTD. Effective date: 20090810 |
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| C17 | Cessation of patent right | ||
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Granted publication date: 20060802 Termination date: 20140604 |