CN1583063A - Extraction of effective components from frankinscene and its preparation and use - Google Patents
Extraction of effective components from frankinscene and its preparation and use Download PDFInfo
- Publication number
- CN1583063A CN1583063A CN 200410024253 CN200410024253A CN1583063A CN 1583063 A CN1583063 A CN 1583063A CN 200410024253 CN200410024253 CN 200410024253 CN 200410024253 A CN200410024253 A CN 200410024253A CN 1583063 A CN1583063 A CN 1583063A
- Authority
- CN
- China
- Prior art keywords
- olibanum
- effective component
- extraction
- ether
- time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000605 extraction Methods 0.000 title claims description 29
- 238000002360 preparation method Methods 0.000 title claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 48
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 42
- 239000004863 Frankincense Substances 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 33
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract 2
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000000243 solution Substances 0.000 claims description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- 238000001556 precipitation Methods 0.000 claims description 11
- 229960004756 ethanol Drugs 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 238000001953 recrystallisation Methods 0.000 claims description 5
- 239000012043 crude product Substances 0.000 claims description 4
- 208000006820 Arthralgia Diseases 0.000 claims description 3
- 208000025747 Rheumatic disease Diseases 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000003208 petroleum Substances 0.000 claims description 3
- 230000000552 rheumatic effect Effects 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 6
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 241000700159 Rattus Species 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001387 anti-histamine Effects 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 235000019890 Amylum Nutrition 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
The left back pawl positive number of group dosage animal constant volume (ml) | Cause scorching back different time (h) paw swelling (ml) |
0.5??????????1????????????2?????????????4?????????????6 | |
Matched group equivalent 10 0.94 ± 0.05 Olibanum group 0.5 10 0.91 ± 0.09 Olibanum group 1.0 10 0.96 ± 0.08 | 1.79±0.09???1.85±0.09???1.79±0.09????1.75±0.09????1.61±0.09 1.57±0.09???1.56±0.09???1.48±0.09????1.42±0.10????1.33±0.09 22.1%???????26.3%???????30.7%????????35.7%????????30.4% 1.63±0.08???1.62±0.08???1.55±0.09????1.42±0.10????1.32±0.09 24.1%???????28.3%???????35.7%????????37.7%????????30.1% |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410024253 CN1583063B (en) | 2004-06-10 | 2004-06-10 | Extraction of effective components from frankinscene and its preparation and use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410024253 CN1583063B (en) | 2004-06-10 | 2004-06-10 | Extraction of effective components from frankinscene and its preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1583063A true CN1583063A (en) | 2005-02-23 |
CN1583063B CN1583063B (en) | 2012-03-28 |
Family
ID=34600853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410024253 Expired - Lifetime CN1583063B (en) | 2004-06-10 | 2004-06-10 | Extraction of effective components from frankinscene and its preparation and use |
Country Status (1)
Country | Link |
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CN (1) | CN1583063B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100569245C (en) * | 2005-06-02 | 2009-12-16 | 成都中医药大学 | The purposes of Olibanum in the medicine of preparation treatment gout |
CN101775058B (en) * | 2009-01-08 | 2012-07-18 | 凌沛学 | Preparation and application of pharmaceutical preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense |
CN102811728A (en) * | 2010-03-15 | 2012-12-05 | 莱拉营养食品有限公司 | Boswellia oil, its fractions and compositions for enhancing brain function |
CN104703617A (en) * | 2012-09-21 | 2015-06-10 | 阿波卡-阿格里科拉共同股份公司 | New incense extract fractions and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629351A (en) * | 1995-04-13 | 1997-05-13 | Council Of Scientific & Industrial Research | Boswellic acid compositions and preparation thereof |
-
2004
- 2004-06-10 CN CN 200410024253 patent/CN1583063B/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100569245C (en) * | 2005-06-02 | 2009-12-16 | 成都中医药大学 | The purposes of Olibanum in the medicine of preparation treatment gout |
CN101775058B (en) * | 2009-01-08 | 2012-07-18 | 凌沛学 | Preparation and application of pharmaceutical preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense |
CN102811728A (en) * | 2010-03-15 | 2012-12-05 | 莱拉营养食品有限公司 | Boswellia oil, its fractions and compositions for enhancing brain function |
CN104703617A (en) * | 2012-09-21 | 2015-06-10 | 阿波卡-阿格里科拉共同股份公司 | New incense extract fractions and uses thereof |
CN104703617B (en) * | 2012-09-21 | 2019-03-08 | 阿波卡-阿格里科拉共同股份公司 | New spice extract fraction and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN1583063B (en) | 2012-03-28 |
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PB01 | Publication | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Extraction of effective components from frankinscene and its preparation and use Effective date of registration: 20181213 Granted publication date: 20120328 Pledgee: CITIC Bank Limited by Share Ltd. Zibo branch Pledgor: SHANDONG QIDU PHARMACEUTICAL Co.,Ltd. Registration number: 2018370000224 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200426 Granted publication date: 20120328 Pledgee: CITIC Bank Limited by Share Ltd. Zibo branch Pledgor: SHANDONG QIDU PHARMACEUTICAL Co.,Ltd. Registration number: 2018370000224 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
CX01 | Expiry of patent term |
Granted publication date: 20120328 |
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CX01 | Expiry of patent term |