CN1579465A - Medicinal composition for treating nervous system disease and its preparation method - Google Patents
Medicinal composition for treating nervous system disease and its preparation method Download PDFInfo
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- CN1579465A CN1579465A CN 03153205 CN03153205A CN1579465A CN 1579465 A CN1579465 A CN 1579465A CN 03153205 CN03153205 CN 03153205 CN 03153205 A CN03153205 A CN 03153205A CN 1579465 A CN1579465 A CN 1579465A
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- schisandrae chinensis
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Abstract
The invention relates to a medicine compound from Chinese traditional medicines and its manufacturing method, the utilization of the medicine and its ingredients. The medicine is applied to cure spirit and nerve system diseases, such as anxiety neurosis and depressions.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition that derives from Chinese medicine, it preparation method, it in medication preparation purposes and comprise its medicine, this medicine is used for the treatment of diseases of mental and nervous system, for example anxiety neurosis and depression.
Background technology
Scientific and technological progress and socio-economic development cause change of human diseases and concept of health and spectrum of disease generation great variety.Relevant data data according to the WHO issue: world's spirit neuropathy incidence rate significantly rises since 1998, account for the spiritual neuropathy patient of global population 1% and the mentally disturbed numeral of falling ill at present, expectation will rise to second of global disease rank in 2002.Therefore, countries in the world are all actively seeking treatment or are improving the development of efficient, nontoxic, the newtype drug that has no side effect of spiritual neuropathy.WHO proposed " mental health whole world new strategy " in 1999.All are disabled because of disease and damage and loses 12% of productivity's population to point out mental disease in 1998 to estimate to account for the whole world, and its Countries with moderately high incomes account for 23%, mediumly account for 12% with low income country.In the prevailing medical system of traditional biological medical model, to spiritual neuropathy attention degree deficiency, even if receive treatment rate also only about 35.5% the patient with phychlogical problems of developed country.According to the interrelated data statistics, since the eighties, China's mental disorder sickness rate is ascendant trend year by year.By " Chinese mental sickness classification and diagnostic criteria ", spiritual neuropathy sickness rate such as anxiety neurosis, depression sharply rises among the crowd.
The anxiety neurosis cardinal symptom changes a lot of, and its canonic form is not for there being the on tenterhooks and frightened of definite objective objects and concrete and fixed idea content; The patient feels nervousness, nervous easily all day; Usually be on tenterhooks, walk up and down, even run and shout, also can show as and involuntaryly tremble or shake; Often with perspiration, xerostomia, throat feel oppressed, sensation of oppression over the chest with shortness of breath, dyspnea, perpendicular hair, cardiopalmus, hecticly turn white, the especially two skelasthenia senses etc. of nausea and vomiting, urgent micturition, frequent micturition, dizziness, whole body.Can find during inspection that acra trembles, signs such as tendon reflex is active, tachycardia and platycoria.The course of disease has chronic undulatory property tendency.
And the most outstanding clinical manifestation of depression is depressed, continues at least 2 weeks, and it is bad that the patient often feels mental state, feels down in spirits, or anxiety, agitation, is on tenterhooks; To daily routines forfeiture interest, the happy sense of forfeiture, pinched look is weighed down with anxieties all day; Energy goes down, and usually feels that persistence is tired; Thinking lives does not look like, and severe patient is filled with despair helpless, and to live is no better than to die, and one day seems like a year, and most of patient has the idea that finishes own life.Wherein also truly have and be committed to action, cause adverse consequences.The patient usually feels that thinking is slack-off, brain is bad to be made, the each side ability has all descended, the self-accusation of usually feeling compunction, self evaluation is low excessively, and obviously study and work is fine, but dissatisfied to own everything, oneself some minor errors, indisposition is in the past said that all becoming is monstrous crimes, even thinks and oneself be guilty of a crime for which even death cannot atone, this be cause committing suiside, the principal element of autotomy.Patient's psychomotor obviously suppresses, association's difficulty, and speech reduces, and voice are overcast, and are slow in action.Sometimes keep oneself to oneself, indifferent emotional affection, unable study, work can not be managed household affairs, severe patient in silence, motionless, do not eat, do not drink.The patient usually appetite occurs, libido obviously goes down, and obviously becomes thin, and loses weight; Insomnia is serious, most difficulty falling asleeps, and nightmare is easily waken up, and early awakening can't be fallen asleep after waking up etc.
The toxicity and the side effect of existing anxiety, antidepressant drug, in addition take anxiety for a long time, antidepressant drug may cause problems such as spiritual nervous system disorders, has caused extensive concern.Therefore be necessary to develop determined curative effect, have no side effect, no dependence and withdrawal symptom, new drug with low cost to be to adapt to the urgent need in clinical treatment field.
The outlook on health of the seven emotions that Chinese medicine is traditional-function correlation theory and psychosoma one and treatment are seen, and be objective and grasped life and healthy deep intension all sidedly.Chinese medicine thinks that feelings will illness is most low with " The heart controls mental activities " physiological function and/or disorderly directly related; The people is the easiest heart that influences in social role change and procedure of adaptation, and " grieved sorrow is then aroused in interest, shake of the heart leading to shakes of all ZANG FU-organs " causes the generation of spiritual neurological symptom/disease, and directly influences the whole vital movement state of human body.Therefore, should certainly catch " principal contradiction " in the treatment, promptly to the attention and the adjustment of " The heart controls mental activities " physiological function.Simultaneously, Chinese medicine thinks that people's all of spiritual neural state are unusual, is all certainly existing certain body and is changing the basis, or the unbalance of some negative and positive of qi and blood taken place, and opposes to treat isolated and one-sided people's body health and Mental Health in a word; Therefore Chinese medicine can be avoided the limitation that the sort of psychosoma branch is discussed, psychosoma is divided and ruled from system.The psychosoma that this psychosoma dependency with the people directly applies to guiding clinical treatment is integrated, the organic conception of concern social nature of man survival condition, is thousands of years of Chinese medicine to be good at the theoretical direction of adjusting the spiritual neuropathy clinical advantage of treatment.The long tradition of Chinese medicine feelings will-internal organs relevant disease and/or spiritual nervous system disease and distinguished curative effect are the clinical practice foundations of this developmental research.Medicine screening of spirit neuropathy and development and research are necessary to accept the inspiration of this traditional organism thinking pattern of Chinese medicine system very much.
The herbal mixture of more known treatment anxiety neurosis of prior art and depression.CN 1121811A discloses neurosal pharmaceutical formulation and method for makings thereof such as one group of Cure for insomnia, dreaminess, headache, dizziness, hypomnesis, forms basic prescription by medicines such as Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B1 and vitamin Bies.CN 1129569A discloses a kind of psychotic medicine for alleviating mental depression that is used for, and adopts the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Fructus Aurantii, Fructus Aurantii Immaturus, Rhizoma Acori Graminei, Rhizoma Cyperi, Endothelium Corneum Gigeriae Galli, Oletum Trogopterori, Radix Salviae Miltiorrhizae to make.CN 1395956A relates to a kind of Chinese medicine preparation for the treatment of depression, anxiety neurosis, is made up of Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, Fructus Gardeniae and Radix Curcumae four flavor Chinese medicines.The invention provides a kind of Chinese medicine composition that is different from prior art fully, can be used for treating anxiety neurosis and depression etc.
Summary of the invention
The present invention relates to a kind of pharmaceutical composition that derives from Chinese medicine, it preparation method, it in medication preparation purposes and comprise its medicine, this medicine is used for the treatment of diseases of mental and nervous system, for example anxiety neurosis and depression.Particularly, the present invention relates to a kind of pharmaceutical composition, it is characterized in that making by following traditional Chinese medicine raw:
Radix Ginseng 6-20g Semen Ziziphi Spinosae 6-30g Fructus Schisandrae Chinensis 6-20g Poria 6-20g
Radix Polygalae 6-20g Radix Asparagi 6-20g Radix Rehmanniae Preparata 6-20g Cortex Cinnamomi 3-15g
Rhizoma Corydalis 6-30g Radix Ophiopogonis 0 or the 6-20g Radix Rehmanniae 0 or 6-20g
Wherein Radix Ginseng can replace with Radix Panacis Quinquefolii.
On the other hand, the present invention relates to preparation of drug combination method of the present invention, this method is with Fructus Schisandrae Chinensis, Rhizoma Corydalis, Radix Polygalae ethanol extraction; Cortex Cinnamomi is extracted volatile oil with steam distillation; With Cortex Cinnamomi medicinal residues, Semen Ziziphi Spinosae, Poria, Radix Asparagi, Radix Rehmanniae Preparata and optional Radix Ophiopogonis, Radix Rehmanniae water extraction; Merge above-mentioned ethanol extraction, water extract, add Radix Ginseng or Radix Panacis Quinquefolii fine powder, Cortex Cinnamomi volatile oil.
On the other hand, the present invention relates to a kind of pharmaceutical composition, it is characterized in that making by following traditional Chinese medicine raw:
Radix Ginseng 6-20g Semen Ziziphi Spinosae 6-30g Fructus Schisandrae Chinensis 6-20g Poria 6-20g
Radix Polygalae 6-20g 6-20g Radix Ophiopogonis Cinnabaris 1-6g Semen Plantaginis 6-15g
Radix Glycyrrhizae 5-10g Rhizoma Dioscoreae 6-15g Cortex Cinnamomi 0 or 3-15g Radix Asparagi 0 or 6-20g
Concha Ostreae 0 or 10-15g Radix Rehmanniae Preparata 0 or 6-20g Dens Draconis 0 or 12-20g
Wherein Radix Ginseng can replace with Radix Panacis Quinquefolii.
On the other hand, the present invention relates to preparation of drug combination method of the present invention, this method is with Fructus Schisandrae Chinensis, Radix Polygalae ethanol extraction; Alternatively Cortex Cinnamomi is extracted volatile oil with steam distillation; With Semen Ziziphi Spinosae, Poria, Radix Ophiopogonis, Semen Plantaginis, Radix Glycyrrhizae, Rhizoma Dioscoreae and optional Cortex Cinnamomi medicinal residues, Radix Asparagi, Concha Ostreae, Radix Rehmanniae Preparata, Dens Draconis water extraction; Merge above-mentioned ethanol extraction, water extract, add Radix Ginseng or Radix Panacis Quinquefolii fine powder, Cinnabaris fine powder and optional Cortex Cinnamomi volatile oil.
On the other hand, the present invention relates to the purposes of pharmaceutical composition of the present invention in medication preparation, this medicine is used for the treatment of diseases of mental and nervous system; This diseases of mental and nervous system is anxiety neurosis or depression.
On the other hand, the present invention relates to a kind of medicine for the treatment of diseases of mental and nervous system, comprise pharmaceutical composition of the present invention as effective ingredient and pharmaceutically acceptable carrier; This diseases of mental and nervous system is anxiety neurosis or depression; This medicine is an oral dosage form.
Effect experiment:
Medicine of the present invention is pressed 6.6g/kg/d, 3.3g/kg/d, 1.66g/kg/d filling stomach to mice; 3.24g/kg/d, 1.62g/kg/d, 0.81g/kg/d irritate stomach and give rat; 2.2g/kg/d, 1.1g/kg/d, 0.55g/kg/d irritate stomach and give domestic cat, proof by experiment, medicine of the present invention has following pharmacological action.
1, angst resistance effect:
(1) on rat Vogel drinking-water conflict anxiety model, medicine of the present invention when 1.62g/kg/d dosage, the number of shocks in the time of can obviously increasing the drinking times of rat and drinking-water.
(2) on the anxiety model of the overhead cross of rat labyrinth, medicine of the present invention can obviously increase the number of times that enters out arm and at the percentage ratio of opening the arm time of staying when 1.62g/kg/d dosage.
(3) mice light and shade case is probed on the anxiety model, and medicine of the present invention can obviously prolong the time of staying of mice at camera-lucida when 3.3g/kg/d dosage, makes simultaneously in the time of staying of camera bellows to shorten, and does not have obvious influence but mice is worn the case number of times.
(4) to the influence of anxiety rat model hypothalamus neurotransmitter content: medicine of the present invention can make the content of DA, NE in the anxiety rat model brain obviously reduce when 3.24g/kg/d, 1.62g/kg/d dosage, becomes one of its mechanism antianxity.
2, to the influence of mice autonomic activities:
Medicine of the present invention can reduce normal mouse in institute's amount of reagent scope and amfetamine brings out the movable movable number of times that strengthens mice.
3, to the influence of mice sleep:
Medicine of the present invention can make prolong the length of one's sleep of pentobarbital sodium inducing mouse in institute's amount of reagent scope; The sleeping number of mice when heavy dose of group can increase pentobarbital sodium sub-threshold lull dosage.
4, anticonvulsant action:
Medicine of the present invention can obviously prolong the incubation period that pentylenetetrazole causes mice convulsion in institute's amount of reagent scope, and the effect of obvious reduction mortality rate is arranged.
5, to the influence of mice stress ability:
Medicine of the present invention can obviously prolong breathing behind the mice broken end and hold time in institute's amount of reagent scope.
6, to the influence of learning and memory of little mouse:
Medicine of the present invention has upset SP to cause that mouse memory obtains the effect of infringement when middle dosage, and the memory pick-up rate is increased, and errors number reduces; There is upset ethanol to cause the effect of memory represents infringement during large, medium and small dosage, the movement time and the distance of swimming are shortened.
7, to the influence of vegetative nerve function:
During the big or middle dosage of medicine of the present invention, can obviously suppress the enhancing of the cat vegetative nerve function that causes by epinephrine, the blood pressure of cat, heart rate are obviously reduced.
Long term toxicity test
Rat is irritated continuous 9 weeks of stomach medicine 5g of the present invention crude drug/kg/d, 10g crude drug/kg/d, 20g crude drug/kg/d (be equivalent to people's clinical medicine dose 16.6,33.3 and 66.6 times) respectively, observed for 2 weeks after the drug withdrawal, ordinary circumstance, body weight to animal do not have obvious influence, ten biochemical indicators such as peripheral hemogram regulating liver-QI, renal function all fluctuate in normal range, weight, macroscopy to important organ there is no significant change, also do not see have because the caused obvious pathomorphology of medicine changes through pathological study.
Acute toxicity test
With medicine of the present invention with in the dose of the tolerant Cmax of animal, maximum volume one day continuous irritate the stomach mices three times after, observed continuously 7 days, animal dead does not take place in the result, body weight rises appreciably.Total dosage is 120g crude drug/kg, is equivalent to 400 times of clinical consumption, is reference data for clinical drug use.
Clinical drug taking dose of the present invention is every day 3 times, each 6 grams, and 20 days is a course of treatment.
The specific embodiment
The following example only supplies to set forth the present invention, and unrestricted.
Embodiment 1
Get Radix Ginseng 6g, Semen Ziziphi Spinosae 10g, Poria cum Radix Pini 15g, Radix Polygalae 10g, Radix Asparagi 15g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 6g, Radix Rehmanniae Preparata 10g, Semen Plantaginis 15g, Radix Glycyrrhizae 6g, Rhizoma Dioscoreae 10g, Cinnabaris 1g, Dens Draconis 15g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 2
Get Radix Ginseng 6g, Semen Ziziphi Spinosae 12g, Poria 10g, Radix Polygalae 10g, Radix Asparagi 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 12g, Cortex Cinnamomi 6g, Radix Rehmanniae Preparata 10g, Semen Plantaginis 6g, Radix Glycyrrhizae 10g, Rhizoma Dioscoreae 6g, Cinnabaris 1g, Dens Draconis 12g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 3
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Cinnabaris 1g, Radix Polygalae 10g, Radix Asparagi 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Dens Draconis 20g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 4
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Asparagi 15g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 10g, Radix Glycyrrhizae 6g, Rhizoma Dioscoreae 10g, Cinnabaris 6g, Concha Ostreae 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 5
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 15g, Semen Plantaginis 10g, Rhizoma Dioscoreae 15g, Cinnabaris 1g, Dens Draconis 15g, Arisaema Cum Bile 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 6
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 15g, Semen Plantaginis 10g, each 10g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Paeoniae Alba 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 7
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Asparagi 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Semen Plantaginis 6g, Cinnabaris 2g, Concha Ostreae 10g, Radix Platycodonis 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 8
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 15g, Concha Ostreae 10g, Fructus Schisandrae Chinensis 15g, Cortex Cinnamomi 5g, Semen Plantaginis 10g, Radix Glycyrrhizae 6g, Rhizoma Dioscoreae 15g, Cinnabaris 1g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 9
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Asparagi 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Radix Glycyrrhizae 10g, Rhizoma Dioscoreae 15g, Cinnabaris 1g, Concha Ostreae 15g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 10
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Radix Glycyrrhizae 10g, Rhizoma Dioscoreae 15g, Cinnabaris 1g, Concha Ostreae 15g, Rhizoma Cyperi 10g, Rhizoma Atractylodis Macrocephalae 15g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 11
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 6g, Poria 15g, Radix Polygalae 10g, Radix Asparagi 10g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 6g, Semen Plantaginis 10g, Radix Glycyrrhizae 5g, Rhizoma Dioscoreae 10g, Cinnabaris 1g, three in Rhizoma Zingiberis Recens; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 12
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 10g, Radix Polygalae 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 6g, Semen Plantaginis 10g, Rhizoma Dioscoreae 10g, Radix Curcumae 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 13
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 10g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Radix Glycyrrhizae 10g, Rhizoma Dioscoreae 15g, Cinnabaris 1g, Fructus Toosendan 10g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 14
Get Radix Ginseng 6g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 5g, Semen Plantaginis 15g, Cinnabaris 1g, Concha Ostreae 15g, Radix Curcumae 15g, Radix Scutellariae 15; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 15
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 6g, Radix Rehmanniae Preparata 10g, Semen Plantaginis 10g, Radix Glycyrrhizae 10g, Cinnabaris 1g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 16
Get Radix Ginseng 10g, Semen Ziziphi Spinosae 15g, Poria 15g, Radix Polygalae 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Cortex Cinnamomi 6g, Radix Rehmanniae Preparata 10g, Semen Plantaginis 10g, Radix Glycyrrhizae 10g, Rhizoma Dioscoreae 15g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 15g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 17
Get Radix Panacis Quinquefolii 10g, Semen Ziziphi Spinosae 10g, Radix Rehmanniae Preparata 10g, Fructus Schisandrae Chinensis 10g, Radix Polygalae 10g, Radix Asparagi 10g, Rhizoma Corydalis 10g, Poria 10g, Cortex Cinnamomi 6g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 18
Get Radix Panacis Quinquefolii 10g, Radix Rehmanniae Preparata 10g, Fructus Schisandrae Chinensis 10g, Radix Asparagi 10g, Semen Ziziphi Spinosae (parched) 10g, Rhizoma Corydalis 10g, Radix Polygalae 10g, Cortex Cinnamomi 6g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 19
Get Radix Panacis Quinquefolii 6g, Fructus Schisandrae Chinensis 6g, Radix Polygalae 6g, Semen Ziziphi Spinosae (parched) 6g, Radix Asparagi 6g, Radix Ophiopogonis 6g, Rhizoma Corydalis 6g, Radix Rehmanniae 6g, Radix Rehmanniae Preparata 6g, Cortex Cinnamomi 5g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 20
Get Radix Panacis Quinquefolii 12g, Radix Rehmanniae 10g, Radix Rehmanniae Preparata 10g, Fructus Schisandrae Chinensis 12g, Radix Polygalae 10g, Rhizoma Corydalis 10g, Radix Asparagi 12g, Semen Ziziphi Spinosae (parched) 10g, Cortex Cinnamomi 6g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 21
Get Radix Panacis Quinquefolii 10g, Radix Rehmanniae 10g, Radix Rehmanniae Preparata 10g, Fructus Schisandrae Chinensis 10g, Radix Polygalae 10g, Semen Ziziphi Spinosae (parched) 10g, Radix Asparagi 10g, Radix Ophiopogonis 10g, Rhizoma Corydalis 10g, Poria 10g, Cortex Cinnamomi 4g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Embodiment 22
Get Radix Panacis Quinquefolii 12g, Fructus Schisandrae Chinensis 12g, Semen Ziziphi Spinosae (parched) 12g, Radix Polygalae 9g, Radix Rehmanniae Preparata 9g, Radix Asparagi 9g, Rhizoma Corydalis 9g, Cortex Cinnamomi 6g; Make granule, tablet, pill, capsule etc. according to aforementioned preparation method.
Claims (9)
1, pharmaceutical composition is characterized in that being made by following traditional Chinese medicine raw:
Radix Ginseng 6-20g Semen Ziziphi Spinosae 6-30g Fructus Schisandrae Chinensis 6-20g Poria 6-20g
Radix Polygalae 6-20g Radix Asparagi 6-20g Radix Rehmanniae Preparata 6-20g Cortex Cinnamomi 3-15g
Rhizoma Corydalis 6-30g Radix Ophiopogonis 0 or the 6-20g Radix Rehmanniae 0 or 6-20g
Wherein Radix Ginseng can replace with Radix Panacis Quinquefolii.
2, the preparation of drug combination method of claim 1 is characterized in that this method is with Fructus Schisandrae Chinensis, Rhizoma Corydalis, Radix Polygalae ethanol extraction; Cortex Cinnamomi is extracted volatile oil with steam distillation; With Cortex Cinnamomi medicinal residues, Semen Ziziphi Spinosae, Poria, Radix Asparagi, Radix Rehmanniae Preparata and optional Radix Ophiopogonis, Radix Rehmanniae water extraction; Merge above-mentioned ethanol extraction, water extract, add Radix Ginseng or Radix Panacis Quinquefolii fine powder, Cortex Cinnamomi volatile oil.
3, pharmaceutical composition is characterized in that being made by following traditional Chinese medicine raw:
Radix Ginseng 6-20g Semen Ziziphi Spinosae 6-30g Fructus Schisandrae Chinensis 6-20g Poria 6-20g
Radix Polygalae 6-20g 6-20g Radix Ophiopogonis Cinnabaris 1-6g Semen Plantaginis 6-15g
Radix Glycyrrhizae 5-10g Rhizoma Dioscoreae 6-15g Cortex Cinnamomi 0 or 3-15g Radix Asparagi 0 or 6-20g
Concha Ostreae 0 or 10-15g Radix Rehmanniae Preparata 0 or 6-20g Dens Draconis 0 or 12-20g
Wherein Radix Ginseng can replace with Radix Panacis Quinquefolii.
4, the preparation of drug combination method of claim 3 is characterized in that this method is with Fructus Schisandrae Chinensis, Radix Polygalae ethanol extraction; Alternatively Cortex Cinnamomi is extracted volatile oil with steam distillation; With Semen Ziziphi Spinosae, Poria, Radix Ophiopogonis, Semen Plantaginis, Radix Glycyrrhizae, Rhizoma Dioscoreae and optional Cortex Cinnamomi medicinal residues, Radix Asparagi, Concha Ostreae, Radix Rehmanniae Preparata, Dens Draconis water extraction; Merge above-mentioned ethanol extraction, water extract, add Radix Ginseng or Radix Panacis Quinquefolii fine powder, Cinnabaris fine powder and optional Cortex Cinnamomi volatile oil.
5, claim 1 or 3 the purposes of pharmaceutical composition in medication preparation, this medicine is used for the treatment of diseases of mental and nervous system.
6, according to the purposes of claim 5, wherein this diseases of mental and nervous system is anxiety neurosis or depression.
7, the medicine of treatment diseases of mental and nervous system is characterized in that comprising the pharmaceutical composition of claim 1 or 3 as effective ingredient and pharmaceutically acceptable carrier.
8, according to the medicine of claim 7, wherein this diseases of mental and nervous system is anxiety neurosis or depression.
9,, it is characterized in that this medicine is an oral dosage form according to the medicine of claim 7 or 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03153205 CN1277567C (en) | 2003-08-07 | 2003-08-07 | Medicinal composition for treating nervous system disease and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03153205 CN1277567C (en) | 2003-08-07 | 2003-08-07 | Medicinal composition for treating nervous system disease and its preparation method |
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| CN1579465A true CN1579465A (en) | 2005-02-16 |
| CN1277567C CN1277567C (en) | 2006-10-04 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703622A (en) * | 2009-09-17 | 2010-05-12 | 杭州六易科技有限公司 | Preparation method of buccal tablet for improving sleeping |
| CN101310740B (en) * | 2007-05-24 | 2012-12-26 | 上海双基药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN103127346A (en) * | 2013-02-17 | 2013-06-05 | 王春霞 | Traditional Chinese medicinal composition for treating depression after stroke |
| CN103344738A (en) * | 2013-07-04 | 2013-10-09 | 北京北陆药业股份有限公司 | Detection method of nine-component heart-calming particle |
| CN105797088A (en) * | 2016-05-24 | 2016-07-27 | 包晓娜 | Traditional Chinese medicinal composition for treating anxiety |
-
2003
- 2003-08-07 CN CN 03153205 patent/CN1277567C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310740B (en) * | 2007-05-24 | 2012-12-26 | 上海双基药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN101703622A (en) * | 2009-09-17 | 2010-05-12 | 杭州六易科技有限公司 | Preparation method of buccal tablet for improving sleeping |
| CN101703622B (en) * | 2009-09-17 | 2013-04-17 | 杭州六易科技有限公司 | Preparation method of buccal tablet for improving sleeping |
| CN103127346A (en) * | 2013-02-17 | 2013-06-05 | 王春霞 | Traditional Chinese medicinal composition for treating depression after stroke |
| CN103127346B (en) * | 2013-02-17 | 2014-04-02 | 王春霞 | Traditional Chinese medicinal composition for treating depression after stroke |
| CN103344738A (en) * | 2013-07-04 | 2013-10-09 | 北京北陆药业股份有限公司 | Detection method of nine-component heart-calming particle |
| CN105797088A (en) * | 2016-05-24 | 2016-07-27 | 包晓娜 | Traditional Chinese medicinal composition for treating anxiety |
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| Publication number | Publication date |
|---|---|
| CN1277567C (en) | 2006-10-04 |
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