CN1565462A - Itch relieving detumescent medicine - Google Patents
Itch relieving detumescent medicine Download PDFInfo
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- CN1565462A CN1565462A CN 03133456 CN03133456A CN1565462A CN 1565462 A CN1565462 A CN 1565462A CN 03133456 CN03133456 CN 03133456 CN 03133456 A CN03133456 A CN 03133456A CN 1565462 A CN1565462 A CN 1565462A
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- medicine
- antipruritic
- tannic acid
- serge blue
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Abstract
The invention discloses an itch relieving detumescent medicine, which comprises methylene blue and tannic acid, and can be made into various dosage forms.
Description
Technical field the present invention relates to a kind of antipruritic, detumescence medicine, and a kind of specifically symptoms such as the pruritus that caused, redness that insects such as mosquito, midge, flea are bitten have medicine antipruritic, the detumescence effect.Behind mosquito, midge, the flea bite human body skin, symptoms such as pruritus, redness can appear in the affected part, have seriously disturbed people's orthobiosis.
Background technology is according to Ministry of Public Health unified editing higher medical universities and colleges' teaching materials " skin cypridology " (third edition, 1996 publish) record, and the generation of these symptoms is mainly by 4 kinds of approach: 1, bite mechanical damage in the process.2, the toxicity of the secretions of insect, Excreta, venom etc. stimulates.3, the anaphylactic type that causes of poison gland leachate of insect and antigenic substance that saliva contains.4, the mouthpart of insecticide is left over the foreign body reaction that causes in vivo.Symptoms such as redness, pruritus mainly by the 2nd, the 3rd kind of reason cause.
At present, biting the pruritus, the redness that are caused at mosquito, midge, flea etc. does not still have than good method, and symptom the lighter will not treat substantially, and heavier person can give following a few class Drug therapy:
1. nice and cool class medicine.This class medicine is to be the various kinds of drug that substrate is made with the Mentholum, is used for antipruritic by feeling nice and cool.For example menthocamphorate, essential balm.It is the most extensive that this class clinical drug uses, but antipruritic, the detumescence curative effect is relatively poor.
2. alkalescent medicine.By in and the polypide acid venom of discharging come relief of symptoms.Be mainly the ammonia preparation.Because of it has than penetrating odor and remission are not obvious greatly, now substantially need not.
3. anaesthetize the class medicine.Representing medicine is lignocaine, procaine.This class medicine is anaesthetized teleneuron by modes such as local anaesthesia, sealings, plays itching-relieving action.Its shortcoming is used inconvenience for asking weak point as the time spent, and misery is arranged.
4. antihistaminic.This class medicine is gone up H by suppressing histamine and effector lymphocyte
1The combination of receptor, thus the allergy that it causes suppressed, reach antipruritic, detumescence effect.Represent medicine that diphenhydramine, promethazine are arranged.It is bigger in whole body, no specificity, side effect that its shortcoming is a drug effect.Only the critical patient is used.
5. corticosteroid hormone.This class medicine has antiinflammatory, suppresses immunoreation, effects such as antitoxin.Shortcoming is that specificity is low, and side effect is big, is only applicable to the critical patient.
6. Chinese medicine.The traditional Chinese medical science thinks that this kind pruritus, the red and swollen ailment said due to cold or exposure that belongs to invade due to the skin, and the medicines that dispel the wind that adopt give the compound preparation fumigation and wash method that medicines such as Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, the Fructus Kochiae, Folium Artemisiae Argyi, the Radix Stemonae are formed more in the treatment, and its shortcoming is to use inconvenience, weak curative effect.
Summary of the invention the object of the present invention is to provide a kind of antipruritic, detumescence effect that has, and can play therapeutical effect to pruritus, the redness that mosquito, midge, flea etc. bite generation, and rapid-action, easy to use medicine.
Solution of the present invention is based on the understanding of modern medicine to pruritus, red and swollen mechanism of production, the toxicity that is primarily aimed at insect secretions, Excreta, venom etc. stimulates, and the process of the anaphylactic type that causes of the antigenic substance that contains of poison gland leachate and saliva.Become to be grouped into for two kinds by serge blue and tannic acid, by antipruritic, the repercussive effect of approach performance of block nerves tip sensory function and precipitation allergic protein.
The present invention is made by following component dry powder: (consumption is a weight portion)
Serge blue 1-200 part tannic acid 20-200 part
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Serge blue 1-20 part tannic acid 20-100 part
Pharmaceutical formulation optimum weight proportioning of the present invention is:
20 parts of 2 parts of tannic acids of serge blue
Most preferred dosage form of the present invention is for making the mixture of solvent with water.
The dry powder blend of above-mentioned arbitrary component can be obtained this medicine after evenly.Materials such as this medicine is water-soluble, ethanol, glycerol.This medicine can add the solvent of arbitrary umber, directly acts on the part of pruritus, redness.
An important feature of the present invention is a serge blue with after tannic acid mixes, and it is antipruritic, the detumescence effect plays joint action of potentiation, obviously is better than using separately serge blue and tannic acid preparation.Serge blue and tannic acid have certain antipruritic, detumescence effect respectively, but use is wherein a kind of separately, and clinical efficacy is relatively poor, does not reach therapeutic effect, so do not use these two kinds of medicines to come antipruritic, detumescence in clinical substantially.Medical research confirms that skin has the certain absorption effect, when skin bitten swelling appears and after, permeability strengthens, its Absorption can strengthen 2-6 doubly, is suitable for the affected part topical.
Serge blue is mainly used in cyanide and nitrite poisoning at present as a kind of reductant-oxidant.In recent years studies confirm that serge blue can act on teleneuron, cause the damage of nerve marrow reversibility, scratchiness is temporarily disappeared.Its redox also can destroy antigenic substance, weakens the allergy effect.Tannic acid turns usefulness into by tanning, can precipitating proteins, and react with alkaloid and detoxify.After absorbing the affected part, can make the antigenic substance degeneration, suppress allergy, the astriction that itself has energy vasoconstrictive disappears redness.Serge blue can enter affected part (the swelling position after biting) by skin absorbs rapidly with after tannic acid mixes, and plays significantly antipruritic, detumescence effect.
The specific embodiment is share antipruritic, the repercussive effect in back in order to prove serge blue and tannic acid, and the inventor entrusts Hospital Attached to Liaoning Inst. of Traditional Chinese Medicine that serge blue and the tannic acid unguentum that the inventor provides carried out clinical observation in July, 1999.Being prepared as of serge blue and tannic acid unguentum: serge blue 1 gram (net weight), tannic acid 4 grams (net weight) add suitable quantity of water and friendship board vanishing cream 50 grams stir and mix homogeneously.The matched group medicine consists of: matched group 1: serge blue 1 gram (net weight) adds suitable quantity of water and friendship board vanishing cream 50 grams stir and mix homogeneously.Matched group 2: tannic acid 4 grams (net weight) add suitable quantity of water and friendship board vanishing cream 50 grams stir and mix homogeneously.Therapeutic Method: the treatment group is identical with the matched group method.Unguentum directly is applied to the affected part, exceeds to cover red and swollen position, every day 3-4 time, 3 days is a course of treatment.This hospital dermatology department, surgery are used serge blue and the tannic acid unguentum has been treated 134 routine patients from a year August in August, 1999 to 2000, and its conclusion is: the clinical efficacy of use in conjunction serge blue and tannic acid obviously is better than using separately serge blue or tannic acid.
Another important feature of invention is that serge blue and tannic acid chemical property are stable, and the two after mixing chemical reaction does not take place, does not produce novel substance, avirulence.On this basis, can be made into various dosage forms such as mixture, tincture, unguentum.Especially with mixture curative effect the best.This medicine can add essence or some other chemical substance and antipruritic, detumescence effect does not go down.This medicine is under some Reducing agent effect (adding zinc powder as dilute sulfuric acid), and its blueness can temporarily disappear and take off, but does not influence its curative effect.
The present invention shows that through result in clinical application following advantage is arranged:
This drug effect time fast, be coated with and put in affected part several seconds to one minute most patients affected part itch symptom on the skin Disappear. Red and swollen basic the disappearance leaves no trace in 2-12 hour.
2. this pharmaceutical physicochemistry stable in properties can long-term storage in closed environment, can stablize in various solvents and deposit .
3. this medicine can add other material, makes new preparation, as long as tannic acid, the composition of serge blue own are not destroyed Fall, it is antipruritic, the detumescence effect is substantially constant.
4. after this drug therapy, the various functions of illing skin (comprising the pain sensation, sense of touch, temperature sensation) can be shorter Recover fully in time (several days), do not stay any sequelae.
5. this pharmaceutical properties is stable, uses safety, has no side effect. For example blue-black ink namely is to contain serge blue and tan The mixed liquor of acid. Serge blue and tannic acid extensively are present in each Plants, the mineral, become as medicine and food in clinical Divide (containing tannic acid in the routine tealeaves) to be extensive use of no obvious adverse reaction. Serge blue intravenous injection 500mg according to reports Still use safety.
6. this medicine can be made into various formulations, and is clinical easy to use.
Claims (7)
1. one kind has medicine antipruritic, the detumescence effect, it is characterized in that it is the medicament of being made by the following weight proportion raw material.
Serge blue 1-200 part tannic acid 20-200 part
2. according to claim 1 have a medicine antipruritic, the detumescence effect, and wherein the weight proportion of each raw material is:
Serge blue 1-20 part tannic acid 20-100 part
3. according to claim 1 have a medicine antipruritic, the detumescence effect, and wherein the weight proportion of each raw material is:
20 parts of 2 parts of tannic acids of serge blue
4 describedly have a medicine antipruritic, the detumescence effect according to claim 1,2 or 3, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
5. according to claim 4 have a medicine antipruritic, the detumescence effect, it is characterized in that said medicament is mixture, unguentum, tincture.
6. according to claim 1,2 or 3 described and medicines, it is characterized by its raw material and contain with serge blue or rub plant or the mineral that acid is active ingredient.
7. according to claim 1,2 or 3 described medicines, it is characterized by with the said medicine is ingredient, and has other preparation antipruritic, the detumescence effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03133456 CN1565462A (en) | 2003-06-17 | 2003-06-17 | Itch relieving detumescent medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03133456 CN1565462A (en) | 2003-06-17 | 2003-06-17 | Itch relieving detumescent medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1565462A true CN1565462A (en) | 2005-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03133456 Pending CN1565462A (en) | 2003-06-17 | 2003-06-17 | Itch relieving detumescent medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840902A (en) * | 2019-12-05 | 2020-02-28 | 河北医科大学 | Application of tannic acid in preparing medicine for inhibiting pruritus |
-
2003
- 2003-06-17 CN CN 03133456 patent/CN1565462A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840902A (en) * | 2019-12-05 | 2020-02-28 | 河北医科大学 | Application of tannic acid in preparing medicine for inhibiting pruritus |
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