CN1562348A - 治疗不育症的lhrh-拮抗剂 - Google Patents
治疗不育症的lhrh-拮抗剂 Download PDFInfo
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- CN1562348A CN1562348A CN 200410049113 CN200410049113A CN1562348A CN 1562348 A CN1562348 A CN 1562348A CN 200410049113 CN200410049113 CN 200410049113 CN 200410049113 A CN200410049113 A CN 200410049113A CN 1562348 A CN1562348 A CN 1562348A
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- CN
- China
- Prior art keywords
- lhrh
- cetrorelix
- treatment
- hmg
- dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Cetrorelix受控促卵巢成熟法(COS/ART)进程 |
接受治疗者人数 | 阶段 | 剂量/天(毫克) | 剂量学(天数) | |
14 | II期/初步验证 | 3 | 3-10 | |
19 | II期/初步验证 | 1 | 3-10 | |
11 | II期/初步验证 | 0.5 | 3-10 | |
3230(28) | II期/剂量摸索/最小有效量 | 0.50.25最小有效量0.10无效量 | 3-7/14 | |
21 | II期/初步验证 | 5 | 1或2 | |
18 | II期/初步验证 | 3 | 1或2 | |
3230 | II期/剂量摸索/最小有效量 | 3最小有效量2无效量 | 11 | |
总计II期 | 235已完成 | 71人怀孕(30%)16人正在怀孕 | 44名健康儿童 |
阶段: | hMG2阶段d1→直至hCG日 | 使用hCG4,如果: | hMG阶段后 | ||||||||
治疗/研究 | Cetrorelix | 领先卵泡:≥20毫米φ或E2≥1,200微微克/毫升 | |||||||||
参数: | pre | hMG日11周期的第2或3天 | hMG天数d2-d5 | hMG日即d6 | hMG的第二天,即d7直至hCG日 | 取消,如果:12个卵泡以上≥15毫米φ 或E2≥4,000微微克/毫升(≥14,684微微摩尔/升) | OPU | ET | ET后6-8天 | 最后记录:ET后20-25天 | |
筛选数据 | X | 怀孕和婴儿跟踪研究跟踪研究:复位周期 | |||||||||
试验表尾 | X6 | ||||||||||
Cetrorelix0.25mg s.c.每日 | X | X | X | ||||||||
hMG注射(2/3/4+) | X1 2 Amp | X 2 Amp | X2 2+++ Amp | X2 2+++Amp | X2 2+++Amp | ||||||
→hCG10,000国际单位静脉注射 | X3 | ||||||||||
超声波(USS) | X | X | (X)可选的 | (X)可选的 | X | X | X | ||||
激素:(hCG)LH,FSH,E2,P | X | X1 | X | X每日 | X7 2次:早晨和hCG给药以后 | X | X | X | X | ||
实验室(Hemat临麻化学) | X | X | X | X | |||||||
黄体期维持→hCG或黄体酮 | X5 | X5 | |||||||||
耐受性/AE`s | X | 回访每一位病人 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410049113 CN1562348A (zh) | 1997-05-16 | 1997-05-16 | 治疗不育症的lhrh-拮抗剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410049113 CN1562348A (zh) | 1997-05-16 | 1997-05-16 | 治疗不育症的lhrh-拮抗剂 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 97111580 Division CN1199642A (zh) | 1997-05-16 | 1997-05-16 | 治疗不育症的lhrh-拮抗剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1562348A true CN1562348A (zh) | 2005-01-12 |
Family
ID=34481916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410049113 Pending CN1562348A (zh) | 1997-05-16 | 1997-05-16 | 治疗不育症的lhrh-拮抗剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1562348A (zh) |
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1997
- 1997-05-16 CN CN 200410049113 patent/CN1562348A/zh active Pending
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