CN1557508A - Adhesion preventing membrane and its preparing method - Google Patents
Adhesion preventing membrane and its preparing method Download PDFInfo
- Publication number
- CN1557508A CN1557508A CNA2004100235200A CN200410023520A CN1557508A CN 1557508 A CN1557508 A CN 1557508A CN A2004100235200 A CNA2004100235200 A CN A2004100235200A CN 200410023520 A CN200410023520 A CN 200410023520A CN 1557508 A CN1557508 A CN 1557508A
- Authority
- CN
- China
- Prior art keywords
- water
- adhesion preventing
- film
- present
- soluble chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003405 preventing effect Effects 0.000 title abstract description 8
- 238000000034 method Methods 0.000 title abstract 2
- 239000012528 membrane Substances 0.000 title description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229920001661 Chitosan Polymers 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims description 18
- 230000000181 anti-adherent effect Effects 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 9
- 206010052428 Wound Diseases 0.000 abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 238000007766 curtain coating Methods 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
- 239000010408 film Substances 0.000 description 19
- 208000031737 Tissue Adhesions Diseases 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Abstract
The present invention discloses adhesion preventing film and its preparation process. The present invention features that the adhesion preventing film is prepared with water soluble chitosan as main material in 0.5-10 wt%, propanetriol in 0-10 wt% and water in 80-98 wt%, and through curtain coating process. It has obvious post-operation adhesion preventing effect, as well as functions of stopping bleeding, protecting and repairing wound, bacteriostasis and promoting wound healing, and is one ideal degradable post-operation adhesion preventing film.
Description
(1) relate to the field:
The present invention relates to medical material tech field, is a kind of anti-tissue adhesion film and preparation method thereof specifically.
(2) background technology:
Development along with Medical Technology, multiple disease can be cured after performing the operation fully, as everyone knows, easily adhesion between operation back operation wound face and the body tissue is in order to prevent its adhesion, people have done a large amount of work, the anti diaphragm that at present existing synthetic material is made because this product is acid in human body, easily causes acid inflammation, this product in the human body degraded slowly is unfavorable for absorption of human body simultaneously.
(3) summary of the invention:
Purpose of the present invention is intended to overcome above-mentioned deficiency, and a kind of degradable anti-tissue adhesion film of mainly being made by the natural biologic material chitosan is provided, mainly solve in the prior art the easy adhesion of postoperative and the adherence preventing material problems such as being unfavorable for absorption of human body slowly that easily causes inflammation and degrade.
Another object of the present invention provides a kind of preparation method of Antiadhesive film.
In order to achieve the above object, the present invention is achieved in that a kind of Antiadhesive film, and what it was special is to be that it contains the water-soluble chitosan of 0.5-10%, the glycerol of 0-10% and the water of 80-98% by weight percentage.
Realize that a kind of best mode of the present invention is, it contains 5% water-soluble chitosan, 5% glycerol and 90% water by weight percentage for it.
The preparation method of a kind of Antiadhesive film of the present invention, its processing step is as follows: water-soluble chitosan is soluble in water, add glycerol, stir, place drying cupboard to carry out making after the drying.
A kind of Antiadhesive film of the present invention is a kind of semitransparent thin film; main component is a chitosan; it takes from the arthropodan shell in deep-sea; make through deacetylated; it is a kind of pure natural macromolecule polysaccharide body; can be absorbed by the body functions such as it has human body immunity improving power, blood fat reducing, blood pressure lowering, pipe intestinal protection reparation, suppresses tumor, blood sugar lowering, reinforcement liver function, antibacterial, hemostasis.
When a kind of Antiadhesive film of the present invention uses, be placed on hands and state between wound face and the body tissue and form artificial barrier, realize the anti purpose, be absorbed by the body along with the healing of wound face can be degraded into the glucosamine monomer gradually simultaneously.
Compared with the prior art a kind of Antiadhesive film of the present invention and preparation method thereof has outstanding substantive distinguishing features and marked improvement: 1, have the epithelial cell of promotion and increase, be suppressed to the dual function of fibroblast growth, it is synthetic to have reduced collagen fiber, reaches the purpose of Film with Preventing Adhesion; 2, have anastalsis, it is hemorrhage to have reduced surgical wound surface, can prevent that adhesion from taking place; 3, have the biological barrier effect, owing to be membrane structure before its degraded, the degraded back forms the colloid network structure and plays the biological barrier effect, thereby reaches the purpose of Film with Preventing Adhesion; 4, the effect that has antibacterial and enhance immunity promotes quick, the normal healing of wound after surgery, prevents tissue adhesion.
(4) specific embodiment:
In order to understand better and to implement, describe a kind of Antiadhesive film of the present invention and preparation method thereof in detail below in conjunction with embodiment.
Embodiment 1, and the 0.5g water-soluble chitosan is dissolved in the 89.5g water, adds 10g glycerol, stirs, and places drying cupboard to carry out drying, makes translucent sheet film.
Embodiment 2, and the 10g water-soluble chitosan is dissolved in the 82g water, add 8g glycerol, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Embodiment 3, and the 10g water-soluble chitosan is dissolved in the 80g water, add 10g glycerol, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Embodiment 4, and the 1g water-soluble chitosan is dissolved in the 98g water, add 1g glycerol, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Embodiment 5, and the 5g water-soluble chitosan is dissolved in the 90g water, add 5g glycerol, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Embodiment 6, and the 6g water-soluble chitosan is dissolved in the 94g water, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Embodiment 7, in the molten sub-98g water of 2g water-soluble chitosan, stir, and place drying cupboard to carry out drying, make translucent sheet film.
Claims (3)
1, a kind of Antiadhesive film is characterized in that it contains the water-soluble chitosan of 0.5-10%, the glycerol of 0-10% and the water of 80-98% by weight percentage.
2,, it is characterized in that by weight percentage it contains 5% water-soluble chitosan, 5% glycerol and 90% water by the described a kind of Antiadhesive film of claim 1.
3, the preparation method of the described a kind of Antiadhesive film of claim 1-2, its processing step is as follows: water-soluble chitosan is soluble in water, add glycerol, stir, place drying cupboard to carry out making after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023520 CN1229148C (en) | 2004-01-13 | 2004-01-13 | Adhesion preventing membrane and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023520 CN1229148C (en) | 2004-01-13 | 2004-01-13 | Adhesion preventing membrane and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1557508A true CN1557508A (en) | 2004-12-29 |
| CN1229148C CN1229148C (en) | 2005-11-30 |
Family
ID=34352164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410023520 Expired - Lifetime CN1229148C (en) | 2004-01-13 | 2004-01-13 | Adhesion preventing membrane and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1229148C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099874B (en) * | 2006-07-04 | 2010-08-25 | 孙雨龙 | Biological coupling material and its preparing method |
| CN101361751B (en) * | 2008-09-28 | 2010-10-20 | 浙江曙光科技有限公司 | Moisture absorption self-adhesion barrier film capable of preventing postoperative adhesions and preparation method thereof |
| CN102397587A (en) * | 2010-09-08 | 2012-04-04 | 舒朝锋 | Intrauterine adhesion resisting material, preparation technology thereof, and purpose thereof |
| CN104958789A (en) * | 2015-07-27 | 2015-10-07 | 大连大学 | Preparation method of composite film for preventing postoperative adhesion |
| CN104958790A (en) * | 2015-07-27 | 2015-10-07 | 大连大学 | Composite membrane for preventing postoperative adhesion |
-
2004
- 2004-01-13 CN CN 200410023520 patent/CN1229148C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099874B (en) * | 2006-07-04 | 2010-08-25 | 孙雨龙 | Biological coupling material and its preparing method |
| CN101361751B (en) * | 2008-09-28 | 2010-10-20 | 浙江曙光科技有限公司 | Moisture absorption self-adhesion barrier film capable of preventing postoperative adhesions and preparation method thereof |
| CN102397587A (en) * | 2010-09-08 | 2012-04-04 | 舒朝锋 | Intrauterine adhesion resisting material, preparation technology thereof, and purpose thereof |
| CN104958789A (en) * | 2015-07-27 | 2015-10-07 | 大连大学 | Preparation method of composite film for preventing postoperative adhesion |
| CN104958790A (en) * | 2015-07-27 | 2015-10-07 | 大连大学 | Composite membrane for preventing postoperative adhesion |
| CN104958789B (en) * | 2015-07-27 | 2018-01-23 | 大连大学 | Prevent the preparation method of the composite membrane of postoperative intestinal adhesion |
| CN104958790B (en) * | 2015-07-27 | 2018-01-23 | 大连大学 | Prevent the composite membrane of postoperative intestinal adhesion |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1229148C (en) | 2005-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Yantai million medical supplies Co.,Ltd. Assignor: Du Benli Contract record no.: 2011370000471 Denomination of invention: Adhesion preventing membrane and its preparing method Granted publication date: 20051130 License type: Exclusive License Open date: 20041229 Record date: 20111107 |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20051130 |