CN1544947A - Near infrared tissue non-destructive testing method for blood transportation parameter of skeletal muscle metabolism - Google Patents
Near infrared tissue non-destructive testing method for blood transportation parameter of skeletal muscle metabolism Download PDFInfo
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- CN1544947A CN1544947A CNA2003101153966A CN200310115396A CN1544947A CN 1544947 A CN1544947 A CN 1544947A CN A2003101153966 A CNA2003101153966 A CN A2003101153966A CN 200310115396 A CN200310115396 A CN 200310115396A CN 1544947 A CN1544947 A CN 1544947A
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- 210000001519 tissue Anatomy 0.000 title claims abstract description 41
- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000008280 blood Substances 0.000 title claims abstract description 25
- 210000004369 blood Anatomy 0.000 title claims abstract description 25
- 230000004060 metabolic process Effects 0.000 title claims description 6
- 210000002027 skeletal muscle Anatomy 0.000 title abstract 2
- 238000009659 non-destructive testing Methods 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 20
- 239000001301 oxygen Substances 0.000 claims abstract description 20
- 210000003205 muscle Anatomy 0.000 claims abstract description 16
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 9
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 9
- 238000001514 detection method Methods 0.000 claims description 22
- 230000008859 change Effects 0.000 claims description 18
- 230000003287 optical effect Effects 0.000 claims description 12
- 230000000287 tissue oxygenation Effects 0.000 claims description 12
- 230000002503 metabolic effect Effects 0.000 claims description 7
- 230000008557 oxygen metabolism Effects 0.000 claims description 7
- 230000009467 reduction Effects 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 4
- 230000007102 metabolic function Effects 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims description 2
- 108010064719 Oxyhemoglobins Proteins 0.000 abstract description 3
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 239000004973 liquid crystal related substance Substances 0.000 abstract 1
- 230000036770 blood supply Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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Abstract
The invention is a near-infrared nondestructive tissue detecting method for skeletal muscle supersession function's blood transporting parameters, its character: in view of different tested objects (sportsman and non sportsman) and muscle tissue's oxyhemoglobin variation (deta HbO2) as well as reduced hemoglobin variation (deta Hb), it selects proper detecting distance and gives the detecting steps, algorithm and system design which can judge parameters of oxygen supersession ability of muscle tissue. The sensor can be composed of three LEDs and a photoelectric receiver. The whole testing system contains sensor, preamplifying circuit, A/D converter, inserted microprocessor, power supply, liquid crystal and touch screen. It has the advantages of high detecting sensitivity and simple detecting system structure.
Description
Technical field
Muscle metabolism function blood fortune parameter near infrared is organized lossless detection method to belong to spectral technique and is used and biomedical engineering field.
Background technology
With the variable quantity that closes oxygen (and reduction) haemoglobin in the Near-infrared Double wave spectrum method detection of biological tissue, this itself is domestic and international proven technique.But the parameter that is used to evaluate motion blood oxygen metabolism ability has only local organization to close the variable quantity of haemoglobin oxygen and reduction, because motion blood oxygen metabolism ability is gone back the unified actual parameter concentrated expression campaign blood oxygen metabolism ability of neither one at present except relevant with local organization, simultaneously also closely related with the circulation system; There is the influence (outer tissue is meant the tissue that covers outside the tissue to be measured) of outer tissue,, therefore greatly influenced the precision that detects, just should select suitable detection distance at different outer tissue thickness as the covering of fat to muscle.To this problem, the external not document of relevant patent, (its publication number is respectively CN1333001A to domestic disclosed three relevant patents, CN1331953A, CN1365649A) all be to adopt point-blank that arrange and the methods not equidistant a plurality of photosensitive two newspaper pipes of light source, think only relevant with outer tissue from light source signal nearby, and with the remote signal of light source in comprise the information of outer tissue and deep layer tissue to be measured simultaneously, and the method for subtracting each other with the light intensity that two detecting devices receive is to eliminate the influence of outer tissue, as shown in Figure 1, wherein a is a light source, b is a detecting device, and c is probe, and d is a detecting device, e is a deep layer tissue to be measured, and f is an outer tissue.This way reduces system architecture complexity, the weak sensitivity of signal.The present invention then takes an other thinking.Promptly the thickness with outer tissue is parameter, reasonably selects the distance of light source and detecting device, to reduce the influence of outer tissue; And deriving the parameter of blood oxygen metabolism ability in the concentrated expression campaign, both to close the variable quantity of haemoglobin oxygen and reduction relevant with local organization for this parameter, can reflect the distribution capability of heart blood supply ability, blood supply again.
Summary of the invention
The object of the present invention is to provide the simple in structure of a kind of detection method of near infrared tissue oxygenation metabolism assessment parameters and detection system, accuracy of detection is also higher.
The invention is characterized in: it uses three each self energy difference emission wavelengths to be λ
1Ruddiness and wavelength be λ
2The luminotron of infrared light form sensor with the photoelectric receiving tube that is positioned at a side, the centre distance d of three luminotrons and photelectric receiver is at least 30mm, 40mm and 50mm, thickness according to outer tissue during detection is therefrom chosen the light emitting diode with corresponding centre distance, and only order this lumination of light emitting diode, be respectively λ according to detected wavelength
1, λ
2Optical density OD
λ i, i=1,2, calculate respectively two neighbouring samples constantly close the change amount Δ CHbO2 oxygen hemoglobin concentration and reduced hemoglobin concentration, Δ CHb; When exercise load increases progressively, every grade of exercise load is provided with on cycle ergometer, the value addition of Δ CHbO2 under the every stage load that is calculated, Δ CHb is obtained blood volume changing value Δ BV, heart rate HR in the every grade of motion of cardiotach ometer record that provides with prior art, HR can reflect the heart blood supply ability; Calculate the change amount Δ BV of every stage load Δ BV
j, calculate the change amount Δ HR of every stage load Δ HR
j, calculate the parameter oxy value of representing the tissue oxygenation metabolic capability; Above-described method has following steps successively:
(1), measures outer tissue thickness with ultrasonic method and select a fixed light emitting diode with photoelectric receiving tube apart from d according to the thickness of outer tissue according to the object of test and the position of test;
(2) tested object is on cycle ergometer static 1 minute, and the baseline value with general cardiotach ometer test heart rate HR and record and record Δ BV detects and calculate Δ BV through following steps:
(2.1) detect optical density value OD under the centre distance of selected luminotron and photoelectric receiving tube
λ iI=1,2;
Wherein, I
Go intoBe light source power, I
Go outBe that incident light passes through after biological tissue's scattering the luminous power that photoelectric receiving tube is received;
(2.2) detect the blood oxygen condition in time in the change procedure, two neighbouring sample optical density OD at interval
λ iDifference OD
k λ i
Wherein, OD
t λ iAnd OD
T+1 λ iBeing respectively wavelength is λ
iThe time, at t constantly and subsequent t+1 optical density constantly poor;
(2.3) the blood oxygen condition in the change procedure, is inscribed during two neighbouring samples in time, and the concentration change of closing the oxygen haemoglobin is that Δ CHbO2, reduced hemoglobin concentration change are Δ CHb and blood volume changes delta BV, and available following formula is calculated:
ΔBV＝ΔCHbO2+ΔCHb
α wherein
1-α
4For constant but relevant with wavelength,
Wavelength is λ
1Down
α
1Be-1.6～-2.5,
α
3Be 2.6～3.85
Wavelength is λ
2Down
α
2Be-2.5～-3.6,
α
4Be 0.6～1.6
(3) in order to obtain evaluating the dynamic parameter of muscle blood oxygen metabolism, the experimenter does the load incremental motion by every grade of 50W, writes down the value of the Δ BV of motion process under every stage load, heart rate HR under the every stage load of synchronous recording.
(4) calculate the change amount Δ BV of every stage load Δ BV
j, calculate the change amount Δ HR of every stage load Δ HR
j, calculate the parameter oxy that represents the tissue oxygenation metabolic capability.
J represents the progression of exercise load.
Be that when fat thickness was greater than 15mm detecting muscle blood oxygen parameter, the d value was at least 50mm, otherwise is at least 40mm under the situation of fat deposit thickness of muscle when outer tissue.
Under the motion increasing load, obtain the parameter oxy of tissue oxygenation metabolic capability, promptly to close the variable quantity of haemoglobin oxygen and reduction relevant with local organization for this parameter, can reflect the distribution capability of heart blood supply ability and blood supply again.Experimental results show that: the method that the present invention proposes is selected suitable detection distance according to outer tissue thickness, has also improved the intensity of light signal simultaneously, helps improving accuracy of detection, and the circuit of detection system also obtains simplifying; The parameter oxy of the representative tissue oxygenation metabolic capability that the method for utilizing the present invention to propose calculates can evaluate the exercise metabolism ability, sportsman and non athlete's significant difference, and the result is as shown in Figure 6.
Description of drawings:
Fig. 1 has the detection method synoptic diagram now.
Fig. 2 detection method synoptic diagram of the present invention.
Fig. 3 sensor outward appearance arrangenent diagram.
The detection method process flow diagram of the near infrared tissue oxygenation metabolism assessment parameters that Fig. 4 the present invention proposes.
Fig. 5 hardware unit structural drawing.
The load curve map of tissue oxygenation parameter in the incremental motion of Fig. 6.
Embodiment:
The present invention at first requires to determine suitably that according to the thickness of object outer tissue to be measured light source on the sensor arrives detector distance d.The thickness of outer tissue can be obtained by the ultrasonic technique of routine.When outer tissue is thicker, then distance should be got bigger value, is deep into tissue to be measured to guarantee photon energy, and rule of thumb and experimental result, when fat thickness was greater than 15mm when surveying muscle, d got 50mm, was a surname otherwise get 40mm.Multilayer tissue's structure and detection method as shown in Figure 2.1 is to be the light source LS1 of r1 with optical sensor OPSU distance in Fig. 2, the 2nd, with optical sensor OPUS distance be the light source LS2 of r2, the 3rd, with optical sensor OPUS distance be the light source LS3 of r3, the 4th, optical sensor 0PSU, 5 are the 1st layer tissue and represent with T1,6 are the 2nd layer tissue and represent with T2,7 are the 3rd layer tissue and represent that with T3 in the organize models that human muscular tissue's blood oxygen is measured, T1 is a skin, T2 is the muscle hypodermis, and T3 is a musculature.B1, b2, b3 are the track of photon transport.Detect the tissue of different depth, LS is placed on the different distance with optical sensor OPUS, LS3 is luminous, and what detected by OPUS mainly is the information of T1 layer, and LS2 is luminous, and what detected by OPUS is the information of T1 and T2 layer, and LS1 is luminous, and what detected by OPUS mainly is the information of T1, T2 layer and T3 layer.Light source LS1, LS2, LS3 are r to the distance of OPUS
1, r
2, r
3
As shown in Figure 3, the centre distance of three luminotron 1LED1,2LED2,3LED3 and the 4 photoelectric receiving tube OPUS on the sensor is respectively 50mm, 40mm and 30mm.Select a distance in fixed these three distances and make this lumination of light emitting diode according to the fat deposit thickness of muscle in use, all the other two light emitting diodes are then not luminous.Each luminotron should be able to be launched the light of two kinds of wavelength respectively.Wavelength is respectively ruddiness and near infrared light, and is following with λ
1, λ
2The expression different wave length.The change amount of optical density OD by two wavelength correspondences calculates oxyhemoglobin variation delta HbO
2With reduced hemoglobin variation delta Hb.
The effect of bringing after the invention process can reduce: (1) selects suitable surely detection distance under different tissues and corresponding outer tissue thickness.(2) and derive the parameter of blood oxygen metabolism ability in the concentrated expression campaign, promptly to close the variable quantity of haemoglobin oxygen and reduction relevant with local organization for this parameter, can reflect heart blood supply ability and blood supply distribution capability again.
Program flow chart of the present invention is seen Fig. 4.
Use the detection system schematic block circuit diagram of the method for the invention formation and see Fig. 5.
The exemplary hardware device that goes out according to the diffused light principle design as shown in Figure 5.In use, at first utilize ultrasonic method to measure outer tissue thickness and one-tenth-value thickness 1/10 is imported instrument, and use heart rate instrumentation amount heart rate all the time.One of them is selected by system from three LED 1LS, 2LS, 3LS, the principle of selection is: survey muscle when lipfanogen during greater than 15mm, select LS1, get LS2 less than 15mm.Detecting light intensity by photoelectric detector 4OPUS changes, OPUS selects 2CU30S, 4OPUS is connected to prime amplifier TLC27L2 signal is amplified, signal enters sampling holder LF398 and changes by analog-digital converter ADC TLC2543 under microcontroller AT89C52 control, and transformation result deposits storer in.By algorithm that provides in the method and step, calculate oxyhemoglobin variable quantity (Δ HbO
2) and reduced hemoglobin variable quantity (Δ Hb).
Detect the blood oxygen parameter under the increasing load motion, obtained comprehensive blood oxygen parameter oxy.The setting device setting of load that apply by cycle ergometer, the increasing load of employing 0-50 W-100W, the result is as shown in Figure 6.
Claims (3)
1, muscle metabolism function blood fortune parameter near infrared is organized lossless detection method, comprise with the variable quantity of the haemoglobin that closes oxygen and reduction in the Near-infrared Double wave spectrum method detection of biological tissue, it is characterized in that: it uses three each self energy difference emission wavelengths to be λ
1Ruddiness and wavelength be λ
2The luminotron of infrared light form sensor with the photoelectric receiving tube that is positioned at a side, the centre distance d of three luminotrons and photelectric receiver is at least 30mm, 40mm and 50mm, type according to outer tissue during detection is therefrom chosen the light emitting diode with corresponding centre distance, and only order this lumination of light emitting diode, be respectively λ according to detected wavelength
1, λ
2Optical density OD
λ i, i=1,2, calculate respectively two neighbouring samples constantly close the change amount Δ CHbO2 oxygen hemoglobin concentration and reduced hemoglobin concentration, Δ CHb and blood volume changes delta BV=Δ CHbO2+ Δ CHb; Under load incremental motion experiment condition, the synchronous recording heart rate value divided by heart rate change value under every stage load, just can obtain being used for evaluating the parameter of motion tissue oxygenation metabolic capability to the variable quantity of the Δ BV that is calculated under every stage load; Above-described method has following steps successively:
(1), measures outer tissue thickness with ultrasonic method and select a fixed light emitting diode with photoelectric receiving tube apart from d according to the thickness of outer tissue according to the object of test and the position of test;
(2) tested object is on cycle ergometer static 1 minute, and the baseline value with general cardiotach ometer test heart rate HR and record and record Δ BV detects and calculate Δ BV through following following steps.
(2.1) detect optical density value OD under the centre distance of selected luminotron and photoelectric receiving tube
λ i
i＝1，2；
Wherein, I
Go intoBe light source power, I
Go outBe that incident light passes through after biological tissue's scattering the luminous power that photoelectric receiving tube is received;
(2.2) detect the blood oxygen condition in time in the change procedure, two neighbouring sample optical density OD at interval
λ iDifference OD
k λ i
Wherein, OD
t λ iAnd OD
T+1 λ iBeing respectively wavelength is λ
iThe time, at t constantly and subsequent t+1 optical density constantly poor;
(2.3) the blood oxygen condition in the change procedure, is inscribed during two neighbouring samples in time, and the concentration change of closing the oxygen haemoglobin is that Δ CHbO2, reduced hemoglobin concentration change are Δ CHb and blood volume changes delta BV, and available following formula is calculated:
ΔBV＝ΔCHbO2+ΔCHb
α wherein
1-α
4For constant but relevant with wavelength,
Wavelength is λ
1Down
α
1Be-1.6～-2.5,
α
3Be 2.6～3.85
Wavelength is λ
2Down
α
2Be-2.5～-3.6,
α
4Be 0.6～1.6
(3) in order to obtain evaluating the dynamic parameter of muscle blood oxygen metabolism, the experimenter does the load incremental motion by every grade of 50W, writes down the value of the Δ BV of motion process under every stage load, heart rate HR under the every stage load of synchronous recording with the described method of step (2).
(4) calculate the change amount Δ BV of every stage load Δ BV
j, calculate the change amount Δ HR of every stage load Δ HR
j, calculate the parameter oxy that represents the tissue oxygenation metabolic capability.
J represents the progression of exercise load
2, the detection method of near infrared tissue oxygenation metabolism assessment parameters according to claim 1, it is characterized in that: be under the situation of fat deposit of muscle when outer tissue, when fat thickness was greater than 15mm detecting muscle blood oxygen parameter, the d value was at least 50mm, otherwise is at least 40mm.
3, the detection method of near infrared tissue oxygenation metabolism assessment parameters according to claim 1 is characterized in that: under the motion increasing load, obtain the parameter oxy of tissue oxygenation metabolic capability.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310115396 CN1223858C (en) | 2003-11-21 | 2003-11-21 | Near infrared tissue non-destructive testing method for blood transportation parameter of skeletal muscle metabolism |
| KR1020067011264A KR100823977B1 (en) | 2003-11-14 | 2004-11-15 | An apparatus of and method for measuring the parameter of the blood oxygen metabolism in human tissue |
| PCT/CN2004/001301 WO2005099564A1 (en) | 2003-11-14 | 2004-11-15 | An apparatus of and method for measuring the parameter of the blood oxygen metabolism in human tissue |
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| CN 200310115396 CN1223858C (en) | 2003-11-21 | 2003-11-21 | Near infrared tissue non-destructive testing method for blood transportation parameter of skeletal muscle metabolism |
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| WO2017215409A1 (en) * | 2016-06-13 | 2017-12-21 | 北京阿纽山医药科技有限公司 | Portable smart health monitoring device |
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| CN105628481B (en) * | 2015-12-03 | 2018-05-29 | 浙江大学 | A kind of tissue oxygen detection calibration titer configuration device and calibration method |
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| CN110522459A (en) * | 2019-08-22 | 2019-12-03 | 西安交通大学 | Ectoskeleton power-assisted effect testing method is assessed based on infrared spectroscopy detection muscle oxygen content |
| CN113925465A (en) * | 2021-10-20 | 2022-01-14 | 佛山科学技术学院 | Rehabilitation training evaluation method and system based on muscle oxygen feedback information |
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