CN1541646A - Hydroxyl methionine salt trace element additive preparation method - Google Patents

Hydroxyl methionine salt trace element additive preparation method Download PDF

Info

Publication number
CN1541646A
CN1541646A CNA031183395A CN03118339A CN1541646A CN 1541646 A CN1541646 A CN 1541646A CN A031183395 A CNA031183395 A CN A031183395A CN 03118339 A CN03118339 A CN 03118339A CN 1541646 A CN1541646 A CN 1541646A
Authority
CN
China
Prior art keywords
trace element
methionine
hydroxy methionine
salt
additive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA031183395A
Other languages
Chinese (zh)
Inventor
黄逸强
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CNA031183395A priority Critical patent/CN1541646A/en
Priority to AU2003304061A priority patent/AU2003304061A1/en
Priority to PCT/CN2003/000483 priority patent/WO2004096205A1/en
Publication of CN1541646A publication Critical patent/CN1541646A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The additive is hydroxy methionine salt chelate C5H10O1SM, where M is some trace element. It is prepared through chelating reaction of liquid hydroxy methionine and inorganic metal salt aqua in molar ratio of 1 to 1 at 30-80 deg.c pH 5-8 and normal pressure for 0.5-1.0 hr. The trace element additive has high biological valence and low consumption and may be taken by human and animal. It can provide both methionine and trace elements.

Description

The preparation method of Hydroxymethionine salt as trace element additive
Technical field: the preparation method that the present invention relates to a kind of trace mineral supplement.
Background technology: current mankind and animal trace element supplement zinc, ferrum, manganese, cobalt, magnesium, selenium, chromium, copper etc. mostly adopt its inorganic salt form, and absorbing must be by the various biological barrier, and its absorbance is low, and addition is big, and biological value is low; And these inorganic salts have destruction to vitamin isoreactivity material.
Summary of the invention: technical problem to be solved by this invention provides a kind of except that satisfying the nutrition to trace element of animal and human body, and a kind of preparation method of trace mineral supplement of the nutrition of methionine can also be provided.This method technology is simple, with low cost, production efficiency is high, easy popularization, easy-to-operate.
Trace mineral supplement is hydroxy methionine salt chelate (C among the present invention 5H 10O 1SM).
Its preparation method is as follows:
1, the inorganic salt solution of liquid hydroxy methionine and slaine is 1: 1 with mol ratio, and 30～80 ℃ of temperature, in the presence of sodium hydroxide, control pH value 5～8 reacted under the condition of normal pressure 0.8～1.2 hour, generated hydroxy methionine salt chelate; Its reaction equation is as follows:
Figure A0311833900031
2, centrifugalize, washing;
3, dry, pulverize, be packaged into finished product.
Because this chelating salt is to absorb by the aminoacid approach in digestive tract, speed is fast, absorbance improves greatly, the biological value height, can reduce the consumption of additive; The micro-element nutrition of improving humans and animals had good facilitation; Satisfy outside the nutrition of trace element of people and animal, the nutrition of methionine also can be provided, so can promote growth; Can also avoid the destruction of inorganic salt to vitamin isoreactivity material; Can significantly improve the utilization rate of feedstuff.This hydroxy methionine chelate has stable chemical constitution, safety non-toxic, nonirritant.This additive can be widely used in various animals: as pig, fowl, aquatic animal etc., also can be applicable to the people.The present invention has advantages such as technology is simple, with low cost, production efficiency is high, easy popularization, easy-to-operate.
The specific embodiment:
Embodiment 1: methionine hydroxy zinc (C 5H 10O 1SZn) preparation method is used:
(1) hydroxy methionine+zinc sulfate monohydrate+98% sodium hydroxide is under 40 ℃ reaction temperature, and regulating PH is 7, reacts 0.5 hour, obtains methionine hydroxy zinc, and wherein zinc content is 28.1%, hydroxy methionine content 71.9%.Its reaction equation is as follows:
Figure A0311833900041
Centrifugalize, washing; Dry, pulverize, be finished product.Feed boar with this additive 200～400 gram/tons, can promote growth, disease resistance enhancemen; Prolong boar and breed service life; Feed suckling piglet with this additive 200～400 gram/tons, can help improving hemopoietic function and immune function, improve anti-stress ability and immunity, promote growth, significantly improve the economic worth of feedstuff.The barren sow of engrossing then can promote growth, improves feedstuff-meat ratio, improves yellowish pink, makes the Corii Sus domestica skin ruddy, the hair color light.Feed poultry the speed of growth is improved, feedstuff-meat ratio descends, and strengthens the feather glossiness, improves its stress ability, reduces mortality rate.Feed aquatic animal, but enhancing immunity reduces incidence and mortality, promotes growth, reduce disease and take place, improve efficiency of feed utilization.
Embodiment 2: hydroxy methionine iron (C 5H 10O 1SFe) preparation and application:
Hydroxy methionine+ferrous sulfate+98% sodium hydroxide is under 80 ℃ reaction temperature, and regulating PH is 5, reacts 0.8 hour, obtains 115 kilograms of hydroxy methionine irons, centrifugalize, washing; Dry, pulverize, be finished product.Wherein iron content is 21.3%, hydroxy methionine content 52.4%.Its reaction equation is as follows:
Figure A0311833900051
Feed breeding boar with this additive 300～500 gram/tons, can promote growth, disease resistance enhancemen; Prolong breeding boar and breed service life; Feed sow with this additive, can significantly improve the interior ferrum deposit of piglet body in the tire, improve nascent body weight of piglet and survival rate; Concentration of iron improves in the milk; Feed piglet and can effectively prevent piglet anaemia, mortality rate reduces, and significantly improves the piglet hemoglobin level, improves the immune disease-resistance ability, promotes growth.Hello, the fat meat pig then promotes growth, improves feedstuff-meat ratio, improve yellowish pinkly, make the Corii Sus domestica skin ruddy, the hair color light.Feed poultry and help feedstuff-meat ratio, improve the hatching of breeding eggs rate, improve anti-stress ability, reduce mortality rate.Feed aquatic animal and can promote growth, improve survival rate, increase ferrum and absorb.
Embodiment 3: hydroxy methionine copper:
Hydroxy methionine+copper sulphate pentahydrate+sodium hydroxide is under the reaction temperature of 40 ℃ of maintenances, and control PH is 7 reactions 0.5 hour, obtains hydroxy methionine copper, and wherein copper content is 16.3%, and hydroxy methionine content is 73.1%.Its reaction equation is as follows:
Figure A0311833900052
Embodiment 4: hydroxy methionine manganese:
Hydroxy methionine+manganese sulfate monohydrate+98% sodium hydroxide control PH is 6, and keeping reaction temperature is 45 ℃, obtains hydroxy methionine manganese, and wherein manganese content is 21.7%, hydroxy methionine content 52.8%.Reaction equation is as follows:
Figure A0311833900061

Claims (1)

1, a kind of preparation method of Hydroxymethionine salt as trace element additive is characterized in that may further comprise the steps:
(1), liquid hydroxy methionine and metal inorganic salt (sulfate) or oxide water solution be 0.8: 1 with mol ratio, 30～80 ℃ of temperature, or sodium hydroxide exists down, control pH value 5～8 reacted under the condition of normal pressure 0.5～1 hour, obtained hydroxy methionine salt;
(2), centrifugalize, washing;
(3), dry, pulverize, be packaged into finished product.
CNA031183395A 2003-04-30 2003-04-30 Hydroxyl methionine salt trace element additive preparation method Pending CN1541646A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CNA031183395A CN1541646A (en) 2003-04-30 2003-04-30 Hydroxyl methionine salt trace element additive preparation method
AU2003304061A AU2003304061A1 (en) 2003-04-30 2003-06-23 A process for producing an additive comprising a salt obtained from hydroxy methionine and a trace element
PCT/CN2003/000483 WO2004096205A1 (en) 2003-04-30 2003-06-23 A process for producing an additive comprising a salt obtained from hydroxy methionine and a trace element

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA031183395A CN1541646A (en) 2003-04-30 2003-04-30 Hydroxyl methionine salt trace element additive preparation method

Publications (1)

Publication Number Publication Date
CN1541646A true CN1541646A (en) 2004-11-03

Family

ID=33315363

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA031183395A Pending CN1541646A (en) 2003-04-30 2003-04-30 Hydroxyl methionine salt trace element additive preparation method

Country Status (3)

Country Link
CN (1) CN1541646A (en)
AU (1) AU2003304061A1 (en)
WO (1) WO2004096205A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101701004B (en) * 2009-10-30 2013-06-12 长沙兴加生物技术有限公司 Nickel glycinate and preparation method and application thereof
CN101704774B (en) * 2009-10-30 2013-11-20 长沙兴加生物技术有限公司 Hydroxyl nickel methionine and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1310947B1 (en) * 1999-03-05 2002-02-27 Agristudio Srl FOOD SUPPLEMENT CHELATED FOR AGRO-ZOOTECHNICAL USE, AND METHOD FOR OBTAINING THE SAME.
CN1112115C (en) * 2000-08-16 2003-06-25 黄逸强 Hydroxy methionine iron feed additives and its preparing method
CN1338254A (en) * 2000-08-16 2002-03-06 黄逸强 Hydroxymethionine salt as trace element additive and its preparing process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101701004B (en) * 2009-10-30 2013-06-12 长沙兴加生物技术有限公司 Nickel glycinate and preparation method and application thereof
CN101704774B (en) * 2009-10-30 2013-11-20 长沙兴加生物技术有限公司 Hydroxyl nickel methionine and preparation method and application thereof

Also Published As

Publication number Publication date
AU2003304061A1 (en) 2004-11-23
WO2004096205A1 (en) 2004-11-11

Similar Documents

Publication Publication Date Title
US20100266480A1 (en) Method for Preparing a Trace Element Additive Basic Zinc Chloride
CN1064371C (en) Seaweed polysaccharide trace-element complex and its preparation method and usage
CN103224461A (en) Preparation method and application of large-particle crystal form methionine metal chelate
CN102550836A (en) Animal nutrient additive trace element compound bag as well as preparation method and application thereof
CN102524540A (en) Saving trace element compound packet as well as preparation method and application thereof
CN1338254A (en) Hydroxymethionine salt as trace element additive and its preparing process
CN1112115C (en) Hydroxy methionine iron feed additives and its preparing method
CN102948620B (en) Preparation method of modified methionine hydroxy analog-calcium feed additive
CN1541646A (en) Hydroxyl methionine salt trace element additive preparation method
CN1022373C (en) Animal nutrient solution
CN102550830B (en) Method for applying and preparing gamma-aminobutyric acid complex compound
CN1112114C (en) Fodder additive contg. zinc hydroxy methionine and the prepn. method therefor
CN101683119A (en) Hydroxyl methionine iron feed additive and preparation method thereof
CN1235878C (en) Preparation method of additive hydroxy zinc methionine microelement
PT1647542T (en) Method for the production of metal carboxylates-aminoates and their use as growth promoters in animal feed
CN104206809A (en) Organic-zinc chicken feed additive
CN101971916B (en) Liquid compound premixed feed containing mineral substances and amino acid
CN109123101A (en) The application of a kind of preparation method and niacin manganese of niacin manganese in animal feed
CN102007884A (en) Method for producing eggs rich in multiple trace elements
CN103005165A (en) Preparation method of lactobionic acid microelement complex and application of complex as animal feed additive
CN101445264B (en) Preparation method of trace element additive basic copper sulfate
CN101444264B (en) Application of basic copper sulfate as trace element copper source additive in animal feed
CN101597237B (en) Iron (II)-threonine and preparation method and application thereof
EP1536699A2 (en) Use of metal chelates in human or animal feeding
CN1328171C (en) Process for preparing basic zinc chloride of trace mineral supplement

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication