CN1537600A - Xiangsha yangwei hard capsule for nourishing stomach, and its prepn. method - Google Patents
Xiangsha yangwei hard capsule for nourishing stomach, and its prepn. method Download PDFInfo
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- CN1537600A CN1537600A CNA031189547A CN03118954A CN1537600A CN 1537600 A CN1537600 A CN 1537600A CN A031189547 A CNA031189547 A CN A031189547A CN 03118954 A CN03118954 A CN 03118954A CN 1537600 A CN1537600 A CN 1537600A
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Abstract
A dual-phase stomachic capsule with cyperus and amomum features that the extracted volatile oil and the extracted solid granules are filling in same capsule. Its preparing process includes such steps as extracting volatile oil, preparing dripping pills or softgels, conventionally extracting active components from the dregs and other raw materials, separating, granulating, and filling the dripping pills or soft capsule and solid particles in same capsule. Its advantages are less loss of volatile oil and high curative effect.
Description
Technical field
What the present invention relates to is oral capsule preparation and the preparation method that is prepared by the Chinese medicinal plant extract, particularly the double phases hard capsule and the preparation method of the solid particle of while fill cyperus-amomum stomach volatile oil composition and cyperus-amomum stomach lixiviate composition.
Background technology
XIANGSHA YANGWEI WAN is kinds of recording of 2000 editions Chinese Pharmacopoeias, and application is wider clinically, and major function is a warming middle-JIAO for easing the stomach, be used for anorexia, acid regurgitation, gastral cavilty is full vexed, the extremity asthenia, full side is by the 14 flavor Chinese medicine Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Poria, the Rhizoma Pinelliae, Rhizoma Cyperi, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae is formed, wherein the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis, volatile oil content is higher in the Rhizoma Zingiberis Recens ten flavor Chinese crude drugs, has the gastrointestinal smooth of releasing muscular spasm, regulating the flow of QI to ease the stomach, warming the stomach helps digestion, and promotes gastric secretion, strengthening the effect of digestion power, is the effective constituent that mainly contains of preparation.The XIANGSHA YANGWEI WAN of conventional dosage forms, among the preparation technology, do not extract volatile oil, medical material is in crushing process, because heating up in the crushing process, impel volatile oils, volatile oil in production process and in storing loss bigger, affect the treatment performance and pill dose are big, take inconvenience, disintegrate is slow, and dosage form falls behind.Other has the XIANGSHAYANGWEI KELI dosage form is to be improved by pill, and volatile oil adopts and is injected in the granule, airtight infiltration, but that volatile oil can be waved at normal temperatures is diffusing, process, in the storage process, the volatile oil composition has more loss; It further is improved to the conventional capsule dosage form of cyperus-amomum stomach, the conventional capsule dosage form of cyperus-amomum stomach is in preparation technology, generally adopt beta-schardinger dextrin-inclusion volatile oil, this technology is subjected to the influence of inclusion rate, and most of preparation inclusion rates are at 80-90%, beta-schardinger dextrin-and volatile oil ratio 8: 1 are preferable, non-active ingredient amount is big, has increased dose, and patient takes inconvenience, a large amount of beta-schardinger dextrin-s that use increase cost; And production technology and equipment requirements height, technology is difficult to be grasped.In the prescription of cyperus-amomum stomach preparation, the volatile oil composition is very complicated, long time stored in water deduction part or water carry again easily and volatile oil generation chemical change through the composition of alcohol extraction, cause the effective ingredient loss and affect the treatment.Number of patent application 01100749 is a nanometer formulation, though the drug bioavailability height, nano-pulverization, cell wall rupture causes a large amount of volatilizations of volatile oil and loses.And this nanometer Chinese medicine preparation produce and storage process in owing to there is not corresponding good isolation technology, water is carried the extract composition that extract composition or water carries through precipitate with ethanol again effectively separates with volatile oil, cause the effective ingredient loss and affect the treatment.
Summary of the invention
The objective of the invention is to utilize the raw material of conventional XIANGSHA YANGWEI WAN to form and usage ratio, under the prerequisite that does not lessen the curative effect, transform dosage form, make volatile oil in production, storage process, not distribute, distribute less, avoid in storage process and extract composition generation chemical change, and double phases hard capsule of a kind of while fill cyperus-amomum stomach volatile oil composition and cyperus-amomum stomach extract and preparation method thereof is provided.
Technical scheme of the present invention and more excellent technical scheme have following:
A kind of cyperus-amomum stomach double phases hard capsule, wherein the prescription raw material of cyperus-amomum stomach and weight proportion are 149.3 parts of the Radix Aucklandiae, 149.3 parts of Fructus Amomis, 213.3 parts of the Rhizoma Atractylodis Macrocephalaes, 213.3 parts of Pericarpium Citri Reticulataes, 213.3 parts in Poria, 213.3 parts of the Rhizoma Pinelliaes, 149.3 parts of Rhizoma Cyperis, 149.3 parts of Fructus Aurantii Immaturuss, 149.3 parts in Fructus Amomi Rotundus, 213.3 parts of Cortex Magnoliae Officinalis, 149.3 parts of Herba Pogostemonis, 64 parts in Radix Glycyrrhizae, 64 parts in Rhizoma Zingiberis Recens, 106.7 parts in Fructus Jujubae, comprise a hard capsule, the soft capsule or the drop pill of cyperus-amomum stomach volatile oil composition is housed in the hard capsule simultaneously, and the solid particle of cyperus-amomum stomach lixiviate composition.
A kind of cyperus-amomum stomach double phases hard capsule, cyperus-amomum stomach lixiviate composition is the solid particle of cyperus-amomum stomach water deduction part.
A kind of cyperus-amomum stomach double phases hard capsule, cyperus-amomum stomach lixiviate composition is the solid particle of cyperus-amomum stomach water extract-alcohol precipitation composition.
A kind of cyperus-amomum stomach double phases hard capsule is equipped with the volatile oil composition of the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis in soft capsule or the drop pill.
A kind of cyperus-amomum stomach double phases hard capsule is equipped with the volatile oil composition of the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis in soft capsule or the drop pill.
A kind of cyperus-amomum stomach double phases hard capsule, hard capsule model are a kind of in 000,00,0,1, No. 2.
A kind of cyperus-amomum stomach double phases hard capsule, drop pill weight 20-50mg.
A kind of preparation method of cyperus-amomum stomach double phases hard capsule is extracted the volatile oil composition with the prescription raw material of cyperus-amomum stomach earlier through conventional essential oil extraction method, and last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are solidified into solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
A kind of preparation method of cyperus-amomum stomach double phases hard capsule, the prescription raw material of cyperus-amomum stomach is extracted the volatile oil composition earlier through conventional essential oil extraction method, last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are handled through conventional alcohol extraction again, filtration obtains alcohol extract, through concentrating, be solidified into solid particle again; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
A kind of preparation method of cyperus-amomum stomach double phases hard capsule, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Zingiberis Recens, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt supercritical extraction method to obtain the volatile oil composition; Last medicinal residues, medicinal liquid decoct water jointly with the Poria that adds water preheat, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae again and carry and obtain the water extract, filter, concentrate, it is an amount of to add ethanol, making it contain alcohol amount reaches 60-75% and leaves standstill, filters and obtain alcohol extract, through concentrating, get stiff paste, drying under reduced pressure, pulverizing, granulation obtain solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
Principle and advantage of the present invention has:
Adopting the cyperus-amomum stomach double phases hard capsule of the present invention's preparation is the dosage form that the volatile oil composition and the solid particle of extract separate fill.Because volatile oil is volatile, also can wave gradually at normal temperatures and dissipate, volatile oil is made drop pill or soft capsule, the volatilization that has prevented volatile oil is is effectively scattered and disappeared, and collected multiple medical material volatile oil, the volatile oil composition is encased in drop pill or the soft capsule chemical change of having avoided volatile component and granule Chinese medicine composition to cause with physical method.
The present invention has collected the volatile oil composition of raw medicinal material, better utilization the effective ingredient of raw medicinal material, guarantee curative effect of medication.
Water of the present invention is carried extract can remove invalid macromole organic impuritiess such as wherein cellulose, protein, pectin, natural gum with proper methods such as the conventional alcohol extraction sedimentation method or ultrafiltration, at last with the extract medicinal liquid of gained, concentrate drying routinely, adopt a step boiling granulating, get homogeneous granules.
Increase the alcohol extraction step, can remove the macromole organic impurities, under the prerequisite that does not affect the treatment, reduce dose, conveniently take.
Specific embodiment
Embodiment 1:
With reference to the medical material and the usage ratio of 530 pages of the Pharmacopoeias of the People's Republic of China (2000 editions) " XIANGSHA YANGWEI WAN " defined, prescription is decided to be Radix Aucklandiae 149.3g, Fructus Amomi 149.3g, Rhizoma Atractylodis Macrocephalae 213.3g, Pericarpium Citri Reticulatae 213.3g, Poria 213.3g, Rhizoma Pinelliae 213.3g, Rhizoma Cyperi 149.3g, Fructus Aurantii Immaturus 149.3g, Fructus Amomi Rotundus 149.3g, Cortex Magnoliae Officinalis 213.3g, Herba Pogostemonis 149.3g, Radix Glycyrrhizae 64g, Rhizoma Zingiberis Recens 64g, Fructus Jujubae 106.7g, starch 80g makes 1000 capsules.
Method for making: the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis, Rhizoma Zingiberis Recens are extracted volatile oil with steam distillation, and volatile oil is made the drop pill of every 50mg; Medicinal liquid after the distillation, last medicinal residues, decoct with water 2 times with all the other raw material Poria, Radix Glycyrrhizae, Fructus Jujubae, the Rhizoma Pinelliae, the 1st 8 times of water gagings, 2h, the 2nd 6 times of water gagings, 1.5h, merge decoction liquor, concentrate and add ethanol and make and contain the alcohol amount and reach 60%, reclaim ethanol, extract is granulated with a step boiling process, respectively with granule, be filled in the hard capsule seal package with the drop pill of a 50mg.
Specification: every contains granule 0.4g, volatile oil 50mg.
Usage and dosage: 2 times on the one, each 4.
The course of treatment: according to the disease weight, and different patients, select 6-40 days the course of treatment.
We study the influence and the antiinflammatory action of gastrointestinal motility and digestive function the cyperus-amomum stomach biphasic capsule:
1 pair of mouse intestinal propulsion functions influence 30 of mices, male female half and half, be divided into 3 groups at random, ip or ig administration respectively behind the fasting 6h, ig5% charcoal end is suspension 0.2ml/ behind the 20min, and disconnected cervical vertebra is put to death behind the 10min, cuts open immediately and gets intestinal, measure the charcoal end and advance length and intestinal total length, obtain the charcoal end and advance percentage rate, matched group is 72.9 ± 11.2 as a result, and pill 10g/kg is 69.2 ± 11.7, biphasic capsule 10,20g/kg are 69.8 ± 11.9 and 67.5 ± 6.9, do not have significant difference between each group.
2 pairs of mice gastric emptyings influence 30 male and female half and half of mice, divide 3 groups at random, survey methyl orange residual rate (%) in the stomach by methyl orange gastric emptying method, matched group is 36.3 ± 12.5 as a result, pill 5g/kg is 39.2 ± 11.4, biphasic capsule 5,10/kg are respectively 37.7 ± 11.6 and 41.4 ± 16.6, and showing does not all have obvious influence to gastric emptying.
The 3 pairs of rat gastric juice is excretory to be influenced 30 of rats and is divided into 3 groups at random, the ig administration, every day 1 time, continuous 7 days, fasting 12h behind the last medicine, use etherization, the ligation pylorus, the postoperative fasting is put to death after prohibiting water 10h, the ligation cardia of cutting open the belly, collect gastric juice, and survey gastric juice amount, pH value, gastric juice viscosity and peptic activity of stomach (capillary tube method), the results are shown in Table.
Group dosage (g/kg) gastric juice amount (ml) PH viscosity (mm/s) peptic activity of stomach
NS??????????-?????????????13.8±2.6?????????1.25±0.06??????1.162±0.142???????9.76±1.77
Administration 10 7.0 ± 0.8* 1.48 ± 0.10* 1.147 ± 0.047 10.14 ± 1.63
Administration 20 8.6 ± 2.1* 1.28 ± 0.06 1.175 ± 0.029 10.59 ± 1.25
*P＜0.05??
**P＜0.01
By table as seen, biphasic capsule can make gastric secretion reduce, and the gastric juice pH value significantly rises, and the viscosity and the peptic activity of stomach of gastric juice do not had the significance influence.
4 pairs of rat acute gastritis influence 30 of rats; be divided into 3 groups at random; the ig administration; continuous 5d; fasting 24h; before making film behind the 12h last administration 12h, the salicylic acid solution 100mg/kg of ig1%, the cervical vertebra dislocation is put to death behind the 4h; get stomach immediately and cut open inspection; observe the ulcer point, measure the ulcer major diameter, ask its summation as ulcer index; matched group is 10.44 ± 5.12 as a result; pill 10g/kg is 4.58 ± 1.94 (P＜0.01), biphasic capsule 10; 20g/kg is 4.11 ± 1.65 (P＜0.01) and 4.05 ± 2.11 (P＜0.01), shows that the cyperus-amomum stomach biphasic capsule all has obvious protective effect to the salicylic acid gastric ulcer.
5 antiinflammatory actions
Influence to mice auricle swelling, 40 of mices are divided into 4 groups at random, two sides, 30min every Mus auris dextra front and back is coated with dimethylbenzene 25 μ l after the ig administration, put to death mice behind the 15min, get auricle (9mn) and take by weighing Mus ear swelling pain (mg), matched group is 13.5 ± 2.6 as a result, pill 20g/kg is 10.3 ± 3.1 (P＜0.05), biphasic capsule 10,20g/kg are respectively 11.0 ± 1.2 (P＜0.05), 10.3 ± 1.1 (P＜0.01) show that cyperus-amomum stomach capsule xylol induced mice auricle edema has inhibitory action.
The cyperus-amomum stomach biphasic capsule is made up of the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Poria, the Rhizoma Pinelliae etc., has the effect of warming middle-JIAO for easing the stomach.For observing its curative effect, we have carried out clinical verification.
1, data and method
1.1 physical data
Select to be in hospital and the dialectical genus taste of outpatient cold-damp stagnation of QI person totally 200 examples, wherein male 106 examples, women 94 examples, at minimum 21 years old of age, maximum 68 years old, average 41.4 ± 14.7 years old, sick kind comprises chronic gastritis, peptic ulcer etc., and was the shortest 2 weeks of the course of disease, the longest 22 years.Be divided into two groups by the simple randomization method, each 100 example of treatment group and matched group, two groups of no difference of science of statistics (X2 checks P＜0.05) aspect sex, age, sick kind, the course of disease.
1 study subject is selected
The differential diagnosis in tcm standard
Primary symptom: (1) anorexia, (2) acid regurgitation, (3) gastral cavilty is full vexed, (4) extremity asthenia.
Inferior disease: (1) tastelessness and no thirst, (2) borborygmus or continuous and dull pain in the abdomen, (3) diarrhea with loose stool, (4) mouthful general clear saliva.
Sign: (1) light red tongue is fat or have tooth to print, white and thin fur or white greasy, (2) thready and rolling pulse, (3) shallow complexion.
The case inclusion criteria: possess two of primary symptoms, wantonly two can be selected in inferior disease and the sign.
The case exclusion standard
(1) gestation or women breast-feeding their children are to this medicine allergy sufferers at under-18s or over-65s the age.
(2) be associated with serious primary disease such as cardiovascular, liver, kidney and hemopoietic system and psychotic.
(3) do not meet person's standard, not medication in accordance with regulations, influential hobby to this card treatment can't be judged that curative effect or data are intact etc. to affect the treatment or safety judgement person.
2 Therapeutic Method
The treatment group is taken the cyperus-amomum stomach biphasic capsule, one time 4,2 times on the one.Matched group is taken XIANGSHA YANGWEI WAN, one time 9 gram, 2 times on the one.Be a course of treatment January, observes a course of treatment, do not take other medicines in the observation period.Because Chinese Pharmacopoeia does not record granule, capsule, selecting the cyperus-amomum stomach pill of Chinese Pharmacopoeia record clinically for use is matched group.
3 observation index and recording method
By the unified observation table of formulating in therapeutic process with symptom, sign, about lab testing and untoward reaction etc., itemized record on time.
4 curative effect determinate standards
With reference to syndrome scoring method in " new drug treatment senile disease clinical research guideline ", the symptom note of promptly initiatively saying 4 minutes, the symptom of getting are significantly or continue note 3 minutes to occur, and be heavy or be interrupted and note 2 minutes occur when light during symptom, mild symptoms or appearance note once in a while 1 minute, asymptomatic note 0 minute.Appointing in the sign has one all to remember 6 fens.Obtain the total mark value of every example, judge according to the ratio that integrated value changes.
Produce effects: treatment back integrated value descends＞2/3;
Effectively: treatment back integrated value descends＞1/3;
Invalid: treatment back integrated value descends＜1/3.
5 therapeutic outcomes
The comparison of two groups of comprehensive therapeutic effects: two groups of all diseases in case treatment back are all obviously improved, and learn by statistics and handle (grade treatment value method), and the difference of comprehensive therapeutic effect does not have significance (P＜0.05) between two groups.
The comparison of two groups of comprehensive therapeutic effects (%)
Group produce effects enabledisable total effective rate % P value
Treatment organizes 39 54 8 92
Matched group 40 47 14 86＞0.05
Two groups of variations for the treatment of front and back syndrome integrated values: two groups of treatment back syndrome integrated values all significantly reduce (P＜0.01), compare there was no significant difference (P＞0.05) between group, are excellent trend but the effect of treatment group reduction integrated value has than matched group.
Syndrome integrated value before and after two groups of treatments (M ± SD)
After treating before the treatment of group example number
100 32.9 ± 6.2 11.1 ± 8.8* is organized in treatment
Matched group 100 31.2 ± 7.1 14.8 ± 7.7*
Preceding with treatment than * P＜0.01
2.1..3 two groups of primary symptom curative effects relatively: two groups of each primary symptom curative effects are close, learn by statistics and handle (grade treatment value method) there was no significant difference (P＞0.05), with the full vexed the best of gastral cavilty, acid regurgitation, anorexia, extremity asthenia are taken second place to the curative effect of each primary symptom.
Two groups of primary symptom curative effects relatively
Primary symptom treatment of control group group
The effective n produce effects of n produce effects enabledisable
Anorexia 58 14 31 49 13 27 9
Acid regurgitation 61 19 30 58 20 30 8
Gastral cavilty full vexed 72 25 43 79 31 36 12
Extremity asthenia 37 7 12 34 3 13 13
The observation of two groups of each primary symptom onset times: treatment organize each primary symptom onset time (median) than matched group for short, the prompting novel form may absorb rapidly, onset is very fast.
Two groups of each primary symptom onset time medians (my god)
The full vexed extremity asthenia of group anorexia acid regurgitation gastral cavilty
Treatment organizes 655 12
Matched group 877 13
The variation of two groups of treatment front and back xylose absorbances: the xylose absorbance is measured (King's method) medicine box and is provided by biochemical chamber, Academy of Traditional Chinese Medicine, Beijing.The result treats the two groups of xylose absorbances in back and all significantly increases (P＜0.01).Show that this medicine can obviously improve the absorption function of intestinal.Difference there was no significant difference (P＞0.05) between two groups before and after the treatment.
Xylose absorbance before and after two groups of treatments (%, X ± SD)
Difference before the treatment of treatment back before the treatment of group example number
40 16.9 ± 4.6 22.8 ± 5.1* 5.9 ± 4.5 is organized in treatment
Matched group 40 17.8 ± 4.8 22.7 ± 4.9* 5.0 ± 4.2
Preceding with treatment than * P＜0.01
6 safety evaluatios
Two groups of patients all do not find untoward reaction in therapeutic process, hematuria routine, hepatic and renal function are normal, do not occur new ANOMALOUS VARIATIONS after the treatment.
Pill and biphasic capsule compare:
| Item compared | Pill | Biphasic capsule |
| Taking dose | 1 ball/time, 2 times on the one, every ball 9g, taking dose is big. | 4/time, 2 times on the one, every 0.4g, taking dose is little. |
| Volatile oil | Do not extract volatile oil, the effective ingredient of loss volatile oil | Extract volatile oil, and seal preservation, kept the effective ingredient of volatile oil |
| Take property easy to carry | Inconvenient | Convenient |
Capsule and biphasic capsule compare:
| Item compared | Beta-schardinger dextrin-and 2: 1 capsule of volatile oil ratio | Biphasic capsule |
| The volatile oil seal | The volatile oils do not wrapped of part, and contact with granule | Airtight fully, and placed apart with granule |
| Stability | Three months, grain color was deepened obviously | Three months, grain color was constant, and nine months, grain color was constant |
| Item compared | Beta-schardinger dextrin-and 8: 1 capsule of volatile oil ratio | Biphasic capsule |
| Taking dose | 8/time, 2 times on the one | 4/time, 2 times on the one |
| The volatile oil seal | Better | Airtight fully, and placed apart with granule |
| Stability | Three months, grain color was not obvious | Three months, grain color was constant |
| Dose | Greatly | Little |
| Cost | The beta-schardinger dextrin-of a large amount of non-medicines has increased cost, the cost height | Cost is low |
Biphasic capsule and traditional preparation relatively see the following form:
Wherein capsule employing beta-schardinger dextrin-and volatile oil ratio are 8: 1, and loss of volatile oil is less, but non-active ingredient beta-schardinger dextrin-amount is big, has increased dose, increase cost, and patient takes inconvenience.
By relatively reaching pharmacology, clinical practice, prove adopt that the biphasic capsule novel formulation has that taking dose is little, convenient, reliable in quality, advantage evident in efficacy.
Embodiment 2:
Get embodiment 1 identical prescription, every of drop pill contains volatile oil 25mg, every hard capsule contains 2 drop pill, other the operation instructions of taking with embodiment 1.
Embodiment 3:
Get embodiment 1 identical prescription, the alcohol amount that contains that decocts the thing precipitate with ethanol changes 70% ethanol precipitate with ethanol into, and all the other are operated with example 1.
Specification: contain granule 0.35g in every hard capsule, volatile oil 50mg.
Instructions of taking is with embodiment 1.
Embodiment 4:
With reference to the medical material and the usage ratio of 530 pages of the Pharmacopoeias of the People's Republic of China (2000 editions) " XIANGSHA YANGWEI WAN " defined, writing out a prescription is Radix Aucklandiae 102.7g, Fructus Amomi 102.7g, Rhizoma Atractylodis Macrocephalae 146.7g, Pericarpium Citri Reticulatae 146.7g, Poria 146.7g, Rhizoma Pinelliae 146.7g, Rhizoma Cyperi 102.7g, Fructus Aurantii Immaturus 102.7g, Fructus Amomi Rotundus 102.7g, Cortex Magnoliae Officinalis 102.7g, Herba Pogostemonis 102.7g, Radix Glycyrrhizae 44g, Rhizoma Zingiberis Recens 64g, Fructus Jujubae 73.4g, starch 80g makes 1000 capsules.
Press embodiment 1 method of operation in operation, the drop pill specification is the 30mg/ grain, and packing specification is: every contains granule 0.3g, volatile oil 30mg, and usage and dosage: a twice-daily, each 6, it is identical with pharmacopeia side that present embodiment is taken the crude drug amount every day.
Embodiment 5:
A kind of cyperus-amomum stomach double phases hard capsule, wherein the prescription raw material of cyperus-amomum stomach and weight proportion are 149.3 parts of the Radix Aucklandiae, 149.3 parts of Fructus Amomis, 213.3 parts of the Rhizoma Atractylodis Macrocephalaes, 213.3 parts of Pericarpium Citri Reticulataes, 213.3 parts in Poria, 213.3 parts of the Rhizoma Pinelliaes, 149.3 parts of Rhizoma Cyperis, 149.3 parts of Fructus Aurantii Immaturuss, 149.3 parts in Fructus Amomi Rotundus, 213.3 parts of Cortex Magnoliae Officinalis, 149.3 parts of Herba Pogostemonis, 64 parts in Radix Glycyrrhizae, 64 parts in Rhizoma Zingiberis Recens, 106.7 parts in Fructus Jujubae, comprise a hard capsule, the soft capsule of cyperus-amomum stomach volatile oil composition is housed in the hard capsule simultaneously, and cyperus-amomum stomach water is carried the solid particle of the lixiviate composition of handling through precipitate with ethanol again.
Embodiment 6:
A kind of cyperus-amomum stomach double phases hard capsule, wherein the prescription raw material of cyperus-amomum stomach and weight proportion are 149.3 parts of the Radix Aucklandiae, 149.3 parts of Fructus Amomis, 213.3 parts of the Rhizoma Atractylodis Macrocephalaes, 213.3 parts of Pericarpium Citri Reticulataes, 213.3 parts in Poria, 213.3 parts of the Rhizoma Pinelliaes, 149.3 parts of Rhizoma Cyperis, 149.3 parts of Fructus Aurantii Immaturuss, 149.3 parts in Fructus Amomi Rotundus, 213.3 parts of Cortex Magnoliae Officinalis, 149.3 parts of Herba Pogostemonis, 64 parts in Radix Glycyrrhizae, 64 parts in Rhizoma Zingiberis Recens, 106.7 parts in Fructus Jujubae, comprise a hard capsule, the soft capsule of cyperus-amomum stomach volatile oil composition is housed in the hard capsule simultaneously, and the solid particle of cyperus-amomum stomach water-soluble alcohol deduction part.Every contains granule 0.5g, volatile oil 50mg, and usage and dosage: a twice-daily, each 5, all the other press embodiment 1 method of operation in operation.
Embodiment 7:
A kind of cyperus-amomum stomach double phases hard capsule is equipped with the volatile oil composition of the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis in the soft capsule.Other operation, usage and dosage is with embodiment 1.All the other press embodiment 1 method of operation in operation.
Embodiment 8:
A kind of cyperus-amomum stomach double phases hard capsule is equipped with the volatile oil composition of the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis in the drop pill.All the other press embodiment 1 method of operation in operation.
Embodiment 9:
A kind of cyperus-amomum stomach double phases hard capsule, in drop pill that to adorn a weight be 20mg.All the other press embodiment 1 method of operation in operation.
Embodiment 10:
A kind of cyperus-amomum stomach double phases hard capsule, in drop pill that to adorn a weight be 30mg, all the other press embodiment 1 method of operation in operation.
Embodiment 11:
A kind of cyperus-amomum stomach double phases hard capsule, hard capsule model are a kind of in 000,00,0,1, No. 2.
Embodiment 12:
A kind of preparation method of cyperus-amomum stomach double phases hard capsule is extracted the volatile oil composition with the prescription raw material of cyperus-amomum stomach earlier through conventional essential oil extraction method, and last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are solidified into solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
Embodiment 13: a kind of preparation method of cyperus-amomum stomach double phases hard capsule, the prescription raw material of cyperus-amomum stomach is extracted the volatile oil composition earlier through conventional essential oil extraction method, last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are handled through conventional alcohol extraction again, filtration obtains alcohol extract, through concentrating, be solidified into solid particle again; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
Embodiment 14: a kind of preparation method of cyperus-amomum stomach double phases hard capsule, and the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Zingiberis Recens, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt supercritical extraction method to obtain the volatile oil composition; Last medicinal residues, medicinal liquid decoct water jointly with the Poria that adds water preheat, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae again and carry and obtain the water extract, filter, concentrate, it is an amount of to add ethanol, making it contain alcohol amount reaches and 65% leaves standstill, filters and obtain alcohol extract, through concentrating, get stiff paste, drying under reduced pressure, pulverizing, granulation obtain solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.The usage and dosage specification is with embodiment 1.
Embodiment 15: a kind of preparation method of cyperus-amomum stomach double phases hard capsule, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt way of distillation distillation to obtain the volatile oil composition, medicinal residues and Poria, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae behind the collection volatile oil decoct jointly, decoction liquor filters, concentrate, to add ethanol an amount of, making it contain alcohol amount reaches and 60% leaves standstill, filters and obtain alcohol extract, reclaim ethanol, through concentrating, get stiff paste, drying under reduced pressure, pulverizing, one step of employing boiling granulating obtain solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.The usage and dosage specification is with embodiment 1.All the other press embodiment 1 method of operation in operation.
Embodiment 16:
A kind of preparation method of cyperus-amomum stomach double phases hard capsule, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Rhizoma Zingiberis Recens, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopts supercritical extraction method to obtain the volatile oil composition, residue again with the Poria that adds water preheat, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae, Fructus Aurantii Immaturus is common to be decocted 2 times, 8 times of water gagings for the first time, 2h, 6 times of water gagings for the second time, 1.5h, filter, it is an amount of to add ethanol, make it contain the alcohol amount and reach 75%, spray drying gets dry powder, adopts a step boiling granulating, obtains granule, volatile oil is made soft capsule and granule is adorned respectively in the hard capsule, seal, packing.The usage and dosage specification is with embodiment 1.All the other press embodiment 1 method of operation in operation.
Embodiment 17:
A kind of preparation method of cyperus-amomum stomach double phases hard capsule, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Zingiberis Recens, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt supercritical extraction method to obtain the volatile oil composition; Last medicinal residues, medicinal liquid decoct 2 times jointly with the Poria that adds water preheat, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae again, the 1st 2h, 6 times of water gagings, the 2nd 1.5h, 5 times of water gagings, filter, concentrate, it is an amount of to add ethanol, makes it contain the alcohol amount and reaches 72% and leave standstill, filter, reclaim ethanol, get stiff paste, drying under reduced pressure, pulverizing, granulation obtain solid preparation, and volatile oil is made soft capsule.The usage and dosage specification is with embodiment 1.All the other press the operation of embodiment 1 method.
Embodiment 18:
A kind of preparation method of cyperus-amomum stomach double phases hard capsule, the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt way of distillation distillation to obtain the volatile oil composition, medicinal residues and Poria, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae behind the collection volatile oil decoct jointly, decoction liquor 6 times of water gagings, filtrations, concentrate, to add ethanol an amount of, make and contain alcohol amount and reach 68%, leave standstill, filter, reclaim ethanol, adopt a step boiling granulating, obtain granule, volatile oil is made drop pill and granule is respectively charged in the hard capsule, seal, pack.All the other press embodiment 1 method of operation in operation.
Embodiment 19
With reference to the medical material and the usage ratio of 530 pages of the Pharmacopoeias of the People's Republic of China (2000 editions) " XIANGSHA YANGWEI WAN " defined, prescription is decided to be Radix Aucklandiae 112g, Fructus Amomi 112g, Rhizoma Atractylodis Macrocephalae 160g, Pericarpium Citri Reticulatae 160g, Poria 160g, Rhizoma Pinelliae 160g, Rhizoma Cyperi 112g, Fructus Aurantii Immaturus 112g, Fructus Amomi Rotundus 112g, Cortex Magnoliae Officinalis 160g, Herba Pogostemonis 112g, Radix Glycyrrhizae 48g, Rhizoma Zingiberis Recens 48, Fructus Jujubae 80g, starch 80g makes 1000 capsules.
Method for making: the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis, Rhizoma Zingiberis Recens are extracted volatile oil with steam distillation, volatile oil is made the drop pill of every 25mg, medicinal liquid after the distillation, last medicinal residues, medicinal liquid and all the other raw material Poria, Radix Glycyrrhizae, Fructus Jujubae, the Rhizoma Pinelliae decoct with water 2 times, the 1st 8 times of water gagings, 2h, the 2nd 6 times of water gagings, 1.5h, merge decoction liquor, concentrate, spray drying, extract is granulated with a step boiling process, respectively with granule, drop pill is filled in the hard capsule, seal package.All the other press embodiment 1 method of operation in operation.
Specification: every contains granule 0.4g, volatile oil 25mg.
Present embodiment does not adopt precipitate with ethanol to handle, so granule also contains macromole organic impuritiess such as cellulose, protein, pectin, natural gum, but do not affect the treatment, for guaranteeing curative effect, usage and dosage: 2 times on the one, each 5.
This usage and dosage, it is identical with pharmacopeia side to take the crude drug amount every day.Also identical with embodiment 1.
Embodiment 20
Be one group of cyperus-amomum stomach double phases hard capsule below:
The part of double phases hard capsule is loaded specification:
Volatile oil is made the drop pill of 100,50,30,20 milligrams of all sizes.
Volatile oil is made the soft capsule of 100,80,60,50 milligrams of all sizes.
Hard capsule is made the hard capsule of No. 000,00,0,1, all size.
One 100 or 50 or 30 milligrams the drop pill of in No. 000 hard capsule, loading; One 50 milligrams the soft capsule of in No. 2 hard capsules, loading.
Embodiment 21:
With embodiment 1, embodiment 16, and embodiment 17, and embodiment 18, and embodiment 19, the data contrast of cyperus-amomum stomach pill:
Table 21A
Group produce effects enabledisable total effective rate % P value
Embodiment 1 39 54 8 92
Embodiment 16 22 31 6 90
Embodiment 17 18 19 7 84
Embodiment 18 15 20 6 86
Embodiment 19 22 28 9 85
Matched group (40 47 14 86＞0.05
Cyperus-amomum stomach
Pill)
Table 21B
| Essential oil extraction method | Water extract system granule | The water extract is handled through alcohol extraction | Total effective rate % | |
| Embodiment 1 | Steam distillation | Be | Be | 92 |
| Embodiment 16 | Supercritical extraction | Be | Be | 90 |
| Embodiment 17 | Supercritical extraction | Be | Be | 84 |
| Embodiment 18 | Way of distillation distillation | Be | Be | 86 |
| Embodiment 19 | Steam distillation | Be | Not | 85 |
Table 21C
| The Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis, Rhizoma Zingiberis Recens volatile oil | Fructus Aurantii Immaturus volatile oil | Pericarpium Citri Reticulatae volatile oil | Total effective rate % | |
| Embodiment 1 | Have | Have | Have | 92 |
| Embodiment 16 | Have | Do not have | Have | 90 |
| Embodiment 17 | Have | Have | Have | 84 |
| Embodiment 18 | Have | Have | Do not have | 86 |
| Embodiment 19 | Have | Have | Have | 85 |
By top three groups of data contrast, show: extract the volatile oil of one or two kind of raw material less, curative effect is not made significant difference, and be not less than traditional pill; The essential oil extraction method difference does not make significant difference to curative effect; The water extract is handled or is handled without alcohol extraction through alcohol extraction, and curative effect is not made significant difference;
And embodiment 19 shows with embodiment 1 contrast: the water extract is handled through alcohol extraction, can reduce dose.
Water of the present invention is carried extract can remove invalid macromole organic impuritiess such as wherein cellulose, protein, pectin, natural gum with proper methods such as the conventional alcohol extraction sedimentation method or ultrafiltration, at last with the extract medicinal liquid of gained, concentrate drying routinely, adopt a step boiling granulating, get homogeneous granules.
Increase the alcohol extraction step, can remove the macromole organic impurities, under the prerequisite that does not affect the treatment, reduce dose, conveniently take.
Embodiment 22
The part case history
The cyperus-amomum stomach double phases hard capsule of all selecting for use embodiment 1 to be provided is treated:
Case one:
Yuan Zhengfeng, the woman, 40 years old, the worker of Jiangxi Province Medical House, stomachache, abdominal distention 11 years, pain is acute diffuses to the back.Second hospital gastroscope inspection in the Jindezhen City on August 17 calendar year 2001: the antrum reddish yellow is alternate, has everywhere rotten to the cornly, has a small amount of fresh hemorrhagely, and the gastroscopy pathology inspection is diagnosed as chronic gastritis.Chinese medical discrimination is the taste cold-damp stagnation of QI.Oral cyperus-amomum stomach double phases hard capsule one all upper abdominal pain are clearly better, and abdominal distention disappears, and around taking medicine, symptom all disappears, and check in calendar year 2001 December gastroscope on the 18th: gastric antrum erosion healing, pathological examination show that the chronic gastritis degree alleviates.
Case two:
Zhang Qinghua, the man, 45 years old, teacher in the Nanchang 20, the readme repeated relapsing, chronic upper abdominal pain 3 years increases the weight of after meal, companion's acid regurgitation abdominal distention, appetite is not good enough.JIUYUE in 2002 9 days is diagnosed as the moderate chronic gastritis in one attached institute of Jiangxi Medical College do gastroscopy, accompanies slight intestinal epithelial metaplasia.Chinese medical discrimination is a Deficiency and coldness of spleen and stomach, has the stagnation of QI concurrently.Promptly give 2 of oral cyperus-amomum stomach double phases hard capsules one time, one day three times, continuous 5 days, bitterly, the abdominal distention transference cure, heighten than appetite around taking medicine.December in 2002 gastroscope check on the 8th: the gastritis degree alleviates.
Case three:
Fu Zhihong, women, 38 years old, Nanchang citizen.About 1 year of upper abdomen dull pain, sx comes hospital therapy recently.The gastroscopy result is diagnosed as the moderate chronic gastritis, companion's duodenal ulcer.Through treating with the cyperus-amomum stomach biphasic capsule, oral each 2, every day three times, the back Upper abdominal pain disappears all around, and the gastroscope check: the stomach inflammation alleviates, and the duodenal bulbar ulcer reduction of area is little.
Embodiment 23
The content of selection magnolol is investigated the stability and the stability of formulation of volatile oil in biphasic capsule, the beta-schardinger dextrin-embedding capsule.
Adopt the dual-wavelength lamellar scanning method to measure magnolol content in the preparation, it is concrete measures with reference to " time precious traditional Chinese medicines research " 1998 the 9th volume the 1st phase 70-71 pages or leaves " research of cyperus-amomum stomach capsule quality standard ".
Measurement result relatively
| Lot number | Magnolol content % | Grain color changes | ||
| Measure the date | Measure the date | |||
| On August 20th, 2002 | On December 20th, 2002 | |||
| Beta cyclodextrin | ????020813 | ?0.561 | ??0.423 | Change color is obvious |
| ????020814 | ?0.585 | ??0.482 | Change color is obvious | |
| ????020815 | ?0.596 | ??0.446 | Change color is obvious | |
| Biphasic capsule | ????020710 | ?0.596 | ??0.581 | The color no change |
| ????020711 | ?0.613 | ??0.568 | The color no change | |
| ????020712 | ?0.694 | ??0.634 | The color no change | |
| Biphasic capsule | ????020613 | ?0.601 | ??0.542 | The color no change |
| ????020614 | ?0.586 | ??0.539 | The color no change | |
| ????020615 | ?0.652 | ??0.594 | The color no change | |
The result shows, under the long term store condition, compares with the beta-schardinger dextrin-embedding, and with drop pill, soft capsule dress volatile oil, loss of volatile oil is little, and avoids the chemical reaction of volatile oil composition and granule Chinese crude drug extract.
Numbering: the biphasic capsule of 020710-13 is provided by embodiment 16.Volatile oil parcel form is a soft capsule.
The biphasic capsule of 020614-15 is provided by embodiment 1.Volatile oil parcel form is a drop pill.
Claims (10)
1, a kind of cyperus-amomum stomach double phases hard capsule, wherein the prescription raw material of cyperus-amomum stomach and weight proportion are: 149.3 parts of the Radix Aucklandiae, 149.3 parts of Fructus Amomis, 213.3 parts of the Rhizoma Atractylodis Macrocephalaes, 213.3 parts of Pericarpium Citri Reticulataes, 213.3 parts in Poria, 213.3 parts of the Rhizoma Pinelliaes, 149.3 parts of Rhizoma Cyperis, 149.3 parts of Fructus Aurantii Immaturuss, 149.3 parts in Fructus Amomi Rotundus, 213.3 parts of Cortex Magnoliae Officinalis, 149.3 parts of Herba Pogostemonis, 64 parts in Radix Glycyrrhizae, 64 parts in Rhizoma Zingiberis Recens, 106.7 parts in Fructus Jujubae, it is characterized in that: comprise a hard capsule, the soft capsule or the drop pill of cyperus-amomum stomach volatile oil composition is housed in the hard capsule simultaneously, and the solid particle of cyperus-amomum stomach lixiviate composition.
2, a kind of cyperus-amomum stomach double phases hard capsule according to claim 1 is characterized in that: cyperus-amomum stomach lixiviate composition is the solid particle of cyperus-amomum stomach water deduction part.
3, a kind of cyperus-amomum stomach double phases hard capsule according to claim 1, it is characterized in that: cyperus-amomum stomach lixiviate composition is the solid particle of cyperus-amomum stomach water extract-alcohol precipitation composition.
4, according to claim 1 or 2 or 3 described a kind of cyperus-amomum stomach double phases hard capsules, it is characterized in that: the volatile oil composition that the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis are housed in soft capsule or the drop pill.
5, according to claim 1 or 2 or 3 described a kind of cyperus-amomum stomach double phases hard capsules, it is characterized in that: the volatile oil composition that the Radix Aucklandiae, Fructus Amomi, Rhizoma Zingiberis Recens, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Cortex Magnoliae Officinalis, Herba Pogostemonis are housed in soft capsule or the drop pill.
6, according to claim 1 or 2 or 3 described a kind of cyperus-amomum stomach double phases hard capsules, it is characterized in that: the hard capsule model is a kind of in 000,00,0,1, No. 2.
7, according to claim 1 or 2 or 3 described a kind of cyperus-amomum stomach double phases hard capsules, it is characterized in that: drop pill weight 20-50mg.
8, the preparation method of a kind of cyperus-amomum stomach double phases hard capsule according to claim 1 and 2, it is characterized in that: the prescription raw material of cyperus-amomum stomach is extracted the volatile oil composition earlier through conventional essential oil extraction method, and last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are solidified into solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
9, according to the preparation method of claim 1 or 3 described a kind of cyperus-amomum stomach double phases hard capsules, it is characterized in that: the prescription raw material of cyperus-amomum stomach is extracted the volatile oil composition earlier through conventional essential oil extraction method, last medicinal residues, medicinal liquid and the water-soluble substances of all the other raw materials after conventional water is carried are handled through conventional alcohol extraction again, filtration obtains alcohol extract, through concentrating, be solidified into solid particle again; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
10, the preparation method of a kind of cyperus-amomum stomach double phases hard capsule according to claim 9 is characterized in that: the Radix Aucklandiae, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Amomi Rotundus, Rhizoma Zingiberis Recens, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Herba Pogostemonis adopt supercritical extraction method to obtain the volatile oil composition; Last medicinal residues, medicinal liquid decoct water jointly with the Poria that adds water preheat, Fructus Jujubae, the Rhizoma Pinelliae, Radix Glycyrrhizae again and carry and obtain the water extract, filter, concentrate, it is an amount of to add ethanol, making it contain alcohol amount reaches 60-75% and leaves standstill, filters and obtain alcohol extract, through concentrating, get stiff paste, drying under reduced pressure, pulverizing, granulation obtain solid particle; With the fill of volatile oil composition in soft capsule or drop pill, in the hard capsule of again soft capsule or drop pill and solid particle being packed into.
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| CN 03118954 CN1317023C (en) | 2003-04-16 | 2003-04-16 | Xiangsha yangwei hard capsule for nourishing stomach, and its prepn. method |
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|---|---|---|---|
| CN 03118954 CN1317023C (en) | 2003-04-16 | 2003-04-16 | Xiangsha yangwei hard capsule for nourishing stomach, and its prepn. method |
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| CN1317023C CN1317023C (en) | 2007-05-23 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425304C (en) * | 2005-04-30 | 2008-10-15 | 杨小林 | Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process |
| CN116159121A (en) * | 2022-12-23 | 2023-05-26 | 贵州威利德制药有限公司 | Preparation method of stomach-nourishing medicine combination with amomum vilosum |
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2003
- 2003-04-16 CN CN 03118954 patent/CN1317023C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425304C (en) * | 2005-04-30 | 2008-10-15 | 杨小林 | Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process |
| CN116159121A (en) * | 2022-12-23 | 2023-05-26 | 贵州威利德制药有限公司 | Preparation method of stomach-nourishing medicine combination with amomum vilosum |
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