CN1537592A - Yinqin tablet contg. Chinese medicines, and its prepn. method - Google Patents
Yinqin tablet contg. Chinese medicines, and its prepn. method Download PDFInfo
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- CN1537592A CN1537592A CNA031183174A CN03118317A CN1537592A CN 1537592 A CN1537592 A CN 1537592A CN A031183174 A CNA031183174 A CN A031183174A CN 03118317 A CN03118317 A CN 03118317A CN 1537592 A CN1537592 A CN 1537592A
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Abstract
An improved Chinese dmedicine 'Yinqin tablet' for treating cold fever, cough, pharyngalgia and upper respiratory tract infection is prepared through decocting raw materials and depositing in alcohol while collecting volatile oil, including the volatile oil by cyclodextrin, concentrating, drying, and tabletting. Its advantages are high curative effect, quickly taking its effect and high safety.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine, relates in particular to Yinqin tablet and preparation method.
Background technology
Tablet is the pharmaceutical formulation of using always, according to the relevant drug act of China, changes dosage form as a kind of new drug research, and original dosage form of Yinqin tablet is silver-colored a kind of reed mentioned in ancient books capsule, has listed in national Bureau of Drugs Supervision's country's standard for traditional Chinese medicines compilation (terrestrial reference rises the GB tentative standard).The technology characteristics of former dosage form is: four Chinese medicine is all made decocting in water precipitate with ethanol dried cream powder in the prescription, adds auxiliary materials and mixing again, encapsulated forming.This capsule dose is big, one time 5, dysphagia, the volatile ingredient loss has certain influence to curative effect in the production process in addition, and this pharmaceutically dosage form is single, far can not satisfy people's medication demand, its quality standard still can further improve simultaneously, based on this, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, control criterion simultaneously improves the quality, guarantee the quality monitoring of product, improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of Yinqin tablet and preparation method, improve the quality of products and curative effect, increase the stability of product, enrich medicine variety, to satisfy and to ensure people's medication demand better.
1, the preparation method sheet of Yinqin tablet is drawn together following steps:
1.1 the prescription of Yinqin tablet is formed
Flos Lonicerae 1250-6250g Radix Scutellariae 900-4500g Folium Notoginseng 700-3500g
Herba Houttuyniae 1000-5000g
Right amount of auxiliary materials is made 1000 altogether.
Optimum formula is
Flos Lonicerae 2500g Radix Scutellariae 1800g Folium Notoginseng 1400g
Herba Houttuyniae 2000g
Right amount of auxiliary materials is made 1200 altogether.
1.2 the preparation technology of Yinqin tablet
Technology one, will write out a prescription in four Chinese medicine be up to the standards standby respectively; Above four Chinese medicine material is ground into coarse powder/make decoction pieces, decocts with water 2-3 time, and each 0.5-3 hour, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.05-1.20 (20 ℃), adds ethanol and reaches 50-80% to containing the alcohol amount, left standstill 24 hours, and filtered, filtrate recycling ethanol is condensed into the thick paste that relative density is 1.20-1.40 (60 ℃), cold drying is ground into powder, adds right amount of auxiliary materials, mixing, behind direct compression or the granulation low temperature after drying, tabletting, coating, quality inspection, promptly.
Technology two, will write out a prescription in four Chinese medicine be up to the standards standby respectively; Four flavors are ground into coarse powder in will writing out a prescription, and add water steaming and decocting 2-3 time, and each 0.5-3 hour, it was standby to collect volatile oil and water boiling liquid; Above-mentioned volatile oil adds an amount of cyclodextrin inclusion compound, makes the cyclodextrin of volatile oil clathrate or add an amount of anhydrous alcohol solution standby; Water boiling liquid filters, concentrate drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate drying, spray adds above-mentioned volatile oil ethanol solution mixing, tabletting/above-mentioned dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting after direct compression or the granulation cold drying, coating, quality inspection, packing promptly.
Technology three, will write out a prescription in four Chinese medicine be up to the standards standby respectively; Four flavors are ground into coarse powder in will writing out a prescription, and add water steaming and decocting 2-3 time, and each 0.5-3 hour, it was standby to collect volatile oil and water boiling liquid; Above-mentioned volatile oil adds an amount of cyclodextrin inclusion compound, makes the cyclodextrin of volatile oil clathrate or add an amount of anhydrous alcohol solution standby; Water boiling liquid filters, and filtrate is concentrated into the clear paste that relative density is 1.05-1.20 (20 ℃), adds ethanol and reaches 50-80% to containing the alcohol amount, left standstill 24 hours, and filtered, the filtrate recycling ethanol concentrate drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate drying, spray adds above-mentioned volatile oil ethanol solution mixing, tabletting, coating/above-mentioned dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting after direct compression or the granulation cold drying, coating, quality inspection, packing is promptly.
1.3 by the technology gained is tablet
Prepared tablet is a Film coated tablets in the technology, and its film-coat material all adopts stomach dissolution type film-coat pre-mixing agent (Opadry).
Added adjuvant can be microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP in the technology
30, any or multiple mixing in the micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, magnesium stearate uses.
Being ground into coarse powder in the technology was 5-40 purpose coarse powder, was preferably 10-20 order coarse powder.
In the technology decocting boil/condition of water steaming and decocting is: decoction/steaming and decocting 2-3 time, amount of water is doubly measured for 6-12 for the first time, second and third time doubly measured for 4-10,, 0.5-3 hour at every turn.Best is decoction/steaming and decocting three times, and amount of water is 10 times of amounts for the first time, and second and third time is 8 times of amounts, 1 hour for the first time, and second and third time each 45 minutes.
Dry vacuum drying or the spray drying of adopting in the technology, the vacuum drying temperature is controlled at 50-90 ℃, is preferably 60 ℃.Spray drying is for to be concentrated to the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.10 (60 ℃), and inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.The drying of sheet adopts vacuum drying.
The relative density that is condensed into clear paste in the technology one is 1.05-1.20 (20 ℃), and preferably relative density is 1.06-1.08 (20 ℃).
The relative density that is condensed into thick paste in the technology one is 1.20-1.40 (60 ℃), and best relative density is 1.32-1.35 (60 ℃).
Precipitate with ethanol reaches 50-80% for adding ethanol to containing alcohol amount in the technology one, is preferably to contain the alcohol amount and reach 65%.
Cyclodextrin of volatile oil clathrate preparation in the technology two: cyclodextrin can adopt a kind of in beta-schardinger dextrin-, the hydroxyl beta-schardinger dextrin-, the ratio of volatile oil and beta-schardinger dextrin-is 1: 5-15 (ml/g), optimal proportion is 1: 8 (ml/g), the ratio of volatile oil and hydroxyl beta-schardinger dextrin-is 1: 2-10 (ml/g), optimal proportion are 1: 5 (ml/g).
2, the quality control of this product mainly is discriminating, inspection, three aspects of assay, and existing having increased differentiated the thin layer of Herba Houttuyniae; Heavy metal, arsenic salt have been carried out limit examine; Increased on the assay to Flos Lonicerae quantitatively.
This invention its superiority compared with the prior art is: production technology more becomes fully rationally, volatile ingredient can better keep, quality standard has had further raising, make product that the qualitative, quantitative control method of more comprehensive science be arranged, make the quality of product that better guarantee arranged.
The specific embodiment
The optimum implementation of this invention is: four Chinese medicine is up to the standards standby respectively in will writing out a prescription; The Fang Zhongsi flavor is ground into coarse powder, adds the water steaming and decocting 3 times, 1 hour for the first time, second and third time each 45 minutes, it is standby to collect volatile oil and water boiling liquid; It is standby that above-mentioned volatile oil adds an amount of dissolve with ethanol; Water boiling liquid filters, and it is the concentrated solution of 1.08-1.10 that filtrate concentrates relative density, and spray drying is collected dried cream powder and appropriate amount of auxiliary materials mixing, granulate, and drying, spray adds above-mentioned volatile oil, mixing, tabletting, coating, quality inspection, packing is promptly.
Claims (10)
1, a kind of Yinqin tablet and preparation method is characterized in that:
(1) be up to the standards prescription drugs standby respectively, Flos Lonicerae, Radix Scutellariae, Folium Notoginseng, Herba Houttuyniae four Chinese medicine material is ground into coarse powder/make decoction pieces, decocts with water each 0.5-3 hour 2-3 time, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.05-1.20 (20 ℃), adds ethanol and reaches 50-80% to containing the alcohol amount, left standstill 24 hours, filter, filtrate recycling ethanol is condensed into the thick paste that relative density is 1.20-1.40 (60 ℃), cold drying, be ground into powder, add right amount of auxiliary materials, mixing is behind direct compression or the granulation low temperature after drying, tabletting, coating, quality inspection, promptly.
(2) be up to the standards prescription drugs standby respectively, with Flos Lonicerae, Radix Scutellariae, Folium Notoginseng, Herba Houttuyniae four flavors are ground into coarse powder, add water steaming and decocting 2-3 time, each 0.5-3 hour, it was standby to collect volatile oil and water boiling liquid, and above-mentioned volatile oil adds an amount of cyclodextrin inclusion compound, it is standby to make cyclodextrin of volatile oil clathrate/add an amount of anhydrous alcohol solution, water boiling liquid filters, and concentrate drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate, drying, spray adds above-mentioned volatile oil ethanol solution mixing, tabletting/above-mentioned dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting after direct compression/granulation cold drying, coating, quality inspection, packing is promptly.
(3) prescription drugs is up to the standards standby respectively, Flos Lonicerae, Radix Scutellariae, Folium Notoginseng, Herba Houttuyniae four Chinese medicine are ground into coarse powder, add water steaming and decocting 2-3 time, each 0.5-3 hour, it was standby to collect volatile oil and water boiling liquid; Above-mentioned volatile oil adds an amount of cyclodextrin inclusion compound, and it is standby to make cyclodextrin of volatile oil clathrate/add an amount of anhydrous alcohol solution; Water boiling liquid filters, and filtrate is concentrated into the clear paste that relative density is 1.05-1.20 (20 ℃), adds ethanol and reaches 50-80% to containing the alcohol amount, left standstill 24 hours, and filtered, the filtrate recycling ethanol concentrate drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate drying, spray adds above-mentioned volatile oil ethanol solution mixing, tabletting, coating/above-mentioned dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting after the direct compression granulation cold drying, coating, quality inspection, packing is promptly.
2, Yinqin tablet according to claim 1 and preparation method is characterized in that: Flos Lonicerae, Radix Scutellariae, Folium Notoginseng, Herba Houttuyniae powder were broken into 5-40 purpose coarse powder in the technology, and the best was a 10-20 order coarse powder.
3, Yinqin tablet according to claim 1 and preparation method, it is characterized in that: in the technology decocting boil/condition of water steaming and decocting is: decoction/steaming and decocting 2-3 time, amount of water is that 6-12 doubly measures for the first time, second and third time doubly measured for 4-10, and each 0.5-3 hour, best was decoction/steaming and decocting three times, amount of water is 10 times of amounts for the first time, second and third time is 8 times of amounts, 1 hour for the first time, and second and third time each 45 minutes.
4, Yinqin tablet according to claim 1 and preparation method, it is characterized in that: the relative density that is condensed into clear paste in the technology is 1.05-1.20 (20 ℃), best relative density is 1.06-1.08 (20 ℃), the relative density that is condensed into thick paste in the technology is 1.20-1.40 (60 ℃), and best relative density is 1.32-1.35 (60 ℃).
5, Yinqin tablet according to claim 1 and preparation method, it is characterized in that: the dry vacuum drying/spray drying that adopts in the technology, the vacuum drying temperature is controlled at 50-90 ℃, the best is 60 ℃, spray drying is for to be concentrated to the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, spray drying, inlet temperature is 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.10 (60 ℃), inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃, and the drying of sheet adopts vacuum drying.
6, Yinqin tablet according to claim 1 and preparation method is characterized in that: precipitate with ethanol reaches 50-80% for adding ethanol to containing the alcohol amount in the technology, and the best reaches 65% for containing the alcohol amount.
7, Yinqin tablet according to claim 1 and preparation method is characterized in that: added adjuvant can be any/multiple mixing use in microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP 30, micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, the magnesium stearate in the technology.
8, Yinqin tablet according to claim 1 and preparation method is characterized in that: prepared tablet is a Film coated tablets in the technology, and its film-coat material all adopts stomach dissolution type film-coat pre-mixing agent Opadry.
9, Yinqin tablet according to claim 1 and preparation method, it is characterized in that: cyclodextrin of volatile oil clathrate preparation in the technology: cyclodextrin can adopt a kind of in beta-schardinger dextrin-, the hydroxyl beta-schardinger dextrin-, the ratio of volatile oil and beta-schardinger dextrin-is 1: 5-15 (ml/g), optimal proportion is 1: 8 (ml/g), the ratio of volatile oil and hydroxyl beta-schardinger dextrin-is 1: 2-10 (ml/g), optimal proportion are 1: 5 (ml/g).
10, Yinqin tablet according to claim 1 and preparation method is characterized in that: have the thin layer of Herba Houttuyniae to differentiate on quality inspection standard; Have that heavy metal must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit detection; The quantitative assay of Flos Lonicerae is arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031183174A CN1537592A (en) | 2003-04-20 | 2003-04-20 | Yinqin tablet contg. Chinese medicines, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031183174A CN1537592A (en) | 2003-04-20 | 2003-04-20 | Yinqin tablet contg. Chinese medicines, and its prepn. method |
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| Publication Number | Publication Date |
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| CN1537592A true CN1537592A (en) | 2004-10-20 |
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| CNA031183174A Pending CN1537592A (en) | 2003-04-20 | 2003-04-20 | Yinqin tablet contg. Chinese medicines, and its prepn. method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211903A (en) * | 2013-04-18 | 2013-07-24 | 黄穆琪 | Extracting treatment method of cordate houttuynia in antiviral particle formula |
-
2003
- 2003-04-20 CN CNA031183174A patent/CN1537592A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211903A (en) * | 2013-04-18 | 2013-07-24 | 黄穆琪 | Extracting treatment method of cordate houttuynia in antiviral particle formula |
| CN103211903B (en) * | 2013-04-18 | 2015-05-27 | 黄穆琪 | Extracting treatment method of cordate houttuynia in antiviral particle formula |
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