CN1526701A - Prepn of guanidyl thiocyanate - Google Patents
Prepn of guanidyl thiocyanate Download PDFInfo
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- CN1526701A CN1526701A CNA031583199A CN03158319A CN1526701A CN 1526701 A CN1526701 A CN 1526701A CN A031583199 A CNA031583199 A CN A031583199A CN 03158319 A CN03158319 A CN 03158319A CN 1526701 A CN1526701 A CN 1526701A
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- guanidine thiocyanate
- thiocyanate
- ratio
- preparation
- filtering
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Abstract
The present invention relates to chemical product and is especially the preparation process of guanidyl thiocyanate. The technological process includes the following steps: melting, dissolving, filtering, dewatering and crystallization, and can obtain high-purity guanidyl thiocyanate. The technological process is simple, practical and reasonable, and the guanidyl thiocyanate product has high quality and high purity over 99%.
Description
Affiliated technical field
The present invention relates to a kind of production method of Chemicals, especially the preparation method of guanidine thiocyanate.
Background technology
Guanidine thiocyanate, chemical name: thiocyanic acid imido urea, English name: Guanidine thio cyanate salt, its molecular formula is: (NH
2)
2C:NHHSCN (118.2).Be the white crystals body, 116～121 ℃ of fusing points, in the time of 20 ℃, the pH value of 6mol/L in water is 4.5～6, solubleness is dissolving fully.Can be used as biochemical reagents, medicine intermediate.Be used for the oil prodution industry degreasing, the strong fat degradation agents of conduct in the daily-use chemical industry, the membranolysis agent in the bio-pharmaceuticals.Its structural formula is:
Present production technique, the product purity that obtains are not very high, and in use, some occasion is just very high to the purity requirement of guanidine thiocyanate.
Summary of the invention
Deficiency for the preparation method that overcomes existing guanidine thiocyanate the invention provides a kind of method, and this method can obtain highly purified guanidine thiocyanate.
The technical solution adopted for the present invention to solve the technical problems is: a kind of preparation method of guanidine thiocyanate has following technical process:
A, be that 2: 1 Guanidinium carbonate and ammonium thiocyanate put into reactor with weight ratio, 50～90 ℃ of reactions 2 hours down, the guanidine thiocyanate crude product.
B, dissolving, at normal temperatures, the guanidine thiocyanate crude product is water-soluble in 1: 1 ratio;
C, filtration are removed impurity such as raw material and reaction pair product with filtering method;
D, dehydration are at high temperature dewatered the mother liquor after filtering;
E, crystallization, the supersaturated solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
Further: again through b, c, d, e step, is 1: 1 with the ratio of water in the b step with the guanidine thiocyanate after the e step wherein, draws more highly purified guanidine thiocyanate, and can repeatedly repeat this step as required.
Its reaction formula is:
Features simple and practical process of the present invention, principle is reasonable, and with the guanidine thiocyanate of the inventive method preparation, quality is good, and the purity height can reach more than 99%, is highly commended by customers deeply.
Specific implementation method
A kind of preparation method of guanidine thiocyanate has following technical process: a, is that 2: 1 Guanidinium carbonate and ammonium thiocyanate put into reactor with weight ratio, 50～90 ℃ of reactions 2 hours down, the guanidine thiocyanate crude product.
B, dissolving, at normal temperatures, the guanidine thiocyanate crude product is water-soluble in 1: 1 ratio;
C, filtration are removed impurity such as raw material and reaction pair product with filtering method;
D, dehydration are at high temperature dewatered the mother liquor after filtering;
E, crystallization, the supersaturated solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
Further: again through b, c, d, e step, is 1: 1 with the ratio of water in the b step with the guanidine thiocyanate after the e step wherein, draws more highly purified guanidine thiocyanate, and can repeatedly repeat this step as required.
Claims (2)
1. guanidine thiocyanate preparation method is characterized in that having following technical process:
A, be that 2: 1 Guanidinium carbonate and ammonium thiocyanate put into reactor with weight ratio, 50～90 ℃ of reactions 2 hours down, the guanidine thiocyanate crude product.
B, dissolving, at normal temperatures, the guanidine thiocyanate crude product is water-soluble in 1: 1 ratio;
C, filtration are removed impurity such as raw material and reaction pair product with filtering method;
D, dehydration are at high temperature dewatered the mother liquor after filtering;
E, crystallization, the supersaturated solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
2. guanidine thiocyanate preparation method according to claim 1, it is characterized in that: with the guanidine thiocyanate after the e step again through b, c, d, e step, be 1: 1 with the ratio of water in the b step wherein, draw more highly purified guanidine thiocyanate, and can repeatedly repeat this step as required.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03158319 CN1235876C (en) | 2003-09-19 | 2003-09-19 | Prepn of guanidyl thiocyanate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03158319 CN1235876C (en) | 2003-09-19 | 2003-09-19 | Prepn of guanidyl thiocyanate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1526701A true CN1526701A (en) | 2004-09-08 |
| CN1235876C CN1235876C (en) | 2006-01-11 |
Family
ID=34287248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03158319 Expired - Fee Related CN1235876C (en) | 2003-09-19 | 2003-09-19 | Prepn of guanidyl thiocyanate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1235876C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112209856A (en) * | 2020-10-15 | 2021-01-12 | 苏州亚科科技股份有限公司 | Preparation method of guanidine thiocyanate |
-
2003
- 2003-09-19 CN CN 03158319 patent/CN1235876C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112209856A (en) * | 2020-10-15 | 2021-01-12 | 苏州亚科科技股份有限公司 | Preparation method of guanidine thiocyanate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1235876C (en) | 2006-01-11 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |