CN103058889A - Production method of guanidinium thiocyanate - Google Patents
Production method of guanidinium thiocyanate Download PDFInfo
- Publication number
- CN103058889A CN103058889A CN 201110315351 CN201110315351A CN103058889A CN 103058889 A CN103058889 A CN 103058889A CN 201110315351 CN201110315351 CN 201110315351 CN 201110315351 A CN201110315351 A CN 201110315351A CN 103058889 A CN103058889 A CN 103058889A
- Authority
- CN
- China
- Prior art keywords
- guanidine thiocyanate
- guanidinium thiocyanate
- production method
- filtering
- crude product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000002425 crystallisation Methods 0.000 claims abstract description 4
- 230000008025 crystallization Effects 0.000 claims abstract description 4
- 230000018044 dehydration Effects 0.000 claims abstract description 4
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 4
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000012043 crude product Substances 0.000 claims description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 3
- 239000006227 byproduct Substances 0.000 claims description 3
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000012452 mother liquor Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a production method of guanidinium thiocyanate, and belongs to the field of chemical industry. The production method of guanidinium thiocyanate is characterized by comprising the following process: dissolution, filtration, dehydration and crystallization. The invention has the advantages of simple and practical process and reasonable principle. The guanidinium thiocyanate prepared by the method provided by the preparation has good quality, high purity, and is highly praised by users.
Description
Technical field
The present invention relates to a kind of production method of guanidine thiocyanate, belong to chemical field.
Background technology
Guanidine thiocyanate can be used as biochemical reagents, and medicine intermediate is used for the oil prodution industry degreasing, and as strong fat degradation agents, present production technique, the product purity that obtains are not very high in the daily-use chemical industry, and in use, some is then very high to the purity requirement of guanidine thiocyanate.
Summary of the invention
Purpose of the present invention: overcome the preparation method's of existing guanidine thiocyanate deficiency, the invention provides a kind of preparation method that can access the guanidine thiocyanate of higher degree.
Technical scheme: a kind of preparation method of guanidine thiocyanate is characterized in that having following technical process:
(1) is that 2: 1 Guanidinium carbonate and ammonium sulfate is put into reactor with weight ratio, 45-95 ℃ of lower reaction 1.5 hours, obtains the guanidine thiocyanate crude product.
(2) dissolving is at normal temperatures, water-soluble with the guanidine thiocyanate crude product in 0.5: 1 ratio;
(3) filter, the impurity such as raw material and reaction by-product are removed with the method for filtering;
(4) dehydration is at high temperature dewatered the mother liquor after filtering;
(5) crystallization, the solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
Advantage of the present invention: features simple and practical process, principle is reasonable, the guanidine thiocyanate of the inventive method preparation, quality is good, and purity is high, deeply is highly commended by customers.
Embodiments of the invention
(1) is that 2: 1 Guanidinium carbonate and ammonium sulfate is put into reactor with weight ratio, 60 ℃ of lower reactions 1.5 hours, obtains the guanidine thiocyanate crude product.
(2) dissolving is at normal temperatures, water-soluble with the guanidine thiocyanate crude product in 0.5: 1 ratio;
(3) filter, the impurity such as raw material and reaction by-product are removed with the method for filtering;
(4) dehydration is at high temperature dewatered the mother liquor after filtering;
(5) crystallization, the solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
Claims (1)
1. the preparation method of a guanidine thiocyanate is characterized in that having following technical process:
(1) is that 2: 1 Guanidinium carbonate and ammonium sulfate is put into reactor with weight ratio, 45-95 ℃ of lower reaction 1.5 hours, obtains the guanidine thiocyanate crude product.
(2) dissolving is at normal temperatures, water-soluble with the guanidine thiocyanate crude product in 0.5: 1 ratio;
(3) filter, the impurity such as raw material and reaction by-product are removed with the method for filtering;
(4) dehydration is at high temperature dewatered the mother liquor after filtering;
(5) crystallization, the solution cooling, condensing crystal has obtained highly purified guanidine thiocyanate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110315351 CN103058889A (en) | 2011-10-18 | 2011-10-18 | Production method of guanidinium thiocyanate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110315351 CN103058889A (en) | 2011-10-18 | 2011-10-18 | Production method of guanidinium thiocyanate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103058889A true CN103058889A (en) | 2013-04-24 |
Family
ID=48101823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110315351 Pending CN103058889A (en) | 2011-10-18 | 2011-10-18 | Production method of guanidinium thiocyanate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103058889A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114057610A (en) * | 2021-11-30 | 2022-02-18 | 湖北省宏源药业科技股份有限公司 | Production method of high-purity guanidine thiocyanate |
-
2011
- 2011-10-18 CN CN 201110315351 patent/CN103058889A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114057610A (en) * | 2021-11-30 | 2022-02-18 | 湖北省宏源药业科技股份有限公司 | Production method of high-purity guanidine thiocyanate |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104788461A (en) | Industrial production method applicable to citric acid tofacitinib | |
| CN104628635B (en) | A kind ofly produce separating-purifying waste residue from picloram and go out the method for high-content picloram | |
| CN103204522A (en) | Preparation method of high-purity mass potassium nitrate | |
| CN103058889A (en) | Production method of guanidinium thiocyanate | |
| CN102690312B (en) | Purification method for lanolin cholesterol | |
| CN103387520A (en) | Preparation method of guandine thiocyanate | |
| CN101585543A (en) | Method for preparing special boric acid of special glass through oxidization and precipitation | |
| CN102285894A (en) | Method for preparing D-L-p-hydroxyphenylglycine | |
| CN102115054A (en) | Method for preparing phosphate and sodium phosphate and lithium sulfate mixed product with manganese-containing waste liquid | |
| CN102120620A (en) | A method for producing manganese nitrate and co-producing lithium sulfate and ammonium nitrate with manganese-containing waste liquid produced by hydroquinone | |
| CN102863355B (en) | Purifying method of N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine | |
| CN102311362A (en) | Method for preparing ethyl hydrazinoacetate hydrochloride | |
| CN102115196A (en) | A method for producing manganese hydroxide and co-producing ammonium sulfate with manganese-containing waste liquid produced by hydroquinone | |
| CN102115185A (en) | A method for producing manganese carbonate and co-producing ammonium sulfate with manganese-containing waste liquid produced by producing hydroquinone | |
| CN102115061A (en) | A method for producing manganese phosphate and co-producing magnesium sulfate and ammonium phosphate with manganese-containing waste liquid produced by hydroquinone | |
| CN102120621A (en) | A method for producing manganese sulfate and co-producing ammonia water with manganese-containing waste liquid produced by hydroquinone | |
| CN102115191A (en) | A method for producing manganese hydroxide and co-producing sodium sulfate and ammonia water with manganese-containing waste liquid produced by hydroquinone | |
| CN102115059A (en) | A method for producing manganese phosphate and co-producing ammonium sulfate and phosphoric acid with manganese-containing waste liquid produced by hydroquinone | |
| CN102115178A (en) | A method for producing manganese sulfide and co-producing magnesium sulfate and ammonium sulfide with manganese-containing waste liquid produced by hydroquinone | |
| CN102115065A (en) | A method for producing manganese phosphate and co-producing zinc sulfate and ammonium phosphate with manganese-containing waste liquid produced by hydroquinone | |
| CN102115058A (en) | A method for producing manganese phosphate and co-producing lithium sulfate and ammonium phosphate with manganese-containing waste liquid produced by hydroquinone | |
| CN101811972A (en) | Method for separating and purifying 2-chlorine-4,6-dinitroresorcinol in dilution crystallization method | |
| CN102115184A (en) | A method for producing manganese sulfide and co-producing ammonium sulfate and ammonium sulfide with manganese-containing waste liquid produced by hydroquinone | |
| CN102115182A (en) | Method for co-production of manganese carbonate, magnesium sulfate and ammonium carbonate from manganese-containing waste liquid generated during hydroquinone production | |
| CN102115057A (en) | A method for producing manganese phosphate and co-producing potassium sulfate and ammonium phosphate with manganese-containing waste liquid produced by hydroquinone |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Wu Jiawang Document name: Notification of before Expiration of Request of Examination as to Substance |
|
| DD01 | Delivery of document by public notice |
Addressee: Wu Jiawang Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130424 |