CN103387520A - Preparation method of guandine thiocyanate - Google Patents
Preparation method of guandine thiocyanate Download PDFInfo
- Publication number
- CN103387520A CN103387520A CN2012101382540A CN201210138254A CN103387520A CN 103387520 A CN103387520 A CN 103387520A CN 2012101382540 A CN2012101382540 A CN 2012101382540A CN 201210138254 A CN201210138254 A CN 201210138254A CN 103387520 A CN103387520 A CN 103387520A
- Authority
- CN
- China
- Prior art keywords
- guanidine thiocyanate
- preparation
- thiocyanate
- guandine
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 title abstract 4
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 10
- 238000002425 crystallisation Methods 0.000 claims abstract description 4
- 230000008025 crystallization Effects 0.000 claims abstract description 4
- 230000018044 dehydration Effects 0.000 claims abstract description 4
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 4
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000012043 crude product Substances 0.000 claims description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 3
- 239000006227 byproduct Substances 0.000 claims description 3
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000012452 mother liquor Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a preparation method of guandine thiocyanate, and belongs to the chemical field. The preparation method of guandine thiocyanate is characterized by comprising the following processes: dissolving, filtering, dehydration and crystallization. The method provided by invention has advantages of simple and practical process and reasonable principle; and the guandine thiocyanate prepared by the method has good quality, high purity and is highly praised by users.
Description
Technical field
The present invention relates to a kind of production method of guanidine thiocyanate, belong to chemical field.
Background technology
Guanidine thiocyanate can be used as biochemical reagents, and medicine intermediate is used for the oil prodution industry degreasing, and in daily-use chemical industry, as strong fat degradation agents, present production technique, the product purity that obtains are not very high, and in use, some is very high to the purity requirement of guanidine thiocyanate.
Summary of the invention
Purpose of the present invention: overcome the preparation method's of existing guanidine thiocyanate deficiency, the invention provides a kind of preparation method that can access the guanidine thiocyanate of higher degree.
Technical scheme: a kind of preparation method of guanidine thiocyanate is characterized in that having following technical process:
A, being 2:1 with weight ratio, Guanidinium carbonate and ammonium sulfate are put into reactor, and reaction is 2 hours under 40-90 ℃, obtains the guanidine thiocyanate crude product;
B, dissolving, at normal temperatures, in the ratio of 0.6:1, that the guanidine thiocyanate crude product is water-soluble;
C, filtration, remove the impurity such as raw material and reaction by-product with the method for filtering;
D, dehydration, at high temperature dewater the mother liquor after filtering;
E, crystallization, solution is cooling, and condensing crystal has obtained highly purified guanidine thiocyanate.
Advantage of the present invention: features simple and practical process, principle is reasonable, the guanidine thiocyanate of the inventive method preparation, quality is good, and purity is high, deeply is highly commended by customers.
Embodiments of the invention
A, being 2:1 with weight ratio, Guanidinium carbonate and ammonium sulfate are put into reactor, and reaction is 2 hours under 55 ℃, obtains the guanidine thiocyanate crude product;
B, dissolving, at normal temperatures, in the ratio of 0.6:1, that the guanidine thiocyanate crude product is water-soluble;
C, filtration, remove the impurity such as raw material and reaction by-product with the method for filtering;
D, dehydration, at high temperature dewater the mother liquor after filtering;
E, crystallization, solution is cooling, and condensing crystal has obtained highly purified guanidine thiocyanate.
Claims (1)
1. the preparation method of a guanidine thiocyanate, is characterized in that having following technical process: A, being 2:1 with weight ratio, Guanidinium carbonate and ammonium sulfate are put into reactor, and reaction is 2 hours under 40-90 ℃, obtains the guanidine thiocyanate crude product; B, dissolving, at normal temperatures, in the ratio of 0.6:1, that the guanidine thiocyanate crude product is water-soluble; C, filtration, remove the impurity such as raw material and reaction by-product with the method for filtering; D, dehydration, at high temperature dewater the mother liquor after filtering; E, crystallization, solution is cooling, and condensing crystal has obtained highly purified guanidine thiocyanate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101382540A CN103387520A (en) | 2012-05-07 | 2012-05-07 | Preparation method of guandine thiocyanate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101382540A CN103387520A (en) | 2012-05-07 | 2012-05-07 | Preparation method of guandine thiocyanate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103387520A true CN103387520A (en) | 2013-11-13 |
Family
ID=49531952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101382540A Pending CN103387520A (en) | 2012-05-07 | 2012-05-07 | Preparation method of guandine thiocyanate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103387520A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114057610A (en) * | 2021-11-30 | 2022-02-18 | 湖北省宏源药业科技股份有限公司 | Production method of high-purity guanidine thiocyanate |
-
2012
- 2012-05-07 CN CN2012101382540A patent/CN103387520A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114057610A (en) * | 2021-11-30 | 2022-02-18 | 湖北省宏源药业科技股份有限公司 | Production method of high-purity guanidine thiocyanate |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131113 |