CN1523008A - Method for manufacturing methionine chromium chelate - Google Patents
Method for manufacturing methionine chromium chelate Download PDFInfo
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- CN1523008A CN1523008A CNA031040780A CN03104078A CN1523008A CN 1523008 A CN1523008 A CN 1523008A CN A031040780 A CNA031040780 A CN A031040780A CN 03104078 A CN03104078 A CN 03104078A CN 1523008 A CN1523008 A CN 1523008A
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Abstract
The present invention relates to a method for preparing methionine chrominium chelate. According to said invention, in the solution the methionine and inorganic chrominium are added according to a certain mole ratio, then pH value of the solution can be regulated so as to make methionine chrominium be precipitated. Said method can be used for preparing three different methionine chrominium chelates and their mole ratios respectively can be 1:1, 2:1, 3:1.
Description
Patent of the present invention relates to method for preparing methionine chrominium chelate, and the chromium methionine huge legendary turtle compound that patent of the present invention is mentioned comprises that methionine(Met) and chromium ratio are 1: 1 in the product, and 2: 1,3: 1 three kinds of chromium methionines.
Chromium (Chromium) is one of essential trace element of Animal nutrition, proposes the sugar tolerance factor hypothesis fifties in eighties of last century, and indicates the active ingredient that trivalent chromium is the sugar tolerance factor.Hereafter, the researchist finds in succession that again chromium can influence mouse, mouse monkey, cavy, rabbit, chicken, turkey, pig, sheep, the metabolism of ox and people's glucose and fat.Particularly enter the nineties in last century, chromium becomes one of the focus in analysis on trace field.Chromium ion has divalence, and trivalent and sexavalence the most important thing is trivalent chromium in organism.Sexavalent chrome is toxic.The canonical biometric function of chromium is as the toughener participation of Regular Insulin and influence sugar, fat and proteinic metabolism, it is a kind of collaborative hormone of Regular Insulin so person is arranged, promote the decomposition of the synthetic and glucose of liver starch with Regular Insulin, promote the picked-up of fatty tissue, be converted into fat thereby help sugar to sugar.Mouse experiment shows that the specific absorption of organic chromium is 10～30 times of inorganic chromium, so trivalent chromium generally adopts organic chromium in actual applications.Studies show that in the sugar tolerance factor, do not have chromium, just do not have activity; And chromium generally combines show activity with amino acid in the sugar tolerance factor, so chromium methionine huge legendary turtle compound synthetic has profound significance.
Chromium methionine is a kind of organo-chromium compound, mainly is used in fodder additives, foodstuff additive, and industry such as medicine.Be used in the feed, can effectively increase lean ratio, improve food conversion ratio, improve surviving rate etc.Prohibite the ideal substitute of the clenbuterol hydrochloride of using as country in feedstuff industry, organic chromium must have very big development prospect along with the raising of people's living standard at feedstuff industry.In the food and medicine industry, be mainly used in diabetics's assisting therapy, as various hypoglycemic capsules, the sugar reducing milk powder of diabetics's special use, the auxiliary composition of hypoglycemic biscuit etc. and slimming health food.
Have in the manufacturing patent of Bao Dao chromium methionine in early days, Japan equals into 4 years patents 6287173, and Poland Patent 254171 is with Chinese patent 98120143.The manufacture method of synthetic chromium methionine compound requires to utilize sodium Metal 99.5 to synthesize as substitute under the liquefied ammonia environment mostly in above-mentioned patent, does not have industrialized utilization to be worth, and perhaps carries out complex process in high temperature and high pressure environment more than 200 ℃.And when producing chromium methionine, obtain solid phase prod and need adopt spray drying technology, the cost height with aforesaid method.
Patent of the present invention proposes a kind of method of producing chromium methionine huge legendary turtle compound at normal temperatures and pressures, and technology is simple, and cost is low, is easy to suitability for industrialized production.Manufacture method of the present invention is to carry out in the aqueous solution, does not adopt liquefied ammonia as reaction medium; Reaction is carried out at normal temperatures and pressures.The reaction process of the chromium methionine that in the aqueous solution, carries out, along with temperature of reaction, the addition of various components, the change of process conditionss such as solution stirring speed all can have influence on the carrying out of whole chemical reaction process.
This patent inventors study repeatedly through a large amount of experiments, and initiative proposition utilizes the both sexes ionization character of chromium methionine, the pH value of regulator solution, the method that the chromium methionine precipitation is separated out.If the potential of hydrogen of the chromium methionine aqueous solution is suitably regulated, cation group is equated with the degree of ionization of anionic group, just to have positive and negative electric charge number identical just for chromium methionine, the pH value of solution can be called the iso-electric point of chromium methionine at this moment, in this iso-electric point, the solubleness minimum of chromium methionine in water, the iso-electric point of measuring chromium methionine is 7.6, the regulator solution pH value is the chromium methionine iso-electric point, in the process near the chromium methionine iso-electric point, a large amount of chromium methionines will precipitate separates out.
Find in the industrial production that the influence that temperature is carried out the time to reaction is bigger, and can bring the reaction product irregular colour even at a lower temperature, regulate problems such as isoelectric precipitation is insufficient.Generally should be at 60～100 ℃, preferentially selecting temperature is 95～100 ℃, in this temperature constant temperature half hour at least.
Find in the industrial production that the excessive of chromium is favourable to reaction, the addition of chromium generally should excessive 10% than according to the evaluation of material balance.Methionine(Met) and chromium ratio are that the addition of inorganic chromium is 110% of a methionine(Met) amount in 1: 1 the product in producing chromium methionine; Methionine(Met) and chromium ratio are that the addition of inorganic chromium is 220% of a methionine(Met) amount in 2: 1 the product in producing chromium methionine; Methionine(Met) and chromium ratio are that the addition of inorganic chromium is 330% of a methionine(Met) amount in 3: 1 the product in producing chromium methionine.
The objective of the invention is to, the ratio of developing methionine(Met) and chromium is 1: 1,2: 1, and a kind of new manufacture method of 3: 1 chromium methionine huge legendary turtle compound.
Manufacture method described in the invention, carry out according to the following step:
A. methionine(Met) adds in the entry, is warming up to 60～100 ℃ of solution temperatures;
B. according to certain mole proportioning, add inorganic chromium, keep temperature, react fully;
C. regulator solution PH makes the chromium methionine precipitation;
D. filtering-depositing, drying and crushing gets final product.
The methionine(Met) of mentioning in the steps A is commercially available food grade methionine(Met) and feed grade methionine, selects in the foodstuff additive purposes different with fodder additives according to product application.
The inorganic chromium of mentioning among the step B refers to the trivalent inorganic chromium, includes but not limited to following material, as trivalent chromium inorganic salt such as chromium chloride, chromium sulphate, chromium nitrate, Plessy's green, basic chromium sulfates, preferentially selects water miscible inorganic chromic salt.
The material of regulating pH value among the step C is an alkaline matter, include but not limited to following alkaline matter, oxyhydroxide as metal, as sodium hydroxide, potassium hydroxide, calcium hydroxide, lithium hydroxide, aluminium hydroxide, and alkaline matter such as ammoniacal liquor, various subsalt, strong base-weak acid salt, preferentially select water miscible alkali metal hydroxide.
Embodiment one
At first 100 gram methionine(Met) are added in 2000 ml waters, open and stir, be warming up to aqueous solution boiling, slowly add chromium trichloride 117 grams, solid is dissolved fully, kept temperature 40 minutes; Slowly adding dense potassium hydroxide solution regulator solution PH is 7.6, strengthens and stirs, and keeps temperature 20 minutes, makes the chromium methionine precipitation fully, centrifugation in link-suspended basket centrifuge while hot, filtering-depositing, drying and crushing.
Utilize Kjeldahl determination to measure methionine content in the finished product, and utilize plasma emission spectrum to measure the content of chromium in the finished product, measurement result shows that the molar ratio of methionine(Met) and chromium is 1: 1.
Embodiment two
At first 100 gram methionine(Met) are added in 2000 ml waters, open stirring, being warming up to aqueous temperature is 70 ℃, slowly adds chromium nitrate 88 grams, and solid is dissolved fully, keeps temperature 60 minutes; Slowly adding strong caustic regulator solution PH is 7.6, strengthens and stirs, and keeps temperature 30 minutes, makes the chromium methionine precipitation fully, centrifugation in link-suspended basket centrifuge while hot, filtering-depositing, drying and crushing.
Utilize Kjeldahl determination to measure methionine content in the finished product, and utilize plasma emission spectrum to measure the content of chromium in the finished product, measurement result shows that the molar ratio of methionine(Met) and chromium is 2: 1.
Embodiment three
At first 100 gram methionine(Met) are added in 2000 ml waters, open stirring, be warming up to 95 ℃ of the aqueous solution, slowly add chromium sulphate 47 grams, solid is dissolved fully, kept temperature 40 minutes; Slowly adding strong aqua regulator solution PH is 7.6, strengthens and stirs, and keeps temperature 20 minutes, makes the chromium methionine precipitation fully, centrifugation in link-suspended basket centrifuge while hot, filtering-depositing, drying and crushing.
Utilize Kjeldahl determination to measure methionine content in the finished product, and utilize plasma emission spectrum to measure the content of chromium in the finished product, measurement result shows that the molar ratio of methionine(Met) and chromium is 3: 1.
Claims (3)
1, method for preparing methionine chrominium chelate is characterized in that carrying out according to the following step:
A. methionine(Met) is added in the entry elevated temperature;
B. according to certain mole proportioning, add inorganic chromium, keep temperature for some time, react fully;
C. the regulator solution pH value makes the chromium methionine precipitation;
D. filtering-depositing, drying and crushing gets final product;
2, according to the manufacture method of claim 1 described chromium methionine, it is characterized in that the indication chromium methionine is, the molar ratio of methionine(Met) and chromium is 1: 1,2: 1,3: 1 three kinds.
3, the manufacture method of chromium methionine according to claim 1, the material that it is characterized in that regulator solution pH value used among the step C are the material that is alkalescence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031040780A CN1523008A (en) | 2003-02-21 | 2003-02-21 | Method for manufacturing methionine chromium chelate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031040780A CN1523008A (en) | 2003-02-21 | 2003-02-21 | Method for manufacturing methionine chromium chelate |
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| CN1523008A true CN1523008A (en) | 2004-08-25 |
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| CNA031040780A Pending CN1523008A (en) | 2003-02-21 | 2003-02-21 | Method for manufacturing methionine chromium chelate |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516142A (en) * | 2011-11-01 | 2012-06-27 | 中国科学院过程工程研究所 | Preparation method of chromium methionine chelate |
| CN112209821A (en) * | 2020-11-05 | 2021-01-12 | 建明(中国)科技有限公司 | Preparation method of chromium propionate |
-
2003
- 2003-02-21 CN CNA031040780A patent/CN1523008A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516142A (en) * | 2011-11-01 | 2012-06-27 | 中国科学院过程工程研究所 | Preparation method of chromium methionine chelate |
| CN102516142B (en) * | 2011-11-01 | 2014-07-02 | 中国科学院过程工程研究所 | Preparation method of chromium methionine chelate |
| CN112209821A (en) * | 2020-11-05 | 2021-01-12 | 建明(中国)科技有限公司 | Preparation method of chromium propionate |
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Effective date of registration: 20051230 Address after: Nanshan District Ma Liuzhou Industrial Zone of Shenzhen City, Guangdong Province, building 202 day flight Applicant after: Shenzhen Hadak Industrial Co.,Ltd. Address before: Nanshan District Ma Liuzhou Industrial Zone of Shenzhen City, Guangdong Province, building 202 day flight Applicant before: Zhou Tao |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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