CN1519041A - 超声微泡造影剂用于形成毛细血管栓塞的医疗装置的设置方法及装置 - Google Patents
超声微泡造影剂用于形成毛细血管栓塞的医疗装置的设置方法及装置 Download PDFInfo
- Publication number
- CN1519041A CN1519041A CNA031528953A CN03152895A CN1519041A CN 1519041 A CN1519041 A CN 1519041A CN A031528953 A CNA031528953 A CN A031528953A CN 03152895 A CN03152895 A CN 03152895A CN 1519041 A CN1519041 A CN 1519041A
- Authority
- CN
- China
- Prior art keywords
- contrast agent
- ultrasonic
- microbubble contrast
- ultrasound
- embolism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002872 contrast media Substances 0.000 title claims abstract description 52
- 208000005189 Embolism Diseases 0.000 title claims description 61
- 238000002604 ultrasonography Methods 0.000 title claims description 60
- 238000000034 method Methods 0.000 title claims description 14
- 229940039231 contrast media Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 13
- 238000011282 treatment Methods 0.000 claims description 44
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 238000002601 radiography Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 208000007536 Thrombosis Diseases 0.000 abstract description 8
- 206010028980 Neoplasm Diseases 0.000 description 71
- 239000003153 chemical reaction reagent Substances 0.000 description 25
- 208000001435 Thromboembolism Diseases 0.000 description 24
- 210000004204 blood vessel Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 15
- 201000011510 cancer Diseases 0.000 description 13
- 238000002560 therapeutic procedure Methods 0.000 description 12
- 206010028851 Necrosis Diseases 0.000 description 9
- 230000017074 necrotic cell death Effects 0.000 description 9
- 208000035269 cancer or benign tumor Diseases 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000002512 chemotherapy Methods 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- PRPAGESBURMWTI-UHFFFAOYSA-N [C].[F] Chemical compound [C].[F] PRPAGESBURMWTI-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000000527 sonication Methods 0.000 description 3
- 238000002525 ultrasonication Methods 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 102000008100 Human Serum Albumin Human genes 0.000 description 2
- 108091006905 Human Serum Albumin Proteins 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000018578 heart valve disease Diseases 0.000 description 2
- 230000036031 hyperthermia Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 208000035657 Abasia Diseases 0.000 description 1
- 108010056388 Albunex Proteins 0.000 description 1
- 108010008908 FS 069 Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010068771 Soft tissue neoplasm Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004088 pulmonary circulation Effects 0.000 description 1
- 230000000191 radiation effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Images
Landscapes
- Surgical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
装置工作原理微波射频HIFU本发明 | 优点1.加热稳定2.浅表疗效好3.多源可扩大辐射面4.可行腔内治疗1.可加热较大的体积2.配备外循环冷却水袋后,可加热较深或较大的瘤体1.穿透性能好2.可治疗浅表及深部的肿瘤3.高能聚焦肿瘤灭活效率高1.穿透性能好,治疗能量低,无创无损伤2.治疗定位精确,效率高3.可治疗浅表及深部的肿瘤 | 缺点1.穿透浅,2.测温难3.需配辐射防护4.调整较难1.易损伤皮下脂肪2.场强分布不均3.深部疗效不佳4.价格较贵1.含气脏器、骨等不能治疗2.操作繁杂3.测温困难4.价格昂贵1.含气脏器、骨等不能治疗2.治疗前需输注微泡试剂 | 应用范围1.体表部位,如乳腺、头颈、肢体等的浅表肿瘤2.食道、直肠、宫颈等管腔内的肿瘤1.体积较大的肿瘤2.瘤体位置较深的肿瘤1.体积适中的肿瘤2.瘤体位置较深的肿瘤1.体积适中的肿瘤2.瘤体位置较深的肿瘤 |
治疗前1天 | 治疗后1天 | 生长率 | |||||
a | b | V | a | B | V | (%) | |
1 | 12.96 | 8.04 | 418.878 | 16.52 | 9.98 | 822.699 | 96.405 |
2 | 14.42 | 7.62 | 418.644 | 13.78 | 8.24 | 467.814 | 11.745 |
3 | 16.32 | 10.58 | 913.401 | 13.62 | 10.22 | 711.294 | -22.127 |
4 | 14.52 | 8.48 | 522.069 | 13.78 | 8.02 | 443.167 | -15.113 |
5 | 10.3 | 5.92 | 180.488 | 9.98 | 5.74 | 164.408 | -8.908 |
治疗后2天 | 生长率 | 治疗后3天 | 生长率 | |||||
a | b | V | % | a | b | V | ||
17.79 | 11.38 | 1151.942 | 175.007 | 18.80 | 12.40 | 1445.344 | 245.051 | |
15.52 | 8.18 | 519.240 | 24.029 | 17.0 | 8.16 | 565.977 | 35.193 | |
13.46 | 10.30 | 713.985 | -21.832 | 12.96 | 10.42 | 703.575 | -22.971 | |
12.68 | 7.42 | 349.057 | -33.139 | 12.44 | 7.32 | 333.382 | -36.161 | |
10.24 | 5.58 | 159.418 | -11.673 | 10.78 | 6.12 | 201.879 | 11.852 |
Claims (8)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031528953A CN1298400C (zh) | 2003-09-01 | 2003-09-01 | 超声微泡造影剂用于形成毛细血管栓塞的医疗装置 |
PCT/CN2004/000555 WO2005039526A1 (fr) | 2003-08-18 | 2004-05-28 | Procede, reactif et dispositif permettant d'emboliser des vaisseaux capillaires dans une tumeur au moyen d'un reactif supersonique a petites bulles |
US10/556,237 US20070060906A1 (en) | 2003-08-18 | 2004-05-28 | Method, reagent, and device for embolizing blood vessels in tumors with ultrasonic radiation micro-bubble reagent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031528953A CN1298400C (zh) | 2003-09-01 | 2003-09-01 | 超声微泡造影剂用于形成毛细血管栓塞的医疗装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1519041A true CN1519041A (zh) | 2004-08-11 |
CN1298400C CN1298400C (zh) | 2007-02-07 |
Family
ID=34287054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031528953A Expired - Fee Related CN1298400C (zh) | 2003-08-18 | 2003-09-01 | 超声微泡造影剂用于形成毛细血管栓塞的医疗装置 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1298400C (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101797424A (zh) * | 2010-03-26 | 2010-08-11 | 深圳市一体医疗科技有限公司 | 用于治疗肿瘤的超声探头、治疗系统及使用方法 |
WO2010127546A1 (zh) * | 2009-05-07 | 2010-11-11 | Liu Zheng | 微泡在制备用于联合超声产生高强度空化作为抗肿瘤新生血管药物的用途 |
CN102548614A (zh) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | 使用超声空化的肿瘤治疗 |
CN104856740A (zh) * | 2015-04-30 | 2015-08-26 | 江苏汉美科技有限公司 | 超声微泡造影剂进行肿瘤毛细血管栓塞的组合装置 |
CN103893919B (zh) * | 2014-03-26 | 2017-02-08 | 哈尔滨医科大学 | 一种动脉粥样硬化声动力治疗系统 |
WO2022042531A1 (zh) * | 2020-08-24 | 2022-03-03 | 清华大学 | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4768914B2 (ja) * | 2000-12-26 | 2011-09-07 | 株式会社東芝 | 超音波診断装置 |
-
2003
- 2003-09-01 CN CNB031528953A patent/CN1298400C/zh not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102548614A (zh) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | 使用超声空化的肿瘤治疗 |
WO2010127546A1 (zh) * | 2009-05-07 | 2010-11-11 | Liu Zheng | 微泡在制备用于联合超声产生高强度空化作为抗肿瘤新生血管药物的用途 |
CN101797424A (zh) * | 2010-03-26 | 2010-08-11 | 深圳市一体医疗科技有限公司 | 用于治疗肿瘤的超声探头、治疗系统及使用方法 |
CN101797424B (zh) * | 2010-03-26 | 2012-03-21 | 深圳市一体医疗科技股份有限公司 | 用于治疗肿瘤的超声探头及治疗系统 |
CN103893919B (zh) * | 2014-03-26 | 2017-02-08 | 哈尔滨医科大学 | 一种动脉粥样硬化声动力治疗系统 |
CN104856740A (zh) * | 2015-04-30 | 2015-08-26 | 江苏汉美科技有限公司 | 超声微泡造影剂进行肿瘤毛细血管栓塞的组合装置 |
WO2022042531A1 (zh) * | 2020-08-24 | 2022-03-03 | 清华大学 | 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法 |
US12023055B2 (en) | 2020-08-24 | 2024-07-02 | National Tsing Hua University | Balloon catheter system assisted by ultrasound and microbubbles and method for vasodilation |
Also Published As
Publication number | Publication date |
---|---|
CN1298400C (zh) | 2007-02-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1711109B1 (en) | Localized production of microbubbles and control of cavitational and heating effects by use of enhanced ultrasound | |
Marberger et al. | Extracorporeal ablation of renal tumours with high-intensity focused ultrasound. | |
Frenkel | Ultrasound mediated delivery of drugs and genes to solid tumors | |
Miller et al. | Overview of therapeutic ultrasound applications and safety considerations | |
Vaezy et al. | Image-guided acoustic therapy | |
Burke et al. | Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating | |
CA2621354A1 (en) | Method for treating subcutaneous tissues | |
ter Haar | Intervention and therapy | |
CN1298400C (zh) | 超声微泡造影剂用于形成毛细血管栓塞的医疗装置 | |
WO2006072200A1 (fr) | Adjuvant d’emulsions au fluorocarbure pour un traitement hifu et utilisation de celui-ci | |
ter Haar | Ultrasound bio-effects and safety considerations | |
Takegami et al. | Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal and therapeutic effects of high-intensity focused ultrasound | |
Marberger | Ablation of renal tumours with extracorporeal high-intensity focused ultrasound. | |
Curra et al. | Therapeutic ultrasound: Surgery and drug delivery | |
Feril et al. | Therapeutic potential of low-intensity ultrasound (part 1): thermal and sonomechanical effects | |
Latifi et al. | Focused ultrasound tumour ablation in small animal oncology | |
Crum et al. | Sound therapy | |
KONDO et al. | Novel therapeutic applications of ultrasound. Utilization of thermal and cavitational effects | |
Izadifar et al. | Applications and safety of therapeutic ultrasound: current trends and future potential | |
CN1513440A (zh) | 超声微泡造影剂形成毛细血管栓塞制备肿瘤药物的用途 | |
Glickstein et al. | Therapeutic Ultrasound | |
Rybyanets et al. | Theoretical modeling and experimental study of HIFU transducers and acoustic fields | |
CN2810654Y (zh) | 超声辐射微泡试剂致肿瘤血管栓塞的装置 | |
Saffari | Therapeutic ultrasound–Exciting applications and future challenges | |
Barkman | Thermotherapy: feasibility study using a single focussed ultrasound transducer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU HANMEI SCIENCE AND TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: WU WEI Effective date: 20100528 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 210009 NO.87, DINGJIAQIAO ROAD, NANJING CITY, JIANGSU PROVINCE TO: 225300 NO.2, YAOCHENG AVENUE, CHINA MEDICAL CITY, MEDICINE NEW+HIGH-TECH ZONE, TAIZHOU CITY, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20100528 Address after: 225300, 2, medicine city, Taizhou pharmaceutical high tech Zone, Jiangsu, China Patentee after: Jiangsu Hanmei Technologies Co., Ltd. Address before: Ding Jia Qiao Road Nanjing City, Jiangsu province 210009 No. 87 Patentee before: Wu Wei |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070207 Termination date: 20120901 |