CN1515251A - Composition with function of beautifying face and its application - Google Patents

Composition with function of beautifying face and its application Download PDF

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Publication number
CN1515251A
CN1515251A CNA03150633XA CN03150633A CN1515251A CN 1515251 A CN1515251 A CN 1515251A CN A03150633X A CNA03150633X A CN A03150633XA CN 03150633 A CN03150633 A CN 03150633A CN 1515251 A CN1515251 A CN 1515251A
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weight portion
application
arbitrary described
described compositions
isoflavone
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莉 马
马莉
李爱英
张玮偲
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Abstract

The present invention relates to a composition with function of beautifying face and its application. The composition contains no any chemical synthetic components and additive, and is composed of 15-500 weight portions of isoflavone which is soybean isoflavone and 20-500 weight portions of protocyanidine which is grape-seed extract protocyanidine. The composition has the good synergistic action for beautifying and nourishing face, and said composition also relates to the application for preparing medicines for curing menopausal syndrome, osteoporosis, cancers, cardiovascular disease and for raising and regulating immunity.

Description

A kind of composition and use thereof with beautification function
Technical field
The present invention relates to a kind of compositions with beautification function, the characteristics of said composition are made up of the natural drug of integration of edible and medicinal herbs, do not contain any chemosynthesis composition and additive.
Background technology
The women is after adolescence, and intravital estrogen begins to reduce gradually, and some uncomfortable diseases appear in human body, at this moment the women shows senile symptom, and the no longer so smooth exquisiteness of skin engenders tiny wrinkle on the face, chloasma has also occurred, even disease just slowly follows up.Modern medicine proves that this all is that oestrogen deficiencies causes due to the estrogen secretion disorder, and in time these situations of complementing estrogen just may not can take place, and worsens even taken place also can not move towards.
Free radical is some high energy molecules, and it can damage body tissue by Oxidation, causes human organ aging, has the oxidative damage of more than 70 kind of disease and radical pair body that substantial connection is arranged among the mankind; Free radical also is to cause one of aged major reason, tool estimates that the aging of about 80%-90%, degenerative disorders are all relevant with free radical, comprising cancer, senile dementia, Parkinson's disease, skin black speck deposition, cataract, heart disease or the like, so it is most important for the health and the young body constitution of health to eliminate harmful free radicals.
Asking beauty is each woman's target, but skin ageing allows woman's beauty decorporate, and how to allow skin remain under the young slick state, becomes one of important topic of keeping beautiful appearance.The health care idea of modern female changes, and beginning is used for the expense that originally was used to improve looks or make up to be own complementing estrogen, removes intravital free radical, tries to achieve real beauty treatment and health.Disclosed at present application number is the patent of invention with looks improving and the skin nourishing health-care effect of 00121388.1 (Granted publication CN1111068C), 02159456.2 (Granted publication CN1425439A), 01144799.0 (Granted publication CN1429585A), these products exist that the health nutrient composition is narrow, effect is single, contain the chemosynthesis composition, take effect slow, defective such as side effect arranged, can not satisfy people and advocate healthy value natural, back to nature day by day, therefore, need improve existing cosmetics.
At present, we find that soybean isoflavone, the common component of Semen Vitis viniferae extract procyanidin OPC have synergism aspect looks improving and the skin nourishing, and the present invention is the improvement to the product of prior art.
Summary of the invention
The looks improving and the skin nourishing, anti-aging beauty-care compositions and the purposes that the purpose of this invention is to provide a kind of safety non-toxic.
Solution of the present invention is based on understanding and the Therapeutic Principle of present medical science to female aging mechanism, with reference to the modern pharmacological research achievement, from natural plants, filter out and have endocrine regulation estrogen, remove intravital free radical, high-efficiency antioxidant, replenish the calcareous of needed by human body, aminoacid, trace element, microcirculation improvement, the homologous natural edible-plant of medicated diet, skim the cream off milk, satisfy antioxidation nutrient Deficiency of Intake fully, the health senilism that oestrogen deficiencies or estrogen secretion disorder are caused, lusterless complexion, each age women's that health is wan and sallow somatogenic need, improve female body health, make female cosmetic moistening, the youth is everlasting.
Compositions of the present invention is to be made by the raw material of following component:
Isoflavone 15-500 weight portion and procyanidin 20-500 weight portion.
Composite formula weight portion ratio range of the present invention can be:
Isoflavone 50-350 part procyanidin 100-300 part.
The formula optimization weight portion ratio range of the present composition is:
Isoflavone 100-300 part procyanidin 100-250 part.
The prescription of the present composition more preferably weight portion ratio range is:
Isoflavone 150 (9CI)-250 part procyanidin 150-200 part.
The formula optimization weight portion ratio range of the present composition also can be:
Soybean isoflavone 150-250 part Semen Vitis viniferae extract procyanidin 150-200 part.
The present composition can be made said dosage form on any pharmaceutics, for example: capsule, tablet, oral liquid etc.
The present composition also can be made into varieties of food items, as: beverage, wine, cookies, confection etc.
The preparation of compositions method that the present invention has beautification function is: raw material of Chinese medicine extracts according to a conventional method, gets water and carries and ethanol extract, and wherein alcohol can be the ethanol extraction of 50-95% with concentration; Cross 120 mesh sieves, oven dry adds acceptable auxiliary mixing on the pharmaceutics, and capsule is made in filling in Capsules; Or compacting in flakes.
Soybean isoflavone, be the pure natural plant estrogen that from the natural plants Semen sojae atricolor, extracts, body estrogen had dual regulation, has slow down aging, the function of looks improving and the skin nourishing is used for the wan and sallow women of health senilism, lusterless complexion, health that estrogen secretion is not enough and the estrogen secretion disorder is caused.
Semen Vitis viniferae extract procyanidin OPC is a pure natural substance, is to find one of efficient antioxidants of plant origin so far, mainly contains functions such as antiinflammatory, antihistamine, anti-allergen, antioxidant, beauty treatment, blood circulation promoting; In the body and in vitro tests shows, the antioxidant effect of Semen Vitis viniferae extract, be vitamin C and vitamin E 20-50 doubly.Superpower antioxidation efficient has the powerful effect of removing free radical, improving body immunity.So Semen Vitis viniferae extract is to the human body antioxidation, improving immunity has splendid effect.
Margarita is the Margarita that Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis Cumingii (Lea) or cristaria plicata Cristaria plicata bivalve irriates such as (Leach) form.That Margarita is rich in is calcareous, aminoacid, trace element etc., has the generation that suppresses old and feeble plain lipofuscin, delicate skin, eliminates effects such as flaw, removing toxic substances and promoting granulation, removing nebula make eye bright, and has high medicinal, its cosmetic values.
Radix Ginseng is the dry root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey., hides sweet, little hardship, slightly warm in nature; Return lung, spleen, heart channel, have strongly invigorating primordial QI, effects such as increasing intelligence of calming the nerves, quench one's thirst, palpitate with fear insomnia, cold womb has better curative effect for lustreless complexion, interior-heat.Radix Ginseng makes skin capillary vascular expansion, and the accelerate blood circulation strengthens cell viability, promotes the nutrition supply of hair follicle, and therefore cosmetic result is preferably arranged.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels. sweet in the mouth, suffering, and warm in nature; Return liver, the heart, spleen channel, invigorate blood circulation, the dispel effect of silt tissue regeneration promoting that having enriches blood, Radix Angelicae Sinensis contains abundant trace element, can skin nutrition, prevent coarsely, can be used for acne, brown patch, freckle and alopecia; Its cosmetology effect of Radix Angelicae Sinensis from Radix Angelicae Sinensis can skin expansion blood capillary, accelerate blood circulation, therefore curative effect preferably do not arranged for the complexion due to blood deficiency is flourish, take Radix Angelicae Sinensis for a long time, can make skin of face reappear ruddy color and luster.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Acrid in the mouth, warm in nature is returned liver, gallbladder, pericardium channel.The effect that blood-activating and qi-promoting, wind-expelling pain-stopping are arranged.Modern study is found: Rhizoma Chuanxiong has good regulating action to microcirculqtory system, and its infusion has stronger restraint to some pathogenic dermatophytes.The effect that Rhizoma Chuanxiong also has vitamin antagonist E to lack.In addition, the activity that Rhizoma Chuanxiong can also restraint of tyrosinase, thus can play therapeutical effect to black speck, freckle, senile plaque.
An important feature of the present invention is that suitable crowd is extensive, is applicable to the health senilism that antioxidation nutrient Deficiency of Intake, oestrogen deficiencies or estrogen secretion disorder are caused, lusterless complexion, the wan and sallow women of health.Its outward manifestation is:
1, senile symptoms such as pachylosis, face dimness, chloasma, withered and yellowish hairs appear.
2, insomnia, forgetful, hyperhidrosis, long-term sleep quality are not high, the people of the mental hypophrenia.
3, often constipation, vexed gas are hot-tempered, halitosis bitter taste, the speckle person of increasing on the face.
4, vexed, irascible, being happy and angry uncertainly, weak, the menoxenia of headache appear.
5, often feel bone arthralgia from head to foot, loss of tooth is easy to fracture, and often with pudendum, vagina, urinary tract infection etc.
6, sexual life indifference, pain.
Another important feature that the present invention has is to select phytoestrogen composition soybean isoflavone in the medicament for use, its dual regulation makes it become the too much or very few two-ways regulation agent of female estrogen, also is all estrogen succedaneums of irreplaceable unique the best of existing at present medicine and plant.Secular clinical trial certificate: the present composition can be prevented and treated climacteric syndrome, osteoporosis, blood fat rising, prevention senile dementia etc.; For the horizontal person of high estrogen, show as the estrogen antagonist activity, can prevent and treat breast carcinoma, endometritis; Have the two-ways regulation equilibrium function, experimental data sees below in detail.
Another important feature that the present invention also has is to contain efficient antioxidants composition Semen Vitis viniferae extract procyanidin OPC in the compositions, ability with very powerful removing free radical has the health-care effect of following some aspects:--reduce the initiation potential of following disease: heart disease; Cancer; Senilism; Arthritis; Surpass 70% with the free radical diseases associated; Strengthen the blood vessel wall resistance; Strengthen the function of blood capillary, vein, tremulous pulse; Alleviate the seriousness of athletic injury; Prevention is also alleviated varicosis; Alleviate edema and shank swelling; Treat chronic venous afunction; Reduce the initiation potential of diabetes; Improve the pliability of blood rbc film; Strengthen skin elasticity and soft and smooth property, make skin keep its elasticity and moisture, delay the generation of wrinkle; The prevention sunray is to the radiation damage of skin, skin whitening; Antiinflammatory improves joint flexibility, alleviates the pain due to the arthroncus, alleviates diabetic retinopathy, prevention by it cause blind; Antiallergic; But the enhance immunity ability reduces the frequency that flu takes place, and alleviates its seriousness; Remarkable to the acute gastric ulcer effect due to the anxiety, also effective to other digestive system inflammation.
In addition, in compositions of the present invention, 18 seed amino acids and tens of kinds of trace element such as protein and a large amount of activated calciums of also containing needed by human can strengthen the function that body immunity, beauty treatment, the cell regeneration of promotion skin collagen, defying age, promotion are grown, strengthened cardiovascular system.
The clinical use result of the present invention shows that following advantage is arranged:
1. inventing and selecting the homologous natural edible-plant of medicated diet for use is raw material, and common component has synergism aspect looks improving and the skin nourishing.
2. consumption is little clinically in the present invention, instant effect, and targeting is strong, and the bioavailability height is made up of pure natural plant, does not contain any chemosynthesis composition and additive, safety non-toxic.
3. endocrine regulation of the present invention, high-efficiency antioxidant, anticancer, anti-angiocardiopathy, immunomodulating are different from general cosmetics.
4. safety of the present invention, efficient, excellent quality.
For verify looks improving and the skin nourishing of the present invention, improve climacteric syndrome, the effect of anti-angiocardiopathy, take through the women of 50 routine different occupation, age, education degree and living environment, observed three months, one month is a course of treatment, totally three courses of treatment, the result is as follows:
Time Curative effect
After taking a week Sleep, relieving constipation improve.
After taking for two weeks Bitter taste, halitosis, pachylosis, acne are improved; Sleep quality is clearly better.
After taking for three weeks Skin is smooth gradually, elasticity is improved, skin is gradually white, complexion is moistened.
Took one month Menstruation improvement, energy are gradually multiple, breast is more preceding fuller, and vaginal secretions increases.
Take one and a half months Skin lubrication, flexible, QI and blood and suitable, have rosy cheeks, the mottle desalination.
Took two months Emotion improvement, blood pressure reduction, cholesterol reduction, whiteness of skin, life quality obviously improve.
Took three months Chloasma disappears, libido strengthens, and the bone arthralgia obviously alleviates or disappears from head to foot.
Take for a long time Looks improving and the skin nourishing, delaying female aging, retain youthful vitality.
Through trimestral observation, as follows to following symptom treatment result:
Symptom Effective percentage
Skin aging ????100%
Irritated irritability ????85%
Constipation ????98%
Insomnia forgetfulness ????99%
The bone arthralgia ????88%
Chloasma ????85%
Sexual disorder ????90%
Menoxenia ????85%
Mastatrophy ????85%
Blood pressure reduces ????92%
Cholesterol reduces ????95%
Antitumaous effect of the present invention is taken through 10 routine patient with breast cancers, receives good efficacy, now is described below:
Clinical data: physical data, 10 routine patients are the women, age 41-62 year, average 55 years old, make a definite diagnosis after the breast carcinoma not underwent operative and put, chemotherapy, merely by therapist 4 examples of the present invention, all the other 6 examples are with present composition disease controlling person behind underwent operative and the chemicotherapy.
Clinical manifestation: the lump of breast carcinoma from the beginning of matter firmly not bitterly, surface irregularity, obscure boundary, with epidermis or with the adhesion of following covering weave, be difficult for promoting; Breast carcinoma is burst, broken after, many depressions in the middle of the open sore part, as protruding then as the magic flower Punica granatum L., permanent current sewage, smelly dirty, gently wipe away then hemorrhage; The normal appearance often accompanies emaciated physique, shortness of breath and palpitation, fatigue and weakness, insomnia dizziness, menoxenia, nausea and vomiting, diet difficulty to advance after radiotherapy, the chemotherapy.
Instructions about how to take medicine: this compositions is large dose oral administration every day, and sub-service sooner or later is with the control cancer metastasis; In addition, the patient all drinks Radix Panacis Quinquefolii water 10~20ml per morning.
The result: among the 10 routine patients, underwent operative and radiotherapy, chemotherapy are not obeyed the 4 routine patients of this combination treatment merely, and treatment back symptom is relatively stable, though lump does not disappear, the long period does not make progress again, follows up a case by regular visits to respectively 3 years, still can live as ordinary person.Wherein nearly 1 year local time of 1 example has the stream yellow fluid to ooze out outer other discomfort of also not having.The person of taking traditional Chinese medicine after all the other 5 routine underwent operative, radiotherapy, the chemotherapy follows up a case by regular visits to and does not find more than 3 years to shift or recurrence.
Another effect of the present composition is the application that is used for strengthening and regulating the medicine of immunity in preparation.Antioxidation is the important way of slow down aging, with advancing age, body's immunological function significantly descends, as seen, the relation of defying age and enhancing human body immunity power is very close, for understanding this side's pair cell Immune Effects, carry out following experiment: preparation immunologic hypofunction white mice animal model, through irritating stomach,, observe its pair cell Immune Effects by surveying lymhocyte transformation rate and E garland form rate:
Animal selects 2-4 week Kunming white mice, and body weight 18-22 kilogram is divided into 3 groups at random, and 10 every group, establish normal group, hydrocortisone group, hydrocortisone and add present composition group, serve on for 4 weeks; The result: stimulation index is changeed in the pouring of hydrocortisone group and E garland formation rate is starkly lower than the normal control group, and both relatively have significant difference P<0.001, and the success of hydrocortisone induced mice immunologic hypofunction model is described; Hydrocortisone adds present composition group drench to change stimulation index and E garland formation rate apparently higher than the hydrocortisone group, both relatively have significant difference P<0.001, and be higher than normal control group P<0.01, illustrate that this compositions has the effect that improves the white mice cellular immune function.
The specific embodiment
Embodiment 1
Soybean isoflavone 100 weight portions, Semen Vitis viniferae extract procyanidin 80 weight portions add suitable adjuvant and mix, and capsule is made in filling in Capsules.
Embodiment 2
Soybean isoflavone 500 weight portions, Semen Vitis viniferae extract procyanidin 400 weight portions mix, and add soybean salad oil, change glue, are pressed into soft capsule, low-temperature shaped drying.
Embodiment 3
Soybean isoflavone 200 weight portions, Semen Vitis viniferae extract procyanidin 200 weight portions, water soluble Margarita ultrafine powder 100 weight portions, Herb Gynostemmae Pentaphylli general glycoside 40 weight portions add magnesium stearate, and mix homogeneously is pressed into tablet.
Embodiment 4
Soybean isoflavone 200 weight portions, Semen Vitis viniferae extract procyanidin 150 weight portions, Radix Ginseng, each 5 weight portion water extraction of Flos Chrysanthemi get extract, add Mel 10 weight portions, and suitable supplementary product starch mix homogeneously is made honey pill agent.
Embodiment 5
Radix Angelicae Sinensis 6 weight portions are used 60% ethanol extraction, get Radix Angelicae Sinensis extract, add soybean isoflavone 80 weight portions, Semen Vitis viniferae extract procyanidin 100 weight portions, add microcrystalline Cellulose, magnesium stearate mix homogeneously, are pressed into tablet.
Embodiment 6
Rhizoma Chuanxiong, Radix Angelicae Sinensis, each 6 weight portion of Fructus Lycii, steeped 10 hours with 8 times water loggings, decocted 30 minutes, concentrate decocting liquid, get extract extractum, add soybean isoflavone 400 weight portions, Semen Vitis viniferae extract procyanidin 300 weight portions and suitable adjuvant and mix, capsule is made in filling in Capsules.
Embodiment 7
Soybean isoflavone 60 weight portions, Semen Vitis viniferae extract procyanidin 40 weight portions, Ganoderma spore powder 20 weight portions, solatene 40 weight portions add starch and mix, and capsule is made in filling in Capsules.
Embodiment 8
Radix Polygoni Multiflori 30 weight portions extract with 10 times of water gagings, concentrate, and drying adds soybean isoflavone 15 weight portions, Semen Vitis viniferae extract procyanidin 20 weight portions, adds starch 20 weight portions, mixes, and capsule is made in filling in Capsules.
Embodiment 9
Soybean isoflavone 15 weight portions, Semen Vitis viniferae extract procyanidin 20 weight portions, solatene 40 weight portions add starch 20 weight portions, mix, and capsule is made in filling in Capsules.

Claims (11)

1. the compositions with beautification function is characterized in that containing following component: isoflavone 15-500 weight portion and procyanidin 20-500 weight portion.
2. compositions according to claim 1 is characterized in that containing following component: isoflavone 50-350 weight portion and procyanidin 100-300 weight portion.
3. according to the arbitrary described compositions of claim 1-2, it is characterized in that: isoflavone is a soybean isoflavone, and procyanidin is the Semen Vitis viniferae extract procyanidin.
4. according to the arbitrary described compositions of claim 1-3, it is characterized in that: also comprise in following weight parts raw material water extract and the alcohol extract one or more: Radix Ginseng 5-15 weight portion, Flos Chrysanthemi 6-12 weight portion,
Radix Angelicae Sinensis 6-12 weight portion, Rhizoma Chuanxiong 6-12 weight portion, Radix Polygoni Multiflori 5-30 weight portion, Fructus Lycii 5-15 weight portion, Radix Rehmanniae 5-12 weight portion.
5. compositions according to claim 4, it is characterized in that: also can add Mel 5-15 weight portion, Herb Gynostemmae Pentaphylli general glycoside 5-60 weight portion, water soluble Margarita ultrafine powder 20-100 weight portion, one or more in Ganoderma spore powder 5-30 weight portion, the solatene 20-100 weight portion.
6. the application of the arbitrary described compositions of claim 1-5 in the medicine of preparation treatment climacteric syndrome.
7. the application of the arbitrary described compositions of claim 1-5 in the medicine of preparation treatment osteoporosis.
8. the application of the arbitrary described compositions of claim 1-5 in the medicine of the anti-curing cancers of preparation.
9. the application of the arbitrary described compositions of claim 1-5 in the medicine of the anti-angiocardiopathy of preparation.
10. the arbitrary described compositions of claim 1-5 is used for strengthening and regulating the application of the medicine of immunity in preparation.
CNA03150633XA 2003-08-25 2003-08-25 Composition with function of beautifying face and its application Pending CN1515251A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007147319A1 (en) * 2006-06-16 2007-12-27 Hubei Yangguang Scientific And Technological Medicines Co., Ltd Yin-nourishing capsule
CN100443115C (en) * 2006-04-27 2008-12-17 北京东方兴企食品工业技术有限公司 Granule with beauty and health function
CN1709383B (en) * 2005-06-22 2010-08-25 白新鹏 Beauty spot-eliminating capsule agent
CN101112466B (en) * 2007-07-31 2010-09-22 浙江杭州鑫富药业股份有限公司 Compound composition for treating chloasma and stimulating evacuation of the bowels and uses thereof
CN102613568A (en) * 2012-04-19 2012-08-01 石药集团中奇制药技术(石家庄)有限公司 Composition having two functions of removing chlosma and increasing bone density
CN102755493A (en) * 2012-08-07 2012-10-31 广东丸美生物技术股份有限公司 External use drug for treating climacteric syndrome and preparation method thereof
CN103211071A (en) * 2013-05-20 2013-07-24 北京绿源求证科技发展有限责任公司 Food health tea infusion for preventing osteoporosis
CN104523787A (en) * 2014-12-05 2015-04-22 黑龙江众生生物工程有限公司 Production method of tablet for enhancing immunity and removing chloasma
CN104940241A (en) * 2015-05-29 2015-09-30 湖北圣峰药业有限公司 Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes
CN109007833A (en) * 2018-08-22 2018-12-18 广州市顺芝堂生物科技有限公司 It is a kind of to adjust the composition of immune function of human body, capsule and preparation method thereof

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1709383B (en) * 2005-06-22 2010-08-25 白新鹏 Beauty spot-eliminating capsule agent
CN100443115C (en) * 2006-04-27 2008-12-17 北京东方兴企食品工业技术有限公司 Granule with beauty and health function
WO2007147319A1 (en) * 2006-06-16 2007-12-27 Hubei Yangguang Scientific And Technological Medicines Co., Ltd Yin-nourishing capsule
CN101112466B (en) * 2007-07-31 2010-09-22 浙江杭州鑫富药业股份有限公司 Compound composition for treating chloasma and stimulating evacuation of the bowels and uses thereof
CN102613568A (en) * 2012-04-19 2012-08-01 石药集团中奇制药技术(石家庄)有限公司 Composition having two functions of removing chlosma and increasing bone density
CN102755493A (en) * 2012-08-07 2012-10-31 广东丸美生物技术股份有限公司 External use drug for treating climacteric syndrome and preparation method thereof
CN102755493B (en) * 2012-08-07 2014-09-03 广东丸美生物技术股份有限公司 External use drug for treating climacteric syndrome and preparation method thereof
CN103211071A (en) * 2013-05-20 2013-07-24 北京绿源求证科技发展有限责任公司 Food health tea infusion for preventing osteoporosis
CN104523787A (en) * 2014-12-05 2015-04-22 黑龙江众生生物工程有限公司 Production method of tablet for enhancing immunity and removing chloasma
CN104940241A (en) * 2015-05-29 2015-09-30 湖北圣峰药业有限公司 Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes
CN104940241B (en) * 2015-05-29 2018-09-21 湖北圣峰药业有限公司 A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women
CN109007833A (en) * 2018-08-22 2018-12-18 广州市顺芝堂生物科技有限公司 It is a kind of to adjust the composition of immune function of human body, capsule and preparation method thereof

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