CN1509749A - Preparation of papaya protease hydrolysed seven star fish protein nucleic acid and its making method - Google Patents
Preparation of papaya protease hydrolysed seven star fish protein nucleic acid and its making method Download PDFInfo
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- CN1509749A CN1509749A CNA021586284A CN02158628A CN1509749A CN 1509749 A CN1509749 A CN 1509749A CN A021586284 A CNA021586284 A CN A021586284A CN 02158628 A CN02158628 A CN 02158628A CN 1509749 A CN1509749 A CN 1509749A
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- hydrolysis
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- caricin
- radix
- lampetra mori
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Abstract
A papaya proteinas hydrolyzed Myctophidae's DNA preparation for treating rheumatoid arthritis and improving physical strength is prepared from Myctophidae and the Chinese-medicinal materials chosen from the first group containing 5 Chinese medicinal materials including homalomena rhizome, fragrant solomonseal rhizome, etc and the second group containing 15 Chinese-medicinal materials including prepared rehmannia root, wolfberry fruit, etc.
Description
Technical field
The present invention relates to a kind of preparation for the treatment of rheumatic arthritis, particularly a kind of caricin hydrolysis Lampetra mori protein nucleic acid preparation and preparation method thereof.
Background technology
Lampetra mori has another name called Zhang Gongyu, it is particularly wild animal in the water that abounds with of Guangxi China of subtropical zone, primary in stretch of flatland in a hilly area river, its reproductive capacity and vitality are extremely strong, being everlasting whenever raining jumps on the water surface can reach more than 2 meters high, the time drop on the land, bank, reach a few hours, climb full Formica fusca on one's body, still can bring back to life and put into water after stiff.
Experiment showed, DNA extraction, take and to treat rheumatic arthritis and can improve muscle power Lampetra mori.
China is the east yellow, and not as good as west ethnic group, especially west black race, physical ability is strong on muscle power.Therefore, extracting Lampetra mori protein nucleic acid (DNA) with physical strength reinforcing, improve health status, is to improve athlete's endurance to strengthen one of approach of athlete's physical ability.
Content of the present invention
The purpose of this invention is to provide a kind of caricin hydrolysis Lampetra mori protein nucleic acid preparation, be used for the treatment of rheumatic arthritis and physical strength reinforcing and improve endurance, improve health status.It is the preparation that a kind of Lampetra mori comprehensive utilization of resources is produced.
The objective of the invention is to realize by following technical scheme.
Caricin hydrolysis Lampetra mori protein nucleic acid preparation of the present invention, it is characterized in that it by following component by weight ratio form:
Major ingredient: Lampetra mori 90-92
Adjuvant: Chinese herbal medicine 8-10
Be following group one of by weight proportion in the described adjuvant Chinese herbal medicine:
First group is: Radix Linderae Chunii 18-20, Radix Flemingiae Philippinensis 18-20, Rhizoma Homalomenae 18-20, Styrax 10-12, Rhizoma Polygonati Odorati 14-16;
Second group is: Radix Linderae Chunii 18-20, Radix Flemingiae Philippinensis 18-20, Rhizoma Homalomenae 18-20, Styrax 10-12, Rhizoma Polygonati Odorati 14-16, Radix Rehmanniae Preparata 28-32, Fructus Corni 10-12, Radix Trichosanthis 14-16, Polyporus 14-16, Rhizoma Alismatis 1-16, Fructus Lycii 18-20, Radix Et Rhizoma Rhei 8-10, Cortex Moutan 8-10, thunder Radix Pini massonianae 14-16, Rhizoma Polygoni Cuspidati 14-16.
The manufacture method of described caricin hydrolysis Lampetra mori protein nucleic acid preparation comprises following step preface:
(1) gets the raw materials ready: prepare the major ingredient Lampetra mori by prescription, press one group of the regulation of filling a prescription in the described adjuvant component and prepare adjuvant;
(2) major ingredient cuts open broken: Lampetra mori is cut abdomen gill, select for use by the 90-92 weight quota, blend;
(3) major ingredient hydrolysis: add caricin in the Lampetra mori after will blending, stir evenly, be hydrolyzed;
(4) major ingredient concentrates: the Lampetra mori protein solution after the hydrolysis is heated after 100 ℃, and slow fire decocted 3 hours;
(5) major ingredient filters: will be behind the hydrolysis Lampetra mori protein solution elimination residue and impurity of decoction, and it is stand-by to get liquid;
(6) the adjuvant Chinese medicinal herbs was soaked 1 hour;
(7) the adjuvant Chinese medicinal herbs is decocted with water, water is heated slow fire decocted 2 hours after 100 ℃, taking liquid decocts with water again, water is heated slow fire decocted 2 hours after 100 ℃, and taking liquid mixes the secondary medicinal liquid, the decocting and concentrating after 100 ℃ of heating, taking liquid;
(8) filter: medicinal liquid elimination impurity;
(9) mix: the major ingredient medicinal liquid and the adjuvant medicinal liquid that goes on foot preface (8) of described step preface (5) are mixed into preparation.
The vigor of the caricin that adds in the described hydrolysis step preface (3) is 180-230 ten thousand u/g, and hydrolysis time is 12 hours.
The weight of the caricin of described adding is the 1-3% of Lampetra mori.
The secondary medicinal liquid is mixed the decoction of heating in the described step preface (7), when being adjuvant Chinese medicinal herbs weight to medicinal liquid weight till,
In the present invention's prescription, Lampetra mori is a major ingredient; Adjuvant divides two groups, and major ingredient cooperates with first group of adjuvant and is used for body-building; Major ingredient cooperates with second group of adjuvant, is used for the treatment of rheumatic arthritis, but also health invigorating and endurance.
Below be the effect of each component of adjuvant among the present invention:
1, Fructus Corni: go into the Liver and kidney warp, invigorating the liver and kidney, arresting seminal emission arresting sweating.
2, Fructus Lycii: go into the kidney lung meridian, invigorating the liver and kidney, lung moistening makes eye bright.
3, Polyporus: go into kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen.
4, Rhizoma Alismatis: go into kidney, urinary bladder channel, diuretic, clearing away damp-heat.
5, Radix Et Rhizoma Rhei: go into spleen, stomach, large intestine, the heart, Liver Channel, purge heat, removing heat from blood, eliminating blood stasis and inducing menstruation.
6, ripe yellow ground: go into the heart, liver, kidney channel, nourishing YIN and supplementing blood.
7, Cortex Moutan: go into the heart, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting competent silt.
8, Radix Trichosanthis: go into lung, stomach warp, clearing away heat and promoting production of body fluid, detumescence and apocenosis.
9, Gotu Kola: go into the kidney Liver Channel, antiinflammatory, detoxifcation.
10, Rhizoma Polygoni Cuspidati: go into liver, gallbladder, lung meridian, the analgesic therapy of invigorating blood circulation, clearing away heat-damp and promoting diuresis, detoxifcation.
11, Radix Linderae Chunii: go into the kidney spleen channel, promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling, rheumatic ostalgia.
12, Rhizoma Homalomenae: go into the liver lung meridian, wind-damp dispelling, strengthening bone and muscle, alleviating pain and detumescence.
13, Radix Flemingiae Philippinensis: go into kidney stomach warp, expelling wind and removing dampness, repercussive detoxifcation, dispelling the wind and dampness pathogens arthralgia pain.
14, Rhizoma Polygonati Odorati: go into lung stomach warp, nourishing YIN and moistening the lung promotes the production of body fluid.
15, Styrax: go into heart spleen channel, have one's ideas straightened out, dirt eliminating, pain relieving.
In this preparation, can also suitably add with the food adjuvant, to improve taste.
In sum, the present invention utilizes the extremely strong wild animal Lampetra mori of vitality to be primary raw material, adopts in addition hydrolysis of caricin, cut its micel to cut open, discharge its nutrient substance, hydrolysis produces hydrolysis Lampetra mori protein nucleic acid (DNA), to replenish the various trace element of needed by human body.Adopt the Chinese crude drug component for assisting a ruler in governing a country,, improve the body and culature to improve physical ability.Cooperation by primary raw material Lampetra mori and adjuvant component reaches the blood circulation promoting and blood stasis dispelling bone and muscle strengthening, improves the effect of physical ability.The present invention has following advantage:
1, process with vitality extremely strong aquatic animal and functional plants, without any side effects.
2, adopt hydrolyzed protein nucleic acid, take in human body, replenish body trace element, and strengthen its effect vigor.
3, at rheumatism, to get injured by a fall the stasis of blood long-pending, can activating blood circulation and dissipating blood stasis, bone and muscle strengthening, but especially to athlete's stamina intensifying.
4, because the hydrolyzed protein nucleic acid (DNA) that hydrolysis produces easily is absorbed by the body, effect is remarkable.
Embodiment: make oral liquid.
The present invention once used with preparation Lampetra mori oral liquid by name, and effect is remarkable.
1, prescription: form with following component:
90 kilograms of the Lampetra moris that major ingredient gills
Adjuvant: 10 kilograms
In described 10 kilograms of adjuvants, form by the component of following ratio by weight:
First group is: Radix Linderae Chunii 20, Radix Flemingiae Philippinensis 20, Rhizoma Homalomenae 20, Styrax 10, Rhizoma Polygonati Odorati 15, or:
Second group is: Radix Linderae Chunii 20, Radix Flemingiae Philippinensis 20, Rhizoma Homalomenae 20, Styrax 10, Rhizoma Polygonati Odorati 15, Radix Rehmanniae Preparata 30, Fructus Corni 12, Radix Trichosanthis 15, Polyporus 15, Rhizoma Alismatis 20, Fructus Lycii 20, Radix Et Rhizoma Rhei 10, Cortex Moutan 10, thunder Radix Pini massonianae 15, Rhizoma Polygoni Cuspidati 15.；
2, manufacture method is:
(1) get the raw materials ready: by preparing major ingredient in the prescription, prepare adjuvant by first group or second group,
(2) cut open broken: after Lampetra mori cut abdomen and gill, select 90 kilograms for use, blend,
(3) hydrolysis: the adding vigor is 1.8 kilograms of the caricins of 2,000,000 u/g in the Lampetra mori after will blending, and is hydrolyzed, and the time is 12 hours, forms the hydrolyzed protein solution that contains nucleic acid,
(4) concentrate: hydrolyzed protein solution is heated after 100 ℃, and slow fire decocted 3 hours;
(5) filter: will be behind the hydrolyzed protein solution elimination residue and impurity of decoction, taking liquid is stand-by.
(6) the adjuvant Chinese medicinal herbs was soaked 1 hour;
(7) the adjuvant Chinese medicinal herbs is added 100 kilograms of decoctions of water, water is heated, and slow fire decocted taking liquid 2 hours after 100 ℃, add 50 kilograms of decoctions of water again, water heated, and slow fire decocted 2 hours after 100 ℃, after getting the secondary medicinal liquid and mixing, heated till decocting and concentrating heavily is 10 kilograms to medicinal liquid after 100 ℃;
(8) filter: medicinal liquid elimination impurity;
(9) mix: the major ingredient medicinal liquid and the adjuvant medicinal liquid that goes on foot preface (8) of described step preface (5) are mixed into preparation.
Effect
The present invention was the clinical practice of preparation title with the Lampetra mori oral liquid once, random statistical treatment rheumatic arthritis 40 examples, and effect is remarkable, and when curing with rheumatic arthritis, the raising physical ability is all had good therapeutic effect.
1, case history is selected
Among the patient, male 16 people, women 24 people; The oldest 70 years old, minimum 28 years old, ill maximum duration 8 years generally was to overwork or Changes in weather and bringing out half a year shortest time.
2, diagnostic criteria
There are arthralgia, redness, activity to be obstructed or inconvenient activity,, are diagnosed as rheumatic arthritis through check erythrocyte sedimentation rate, anti-" 0 " all no abnormal person.
3, curative effect is judged
(1) cure: control the back subjective symptoms and disappear, erythrocyte sedimentation rate, anti-" 0 " recover normal.
(2) take a turn for the better: control the back subjective symptoms and disappear, but erythrocyte sedimentation rate, anti-" 0 " do not recover normal.
(3) invalid: the commentaries on classics of not getting better after controlling, erythrocyte sedimentation rate, anti-" 0 " persistent anomaly.
4, Therapeutic Method
Withdraw after making a definite diagnosis and use other antirheumatics, oral medicine of the present invention, everyone every day 3 times, 20 is a course of treatment.
5, therapeutic outcome
Cure 16 examples, 20 examples that take a turn for the better, invalid 4 routine total effective rates 90%, period in a medicine on inspection, hemogram, liver, renal function no abnormality seen.In the now further expanding test.
Typical case case history such as the Zhang of Nanning city silk spinning factory, cotton mill, Nanning City Wang 2 people respectively 56,58 years old male.The former is because of rheumatic arthritis paralysis 2 years, and the latter paralysed 3 years because of rheumatic arthritis and can not sit and see TV, after taking one month, can get up and walk, and takes exercise by running, and sits quietly and sees TV 3 hours, and recovered sexual function.
Carried out at the test of ascending a height and run that improves human body physical agility, do not take with taking and have obviously difference, mainly show the mental status, asthma and endurance aspect, the user do not pant in the test of ascending a height and run of regulation, tired, not user's asthma has tired sensation.
In the now further expanding test of preparation of the present invention.
Claims (5)
1, a kind of caricin hydrolysis Lampetra mori protein nucleic acid preparation, it is characterized in that it by following component by weight ratio form:
Major ingredient: Lampetra mori 90-92
Adjuvant: Chinese herbal medicine 8-10
Be following group one of by weight proportion in the described adjuvant Chinese herbal medicine:
First group is: Radix Linderae Chunii 18-20, Radix Flemingiae Philippinensis 18-20, Rhizoma Homalomenae 18-20, Styrax 10-12, Rhizoma Polygonati Odorati 14-16;
Second group is: Radix Linderae Chunii 18-20, Radix Flemingiae Philippinensis 18-20, Rhizoma Homalomenae 18-20, Styrax 10-12, Rhizoma Polygonati Odorati 14-16, Radix Rehmanniae Preparata 28-32, Fructus Corni 10-12, Radix Trichosanthis 14-16, Polyporus 14-16, Rhizoma Alismatis 1-16, Fructus Lycii 18-20, Radix Et Rhizoma Rhei 8-10, Cortex Moutan 8-10, thunder Radix Pini massonianae 14-16, Rhizoma Polygoni Cuspidati 14-16.
2. the manufacture method of caricin hydrolysis Lampetra mori protein nucleic acid preparation according to claim 1 is characterized in that comprising following step preface:
(1) gets the raw materials ready: prepare the major ingredient Lampetra mori by prescription, press one group of the regulation of filling a prescription in the described adjuvant component and prepare adjuvant;
(2) major ingredient cuts open broken: Lampetra mori is cut abdomen gill, select for use by the 90-92 weight quota, blend;
(3) major ingredient hydrolysis: add caricin in the Lampetra mori after will blending, stir evenly, be hydrolyzed;
(4) major ingredient concentrates: the Lampetra mori protein solution after the hydrolysis is heated after 100 ℃, and slow fire decocted 3 hours;
(5) major ingredient filters: will be behind the hydrolysis Lampetra mori protein solution elimination residue and impurity of decoction, and it is stand-by to get liquid;
(6) the adjuvant Chinese medicinal herbs was soaked 1 hour;
(7) the adjuvant Chinese medicinal herbs is decocted with water, water is heated slow fire decocted 2 hours after 100 ℃, taking liquid decocts with water again, water is heated slow fire decocted 2 hours after 100 ℃, and taking liquid mixes the secondary medicinal liquid, the decocting and concentrating after 100 ℃ of heating, taking liquid;
(8) filter: medicinal liquid elimination impurity;
(9) mix: the major ingredient of described step preface (5) is got liquid be mixed into preparation with the adjuvant medicinal liquid that goes on foot preface (8).
3. the manufacture method of caricin hydrolysis Lampetra mori protein nucleic acid preparation according to claim 2 is characterized in that: the vigor of the caricin that adds in the described hydrolysis step preface (3) is 180-230 ten thousand u/g, and hydrolysis time is 12 hours.
4. the manufacture method of caricin hydrolysis Lampetra mori protein nucleic acid preparation according to claim 3, the weight that it is characterized in that the caricin of described adding is the 1-3% of Lampetra mori.
5. the manufacture method of caricin hydrolysis Lampetra mori protein nucleic acid preparation according to claim 2 is characterized in that: the secondary medicinal liquid is mixed in the described step preface (7), the decocting and concentrating of heating, when being adjuvant Chinese medicinal herbs weight to medicinal liquid weight till.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021586284A CN1296085C (en) | 2002-12-25 | 2002-12-25 | Preparation of papaya protease hydrolysed seven star fish protein nucleic acid and its making method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021586284A CN1296085C (en) | 2002-12-25 | 2002-12-25 | Preparation of papaya protease hydrolysed seven star fish protein nucleic acid and its making method |
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| Publication Number | Publication Date |
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| CN1509749A true CN1509749A (en) | 2004-07-07 |
| CN1296085C CN1296085C (en) | 2007-01-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112869132A (en) * | 2019-12-01 | 2021-06-01 | 康景升 | Health product for treating cardiovascular and cerebrovascular diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251764A (en) * | 1998-10-21 | 2000-05-03 | 姜秦川 | Exterior-applied ointment for treating rheumatic arthritis |
| CN1169541C (en) * | 2001-05-04 | 2004-10-06 | 刘玉福 | Medicine for treating rheumatoid arthritis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112869132A (en) * | 2019-12-01 | 2021-06-01 | 康景升 | Health product for treating cardiovascular and cerebrovascular diseases |
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| CN1296085C (en) | 2007-01-24 |
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