CN1506087A - Fat-eliminating liver-protecting medicine capsule for treating hepatosis and its prepn - Google Patents
Fat-eliminating liver-protecting medicine capsule for treating hepatosis and its prepn Download PDFInfo
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- CN1506087A CN1506087A CNA021496390A CN02149639A CN1506087A CN 1506087 A CN1506087 A CN 1506087A CN A021496390 A CNA021496390 A CN A021496390A CN 02149639 A CN02149639 A CN 02149639A CN 1506087 A CN1506087 A CN 1506087A
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- rhizoma curcumae
- radix paeoniae
- curcumae longae
- paeoniae rubra
- poria
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Abstract
The medicine capsule for treating hepatosis is prepared with turmeric in 59-74 wt%, red peony root in 15-25 wt% and tuckahoe in 13-15 wt%. The preparation process includes the steps of preparing fine tuckahoe powder, turmeric piece and red peony root piece; twice ethanol extraction of turmeric piece to obtain turmeric extractive; water extraction to obtain red peony root extractive; mixing fine tuckahoe powder, turmeric extractive and red peony root extractive; depression drying the mixture at 80 deg.c, crushing, pelletizing and capsulizing. The medicine of the present invention has excellent curative effect on fatty liver, hepatocirrhosis, liver cancer, etc.
Description
Technical field
The present invention relates to treat the medicine of hepatopathy, more particularly, relate to a kind of with the Chinese herbal medicine be feedstock production be used to prevent and treat fat hepatitis that hyperlipemia causes, can block/reverse fatty liver and promote the disappear fat liver protecting capsule medicine of hepatic fibrosis to liver cirrhosis and hepatocarcinoma development, the invention still further relates to the method for this medicine of preparation.
Background technology
Hepatic fibrosis is the pathologic basis of many chronic hepatopathys, the increasing the weight of gradually of hepatic fibrosis can make progress into liver cirrhosis and hepatocarcinoma, be " trilogy " of chronic hepatopathy progress, fatty liver is the key factor that promotes hepatic fibrosis, slow down, stop and reverse this process, can prevent and treat liver cirrhosis and hepatocarcinoma effectively.The existing Chinese and western drugs that protects the liver the therapy employing reaches over one hundred kind, through the observation that studies for a long period of time, fails to confirm its curative effect mostly, the effect that also has the promotion hepatic fibrosis that has.Fatty liver is meant because the excess fat (being mainly triglyceride) that the outer reason of liver itself (as common chronic viral hepatitis) and liver causes is gathered associated diseases lastingly in liver.Common cause has the damage of excessive drinking, malnutrition, obesity, small intestinal by-pass operation, diabetes, 17-hydroxy-11-dehydrocorticosterone, gestation, hepatitis and medicine or poisonous substance.Normal intrahepatic fat content only accounts for 3%～5% of liver weight in wet base, when athero, the fat mass of liver can up to liver heavy 40%～50%.Fatty liver is a commonly encountered diseases, and the foreign scholar reports that when making the liver biopsy specimen its sickness rate accounts for 26.5%, and is in rising trend in recent years.
Since proposing fatty liver from pathological angle the fifties, the research of fatty liver many new viewpoints have been produced.Before the sixties, the cause of disease of fatty liver mainly is to be the malnutrition of representative with the kwashiorkor.After the eighties, overnutrition type obesity, excessive drinking, diabetes and medicine hepatic injury become the important cause of disease of fatty liver, but still have 20% fatty liver etiology unknown.Discovered in recent years, fatty liver become one of many gastrointestinal disease and chronic hepatopathy and sexually revise excessively.Most of fatty liver prognosis bonas, but still have part particularly may continue to develop into hepatic fibrosis and liver cirrhosis with the fatty liver of inflammation, it is agnogenio.
The morbidity of fatty liver and age, sex, blood fat, blood glucose, blood pressure and obesity etc. are closely related.Be addicted to drink, high fat and protein diet, snack, hypersomnia etc. all are hazard factors of fatty liver just before going to bed.Can predict, along with the transformation of people life style, the increase of aging population, the prevalence of fatty liver and relevant disease thereof will be growing on and on.For the clinical diagnosis of fatty liver, iconography (particularly ultrasonic) may be one of effective means.External recently report is compared with histology, and ultrasonographic positive predictive value is 67%, and is obvious more if fat becomes, and its positive value is taller.Mathiesen etc. have reported among the asymptomatic patient that Northern Europe 150 routine unknown cause transaminases slightly increase to moderate, have wherein confirmed to have 60 examples (40%) patient to be fatty liver through the liver biopsy.Although the liver biopsy is " goldstandard " of diagnosis, simple fatty liver can be done the liver biopsy as being secondary to the overweight people.Still lack at present the high fatty liver biochemical indicator of specificity, sensitivity and accuracy.
Ludwig in 1980 propose non-ethanol fat hepatitis (nonalcoholic steatosishepatitis, NASH).Because up to 40% NASH etiology unknown, and the course of disease often is invisible, in case find its inflammation of accompanying, necrosis and fibrosis existence in various degree.Factors such as the pathogenesis of known ALD is sent out with heredity, environment, hormone, abnormalities of sugar/lipid metabolism, oxidative stress, immunity and answered, the change of liver sieve are relevant.The pathological change that NASH is similar to having of ALD, both have two common pathogenesis at least.The one, oxidative stress/lipid peroxidation, but both are the expression of inducing hepatocyte cytochrome p 450 II E1 (CYP II E1) all, thereby produce the damaging reaction that free radical causes lipid peroxidation, CYP IIE1 induces the consumption that still can increase hepatic tissue oxygen, and the end-product malonaldehyde of lipid peroxidation can form adduct with protein, thereby activates the immunoreation of body and participate in hepatic injury; The 2nd, the infringement of the cytokine of endotaxin mediate, the permeability of gastrointestinal mucosa raises during ALD, and the material that makes endotoxin liopopolysaccharides in the blood increases and damages the function of reticuloendothelial system.Liopopolysaccharides can mediate by the cytokine especially release of TNF α hepatocellular toxic action, and the level of TNF α becomes positive correlation with alcoholic liver damage in the blood.Endotoxemia also has higher incidence in NASH patient.The rising of TNF α may play an important role in the pathogenesis of NASH.
Fatty liver can directly also can develop into hepatic fibrosis by inflammation, and the part hepatic fibrosis also can appear at fat and become after the disappearance.Fatty liver hepatic fibrosis and other chronic hepatopathy fibrosiss have common pathogenesis, and HSC plays main effect.Ethanol, acetaldehyde, lipid, fatty acid all can directly activate HSC, also can mediate the activationa and proliferation of HSC by stimulating the Kupfer cell.
Prevention and Management of Fatty Liver the most important thing is to find out and remove the cause of disease.By alleviating alcohol addiction, progressively lose weight (body weight is die-offed then might promote hepatocellular necrosis), treatment diabetes, lipid metabolic disorder and avoid etiological treatment such as liver toxicity medicine, most of Patients with Fatty Liver can reverse.Drug therapy mainly is to improve the oxidation resistance such as the antioxidant of body, the beta oxidation that suppresses fatty acid, inhibition CYPIIE1 activation, antibacterial agent such as TNF-α and soluble recepter, protection hepatocyte ATP storage and use antiendotoxin agent etc.
Summary of the invention
The technical problem to be solved in the present invention provides and a kind ofly prevent and treat fat hepatitis that hyperlipemia causes, can block/reverse fatty liver promotes the disappear fat liver protecting capsule medicine of hepatic fibrosis to liver cirrhosis and hepatocarcinoma development, and the present invention also provides a kind of method for preparing this medicine.
Above-mentioned technical problem solves like this, and a kind of fat liver protecting capsule medicine that disappears that is used for the treatment of hepatopathy is provided, and the medicine in the capsule is made by following component: Rhizoma Curcumae Longae 59-74%, Radix Paeoniae Rubra 15-25%, Poria 12-16%.
The formula optimization ratio range for preparing the fat liver protecting capsule medicine that disappears is: Rhizoma Curcumae Longae 60-63%, Radix Paeoniae Rubra 20-25%, Poria 13-15%.
The best proportioning for preparing the fat liver protecting capsule medicine that disappears is: Rhizoma Curcumae Longae 62.5%, Radix Paeoniae Rubra 24%, Poria 13.5%.
Another problem of the present invention solves like this, and the method that provides a kind of preparation to be used for the treatment of the fat liver protecting capsule medicine that disappears of hepatopathy is got Rhizoma Curcumae Longae 750g, Radix Paeoniae Rubra 300g, Poria 150g for preparing raw material, and preparation process is as follows:
1) preparation Rhizoma Curcumae Longae and Radix Paeoniae Rubra extract
Adopt one of following process to extract Rhizoma Curcumae Longae:
Percolation technology or reflux technique
Adopt one of following process to extract Radix Paeoniae Rubra
Extraction process by water or reflux technique
2) Poria is made powdery, granularity is 40 orders
3) Radix Paeoniae Rubra extract of one of one of getting in two kinds of extraction processes of Rhizoma Curcumae Longae in two kinds of extraction processes of Rhizoma Curcumae Longae extract and Radix Paeoniae Rubra of technology technology respectively mixes, and concentrates, and adds Poria powder, stirs evenly oven dry; Dried cream powder is broken, cross 40 mesh sieves, mix homogeneously, oven dry, 20 mesh sieves are granulated, oven dry, 20 order granulate get product.
In above-mentioned preparation method, it is 20 purpose Turmeric Roots that the percolation technology of described extraction Rhizoma Curcumae Longae comprises the steps: to get granularity, pack in the percolator, add ethanol percolation (can add an amount of acetic acid in the ethanol and transfer PH=3-4), begin to add the infiltration of 2 times of amount ethanol and spend the night, add the ethanol of 8 times of amounts again, speed percolation with 3-4ml/kg, collect percolate, reclaim ethanol, obtain Rhizoma Curcumae Longae extract.
In above-mentioned preparation method, the reflux technique of described extraction Rhizoma Curcumae Longae comprises the steps: to get the Rhizoma Curcumae Longae decoction pieces, add ethanol (can add an amount of acetic acid in the ethanol and transfer PH=3-4), reflux, extract, 2 times, 8 times of amounts for the first time, extracted 2 hours, 6 times of amounts were extracted 1 hour for the second time, and merge extractive liquid, filters, filtrate recycling ethanol gets Rhizoma Curcumae Longae extract.
In above-mentioned preparation method, described Radix Paeoniae Rubra extraction process by water comprises the steps: Radix Paeoniae Rubra is made decoction pieces, extracting in water twice, and 8 times of water gagings extracted 2 hours for the first time, and 6 times of water extracted 1 hour for the second time, and merge extractive liquid, filters, and concentrates, and gets Radix Paeoniae Rubra extract.
In above-mentioned preparation method, described Radix Paeoniae Rubra extracts reflux technique and comprises the steps: Radix Paeoniae Rubra is made decoction pieces, adds alcohol reflux 2 times, for the first time 8 times of amounts, extracted 2 hours, 6 times of amounts were extracted 1 hour for the second time, merge extractive liquid, filters, and reclaims ethanol, gets Radix Paeoniae Rubra extract.
The present invention also provides another kind of preparation to be used for the treatment of the method for the fat liver protecting capsule medicine that disappears of hepatopathy, it is characterized in that, gets Rhizoma Curcumae Longae 750g, Radix Paeoniae Rubra 300g, Poria 150g is as follows for preparation feedstock production step:
1) preparation Rhizoma Curcumae Longae decoction pieces, Radix Paeoniae Rubra decoction pieces
2) Poria is made powdery, granularity is 40 orders
3) Rhizoma Curcumae Longae decoction pieces, Radix Paeoniae Rubra decoction pieces are added alcohol reflux 2 times, 8 times of amounts were extracted 2 hours for the first time, and 6 times of amounts were extracted 1 hour for the second time, and merge extractive liquid, filters, and filtrate recycling ethanol concentrates, extract, the adding Poria powder stirs evenly, and dries; Dried cream powder is broken, cross 40 mesh sieves, mix homogeneously, oven dry, 20 mesh sieves are granulated, oven dry, 20 order granulate make the pharmaceutical capsules finished product.
Above-mentioned according to the fat liver protecting capsule process for preparing medicine that disappears provided by the invention in, described preparation Poria fine powder comprises the steps: 1) with Poria intensive drying under 80 ℃ of temperature; 2) sieve removing dross; 3) pulverization process is also crossed 40 mesh sieves, obtains the Poria fine powder.
Above-mentioned according to the fat liver protecting capsule preparation method that disappears provided by the invention in, described preparation curcuma powder is that curcuma powder is broken into coarse powder, crosses 20 mesh sieves.
Above-mentioned according to the fat liver protecting capsule preparation method that disappears provided by the invention in, preparation Radix Paeoniae Rubra water extract may further comprise the steps: preparation Radix Paeoniae Rubra thin slice; The decocting that 1 part of Radix Paeoniae Rubra thin slice is added 8 deals for the first time boiled 1 hour; Adding for the second time 6 times of water gagings decocted 1 hour; Merge decoction liquor, filter, it is 1.10 o'clock that filtrate is concentrated into relative density, carries out centrifugally operated; Collect centrifugal liquid, it is continued to be concentrated into relative density is 1.25, promptly gets the Radix Paeoniae Rubra water extract.
Above-mentioned according to the fat liver protecting capsule preparation method that disappears provided by the invention in, described the curcuma powder percolator of packing into is carried out ethanol moistening and percolation, collect the percolate that wherein obtains, may further comprise the steps:, add ethanol percolation (can add an amount of acetic acid in the ethanol and transfer PH=3-4) the curcuma powder percolator of packing into; Begin to add 2 times of amount ethanol and soaked into 12 hours, add 75% ethanol of 8 times of amounts again, with the speed percolation of 3-4ml/kg, collect percolate, reclaim ethanol, collection obtains percolate and separates the Rhizoma Curcumae Longae medicinal residues.
The above-mentioned fat liver protecting capsule that disappears has been finished prescription screening, preparation technology's (extraction process, dosage form technology, technological process), quality standard, stability experiment and acute and chronic toxicological experiment.Main pharmacodynamics and Preliminary Clinical Observation have been finished.Experiment and clinical effectiveness show: of the present inventionly thisly disappear that fat liver protecting capsule medicine source is wide, cost is low, technology is advanced, steady quality is reliable, safety non-toxic, determined curative effect, mainly be applicable to abnormal liver function, chronic hepatitis hepatic fibrosis, liver cirrhosis and liver cancer patient that the fatty liver with hyperlipemia causes, can block and part reverses hepatitis → hepatic fibrosis → liver cirrhosis or/and the course of disease progress of hepatocarcinoma.
The specific embodiment
Embodiment 1
The medicine for preparing in the fat liver protecting capsule medicine that disappears is made by following component: Rhizoma Curcumae Longae 59-74%, Radix Paeoniae Rubra 15-25%, Poria 12-16%.
Embodiment 2
The formula optimization ratio range for preparing the fat liver protecting capsule medicine that disappears is: Rhizoma Curcumae Longae 60-63%, Radix Paeoniae Rubra 20-25%, Poria 13-15%.
Embodiment 3
The formula optimization proportioning Rhizoma Curcumae Longae 62.5%, Radix Paeoniae Rubra 25% and the Poria 12.5% that prepare the fat liver protecting capsule medicine that disappears.
Embodiment 4
The formula optimization proportioning for preparing the fat liver protecting capsule medicine that disappears comprises Rhizoma Curcumae Longae 65%, Radix Paeoniae Rubra 22% and Poria 13%.
Embodiment 5
The effective ingredient for preparing the formulation ratio of the fat liver protecting capsule medicine that disappears can be 68.2% Rhizoma Curcumae Longae, 18.2% Radix Paeoniae Rubra and 13.6% Poria on weight.
Embodiment 6
The disappear effective ingredient of formula optimization proportioning of fat liver protecting capsule medicine of preparation can be 71.4% Rhizoma Curcumae Longae, 14.3% Radix Paeoniae Rubra and 14.3% Poria on weight.
The method for preparing the various embodiments described above pharmaceutical capsules is as follows:
Get Rhizoma Curcumae Longae 750g, Radix Paeoniae Rubra 300g, Poria 150g for preparing raw material, preparation process is as follows:
Poria in 80 ℃ of intensive dryings, is pulverized behind the sieve removing dross, crossed 40 mesh sieves, get Poria fine powder (standby); Get the Rhizoma Curcumae Longae decoction pieces, add ethanol (can add an amount of acetic acid in the ethanol and transfer PH=3-4), reflux, extract, 2 times, 8 times of amounts were extracted 2 hours for the first time, 6 times of amounts for the second time, extracted 1 hour, merge extractive liquid, filters, filtrate recycling ethanol, reconcentration to relative density is 1.35 (80 ℃ of surveys), gets Rhizoma Curcumae Longae extract.Radix Paeoniae Rubra is thinly sliced, and add 8 times of water gagings and decoct 2 times, each 1.0 hours, merge decoction liquor, filter, filtrate is concentrated into relative density and is at 1.10 o'clock, and is centrifugal, collects centrifugal liquid, and continuing to be concentrated into relative density is 1.25, gets the Radix Paeoniae Rubra water extract; With the extract of Rhizoma Curcumae Longae and Radix Paeoniae Rubra be ground into the standby Indian Bread of fine powder and mix thoroughly together, 80 ℃ of drying under reduced pressure are pulverized, and granulate, and granulate (20 mesh sieve) incapsulates, and promptly gets the fat liver protecting capsule that disappears.
Claims (10)
1, a kind of fat liver protecting capsule medicine that disappears for the treatment of hepatopathy is characterized in that the medicine in the capsule is made by following component: Rhizoma Curcumae Longae 59-74%, Radix Paeoniae Rubra 15-25%, Poria 12-16%.
2, according to the described fat liver protecting capsule medicine that disappears of claim 1, it is characterized in that wherein the optimum ratio scope of each composition of raw materials is: Rhizoma Curcumae Longae 60-63%, Radix Paeoniae Rubra 20-25%, Poria 13-15%.
3, according to the described fat liver protecting capsule medicine that disappears of claim 1, it is characterized in that the best proportioning of each raw material is: Rhizoma Curcumae Longae 62.5%, Radix Paeoniae Rubra 25%, Poria 12.5%.
4, a kind of preparation is as being used for the treatment of the method for the fat liver protecting capsule medicine that disappears of hepatopathy as described in claim 1 or 2 or 3, gets Rhizoma Curcumae Longae 750g, Radix Paeoniae Rubra 300g, Poria 150g is the preparation raw material, it is characterized in that preparation process is as follows:
1) preparation Rhizoma Curcumae Longae and Radix Paeoniae Rubra extract
Adopt one of following process to extract Rhizoma Curcumae Longae:
Percolation technology or reflux technique
Adopt one of following process to extract Radix Paeoniae Rubra
Extraction process by water or reflux technique
2) Poria is made powdery, granularity is 40 orders;
3) Radix Paeoniae Rubra extract of one of one of getting in two kinds of extraction processes of Rhizoma Curcumae Longae in two kinds of extraction processes of Rhizoma Curcumae Longae extract and Radix Paeoniae Rubra of technology technology respectively mixes, and concentrates, and adds Poria powder, stirs evenly oven dry; Dried cream powder is broken, cross 40 mesh sieves, mix homogeneously, oven dry, 20 mesh sieves are granulated, oven dry, 20 order granulate get product.
5, according to the described preparation method of claim 4, it is characterized in that, the percolation technology of described extraction Rhizoma Curcumae Longae comprises the steps: that it is 20 purpose Turmeric Roots that Rhizoma Curcumae Longae is made granularity, and the percolator of packing into adds ethanol percolation (can add an amount of acetic acid in the ethanol and transfer PH=3-4); Begin to add 2 times of amount ethanol and soaked into 12 hours, add 75% ethanol of 8 times of amounts again, with the speed percolation of 3-4ml/kg, collect percolate, reclaim ethanol, collection obtains percolate and separates the Rhizoma Curcumae Longae medicinal residues, obtains Rhizoma Curcumae Longae extract.
6, according to the described preparation method of claim 4, it is characterized in that the reflux technique of described extraction Rhizoma Curcumae Longae comprises the steps: Rhizoma Curcumae Longae is made decoction pieces, add ethanol (can add an amount of acetic acid in the ethanol and transfer PH=3-4), reflux, extract, 2 times, 8 times of amounts were extracted 2 hours for the first time, for the second time 6 times of amounts, extracted 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol gets Rhizoma Curcumae Longae extract.
According to the described preparation method of claim 4, it is characterized in that 7, described Radix Paeoniae Rubra extraction process by water comprises the steps: Radix Paeoniae Rubra is made decoction pieces, twice of extracting in water, 8 times of water gagings extracted 2 hours for the first time, and 6 times of water extracted 1 hour for the second time, merge extractive liquid, filters, and concentrates, and gets Radix Paeoniae Rubra extract.
8, according to the described preparation method of claim 4, it is characterized in that, described Radix Paeoniae Rubra extracts reflux technique and comprises the steps: Radix Paeoniae Rubra is made decoction pieces, adds alcohol reflux 2 times, for the first time 8 times of amounts, extracted 2 hours, 6 times of amounts were extracted 1 hour for the second time, and merge extractive liquid, filters, reclaim ethanol, get Radix Paeoniae Rubra extract.
9, a kind of method that is used for the fat liver protecting capsule medicine that disappears of treatment hepatopathy as claim 1 or 2 or 3 for preparing is characterized in that, gets Rhizoma Curcumae Longae 750g, Radix Paeoniae Rubra 300g, Poria 150g for preparing raw material, and preparation process is as follows:
1) preparation Rhizoma Curcumae Longae decoction pieces
2) Poria is made powdery, granularity is 40 orders
3) Rhizoma Curcumae Longae decoction pieces, Radix Paeoniae Rubra decoction pieces are added alcohol reflux 2 times, 8 times of amounts were extracted 2 hours for the first time, and 6 times of amounts were extracted 1 hour for the second time, and merge extractive liquid, filters, and filtrate recycling ethanol concentrates, extract, the adding Poria powder stirs evenly, and dries; Dried cream powder is broken, cross 40 mesh sieves, mix homogeneously, oven dry, 20 mesh sieves are granulated, oven dry, 20 order granulate make the pharmaceutical capsules finished product.
10, according to claim 4 or 9 described preparation methoies, it is characterized in that, comprise the steps: in the step of described preparation Poria powder
1) with Poria intensive drying under 80 ℃ of temperature;
2) sieve removing dross;
3) pulverization process is also crossed 40 mesh sieves, obtains the Poria fine powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021496390A CN1309411C (en) | 2002-12-11 | 2002-12-11 | Fat-eliminating liver-protecting medicine capsule for treating hepatosis and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021496390A CN1309411C (en) | 2002-12-11 | 2002-12-11 | Fat-eliminating liver-protecting medicine capsule for treating hepatosis and its prepn |
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| CN1506087A true CN1506087A (en) | 2004-06-23 |
| CN1309411C CN1309411C (en) | 2007-04-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361683C (en) * | 2005-12-26 | 2008-01-16 | 河南省医学科学研究所 | Chinese medicinal preparation for treating fatly liver and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100496592C (en) * | 2005-08-19 | 2009-06-10 | 上海中医药大学 | Compound preparation of Chinese traditional medicine for treating fatty liver, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1086141C (en) * | 1999-11-03 | 2002-06-12 | 郝忠礼 | Medicine for treating early-stage hepatocirrhosis and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361683C (en) * | 2005-12-26 | 2008-01-16 | 河南省医学科学研究所 | Chinese medicinal preparation for treating fatly liver and its preparation method |
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