Background technology
Recent decades in past, based on the purpose of testing pregnant and various Pharmaceutical Analysiss, the existing trend that increases gradually of the analysis of various biological corpse or other object for laboratory examination and chemical testing (biological specimen).Existing considerable time and money devote the exploitation of various analytic systems and technology, more make us trusting and testing result accurately in the hope of obtaining.
Moreover along with constantly spreading unchecked of drug abuse (drugs of abuse), the check of these a little medicines and metabolin thereof and evaluation have become extremely important, have many drug abuse detection methods to be developed.
Chromatograph chromatographic analysis method (Thin Layer Chromatography) is (TLC) in order to detecting the pharmaceutical compositions in the urine, and it needs carefully to prepare a corpse or other object for laboratory examination and chemical testing to be measured carefully and have skill ground that a corpse or other object for laboratory examination and chemical testing to be measured is imposed on to rest on of the same colour in the development chamber (developing chamber) and analyse on the sheet layer by layer.In case chromatograph chromatography sheet takes out from development chamber and drying after, promptly be sprayed on above it with developer.The color development area that manifests on this chromatograph chromatography sheet again with known standard items relatively, to learn the composition thing in the corpse or other object for laboratory examination and chemical testing.This kind analytical approach is a kind ofly to detect various pharmaceutical compositions in the unknown corpse or other object for laboratory examination and chemical testing sample with method for qualitative analysis, and process is tediously long consuming time, needs the experienced technician's interpretive analysis result who is skilled in technique.
Enzyme multiplicity immunochemical test method (Enzyme Multiplied Immuno-chemicalTest) is the sxemiquantitative immune analysis method of drug abuse composition in a kind of detection of biological liquid (biological fluid) (EMIT).This kind laboratory inspection method needs well-trained technician to carry out, and devices needed is also quite expensive.
Radiation immunity analytical approach (Radio-Immuno-Assay) is a kind of lab analysis method in order to the quantitative sensitivity that detects drug abuse (RIA).Various immuno-chemical substances is labeled the material of tool radioactivity, so the utmost point needs carefully to abandon after careful these a little immuno-chemical substances of use and the use.Moreover, because the existence of radiomaterial also needs to obtain a license from government, to be allowed to use this lab analysis method.Gas phase liquid chromatography(LC) analytical approach (Gas LiquidChromatography) (GLC) can provide the Pharmaceutical Analysis result of high accuracy.Yet this kind analytical approach need use expensive instrument and equipment, and its analytic process is also very complicated, and needs to carry out through the technician of highly training.
Above-mentioned known analytical approach all needs adept technician and exquisite complicated instrument and equipment, therefore often makes these a little analytical approachs become quite expensive.
The method of drug abuse composition is to use drug abuse test test paper in the another kind of detection of biological liquid.This kind test paper prepares with a kind of separate procedure, so that it is insensitive but responsive and produce chromogenic reaction for specific composition in the tracer liquid for pH-value.This kind collected on one's body the biological liquid that obtains from a measurand and detected drug abuse that whether specific composition exists and test chromogenic reaction result with test paper and only declare mode via order and draw a conclusion.Though this kind detection method is quick and convenient, judging whether measurand is used on the medicine difficult convincing.
In view of the above, demand providing a kind of method and device of analyzing and identifying specific composition in the fluid sample urgently, it can overcome the disappearance of above-mentioned various existing methods.
Summary of the invention
Fundamental purpose of the present invention provides a kind of user's interface of image capture unit, by the multiple function key that user's interface provides, the user can carry out the choosing of image data frame, scanning, analysis, image data and functions such as analysis result demonstration and printout thereof easily.
Another object of the present invention provides an a kind of software and hardware adaptation arrangement of the image capture unit person of being used in combination interface, can be used for capturing image data through the test piece with a colour developing pattern of detecting liquid sample, the various function keys that provide by user's interface, can directly show and printout test piece colour developing pattern image analysis result, be verified fluid sample with judgement and whether contain the specific composition that desire detects.
Another purpose of the present invention provides an a kind of software and hardware adaptation arrangement of the image capture unit person of being used in combination interface, the image capture analytic function that it can be provided by this software and hardware adaptation arrangement, with screening through checking the various drug abuse inspection test piece chromogenic reaction results of tested object organisms corpse or other object for laboratory examination and chemical testing liquid, to improve the accuracy of drug abuse test piece detection method.
A further object of the present invention provides a kind of test piece colour developing pattern image analysis method, it can be according to the develop the color image data of pattern of test piece, analyze the chromogenic reaction value of a target vitta in the test piece colour developing pattern, to judge that this target vitta corresponding one tested corpse or other object for laboratory examination and chemical testing is positive or negative reaction, whether contain the specific composition that a desire detects to judge this tested corpse or other object for laboratory examination and chemical testing.
According to above-described purpose, the invention provides a kind of user's interface and image data analytical approach thereof of image capture unit.User's interface of the present invention comprises an image the preview window, an image analysing computer data display frame and a function key display box.Image the preview window is in order to show at least one previewing scan image and to select at least one previewing scan image for user's frame, to carry out normality scanning.The image analysing computer data display frame is in order to show the normality scan-image analysis result of at least one previewing scan image that is selected by frame.The function key display box comprises at least one function key, clicks for the user, to carry out desired function.When being applied to the drug abuse inspection technology, acquisition is used through user's interface of the present invention of checking tested object organisms corpse or other object for laboratory examination and chemical testing liquid one scan instrument of can arranging in pairs or groups, the user can directly click various function keys on this user's interface, with the switching of carrying out the choosing of image preview, frame, normality scanning is carried out and various normality scan-image data and analysis result thereof show, and can be with various image datas and analysis result thereof with different display mode printouts.The image capture unit of user's interface of the present invention of arranging in pairs or groups can be used for capturing the image data through the test piece with a colour developing pattern of detecting liquid sample, the various function keys that provide by user's interface, can analyze test piece colour developing pattern image data and directly demonstration and printout test piece colour developing pattern image analysis result, be verified fluid sample with judgement and whether contain the specific composition that desire detects.So the image capture unit of collocation user's interface of the present invention can be in the drug abuse inspection technology, whether the image data of the drug abuse inspection test piece of acquisition through checking tested object organisms corpse or other object for laboratory examination and chemical testing liquid is to contain any illegal drug in the biological corpse or other object for laboratory examination and chemical testing liquid that detects this tested object.
Description of drawings
Fig. 1 is the schematic top view of one scan object locating device of the present invention;
Fig. 2 shows the image data of one scan object of the present invention;
Fig. 3 A shows user's interface synoptic diagram of one preferred embodiment according to the present invention;
Fig. 3 B is the preview image synoptic diagram of image the preview window of Fig. 3 A user interface;
Fig. 4 is the image data analysis result of the printout of printing key as a result of Fig. 3 A user interface;
Fig. 5 is the image data and the analysis result thereof of the reporting printing key printout of Fig. 3 A user interface;
Fig. 6 is the colour developing pattern synoptic diagram of a strip test piece of the present invention;
Fig. 7 is the graph of a relation of the relative image position of image intensity in the colour developing pattern image data of strip test piece of Fig. 6.
Symbol description among the figure
30 image the preview windows
31 sweep object locating devices
32 sweep objects
33 image analysing computer data display frames
34 dendrograms
35 tables of data
36 function key display boxes
The outer framework of 310 rectangles
312 rectangular scanning object placement spaces
314 sweep object image datas
315 bar code pattern
316,317,318,319 strip test pieces
320,321,322,323 color lumps
51 image datas
52 dendrograms
53 tables of data
60 test pieces colour developing pattern image data
Embodiment
Describe the specific embodiment of the present invention in detail below in conjunction with drawings and Examples.
The invention provides a kind of user's interface and image data analytical approach thereof of image capture unit.User's interface of the present invention comprises an image the preview window, an image analysing computer data display frame and a function key display box.Image the preview window is in order to show at least one previewing scan image and to select at least one previewing scan image for user's frame, to carry out normality scanning.The image analysing computer data display frame is in order to show the normality scan-image analysis result of at least one previewing scan image that is selected by frame.The function key display box comprises a preview button, one scan button, an autoscan button, a printing key, a reporting printing key and the automatic printing key of a report as a result.The preview button provides image previewing scan function, the scanning button provides the normality scan function of at least one preview image that execution selected by frame, the autoscan button provides the normality scan function of whole page or leaf preview image, printing key provides at least one preview image normality scan-image analysis of being selected by frame printing function as a result as a result, the reporting printing key provides at least one preview image normality scan-image data selected by frame and analysis thereof printing function as a result, and the automatic printing key of report provide whole page or leaf preview image normality scan-image data and etc. analysis printing function as a result.
At first with reference to Fig. 3 A, it is a preferred embodiment of user's interface of the present invention.One image the preview window 30 is shown in the zone, the right of this user's interface.Ginseng Fig. 3 B, this image preview window 30 demonstrates 12 sweep objects and carries the preview image of the one scan object locating device 31 of these 12 sweep objects.With reference to Fig. 1, it demonstrates a schematic top view of this sweep object locating device 31, this sweep object locating device 31 comprises the outer framework 310 of a dark bottom surface rectangle, for example blue bottom surface, and 12 rectangular scanning object placement spaces 312 are located in the outer framework 310 of this dark bottom surface rectangle.With reference to shown in Figure 2, its demonstration be positioned over a rectangular scanning object placement space 312 one scan object 314 through the picked image data.This sweep object 314 comprises the strip test piece 316,317,318 and 319 and four kind of color lump 320,312,322 and 323 that a bar code pattern 315, four have a colour developing pattern respectively.Bar code pattern 315 is positioned at a precalculated position on the sweep object 314, strip test piece 316,317,318 and 319 vertically is arranged on the sweep object 314 in regular turn, reach color lump 320,312,322 and 323 and vertically arrange and be positioned at the same side of corresponding strip test piece 316,317,318 respectively and 319 in regular turn, distinguish the classification of strip test piece 316,317,318 and 319 in order to the district.The colour developing pattern that each strip test piece 316,317,318 and 319 is had is made up of a control vitta (C) and at least one target vitta (T).Each strip test piece 316,317,318 and 319 colour developing pattern form through checking a fluid sample for example to collect the chromogenic reaction that the urine corpse or other object for laboratory examination and chemical testing from a tested object produced, wherein control corresponding this fluid sample of vitta (C) and produce chromogenic reaction, a specific composition produces chromogenic reaction in corresponding this fluid sample of target vitta (T).Strip test piece 316,317,318 and 319 corresponding different color lumps 320,321,322 and 323 represent each strip test piece 316,317,318 and 319 respectively in order to detect specific compositions different in this fluid sample.Employed strip test piece can be various drug abuse inspection test pieces in this preferred embodiment, and each strip test piece can be designed to different brackets, can equal the zones of different generation chromogenic reaction of strip test piece to a kind of specific composition, two kinds of specific compositions, three kinds of specific compositions, four kinds of specific compositions, five kinds of specific compositions or six kinds of specific compositions etc. in the fluid sample.Multiple with reference to Fig. 3 B, each rectangular scanning object placement space 312 can be placed the sweep object of different sizes in this sweep object locating device 31, and wherein sweep object can comprise the test piece of a slice strip, two strip test pieces, three strip test pieces, four strip test pieces, five strip test pieces and the six strip test pieces with colour developing pattern.The user can be directly on image the preview window 30 the direct frame choosing sweep object 32 of desiring to carry out normality scanning, also can desire to carry out a plurality of sweep objects that normality scans with the time-frame choosing on image the preview window 30, the frame of these a little sweep objects selects order to be stored simultaneously.
One image analysing computer data display frame 33 is shown in the top left zone of this user's interface, the normality scan-image analysis result that it shows at least one sweep object that is selected by frame comprises on the image intensity relative scanning object tables of data 35 of target vitta (T) image position in each strip test piece relatively of tree-shaped Figure 34 of target vitta image position and an image intensity in each strip test piece.In this tables of data 35, has the corresponding bar code number field of sweep object (ID); usually can demonstrate sweep object corresponding and represent sign indicating number; for user identification, and the name field (Name) of the tested object checked of the strip test piece on the sweep object, be available for users to key in voluntarily.In the tables of data 35 on the shown sweep object target vitta image position of each strip test piece according to strip test piece ordering give one the numbering (Item number), make things convenient for the user district to distinguish.Show in each strip test piece target vitta (T) and control vitta (C) in the tables of data 35 simultaneously for the feminine gender (-) of tested fluid sample or the field of positive reaction (+) (target vitta/control vitta) (+/-).For example second strip test piece (numbering 2) on the sweep object, target vitta (T) and control vitta (C) are all positive reaction (+) for tested fluid sample in its strip test piece.The position that is enough to be absorbed and pass through all target vittas of strip test piece when the content of the tested fluid sample of control vitta (C) positive reaction (+) representative by the strip test piece.Therefore, only under the situation of control vitta (C) positive reaction (+), could correctly detect all specific compositions in the tested liquid according to the target vitta chromogenic reaction in the strip test piece.Under control vitta (C) positive reaction (+) situation, in the tested fluid sample of target vitta (T) positive reaction (+) representative, contain the specific composition that this strip test piece institute desire detects.The intensity level of corresponding numbering 2 (intensity) promptly demonstrates the resulting target vitta of image data (T) the image intensity value 117 of image position 2 by analysis in the tables of data 35.In addition, image analysing computer data display frame 33 top area show a plurality of options buttons (object 5, object 6, object 7, object 8, object 9, object 10, object 11, object 12), the corresponding image the preview window 30 of these a little options button orderings is selected order by the frame of the preview image that frame selects.The user can directly click a wherein options button, switches the image data analysis result of the sweep object of image analysing computer data display frame 33 demonstrations through normality scanning.
One function key display box 36 is shown in image analysing computer data display frame 33 belows of user's interface, and it comprises a preview button (Preview), one scan button (Scan), an autoscan button (Auto), a printing key (Print Result), a reporting printing key (Print Report) and a report automatic printing key (Auto Print) as a result.The preview button (Preview) provide the image preview function, scanning button (Scan) provides the normality scan function of at least one preview image that execution selected by frame, autoscan button (Auto) provides the normality scan function of whole page or leaf preview image, and printing key (Print Result) provides at least one preview image normality scan-image analysis of being selected by frame printing function as a result as a result.With reference to figure 4, three preview image normality scan-image analysis results that selected by frame of printing key (Print Result) institute printout as a result, it comprises the image intensity value (Intensity) of the target vitta in each strip test piece on the representative sign indicating number (ID) of sweep object and the corresponding sweep object (with the ItemNumber representative), and wherein the target vitta in each strip test piece can numeral 1,2,3... representative or the specific composition that directly detects with target vitta institute desire be called for short (morphine, cocaine, codeine etc.) representative.Reporting printing key (Print Report) provides at least one preview image normality scan-image data selected by frame and analysis thereof printing function as a result.With reference to figure 5, it is the preview image normality scanning result that is selected by frame of reporting printing key (Print Report) institute printout, comprises the tables of data 53 of the tree-shaped Figure 52 and the relative image position of a corresponding image intensity thereof of image data 51 and the relative image position of a corresponding image intensity thereof.Report normality scan-image data that automatic printing key (Auto Print) provides whole page or leaf preview image and etc. analysis printing function as a result.
An arrange in pairs or groups image capture unit of user's interface of the present invention, the scanner of for example arranging in pairs or groups, can be used for capturing image data through the test piece with a colour developing pattern of detecting liquid sample, the various function keys that provide by user's interface, can analyze test piece colour developing pattern image data and directly demonstration and printout test piece colour developing pattern image analysis result, be verified fluid sample in order to judgement and whether contain the specific composition that desire detects.So the image capture unit of collocation user's interface of the present invention can be applicable to the drug abuse inspection technology, whether one drug abuse inspection test piece image data of the biological corpse or other object for laboratory examination and chemical testing liquid of acquisition through checking a tested object is to contain any illegal drug in the biological corpse or other object for laboratory examination and chemical testing liquid that detects this tested object.
The present invention provides the method for a kind of automatic search test piece colour developing pattern image position on the other hand, it comprises provides one scan object locating device 31, wherein at least one sweep object is to be contained in the one rectangular scanning object placement space 312, and this sweep object comprises at least one strip test piece with a colour developing pattern.This sweep object locating device 31 is installed in the right position place of an image capture unit, for example on the scanning platform, the image data of image capture unit scanning this sweep object locating device 31 of acquisition and at least one sweep object placed within thus.With reference to shown in Figure 2, the image data of this sweep object comprises the colour developing pattern image data of at least one strip test piece.Because sweep object locating device 31 has the outer framework of a dark bottom surface rectangle, it is lower by picked image GTG intensity (gray level), promptly has less pixel value, and the strip test piece on the sweep object is light bottom surface, for example for having the strip test piece of white bottom surface, it is higher by picked image GTG intensity, promptly has big pixel value, so rectangular scanning object placement space 312 the big phenomenon of pixel value drop can obviously occur with the border that is positioned over sweep object wherein.The present invention utilizes the big phenomenon of this adjacent pixel values drop to judge the colour developing pattern image position of this strip test piece.At first, from image capture unit institute picked image data X-direction reference position, the X-direction image position that search adjacent pixel values difference surpasses a predetermined value is made as this rectangular scanning object placement space 312 X-direction border of sweep object therewith.From image capture unit institute picked image data Y direction reference position, the Y direction image position that search adjacent pixel values difference surpasses a predetermined value is made as this rectangular scanning object placement space 312 Y direction border of sweep object therewith.According to rectangular scanning object the placement space 312 corresponding X-axis of X-axis and Y direction border and the Y direction image position of sweep object therewith, and the X-axis of at least one strip test piece in this sweep object and Y direction length, with the image position of the colour developing pattern that determines this strip test piece.As above-mentioned, the colour developing pattern of this strip test piece is formed by a control vitta (C) and at least one target vitta (T), therefore, can hunt out the image position of controlling vitta (C) and target vitta (T) in the strip test piece automatically according to above-mentioned determining step.
The present invention provides a kind of test piece colour developing pattern image analytical approach on the other hand, with reference to shown in Figure 6, provides test piece colour developing pattern image data 60, and it comprises control vitta (C) image data and at least one target vitta (T) image data.Capture at least one sweep trace L-L ' of this test piece colour developing pattern image data 60.According to this sweep trace L-L ', the graph of a relation of individual pixel value indivedual corresponding image positions of controlled vitta (C) and at least one target vitta (T) with it, as shown in Figure 7.Then, try to achieve a chromogenic reaction value R of this target vitta (T) according to formula (I):
R={(M-B)/(A-B)}×100% (I),
Wherein A is one with reference to mean value, the mean value of several pixel values of the light bottom surface of corresponding this strip test piece of image position of the image position of adjacent control vitta (C) and adjacent target vitta (T); For example, with reference to the mean value of several pixel values of the A2 section of the light bottom surface of the corresponding strip test piece of image position one side (T) of several pixel values of the A1 section of the light bottom surface of corresponding this strip test piece of image position one side of the desirable control vitta of mean value A (C) and target vitta (T); B is the image position pixel value of control vitta (C) and the mean value of adjacent several pixel values thereof, and M is the image position pixel value of target vitta (T) and the mean value of adjacent several pixel values thereof.In this test piece colour developing pattern image analytical approach, as the image position pixel value of control vitta (C) and the mean value B of adjacent several pixel values thereof during less than a predetermined pixel value, the positive reaction of chromogenic reaction of representative control vitta (C), be the position of tested fluid sample through all target vittas in the strip test piece, then, try to achieve the chromogenic reaction value R of target vitta just according to formula (I).When chromogenic reaction value R is not less than a predetermined value, be made as the positive reaction of chromogenic reaction of this target vitta, contain this target vitta corresponding one specific composition in the promptly tested fluid sample.As chromogenic reaction value R during, be made as the specific composition that the chromogenic reaction institute desire of this target vitta detects and be not present in the tested fluid sample less than this predetermined value.
The above is specific embodiments of the invention only, is not in order to limit protection scope of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the scope of claims.