CN1496744A - Soup syringe - Google Patents
Soup syringe Download PDFInfo
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- CN1496744A CN1496744A CNA2003101013956A CN200310101395A CN1496744A CN 1496744 A CN1496744 A CN 1496744A CN A2003101013956 A CNA2003101013956 A CN A2003101013956A CN 200310101395 A CN200310101395 A CN 200310101395A CN 1496744 A CN1496744 A CN 1496744A
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- medicinal liquid
- drug solution
- pressurization
- switching device
- solution injector
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Abstract
Provided is a drug solution injection tool that is applicable for many hours without using any large-sized battery to continue the stable injection of the drug solution at a predetermined fixed injection speed, irrespective of the kinds and temperatures of the drug solution to be injected. The drug solution injection tool comprises a pressured drug solution dispensing means, a secondary pressure means in which the drug solution communicates with the pressured drug solution dispensing means via an upstream side channel, an upstream side open/close means located at the upstream side channel and opening or closing drug solution communication between the pressured drug solution dispensing means and the secondary pressure means, a downstream side open/close means located at a downstream side channel provided at the downstream side of the secondary pressure means, and a control means for controlling the open/close timing of the upstream and downstream side open/close means.
Description
Technical field
The present invention relates to blood vessel, epidural space, the drug solution injector with a small amount of administering medical liquids such as subcutaneous.The present invention be more particularly directed to a kind of drug solution injector, be not subjected to the influence of medicinal liquid kind and ambient temperature, can long-term stability provide predefined injection rate.
Background technology
In medicinal liquids such as antibiotics, anticancer preparation, anesthetis, having need be to the material of blood vessel, epidural space, long-time a small amount of administration such as subcutaneous.As the drug solution injector that uses in such medication, known in the past have a syringe pump type, uses power such as motor slowly to push the plunger of syringe and inject medicinal liquid; With the occlusion pump type, with roller slowly extruding extrude medicinal liquid as the body of medicinal liquid path.These drug solution injectors owing to use electric power, need large-sized battery when long-time the use.Therefore, it is heavy that utensil itself becomes, and has the shortcoming that is unfavorable for that the patient carries.In addition, because these medicinal liquid utensil structure complexity have the high shortcoming of price.
In view of the foregoing, also proposed not use electrodynamic drug solution injector.For example, the drug solution injector of record in patent documentation 1 described later connects the flow controlling unit that is made of thin diameter tube in pressurization medicinal liquid generators such as aryballos.In this drug solution injector, during the flow controlling unit of the medicinal liquid of extruding from aryballos by constituting, because the pipe resistance of thin diameter tube can be controlled in predefined certain injection rate by thin diameter tube.
But, utilize the flow-control of the pipe resistance of thin diameter tube like this, be subjected to the very big influence of medicinal liquid viscosity.That is, because the flow F of the medicinal liquid by thin diameter tube defers to Kazakhstan root-Poiseuille law (with reference to following formula 1), so be inversely proportional to the medicinal liquid viscosities il.
In the formula, F: the flow (cm of medicinal liquid
3/ sec)
G: acceleration of gravity (980cm/s)
P: to medicinal liquid applied pressure (kPa)
η: medicinal liquid viscosity (g/cms)
L: the length of thin diameter tube (cm)
π: pi
On the other hand, the viscosity of medicinal liquid is deferred to the character of general fluid, and temperature high viscosity more is low more.Therefore, if the temperature height of medicinal liquid, the flow of medicinal liquid is inversely proportional to it and becomes big.For example, under the situation as the fluorouracil of anti-malignant tumor preparation, be that 1.273g/cms compares with viscosity under 25 ℃, the viscosity degradation under 32 ℃ is to 1.084g/cms.Thereby, under the situation of fluorouracil, to compare during with 25 ℃, the flow under 32 ℃ has approximately become big 17.4%.
In addition, the viscosity of medicinal liquid is different because of the kind of medicinal liquid.For example, the viscosity of described fluorouracil under 25 ℃ is 1.273g/cms, but is 0.898g/cms as the viscosity of cisplatin under 25 ℃ of anti-malignant tumor platinum complex.Thereby because of the difference of medicinal liquid, the flow of medicinal liquid also changes.
Like this, in pressurization medicinal liquid generator, connect the drug solution injector of the flow controlling unit that constitutes by thin diameter tube, change, have the shortcoming that can not get predefined certain injection rate according to the kind of medicinal liquid and the viscosity of temperature medicinal liquid.
In sum, known in the past drug solution injector does not use large-sized battery if having, and then can not use for a long time, or the medicinal liquid injection rate is subjected to the shortcoming of medicinal liquid kind and Temperature Influence.
Te Kaiping 2-11160 communique
Summary of the invention
The present invention finishes in view of the present situation of prior art, and its purpose is to provide a kind of drug solution injector, does not have the shortcoming that known in the past drug solution injector has.Specifically, the invention provides a kind of drug solution injector,, also can use for a long time, and be not subjected to medicinal liquid kind and Temperature Influence, can keep predefined certain injection rate and the stable medicinal liquid that injects even do not use large-sized battery.
The present inventor has carried out wholwe-hearted research in order to solve above-mentioned problem, it found that, by pressurization medicinal liquid generator be connected in the drug solution injector that the flow controlling unit on this device constitutes, as flow controlling unit, do not use thin diameter tube and carry out flow-control by new machinery, can solve above-mentioned problem, thereby finish the present invention.
That is, drug solution injector of the present invention is characterized in that, comprises with lower device (1)～(5):
(1) pressurization medicinal liquid generator is exerted pressure to medicinal liquid, and the messenger drug liquid stream is gone in 1 path;
(2) 2 medicinal liquid pressue devices, be communicated with aforementioned pressurization medicinal liquid generator medicinal liquid by 1 path, wherein 1 path has the size of the medicinal liquid that can accept self-pressurization medicinal liquid generator, and applies low pressure to medicinal liquid, this low pressure less than pressurization medicinal liquid generator to the medicinal liquid applied pressure;
(3) upstream side switching device is arranged in aforementioned 1 path, and being used for the aforementioned pressurization medicinal liquid of switch provides medicinal liquid connected state with aforementioned 2 medicinal liquid pressue devices;
(4) downstream switching device is arranged on 2 paths that are connected setting with the downstream of aforementioned 2 medicinal liquid pressue devices; With
(5) control unit is used to control the timing of the switch of aforementioned upstream side switching device and aforementioned downstream switching device.
According to the preferred embodiment of the present invention, the medicinal liquid pressurization means of pressurization medicinal liquid generator are that rubber elastomer, spring or air are pressed.
According to of the present invention another preferred embodiment, the medicinal liquid pressurization means of 2 medicinal liquid pressue devices are that rubber elastomer, spring or air are pressed.
According to of the present invention another preferred embodiment, upstream side switching device and downstream switching device are for using the one-piece type of solenoid valve type, pressing plate type or plug.
Description of drawings
Fig. 1 is the ideograph of an embodiment of expression drug solution injector of the present invention.
Fig. 2 is that the medicinal liquid of the drug solution injector of presentation graphs 1 illustrated embodiment injects the key diagram of action.
Fig. 3 is the ideograph of another embodiment of expression drug solution injector of the present invention.
Fig. 4 is the ideograph of another embodiment of expression drug solution injector of the present invention.
Fig. 5 is the ideograph of another embodiment of expression drug solution injector of the present invention.
Fig. 6 for expression from directly over see the ideograph of flow controlling unit of the drug solution injector of Fig. 5 illustrated embodiment.
Fig. 7 is the ideograph of another embodiment of expression drug solution injector of the present invention.
Fig. 8 is that the medicinal liquid of the drug solution injector of presentation graphs 7 illustrated embodiment injects the key diagram of action.
The specific embodiment
Below, utilize description of drawings drug solution injector of the present invention, but the present invention is not defined to these.
Fig. 1 is the ideograph of an embodiment of expression drug solution injector of the present invention.Drug solution injector of the present invention comprises the periodic control unit 7 of switch of pressurization medicinal liquid generator 1,2 medicinal liquid pressue devices 5, upstream side switching device 3, downstream switching device 4, the aforementioned upstream side switching device of control and downstream switching device.In embodiment shown in Figure 1, pressurization medicinal liquid generator 1 is connected by 1 path 2 with 2 medicinal liquid pressue devices 5, also is provided with path 62 times in the downstream of 2 medicinal liquid pressue devices 5.
In drug solution injector of the present invention, pressurization medicinal liquid generator 1 stores medicinal liquid, and has to this medicinal liquid and exert pressure and with its function of extruding to 2 medicinal liquid pressue devices 5.As pressurization medicinal liquid generator 1, for example can use the aryballos of the contractility that utilizes rubber elastomer.Medicinal liquid is stored in the expansible aryballos.Aryballos shrink according to the natural agent of caoutchouc elasticity aryballos, and medicinal liquid is extruded to 2 medicinal liquid pressue device 5 sides.Utilize the syringe of spring also to can be used as 1 use of pressurization medicinal liquid generator.Medicinal liquid is stored in syringe inside, uses the plunger of subsidiary rubber-like spring, extrudes from syringe.Also can use the pressurized tank of utilizing air to press.Pressurized tank is made by softish plastic sheeting, leaves in the hard container.Medicinal liquid is stored in the casing, imports air to hard container and makes the casing pressurization and medicinal liquid is extruded from casing.Also can use the casing of the medicinal liquid of will packing into to utilize the mechanical devices that pressurize of pump such as infusion pump.The medicinal liquid of pressurization medicinal liquid generator 1 pressurizes, and preferably sets to become to make medicinal liquid to be forced into about 50～100kPa, extrudes to 2 medicinal liquid pressue device 5 sides.
In drug solution injector of the present invention, No. 2 pressue devices 5 and pressurization medicinal liquid generator 1 are communicated with by medicinal liquid by 1 path 2, and the medicinal liquid that provides from pressurization medicinal liquid generator 1 is provided for the moment, and afterwards, side is extruded by pressurizeing downstream.2 medicinal liquid pressue devices 5 as shown in Figure 1 are made of spring 51, packing ring 52 and cylinder 53, utilize the elastic force of spring to produce internal pressure.Other examples as 2 medicinal liquid pressue devices, can exemplify the thermoplasticity sheet material 54 that replaces packing ring that vinyl chloride, silicone rubber, thermoplastic elastomer etc. are set as shown in Figure 3, produce the device of internal pressure by extrusion spring 51, or it is the device of use rubber elastomer aryballos as shown in Figure 4, but unqualified in these devices.Exert pressure (internal pressure) of No. 2 pressue devices 5 compared with exerting pressure of pressurization medicinal liquid generator 1, sets for little by about 10～20% usually.Therefore, medicinal liquid can flow into No. 2 pressue devices 5 from pressurization medicinal liquid generator 1.
In drug solution injector of the present invention, upstream side switching device 3 is arranged on 1 path 2, has the function of the medicinal liquid connected state of switch pressurization medicinal liquid generator 1 and 2 medicinal liquid pressue devices 5.In addition, in drug solution injector of the present invention, downstream switching device 4 is arranged on 2 paths 6 in 2 medicinal liquid pressue device 5 downstreams, has the function of the medicinal liquid connected state of 2 medicinal liquid pressue devices 5 of switch and 2 paths 6.Consider the least possible device of switch motion energy of preferred upstream side switching device 3 and downstream switching device 4 from the angle that can use for a long time.In addition, upstream side switching device 3 and downstream switching device 4 are unqualified in different devices, also can be devices that has two functions simultaneously.Upstream side switching device 3 as shown in Figure 1 and downstream switching device 4,1 time of solenoid valve type and 2 paths 2 and 6 preferable material are thermoplasticity bodys such as polrvinyl chloride, polyethylene, polybutadiene, silicon.The preferred internal diameter of body is about 0.5mm～5mm.Flowing of medicinal liquid do not limited in 1 time and 2 paths 2 and 6.
In drug solution injector of the present invention, control unit 7 has the periodic function of switch of control upstream side switching device 3 and downstream switching device 4.By the periodic control of this switch, in drug solution injector of the present invention, can reach the medicinal liquid injection rate of regulation.
Below, illustrate that with reference to Fig. 2 the medicinal liquid of an embodiment of drug solution injector of the present invention shown in Figure 1 injects action.
As mentioned above, drug solution injector of the present invention injects medicinal liquid by utilizing the switch timing of control unit 7 control upstream side switching devices 3 and downstream switching device 4.
Upstream side switching device 3 is opened, and under downstream switching device 4 closing state, when medicinal liquid injects the action beginning (Fig. 2 (a)), because exert pressure (internal pressure) of 2 medicinal liquid pressue devices 5 sets exerting pressure less than pressurization medicinal liquid generator 1 for, so medicinal liquid flows into 2 medicinal liquid pressue device 5 inside from pressurization medicinal liquid generator 1, and is stored in medicinal liquid pressue device 5 inside 2 times.At this moment, because the capacity of No. 2 pressue devices 5 is very little, come the self-pressurization medicinal liquid to provide accurate height to refer to 1 medicinal liquid after the beginning medicinal liquid injects action, moment is filled 2 medicinal liquid pressue device 5 inside in fact, becomes as state as described in Fig. 2 (b).
Medicinal liquid is after the end-of-fill of 2 medicinal liquid pressue device 5 inside, and upstream side switching device 3 cuts out, and becomes state shown in Fig. 2 (c).
Then open downstream switching device 4 (Fig. 2 (d)), the medicinal liquid that is stored in 2 medicinal liquid pressue device 5 inside is provided in the patient because exert pressure (internal pressure) of 2 medicinal liquid pressue devices 5 is extruded by 2 paths 6.At this moment, because the capacity of 2 medicinal liquid pressue devices 5 is very little, and 2 medicinal liquid pressue devices 5 are exerted pressure to medicinal liquid, so be stored in the medicinal liquid of 2 medicinal liquid pressue device 5 inside, when downstream switching device 4 is opened, moment property is all emitted to 2 paths 6 in fact, becomes the state shown in Fig. 2 (e).
Medicinal liquid is emitted after the end from 2 medicinal liquid pressue device 5 inside, and downstream time switching device 4 cuts out, and becomes the state shown in Fig. 2 (f) once more.
As mentioned above, by a series of actions that repeats to inject medicinal liquid on a small quantity and routinely to the patient, drug solution injector of the present invention is the stable medicinal liquid that injects under the condition that can keep certain injection rate.For example, the internal capacity of 2 medicinal liquid pressue devices 5 is under the situation of 0.05ml, repeats this medicinal liquid in 1 minute 1 time ratio and injects action, can inject 0.05ml in 1 minute to the patient, the medicinal liquid of 3ml in 1 hour.In addition, be similarly under the situation of 0.05ml, inject action, then can inject 0.1ml in 1 minute, the medicinal liquid of 6ml in 1 hour to the patient if in 1 minute, repeat 2 medicinal liquids at the internal capacity of 2 medicinal liquid pressue devices 5.
Thereby drug solution injector of the present invention by the switch timing of control unit control upstream side switching device and downstream switching device, can be controlled medicinal liquid injection rate (the interior amount of liquid medicine to patient's administration of time per unit).
The invention effect
Drug solution injector of the present invention, different with the existing drug solution injector that on pressurization medicinal liquid generators such as aryballos, connects the flow controlling unit that constitutes by thin diameter tube, control medicinal liquid injection rate (flow) under the situation of the pipe resistance of not utilizing thin diameter tube, even, also can keep predefined certain injection rate so medicinal liquid viscosity changes owing to the variation of medicinal liquid kind and fluid temperature.In addition, drug solution injector of the present invention, to extrude the existing drug solution injector of power different with utilizing electric energy to produce medicinal liquid, do not need electric energy fully, even or need, also just control unit is used for the electric energy of switch upstream side switching device and downstream switching device.Thereby, use even drug solution injector of the present invention is long-time, do not need large-sized battery yet, can reach the lightweight of pump itself.Therefore, drug solution injector of the present invention has the patient of helping and carries, cheap advantage.
Claims (10)
1. a drug solution injector is characterized in that, comprising:
Pressurization medicinal liquid generator is exerted pressure to medicinal liquid, and the messenger drug liquid stream is gone into path 1 time;
2 medicinal liquid pressue devices, be communicated with described pressurization medicinal liquid generator medicinal liquid by 1 path, wherein 1 path has the size of the medicinal liquid that can accept self-pressurization medicinal liquid generator, and applies low pressure to medicinal liquid, this low pressure less than pressurization medicinal liquid generator to the medicinal liquid applied pressure;
The upstream side switching device is arranged in described 1 path, and being used for the described pressurization medicinal liquid of switch provides medicinal liquid connected state with described 2 medicinal liquid pressue devices;
The downstream switching device is arranged on 2 paths that are connected setting with the downstream of described 2 medicinal liquid pressue devices; With
Control unit is used to control the timing of the switch of described upstream side switching device and described downstream switching device.
2. drug solution injector according to claim 1 is characterized in that, the medicinal liquid pressurization means of pressurization medicinal liquid generator are rubber elastomer.
3. drug solution injector according to claim 1 is characterized in that, the medicinal liquid pressurization means of pressurization medicinal liquid generator are spring.
4. drug solution injector according to claim 1 is characterized in that, the medicinal liquid pressurization means of pressurization medicinal liquid generator are that air is pressed.
5. according to each described drug solution injector of claim 1～4, it is characterized in that the medicinal liquid pressurization means of 2 medicinal liquid devices are rubber elastomer.
6. according to each described drug solution injector of claim 1～4, it is characterized in that the medicinal liquid pressurization means of 2 medicinal liquid devices are spring.
7. according to each described drug solution injector of claim 1～4, the medicinal liquid pressurization means that it is characterized in that 2 medicinal liquid devices are that air is pressed.
8. according to each described drug solution injector of claim 1～7, it is characterized in that upstream side switching device and downstream switching device are electromagnetic valve.
9. according to each described drug solution injector of claim 1～7, it is characterized in that upstream side switching device and downstream switching device are pressing plate.
10. according to each described drug solution injector of claim 1～7, it is characterized in that upstream side switching device and downstream switching device are plug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101013956A CN1496744A (en) | 2002-10-18 | 2003-10-17 | Soup syringe |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP304057/2002 | 2002-10-18 | ||
| CNA2003101013956A CN1496744A (en) | 2002-10-18 | 2003-10-17 | Soup syringe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1496744A true CN1496744A (en) | 2004-05-19 |
Family
ID=34256505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101013956A Pending CN1496744A (en) | 2002-10-18 | 2003-10-17 | Soup syringe |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1496744A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103260673A (en) * | 2010-12-15 | 2013-08-21 | 金伯利-克拉克环球有限公司 | Improved large-olume bolus patient controlled drug administration device |
| CN111432860A (en) * | 2017-12-08 | 2020-07-17 | 先进微流控技术股份公司 | Drug delivery device |
| CN108289999B (en) * | 2015-12-10 | 2020-12-01 | 尼普洛株式会社 | Liquid medicine injection device |
-
2003
- 2003-10-17 CN CNA2003101013956A patent/CN1496744A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103260673A (en) * | 2010-12-15 | 2013-08-21 | 金伯利-克拉克环球有限公司 | Improved large-olume bolus patient controlled drug administration device |
| CN103260673B (en) * | 2010-12-15 | 2015-07-29 | 金伯利-克拉克环球有限公司 | The doser of the patient-controlled of the large unit dosage form improved |
| CN108289999B (en) * | 2015-12-10 | 2020-12-01 | 尼普洛株式会社 | Liquid medicine injection device |
| CN111432860A (en) * | 2017-12-08 | 2020-07-17 | 先进微流控技术股份公司 | Drug delivery device |
| CN111432860B (en) * | 2017-12-08 | 2023-08-08 | 坦德姆糖尿病护理瑞士有限责任公司 | Drug delivery device |
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